专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2020181129A1 HIGH ACCURACY NANOPORE-BASED SINGLE MOLECULE SEQUENCING BY SYNTHESIS WITH TAGGED NUCLEOTIDES 审中-公开
公开(公告)号：WO2020181129A1
公开(公告)日：2020-09-10
申请号：PCT/US2020/021253
申请日：2020-03-05
申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK , JU, Jingyue , FULLER, Carl, W. , KUMAR, Shiv , KALACHIKOV, Sergey , LI, Xiaoxu , MOROZOVA, Irina , RUSSO, James , JOCKUSCH, Steffen
发明人： JU, Jingyue , FULLER, Carl, W. , KUMAR, Shiv , KALACHIKOV, Sergey , LI, Xiaoxu , MOROZOVA, Irina , RUSSO, James , JOCKUSCH, Steffen
IPC分类号： G01N33/487 , C12Q1/6869 , C12Q1/6874 , C12N9/12 , C12M1/34 , C12P19/34 , C07H21/04
摘要： Disclosed herein are highly accurate approaches for single molecule electronic nanopore-based SBS.

2. 发明申请

WO2019178393A1 NUCLEOTIDE ANALOGUES AND USE THEREOF FOR NUCLEIC ACID SEQUENCING AND ANALYSIS 审中-公开
公开(公告)号：WO2019178393A1
公开(公告)日：2019-09-19
申请号：PCT/US2019/022326
申请日：2019-03-14
申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK , JU, Jingyue , LI, Xiaoxu , KUMAR, Shiv , CHEN, Xin , RUSSO, James, J. , CHIEN, Minchen , JOCKUSCH, Steffen , TAO, Chuanjuan , WANG, Xuanting , KALACHIKOV, Sergey , MOROZOVA, Irina , SHI, Shundi
发明人： JU, Jingyue , LI, Xiaoxu , KUMAR, Shiv , CHEN, Xin , RUSSO, James, J. , CHIEN, Minchen , JOCKUSCH, Steffen , TAO, Chuanjuan , WANG, Xuanting , KALACHIKOV, Sergey , MOROZOVA, Irina , SHI, Shundi
IPC分类号： A61K31/70 , A61K31/7042 , A61K31/7052 , C07H19/04 , C07H21/00 , C07H21/04
摘要： The invention provides various orthogonal nucleotide analogues and methods for using combinations of said various orthogonal nucleotide analogues for sequencing by synthesis.

3. 发明申请

WO2021007458A1 NOVEL NUCLEOTIDE ANALOGUES AND METHODS FOR USE 审中-公开
公开(公告)号：WO2021007458A1
公开(公告)日：2021-01-14
申请号：PCT/US2020/041455
申请日：2020-07-09
申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK , JU, Jingyue , KUMAR, Shiv , RUSSO, James , LI, Xiaoxu , CHEN, Xin , CHIEN, Minchen , JOCKUSCH, Steffen , WANG, Xuanting , MOROZOVA, Irina , TAO, Chuanjuan , KALACHIKOV, Sergey , SHI, Shundi
发明人： JU, Jingyue , KUMAR, Shiv , RUSSO, James , LI, Xiaoxu , CHEN, Xin , CHIEN, Minchen , JOCKUSCH, Steffen , WANG, Xuanting , MOROZOVA, Irina , TAO, Chuanjuan , KALACHIKOV, Sergey , SHI, Shundi
IPC分类号： C07H21/00 , C12Q1/6823 , C12Q1/6869
摘要： The invention provides various orthogonal nucleotide analogues and methods for using combinations of said various orthogonal nucleotide analogues for sequencing by synthesis.

4. 发明申请

WO2019178393A9 NUCLEOTIDE ANALOGUES AND USE THEREOF FOR NUCLEIC ACID SEQUENCING AND ANALYSIS 审中-公开
公开(公告)号：WO2019178393A9
公开(公告)日：2019-09-19
申请号：PCT/US2019/022326
申请日：2019-03-14
申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK , JU, Jingyue , LI, Xiaoxu , KUMAR, Shiv , CHEN, Xin , RUSSO, James, J. , CHIEN, Minchen , JOCKUSCH, Steffen , TAO, Chuanjuan , WANG, Xuanting , KALACHIKOV, Sergey , MOROZOVA, Irina , SHI, Shundi
发明人： JU, Jingyue , LI, Xiaoxu , KUMAR, Shiv , CHEN, Xin , RUSSO, James, J. , CHIEN, Minchen , JOCKUSCH, Steffen , TAO, Chuanjuan , WANG, Xuanting , KALACHIKOV, Sergey , MOROZOVA, Irina , SHI, Shundi
IPC分类号： A61K31/70 , A61K31/7042 , A61K31/7052 , C07H19/04 , C07H21/00 , C07H21/04
摘要： The invention provides various orthogonal nucleotide analogues and methods for using combinations of said various orthogonal nucleotide analogues for sequencing by synthesis.

5. 发明申请

WO2020023405A1 SINGLE-MOLECULE ELECTRONIC MULTIPLEX NANOPORE IMMUNOASSAYS FOR BIOMARKER DETECTION 审中-公开
公开(公告)号：WO2020023405A1
公开(公告)日：2020-01-30
申请号：PCT/US2019/042864
申请日：2019-07-22
申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK , JU, Jingyue , RUSSO, James, J. , KALACHIKOV, Sergey , TAO, Chuanjuan , KUMAR, Shiv , MOROZOVA, Irina , LI, Xiaoxu
发明人： JU, Jingyue , RUSSO, James, J. , KALACHIKOV, Sergey , TAO, Chuanjuan , KUMAR, Shiv , MOROZOVA, Irina , LI, Xiaoxu
IPC分类号： B82B3/00 , B82Y5/00 , C12Q1/68 , C12Q1/6869 , G01N27/00 , G01N27/26 , C12Q1/6804 , G01N33/48721 , G01N33/6872
摘要： The present application discloses novel and inventive methods, apparatuses, and the required molecules to detect compounds (analytes) utilizing antibodies or other protein-binding molecules and nanopore- detectable tags using specially designed nanopores, coupled with ionic current readout, to provide a single molecule electronic detection solution, offering unique opportunities for multiplexing and quantitation.

6. 发明申请

WO2017176677A1 FLOURESCENCE ENERGY TRANSFER-BASED SINGLE MOLECULE/ENSEMBLE DNA SEQUENCING BY SYNTHESIS 审中-公开
标题翻译：基于荧光能量转移的单分子/整合型DNA合成
公开(公告)号：WO2017176677A1
公开(公告)日：2017-10-12
申请号：PCT/US2017/025848
申请日：2017-04-04
申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
发明人： JU, Jingyue , KUMAR, Shiv , RUSSO, James, J. , JOCKUSCH, Steffen , LI, Zengmin , LI, Xiaoxu , KALACHIKOV, Sergey, M. , MOROZOVA, Irina
IPC分类号： B01L3/00 , C07G11/00 , C07H19/10 , C07H19/14
CPC分类号： C12Q1/6869 , C07H19/10 , C07H19/20
摘要： This invention provides nucleotide analogues each of which comprises a tag comprising one or more Forster resonance energy transfer (FRET) acceptor fluorophores, a nucleotide polymerase having one or more FRET donor fluorophores, and methods for sequencing single-stranded.
摘要翻译：本发明提供了各自包含含有一个或多个Forster共振能量转移（FRET）受体荧光团的标签，具有一个或多个FRET供体荧光团的核苷酸聚合酶的核苷酸类似物，链的。

7. 发明申请

WO2017176679A1 DNA SEQUENCING BY SYNTHESIS WITH NUCLEOTIDE ANALOGUES AND RAMAN DETECTION 审中-公开
标题翻译：与核苷类似物合成DNA测序和拉曼检测
公开(公告)号：WO2017176679A1
公开(公告)日：2017-10-12
申请号：PCT/US2017/025850
申请日：2017-04-04
申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
发明人： JU, Jingyue , KUMAR, Shiv , RUSSO, James, J. , JOCKUSCH, Steffen , LI, Zengmin , LI, Xiaoxu , KALACHIKOV, Sergey, M. , MOROZOVA, Irina
IPC分类号： A61K38/17 , A61K47/69
摘要： This invention provides nucleoside polyphosphate analogues each of which comprises a tag comprising a plurality of Raman-scattering moieties; compounds comprising said nucleoside polyphosphate analogs. This invention also provides nucleotide polymerases with one or more attached and/or conjugated noble metal nanoparticles, wherein the noble metal nanoparticles are surface-enhanced Raman spectroscopy (SERS) substrates thereby creating a region of enhanced sensitivity for surface enhanced Raman spectroscopy (SERS) within or adjacent to the polymerase. This invention also provides a surface with regions of enhanced sensitivity for surface enhanced Raman spectroscopy comprising interspersed rough or nanostructured noble metal surface. This invention also provides methods for determining the sequence of a single stranded DNA or RNA polynucleotide using one or more of nucleoside polyphosphate analogues, polymerase with noble metal nanoparticles, and surface with noble metal.
摘要翻译：本发明提供了核苷多磷酸盐类似物，其各自包含含有多个拉曼散射部分的标签; 包含所述核苷多磷酸盐类似物的化合物。本发明还提供了具有一种或多种附着和/或缀合的贵金属纳米颗粒的核苷酸聚合酶，其中贵金属纳米颗粒是表面增强拉曼光谱（SERS）基底，由此产生用于表面增强拉曼光谱学（SERS）的增强灵敏度的区域或与聚合酶相邻。本发明还提供了一种具有增强的敏感性区域的表面，用于表面增强拉曼光谱，包括散布的粗糙或纳米结构的贵金属表面。本发明还提供了使用核苷多磷酸类似物，具有贵金属纳米颗粒的聚合酶和具有贵金属表面的一种或多种来确定单链DNA或RNA多核苷酸的序列的方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式