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1. 发明申请

WO2010120364A2 IMPEDIMETRIC SENSORS USING DIELECTRIC NANOPARTICLES 审中-公开
标题翻译：使用介电纳米粒子的绝缘传感器
公开(公告)号：WO2010120364A2
公开(公告)日：2010-10-21
申请号：PCT/US2010/001112
申请日：2010-04-14
申请人： THE STATE OF OREGON acting by and through THE STATE BOARD OF HIGHER EDUCATION on behalf of THE PORTLAND STATE UNIVERSITY , SOLANKI, Rajendra
发明人： SOLANKI, Rajendra
IPC分类号： G01N27/26 , G01N33/50 , C12Q1/68
CPC分类号： G01N33/54346 , C12Q1/6825 , C12Q2563/155
摘要： A method for electrochemical impedance spectroscopy uses interdigitated electrodes functionalized with a first species and nanoparticles functionalized with a second species that preferentially attaches to the first species. The nanoparticles are composed of a material with a dielectric constant (k value) greater than 2. The chemically functionalized electrodes are then exposed to a solution containing the chemically functionalized nanoparticles which then become immobilized on the electrodes through the attachment of the first species to the second species. The impedance spectrum is measured and an amount of the first species is then determined from the measured spectrum. Because the high-k dielectric nanoparticles increase the double-layer capacitive impedance, the sensitivity of determining the amount of the first species attached to the second species is enhanced.
摘要翻译：电化学阻抗光谱法的一种方法是使用由第一物质官能化的交错电极和用优先附着于第一物质的第二物质官能化的纳米颗粒。纳米颗粒由具有大于2的介电常数（k值）的材料组成。然后将化学官能化的电极暴露于含有化学官能化纳米颗粒的溶液中，其然后通过将第一种类附着到电极上而固定在电极上第二种。测量阻抗谱，然后从测量的光谱确定第一种的量。因为高k电介质纳米粒子增加了双层电容阻抗，所以确定连接到第二种的第一物质的量的灵敏度得到增强。

2. 发明申请

WO2009023857A1 IMPEDANCE SPECTROSCOPY OF BIOMOLECULES USING FUNCTIONALIZED NANOPARTICLES 审中-公开
标题翻译：使用功能化纳米粒子的生物分子的阻抗谱
公开(公告)号：WO2009023857A1
公开(公告)日：2009-02-19
申请号：PCT/US2008/073382
申请日：2008-08-15
申请人： STATE OF OREGON BY & THROUGH THE STATE BOARD OF HIGHER EDUCATION ON BEHALF OF PORTLAND STATE UNV. , SOLANKI, Rajendra , KING, Jeffrey, S. , SINGH, Kanwar, Vikas
发明人： SOLANKI, Rajendra , KING, Jeffrey, S. , SINGH, Kanwar, Vikas
IPC分类号： G01N27/02 , B82B3/00
CPC分类号： G01N33/5438
摘要： A biosensor system includes a functionalized interdigitated electrode, functionalized nanoparticles, a current/voltage signal generator, and a circuit analyzer. The interdigitated electrode can be functionalized by coating an exposed surface with first biomolecular probes. The nanoparticles are functionalized by coating an outer surface with second biomolecular probes. A signal generator provides a signal (e.g., an alternating current or voltage) having a selected range of frequencies. A circuit analyzer analyzes electrical parameters of the circuit as the signal is applied. Sensitivity is increased by the presence of functionalized nanoparticles in the system. An analytic method includes measuring changes in electrical parameters of the circuit over the range of frequencies. Using these measurements, the biosensor system can determine whether a target biomolecule is bound. The biosensor system can also identify a biomolecule by comparing the detected signal or "electro-fingerprint" with a reference set of signals over the frequency range.
摘要翻译：生物传感器系统包括功能化的叉指电极，功能化纳米颗粒，电流/电压信号发生器和电路分析器。交叉电极可以通过用第一生物分子探针涂覆暴露的表面而被官能化。通过用第二生物分子探针涂覆外表面来使纳米颗粒功能化。信号发生器提供具有选定频率范围的信号（例如，交流电或电压）。电路分析仪分析电路的电气参数。通过系统中官能化纳米颗粒的存在来提高灵敏度。分析方法包括在频率范围内测量电路的电气参数的变化。使用这些测量，生物传感器系统可以确定靶生物分子是否结合。生物传感器系统还可以通过将检测到的信号或“电指纹”与频率范围上的参考信号集进行比较来识别生物分子。

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