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1. 发明申请

WO1995025126A1 ANTIBODIES TO INTERLEUKIN-8 RECEPTORS AND METHODS OF USE 审中-公开
标题翻译：白细胞介素-8受体的抗体及其使用方法
公开(公告)号：WO1995025126A1
公开(公告)日：1995-09-21
申请号：PCT/US1995003032
申请日：1995-03-09
申请人： REPLIGEN CORPORATION , THE TRUSTEES OF BOSTON UNIVERSITY
发明人： REPLIGEN CORPORATION , THE TRUSTEES OF BOSTON UNIVERSITY , LAROSA, Gregory, J. , GREENFIELD, Edward, A. , WITT, Daniel, T. , NAVARRO, Javier , THOMAS, Kathleen, M.
IPC分类号： C07K16/28
CPC分类号： C07K16/2866 , A61K38/00
摘要： Antibodies are raised against recombinant IL-8 receptors and receptor fragments and analogs. Such antibodies are useful in methods of detecting and isolating IL-8 receptors and receptor peptides, detecting neutrophils in biological samples, and in therapeutic compositions to treat inflammation.
摘要翻译：针对重组IL-8受体和受体片段和类似物产生抗体。这些抗体可用于检测和分离IL-8受体和受体肽，检测生物样品中的嗜中性粒细胞和用于治疗炎症的治疗组合物中的方法。

2. 发明申请

WO1992018641A1 INTERLEUKIN-8 RECEPTORS AND RELATED MOLECULES AND METHODS 审中-公开
标题翻译：白细胞介素-8受体及相关分子及方法
公开(公告)号：WO1992018641A1
公开(公告)日：1992-10-29
申请号：PCT/US1992002977
申请日：1992-04-10
申请人： THE TRUSTEES OF BOSTON UNIVERSITY , REPLIGEN CORPORATION
发明人： THE TRUSTEES OF BOSTON UNIVERSITY , REPLIGEN CORPORATION , NAVARRO, Javier , THOMAS, Kathleen, M. , WITT, Daniel, P.
IPC分类号： C12P21/06
CPC分类号： C07K14/7155 , A61K38/00
摘要： Disclosed are cDNAs encoding IL-8 receptors and the recombinant proteins expressed from such cDNAs. The recombinant receptor and receptor fragments and analogs are used in methods of screening candidate compounds for their ability to antagonize interaction between IL-8 and an IL-8 receptor; antagonists are used as therapeutics to reduce inflammation. Antibodies specific for IL-8 receptor (or receptor fragment or analog) and their use as a therapeutic are also disclosed.
摘要翻译：公开了编码IL-8受体的cDNA和从这些cDNA表达的重组蛋白。重组受体和受体片段和类似物用于筛选候选化合物拮抗IL-8和IL-8受体之间相互作用的能力的方法中; 拮抗剂用作治疗剂以减轻炎症。还公开了对IL-8受体（或受体片段或类似物）特异性的抗体及其作为治疗剂的用途。

3. 发明申请

WO1992019723A1 METHOD OF ISOLATING LIGANDS WHICH BIND NEUTROPHIL RECEPTORS 审中-公开
标题翻译：隔离中性粒细胞受体的配体的分离方法
公开(公告)号：WO1992019723A1
公开(公告)日：1992-11-12
申请号：PCT/US1992003432
申请日：1992-04-27
申请人： THE TRUSTEES OF BOSTON UNIVERSITY
发明人： THE TRUSTEES OF BOSTON UNIVERSITY , NAVARRO, Javier
IPC分类号： C12N05/00
CPC分类号： C07K14/4722 , C07K14/705 , G01N33/5008 , G01N33/56972
摘要： Disclosed are methods of determining whether a ligand is capable of binding to a neutrophil receptor. The methods involve (a) providing a neutrophil-derived DNA clone which hybridizes with the second transmembrane domain-encoding sequence of a G-protein-coupled receptor gene or with a DNA fragment which hybridizes with the second transmembrane domain-encoding sequence of a G-protein-coupled receptor gene; (b) introducing the DNA clone into a cell which presents substantially no neutrophil receptor on its surface so that the recombinant protein encoded by the DNA clone is presented on the surface of the cell; (c) contacting the cell, or a membrane fragment thereof, with the ligand to allow formation of an affinity complex between the cell (or membrane) and the ligand; and (d) detecting any such complex formation.
摘要翻译：公开了确定配体是否能够结合嗜中性粒细胞受体的方法。所述方法包括（a）提供嗜中性粒细胞衍生的DNA克隆，其与G蛋白偶联受体基因的第二跨膜结构域编码序列或与G的第二跨膜结构域编码序列杂交的DNA片段杂交蛋白偶联受体基因; （b）将DNA克隆导入到其表面上基本上不含嗜中性粒细胞受体的细胞中，使得由DNA克隆编码的重组蛋白呈现在细胞表面上; （c）使细胞或其膜片段与配体接触以允许在细胞（或膜）和配体之间形成亲和复合物; 和（d）检测任何这样的复合体。

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