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1. 发明申请

WO1997041151A2 CHOLINE BINDING PROTEINS FOR ANTI-PNEUMOCOCCAL VACCINES 审中-公开
标题翻译：用于抗肺气肿疫苗的胆固醇蛋白
公开(公告)号：WO1997041151A2
公开(公告)日：1997-11-06
申请号：PCT/US1997007198
申请日：1997-05-01
申请人： THE ROCKEFELLER UNIVERSITY
发明人： THE ROCKEFELLER UNIVERSITY , MASURE, H., Robert , ROSENOW, Carsten, I. , TUOMANEN, Elaine , WIZEMAN, Theresa, M.
IPC分类号： C07K14/315
CPC分类号： C07K14/3156 , A61K38/00 , A61K39/00 , A61K48/00 , A61K2039/51
摘要： The invention relates to bacterial choline binding proteins (CBPs) which bind choline. Such proteins are particularly desirable for vaccines against appropriate strains of Gram positive bacteria, particularly streptococcus, and more particularly pneumococcus. Also provided are DNA sequences encoding the bacterial choline binding proteins or fragment thereof, antibodies to the bacterial choline binding proteins, pharmaceutical compositions comprising the bacterial choline binding proteins, antibodies to the bacterial choline binding proteins suitable for use in passive immunization, and small molecule inhibitors of choline binding protein mediated adhesion. Methods for diagnosing the presence of the bacterial choline binding protein, or of the bacteria, are also provided. In a specific embodiment, a streptococcal choline binding protein is an enolase, which demonstrates strong affinity for fibronectin.
摘要翻译：本发明涉及结合胆碱的细菌胆碱结合蛋白（CBP）。对于针对革兰氏阳性菌，特别是链球菌，更特别是肺炎球菌的合适菌株的疫苗，这种蛋白质是特别需要的。还提供了编码细菌胆碱结合蛋白或其片段的DNA序列，细菌胆碱结合蛋白的抗体，包含细菌胆碱结合蛋白的药物组合物，适用于被动免疫的细菌胆碱结合蛋白的抗体和小分子抑制剂的胆碱结合蛋白介导的粘附。还提供了用于诊断细菌胆碱结合蛋白或细菌存在的方法。在具体实施方案中，链球菌胆碱结合蛋白是烯醇化酶，其对纤连蛋白表现出强亲和力。

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