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1. 发明申请

WO2019070802A1 USE OF NOVEL BIOMARKERS IN THE DIAGNOSIS, CONFIRMATION, AND TREATMENT OF PARKINSON'S DISEASE 审中-公开
公开(公告)号：WO2019070802A1
公开(公告)日：2019-04-11
申请号：PCT/US2018/054093
申请日：2018-10-03
申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK , THE RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC. , LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY , SULZER, David , SETTE, Alessandro , PETERS, Bjoern , LINDESTAM ARLEHAMN, Cecilia
发明人： SULZER, David , SETTE, Alessandro , PETERS, Bjoern , LINDESTAM ARLEHAMN, Cecilia
IPC分类号： C07K14/705 , C12Q1/6809 , G01N33/50
摘要： The present invention provides methods for assessing whether a subject is at risk of developing Parkinson's disease (PD), diagnosing or confirming whether a subject is afflicted with PD, assessing whether PD has progressed in a subject afflicted with PD, assessing whether PD is developing in a subject who has been identified as being at risk of developing PD, assessing whether a subject afflicted with PD is likely to benefit from a therapy, assessing whether a subject afflicted with PD has benefited from a therapy, treating a subject afflicted with PD, and prophylactically treating a subject who has been identified as being at risk of developing PD. The present invention also provides biomarkers relating to these methods.

2. 发明申请

WO2019070813A2 USE OF PEPTIDES AS BIOMARKERS IN THE DIAGNOSIS, CONFIRMATION AND TREATMENT OF A NEUROLOGICAL DISORDER 审中-公开
公开(公告)号：WO2019070813A2
公开(公告)日：2019-04-11
申请号：PCT/US2018/054109
申请日：2018-10-03
申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK , THE RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC. , LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY , SULZER, David , SETTE, Alessandro
发明人： SULZER, David , SETTE, Alessandro
摘要： The present invention provides methods for assessing whether a subject is at risk of developing a neurological disorder, diagnosing or confirming whether a subject is afflicted with a neurological disorder, assessing whether PD has progressed in a subject afflicted with PD, assessing whether a neurological disorder is developing in a subject who has been identified as being at risk of developing the neurological disorder, assessing whether a subject afflicted with a neurological disorder is likely to benefit from a therapy, assessing whether a subject afflicted with a neurological disorder has benefited from a therapy, treating a subject afflicted with a neurological disorder, and prophylactically treating a subject who has been identified as being at risk of developing a neurological disorder. The present invention also provides epitopes, compounds and compositions relating to these methods.

3. 发明申请

WO2019070813A3 USE OF PEPTIDES AS BIOMARKERS IN THE DIAGNOSIS, CONFIRMATION AND TREATMENT OF A NEUROLOGICAL DISORDER 审中-公开
公开(公告)号：WO2019070813A3
公开(公告)日：2019-04-11
申请号：PCT/US2018/054109
申请日：2018-10-03
申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK , THE RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC. , LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY , SULZER, David , SETTE, Alessandro
发明人： SULZER, David , SETTE, Alessandro
IPC分类号： A61K38/00 , A61K39/00
摘要： The present invention provides methods for assessing whether a subject is at risk of developing a neurological disorder, diagnosing or confirming whether a subject is afflicted with a neurological disorder, assessing whether PD has progressed in a subject afflicted with PD, assessing whether a neurological disorder is developing in a subject who has been identified as being at risk of developing the neurological disorder, assessing whether a subject afflicted with a neurological disorder is likely to benefit from a therapy, assessing whether a subject afflicted with a neurological disorder has benefited from a therapy, treating a subject afflicted with a neurological disorder, and prophylactically treating a subject who has been identified as being at risk of developing a neurological disorder. The present invention also provides epitopes, compounds and compositions relating to these methods.

4. 发明申请

WO2018226590A1 PEPTIDES AS BIOMARKERS IN THE DIAGNOSIS, CONFIRMATION AND TREATMENT OF A NEUROLOGICAL DISORDER AND IMMUNOPROFILING IN NEURODEGENERATIVE DISEASE 审中-公开
公开(公告)号：WO2018226590A1
公开(公告)日：2018-12-13
申请号：PCT/US2018/035870
申请日：2018-06-04
申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK , LA JOLLA INSTITUTE FOR ALLERGY & IMMUNOLOGY , THE RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC. , SULZER, David , SETTE, Alessandro , ARLEHAMN, Cecilia Lindestam , PHAM, John , PETERS, Bjoern
发明人： SULZER, David , SETTE, Alessandro , ARLEHAMN, Cecilia Lindestam , PHAM, John , PETERS, Bjoern
IPC分类号： G01N33/68 , A61K39/00 , G01N33/569
摘要： The present invention provides methods for assessing whether a subject is at risk of developing a neurological disorder, diagnosing or confirming whether a subject is afflicted with a neurological disorder, assessing a neurological disorder is developing in a subject who has been identified as being at risk of developing the neurological disorder, assessing whether a subject afflicted with a neurological disorder is likely to benefit iron a therapy, assessing whether a subject afflicted with a neurological disorder has benefited from a therapy, treating a subject afflicted with a neurological disorder, and prophylactically treating a subject who has been identified as being at risk, of developing a neurological disorder. The present invention also provides epitopes, compounds and compositions relating to these methods.

5. 发明申请

WO2018236986A1 ENGINEERED T-CELL RECEPTORS AND METHODS OF THEIR USE 审中-公开
公开(公告)号：WO2018236986A1
公开(公告)日：2018-12-27
申请号：PCT/US2018/038478
申请日：2018-06-20
申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK , LA JOLLA INSTITUTE FOR ALLERGY & IMMUNOLOGY , THE RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC. , SULZER, David , HO, Patrick , SETTE, Alessandro , PETERS, Bjoern
发明人： SULZER, David , HO, Patrick , SETTE, Alessandro , PETERS, Bjoern
IPC分类号： A61K39/00 , A61K39/395 , A61P25/28
CPC分类号： A61P25/28 , A61K2039/5156 , A61K2039/5158 , C07K14/7051 , C07K16/18 , C07K16/2833 , C07K2317/32 , C07K2317/34 , C07K2319/03
摘要： Novel engineered T-cell receptors including modified TCRs and CARs targeting disease-relevant antigen-MHCs are disclosed. Also provided are novel methods for treating diseases or conditions related to inflammation and/or neurodegenerative disorders.

6. 发明申请

WO2015157117A2 USE OF LEUKOCYTES AND NOVEL BIOMARKERS IN THE DIAGNOSIS, CONFIRMATION, AND TREATMENT OF A NEUROLOGICAL DISORDER 审中-公开
标题翻译：白血病和新生物标志物在神经病学诊断，确认和治疗中的应用
公开(公告)号：WO2015157117A2
公开(公告)日：2015-10-15
申请号：PCT/US2015/024310
申请日：2015-04-03
申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK , JA JOLLA INSTITUTE FOR ALLERGY & IMMUNOLOGY , SULZER, David , SETTE, Alessandro
发明人： SULZER, David , SETTE, Alessandro
IPC分类号： A61K39/395
CPC分类号： G01N33/6896 , A61K39/0007 , A61K2039/577 , A61K2039/605 , G01N33/56972 , G01N2800/2814 , G01N2800/2821 , G01N2800/2835 , G01N2800/50 , G01N2800/52
摘要： The present invention provides methods for assessing whether a subject is at risk of developing a neurological disorder, diagnosing or confirming whether a subject is afflicted with a neurological disorder, assessing whether PD has progressed in a subject afflicted with PD, assessing whether a neurological disorder is developing in a subject who has been identified as being at risk of developing the neurological disorder, assessing whether a subject afflicted with a neurological disorder is likely to benefit from a therapy, assessing whether a subject afflicted with a neurological disorder has benefited from a therapy, treating a subject afflicted with a neurological disorder, and prophylactically treating a subject who has been identified as being at risk of developing a neurological disorder. The present invention also provides epitopes, compounds and compositions relating to these methods.
摘要翻译：本发明提供了评估受试者是否处于发展神经障碍风险，诊断或确认受试者是否患有神经障碍的评估方法，评估PD是否在患有PD的受试者中进展，评估神经障碍是否为发展成被认定有发展神经系统疾病风险的受试者，评估患有神经系统疾病的受试者是否可能受益于治疗，评估患有神经障碍的受试者是否受益于治疗，治疗患有神经障碍的受试者，以及预防性治疗被鉴定为存在发展神经障碍风险的受试者。本发明还提供与这些方法相关的表位，化合物和组合物。

7. 发明申请

WO2009097144A1 MOLECULAR PROBES FOR PET-IMAGING OF DOPAMINE NEUROTRANSMISSION AND NEUROENDOCRINE PROCESSES IN VIVO 审中-公开
标题翻译：多巴胺神经递质和血管内皮细胞过程中PET成像的分子探针
公开(公告)号：WO2009097144A1
公开(公告)日：2009-08-06
申请号：PCT/US2009/000630
申请日：2009-01-30
申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK , SAMES, Dalibor , GUBERNATOR, Niko , VADOLA, Paul , HU, Gang , SULZER, David , SLIFSTEIN, Mark , ABI-DARGHAM, Anissa , LEUNG, David
发明人： SAMES, Dalibor , GUBERNATOR, Niko , VADOLA, Paul , HU, Gang , SULZER, David , SLIFSTEIN, Mark , ABI-DARGHAM, Anissa , LEUNG, David
IPC分类号： A61K31/54 , A61K31/535 , A61K31/497
CPC分类号： C07D491/052 , C07B59/002 , C07D311/16
摘要： The present invention relates to compounds of the general structure (I), wherein Y is O, X is O, bond alpha is absent and bond beta is present, or, Y is H, X is CH, bond alpha is present, and bond beta is is absent, atom Z is a carbon and bonds X, delta and gamma are present, or atom Z is a nitrogen and bonds X, delta and gamma are absent, or atom Z is a nitrogen and bonds X and delta are present and gamma is absent R1, R2, R3, R4, R5 and R6 are various subtitutents as described in the specification.
摘要翻译：本发明涉及通式（I）的化合物，其中Y为O，X为O，不存在α键且存在键β，或Y为H，X为CH，键α为键， β是不存在的，原子Z是碳并且键X，δ和γ存在，或者原子Z是氮并且键X，δ和γ不存在，或者原子Z是氮并键合X和δ存在， γ不存在R1，R2，R3，R4，R5和R6是说明书中所述的各种残基。

8. 发明申请

WO2012064854A1 USE OF GLYCINE UPTAKE INHIBITORS FOR PARKINSON'S DISEASE THERAPY 审中-公开
标题翻译：用于帕金森病治疗的甘油摄取抑制剂的使用
公开(公告)号：WO2012064854A1
公开(公告)日：2012-05-18
申请号：PCT/US2011/059989
申请日：2011-11-09
申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK , SULZER, David , SCHMITZ, Yvonne , SAMES, Dalibor
发明人： SULZER, David , SCHMITZ, Yvonne , SAMES, Dalibor
IPC分类号： A61K38/00 , C12N5/07 , C12N5/16
CPC分类号： C12N5/0619 , A61K31/223 , A61K31/451 , C12N2501/84
摘要： This invention demonstrates a new approach for Parkinson' s disease therapy: rather than focusing on cell survival, our approach focuses on promoting reinnervation of the brain areas that are depleted of dopamine from adjacent areas that survive in the disease. We found that glycine uptake inhibitors enhance NMDA receptor-dependent transmission and promote the striatal dopaminergic reinnervation by altering activity and synaptic transmission while reducing neurotoxicity in a toxin- based mouse model of PD. Disclosed are methods for promoting functional regeneration and sprouting of striatal dopaminergic fibers. Also disclosed are method for treating a disease comprises administering to a subject a compound which promotes functional regeneration and sprouting of striatal dopaminergic fibers.
摘要翻译：本发明展示了帕金森病治疗的新方法：而不是侧重于细胞存活，我们的方法侧重于促进从疾病中存活的相邻区域中消耗多巴胺的脑区域的重塑。我们发现甘氨酸摄取抑制剂通过改变活性和突触传递来增强NMDA受体依赖性传递并促进纹状体多巴胺能神经保护，同时减少基于毒素的PD小鼠模型中的神经毒性。公开了促进纹状体多巴胺能纤维功能再生和发芽的方法。还公开了治疗疾病的方法，包括向受试者施用促进纹状体多巴胺能纤维的功能性再生和发芽的化合物。

9. 发明申请

WO2011094560A1 PH RESPONSIVE FLUORESCENT FALSE NEUROTRANSMITTERS AND THEIR USE 审中-公开
标题翻译： PH反应性荧光假神经递质及其使用
公开(公告)号：WO2011094560A1
公开(公告)日：2011-08-04
申请号：PCT/US2011/022951
申请日：2011-01-28
申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK , SAMES, Dalibor , SULZER, David , LEE, Minhee , GUBERNATOR, Niko
发明人： SAMES, Dalibor , SULZER, David , LEE, Minhee , GUBERNATOR, Niko
IPC分类号： A01N43/16 , A61K31/35
CPC分类号： G01N21/6486 , C07D311/16
摘要： This invention relates to compounds having the following structure: wherein Y is O, X is O, bond α is absent and bond β is present, or Y is H, X is CH, bond α is present, and bond β is absent; atom Z is a carbon and bonds χ, δ and γ are present, or atom Z is a nitrogen and bonds χ, δ and γ are absent, or atom Z is a nitrogen and bonds χ and δ are present and γ is absent. R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 are various substituents as described in the specification.
摘要翻译：本发明涉及具有以下结构的化合物：其中Y为O，X为O，不存在键a，键ß存在，或Y为H，X为CH，存在键a，键ß不存在; 原子Z是碳并键合α，d和？或原子Z是氮并键合α，d和β 不存在，或原子Z为氮并键合？和d存在和？缺席。 R1，R2，R3，R4，R5和R6是说明书中所述的各种取代基。

10. 发明申请

WO2008013997A2 FLUORESCENT SUBSTRATES FOR MONOAMINE TRANSPORTERS AS OPTICAL FALSE NEUROTRANSMITTERS 审中-公开
标题翻译：单色运输机荧光底物作为光学神经递质
公开(公告)号：WO2008013997A2
公开(公告)日：2008-01-31
申请号：PCT/US2007/017014
申请日：2007-07-27
申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK , GUBERNATOR, Niko, Gert , SAMES, Dalibor , SULZER, David , VADOLA, Paul
发明人： GUBERNATOR, Niko, Gert , SAMES, Dalibor , SULZER, David , VADOLA, Paul
IPC分类号： C07D491/14
CPC分类号： C07D493/16 , C07D219/06 , C07D309/30 , C07D311/16 , C07D491/16
摘要： The present invention relates to compounds of the general structure: wherein Y is O, X is O, bond α is absent and bond β is present, or Y is H, X is CH, bond α is present, and bond β is absent; atom Z is a carbon and bonds χ , δ and γ are present, or is a nitrogen and bonds χ , δ and γ are absent; R 1 is -H, -OH, -O-R 7 , -N(H) -R 8 , -N (H) - (CH 2 ) n -NH 2 , -N(R 9 ) (R 10 ), or a piperazine cation; R 2 is either covalently bound to R 9 , or is -H, or is covalently bound to R 3 so as to form a substituted or unsubstituted pyrrole or R 2 is covalently bound to R 9 or R 8 or R 7 ; or R 1 and R 2 are covalently joined to form an aromatic ring; R 3 is either covalently bound to R 2 so as to form a pyrrole, or is, inter alia, -H, -OH, alkyl, or when Z is nitrogen R 3 is =O; R 4 is, inter alia, -H, -OH, or -R 11 NH 2 ; R 5 is, inter alia, -H, -OH, or -R 12 NH 2 , and R 6 is either is covalently bound to R 10 or is -H, or R 6 is covalently bound to R 10 or R 8 or R 7 . This invention also provides processes for making the compounds as well as methods for monitoring activity of monoamine transporters or treating monoamine transporter-associated diseases by employing the compounds.
摘要翻译：本发明涉及通式结构的化合物：其中Y为O，X为O，不存在键a，键ß存在，或Y为H，X为CH，存在键a，键ß不存在; 原子Z是碳并键合α，d和？是否存在，或是氮并键合？，d和？不存在 R 1是-H，-OH，-OR 7，-N（H）-R 8，-N（H） - （ CH 2 N 2，-N（R 9）（R 10） SUB>）或哌嗪阳离子; R 2与R 9共价结合，或者是-H，或者共价键合到R 3，以便形成取代或未取代的未取代的吡咯或R 2 2共价键合到R 9或R 8或R 7上。或R 1和R 2 2共价连接形成芳香环; R 3共价结合到R 2上，以便形成吡咯，或者尤其是-H，-OH，烷基或当Z是氮时R 3 = O; 其中R 4尤其是-H，-OH或-R 11 NH 2; 特别地，R 5是-H，-OH或-R 12 NH 2，和R 6 N 2 >与R 10共价结合或为-H，或R 6共价结合R 10或R 8 或者R 7 。本发明还提供了制备该化合物的方法以及通过使用该化合物来监测单胺转运蛋白的活性或治疗单胺转运蛋白相关疾病的方法。

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