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1. 发明申请

WO2013028510A2 EMBEDDED NANOPATTERNS FOR OPTICAL ABSORBANCE AND PHOTOVOLTAICS 审中-公开
标题翻译：用于光学吸收和光伏的嵌入式纳米器件
公开(公告)号：WO2013028510A2
公开(公告)日：2013-02-28
申请号：PCT/US2012/051325
申请日：2012-08-17
申请人： THE TRUSTEES OF BOSTON COLLEGE , NAUGHTON, Michael, J. , BURNS, Michael, J. , YE, Fan
发明人： NAUGHTON, Michael, J. , BURNS, Michael, J. , YE, Fan
IPC分类号： H01L31/052
CPC分类号： H01L31/035209 , H01L31/02327 , H01L31/0352 , H01L31/0543 , H01L31/0547 , H01L31/056 , H01L31/075 , Y02E10/52 , Y02E10/548
摘要： Devices and methods for enhancing optical absorbance and photovoltaics are disclosed. In some embodiments, a light absorbing device comprises a light absorbing material having a front surface and a back surface, and a planar array of nanostructures embedded within the light absorbing material between the front surface and the back surface of the light absorbing material. The nanostructures may be formed from a metallic material.
摘要翻译：公开了用于增强光吸收和光伏的装置和方法。在一些实施例中，光吸收装置包括具有前表面和后表面的光吸收材料，以及嵌入光吸收材料的前表面和后表面之间的纳米结构的平面阵列。纳米结构可以由金属材料形成。

2. 发明申请

WO2023010032A1 INTERLEUKIN-2 MUTEINS, FUSION PROTEINS, PHARMACEUTICAL COMPOSITIONS, AND THERAPEUTIC APPLICATIONS 审中-公开
公开(公告)号：WO2023010032A1
公开(公告)日：2023-02-02
申请号：PCT/US2022/074181
申请日：2022-07-27
申请人： ANWITA BIOSCIENCES, INC. , ZHONG, Ziyang , YE, Fan , HUANG, Jianing
发明人： ZHONG, Ziyang , YE, Fan , HUANG, Jianing
IPC分类号： A61K38/20 , C07K14/55 , C07K16/28
摘要： Provided herein are interleukin-2 muteins and fusion proteins comprising an interleukin-2 mutein and a half-life-extension domain. Also provided herein are their pharmaceutical compositions and methods of use for treating, preventing, or ameliorating one or more symptoms of a proliferative disease.

3. 发明申请

WO2022212614A1 FUSION PROTEINS, PHARMACEUTICAL COMPOSITIONS, AND THERAPEUTIC APPLICATIONS 审中-公开
公开(公告)号：WO2022212614A1
公开(公告)日：2022-10-06
申请号：PCT/US2022/022697
申请日：2022-03-31
申请人： ANWITA BIOSCIENCES, INC. , ZHONG, Ziyang , YE, Fan , SIEGEL, Matthew , HUANG, Jianing
发明人： ZHONG, Ziyang , YE, Fan , SIEGEL, Matthew , HUANG, Jianing
IPC分类号： C07K14/55 , C07K14/54 , C07K16/00 , A61K38/00
摘要： Provided herein are a fusion protein comprising an interleukin-2 domain, a programmed cell death-1 binding domain, and a half-life-extension domain; and a pharmaceutical composition thereof. Also provided herein is a method of their use for treating, preventing, or ameliorating one or more symptoms of a proliferative disease.

4. 发明申请

WO2008119672A3 METHOD AND SYSTEM FOR RESILIENT PACKET TRACEBACK IN WIRELESS MESH AND SENSOR NETWORKS 审中-公开
公开(公告)号：WO2008119672A3
公开(公告)日：2008-10-09
申请号：PCT/EP2008/053325
申请日：2008-03-19
申请人： INTERNATIONAL BUSINESS MACHINES CORPORATION , IBM UNITED KINGDOM LIMITED , LIU, Zhen , YANG, Hao , YE, Fan
发明人： LIU, Zhen , YANG, Hao , YE, Fan
IPC分类号： H04L29/06 , H04L12/22
摘要： A system and method for packet traceback in a network includes maintaining an identity number (ID) for each node in a network and generating a signature (e.g., a message authentication code (MAC)) using a secret key shared between each node on a forwarding path and a sink. Each forwarding node leaves a mark by appending its ID and a signature in the packet, either in a deterministic manner or with a probability. Upon receiving a packet at the sink, correctness of the signatures included in each packet is verified in the reverse order by which these signatures were appended. A last valid MAC is determined in the forwarding path to determine the locations of compromised nodes that collude in false data injection attacks.

5. 发明申请

WO2008014062A3 SYSTEM AND APPARATUS FOR OPTIMALLY TRADING OFF THE REPLICATION OVERHEAD AND CONSISTENCY LEVEL IN DISTRIBUTED APPLICATIONS 审中-公开
公开(公告)号：WO2008014062A3
公开(公告)日：2008-01-31
申请号：PCT/US2007/071403
申请日：2007-06-15
申请人： INTERNATIONAL BUSINESS MACHINES CORPORATION , LIU, Zhen , YANG, Hoa , YE, Fan , XIA, Hongui
发明人： LIU, Zhen , YANG, Hoa , YE, Fan , XIA, Hongui
IPC分类号： G06F12/00 , G06F17/30
摘要： Methods and systems are provided for optimally trading off replication overhead and consistaicy levels in distributed data replication where nodes are organized in a hierarchy. The root node has the original data that need to be replicated at all other nodes, and the replicated copies have a freshness threshold that must be satisfied. The data are propagated through periodic updates in the hierarchy. Each node periodically sends data to its child nodes. Given the freshness threshold, an algorithm and its distributed protocol can determine the optimal update period for each link of the hierarchy such that the freshness threshold is satisfied for every node and the overall replication overhead is minimized.

6. 发明申请

WO2007149701A2 A METHOD AND SYSTEM FOR FEDERATED RESOURCE DISCOVERY SERVICE IN DISTRIBUTED SYSTEMS 审中-公开
标题翻译：分布式系统中联合资源发现服务的方法与系统
公开(公告)号：WO2007149701A2
公开(公告)日：2007-12-27
申请号：PCT/US2007/070544
申请日：2007-06-06
申请人： INTERNATIONAL BUSINESS MACHINES CORPORATION , LIU, Zhen , YANG, Hao , YE, Fan
发明人： LIU, Zhen , YANG, Hao , YE, Fan
IPC分类号： G06F17/30
CPC分类号： G06F17/30545
摘要： Methods and systems are provided for identifying and allocating resources disposed within a plurality of distributed and autonomous computing systems, each of which may have its own legacy resource discovery service. Resource identification servers disposed within each one of the distributed computing systems communicate resource attribute data to a tree hierarchy of dedicated servers. The resource attribute data are maintained in native formats within the distributed computing systems and are mapped to a common format provided by the dedicated servers. The resource attribute data are aggregated at each node within the tree hierarchy, communicated up through the tree hierarchy to one or more root nodes and replicated down through all of the nodes. Additional system robustness is provided through period resource checks and resource attribute data updates. Resource allocation queries are submitted to any level node within the hierarchy and forwarded to the proper computing system for processing.
摘要翻译：提供了用于识别和分配布置在多个分布式和自主计算系统内的资源的方法和系统，每个计算系统可以具有其自己的传统资源发现服务。布置在分布式计算系统的每一个内的资源识别服务器将资源属性数据传送到专用服务器的树层。资源属性数据以分布式计算系统内的本机格式进行维护，并映射到由专用服务器提供的通用格式。资源属性数据在树层次结构中的每个节点进行聚合，通过树层次结构传递到一个或多个根节点，并通过所有节点进行复制。通过周期资源检查和资源属性数据更新来提供额外的系统稳健性。资源分配查询被提交到层次结构中的任何级节点，并转发到正确的计算系统进行处理。

7. 发明申请

WO2021222150A2 INTERLEUKIN-2 POLYPEPTIDES AND FUSION PROTEINS THEREOF, AND THEIR PHARMACEUTICAL COMPOSITIONS AND THERAPEUTIC APPLICATIONS 审中-公开
公开(公告)号：WO2021222150A2
公开(公告)日：2021-11-04
申请号：PCT/US2021/029264
申请日：2021-04-27
申请人： ANWITA BIOSCIENCES, INC. , YE, Fan , LIAO, Eric , LI, Ella , SIEGEL, Matthew , HUANG, Jianing , ZHONG, Ziyang
发明人： YE, Fan , LIAO, Eric , LI, Ella , SIEGEL, Matthew , HUANG, Jianing , ZHONG, Ziyang
IPC分类号： C12P21/00 , A61P37/04 , C07K14/55 , A61K38/20 , A61K38/00 , C07K2319/31 , C07K2319/33
摘要： Provided herein are an interleukin-2 polypeptide and a fusion protein thereof. Also provided herein are their pharmaceutical compositions and methods of use for treating, preventing, or ameliorating one or more symptoms of a proliferative disease.

8. 发明申请

WO2014197664A1 QA BASED ON CONTEXT AWARE, REAL-TIME INFORMATION FROM MOBILE DEVICES 审中-公开
标题翻译：基于背景知识的质量保证，移动设备的实时信息
公开(公告)号：WO2014197664A1
公开(公告)日：2014-12-11
申请号：PCT/US2014/041029
申请日：2014-06-05
申请人： INTERNATIONAL BUSINESS MACHINES CORPORATION , CALO, Seraphin, Bernard , FAN, James, J. , FREIMUTH, Douglas, M. , GANTI, Raghu, Kiran , YE, Fan
发明人： CALO, Seraphin, Bernard , FAN, James, J. , FREIMUTH, Douglas, M. , GANTI, Raghu, Kiran , YE, Fan
IPC分类号： G06F17/27
CPC分类号： G06F17/30401
摘要： A common infrastructure collects data from a plurality of mobile devices and traditional sensors at Internet scale to respond to natural language queries received at different applications. The infrastructure includes a semantic interpreter to translate the natural language query to a data request specification that is processed by the data collection system. The data collection system includes a phenomenon layer that expresses data and information needs in a declarative fashion and coordinates data collection and processing for queries. An edge layer manages devices, receives collection requirements from the backend layer, configures and instructs devices for data collection, and conducts aggregation and primitive processing of data. This layer contains network edge nodes, such as base stations in a cellular network. Each node manages a set of local data generating networked devices. The device agent data layer using common agents on the networked devices receives data collection instructions and performs data collection.
摘要翻译：公共基础设施从互联网规模的多个移动设备和传统传感器收集数据，以响应在不同应用处接收到的自然语言查询。基础设施包括语义解释器，用于将自然语言查询转换为数据收集系统处理的数据请求规范。数据收集系统包括以声明方式表达数据和信息需求并协调查询的数据收集和处理的现象层。边缘层管理设备，从后端层接收收集要求，配置和指示设备进行数据收集，并进行数据的聚合和原始处理。该层包含网络边缘节点，例如蜂窝网络中的基站。每个节点管理一组生成网络设备的本地数据。使用联网设备上的公用代理的设备代理数据层接收数据收集指令并执行数据收集。

9. 发明申请

WO2011066043A1 SYSTEM AND METHOD FOR PROVIDING QUALITY OF SERVICE IN WIDE-AREA MESSAGING FABRIC 审中-公开
标题翻译：提供广域服务质量的系统和方法
公开(公告)号：WO2011066043A1
公开(公告)日：2011-06-03
申请号：PCT/US2010/053032
申请日：2010-10-18
申请人： INTERNATIONAL BUSINESS MACHINES CORPORATION , KARENOS, Kyriakos , YE, Fan , KIM, Minkyong , LEI, Hui , PENDARAKIS, Dimitrios , YANG, Hao
发明人： KARENOS, Kyriakos , YE, Fan , KIM, Minkyong , LEI, Hui , PENDARAKIS, Dimitrios , YANG, Hao
IPC分类号： G06F15/173
CPC分类号： H04L45/00 , H04L45/24 , H04L45/302
摘要： Techniques for transmitting data according to at least one quality of service requirement. A message path is calculated specifying a sequence of broker computers selected from a network of interconnected broker computers. The message path is statistically estimated to fulfill the at least one quality of service requirement. Quality of service metrics are received about the network of interconnected broker computers. If the message path is determined not to fulfill the quality of service requirement, a new message path is calculated specifying a new sequence of broker computers selected from the network of interconnected broker computers. The new message path is statistically estimated to fulfill the at least one quality of service requirement.
摘要翻译：根据至少一种服务质量要求传输数据的技术。计算消息路径，指定从互连代理计算机的网络中选择的代理计算机的序列。统计估计消息路径以满足至少一个服务质量要求。收到关于互联经纪电脑网络的服务质量指标。如果消息路径被确定为不满足服务质量要求，则计算新的消息路径，指定从互连代理计算机的网络中选择的新的代理计算机序列。统计估计新消息路径以满足至少一个服务质量要求。

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