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1. 发明申请

WO2012170340A3 INSERTABLE NEURAL PROBE WITH FLEXIBLE STRUCTURE 审中-公开
公开(公告)号：WO2012170340A3
公开(公告)日：2012-12-13
申请号：PCT/US2012/040709
申请日：2012-06-04
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , YOON, Euisik , WU, Fan
发明人： YOON, Euisik , WU, Fan
IPC分类号： A61N1/05 , A61N1/36 , A61L27/54 , A61L27/58
摘要： A neural probe (10) is provided for in vivo communication with biological tissue, including stimulating neurons and/or recording neural electrical activity. The probe (10) may be constructed so that the immune response by the biological tissue in which the device is implanted is reduced over known implantable probes. The probe (10) can be constructed with a tip (16) that has a branched configuration, with electrodes (24) located along each of the branches (20). A biodegradable coating (18) is disposed over at least the tip (16) of the probe (10) to provide the probe (10) with sufficient integrity for insertion into the biological tissue and to degrade after insertion. The biodegradable coating (18) can have an anti-inflammatory drug or other bioagent distributed therein for localized release of the bioagent to further reduce the immune response.

2. 发明申请

WO2016149701A1 SYSTEM FOR ANALYZING TISSUE 审中-公开
标题翻译：用于分析组织的系统
公开(公告)号：WO2016149701A1
公开(公告)日：2016-09-22
申请号：PCT/US2016/023437
申请日：2016-03-21
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN
发明人： MYCEK, Mary-Ann , WU, Fan , SCHEIMAN, James, M. , YOON, Euisik , LLOYD, William , LEE, Seung, Yup
IPC分类号： G01N21/17 , G01N21/63 , G02B21/00
CPC分类号： A61B5/1455 , A61B5/0084 , A61B5/0261 , G01N33/54366 , G06T2207/30004
摘要： A system for analyzing tissue includes a platform and an optical sensing unit coupled to the platform. The optical sensing unit has a detector and a plurality of light sources surrounding and electrically isolated from the detector. The optical sensing units obtain optical data for tissue analysis.
摘要翻译：用于分析组织的系统包括平台和耦合到平台的光学感测单元。光学感测单元具有检测器和围绕检测器电隔离的多个光源。光学单元获得用于组织分析的光学数据。

3. 发明申请

WO2006092059A1 DESIGN AND SYNTHESIS OF NOVEL ANTIMICROBIALS 审中-公开
标题翻译：新型抗生素的设计与合成
公开(公告)号：WO2006092059A1
公开(公告)日：2006-09-08
申请号：PCT/CA2006/000314
申请日：2006-03-06
申请人： WU, Fan , WEAVER, Donald , BARDEN, Chris , BYERS, David , MCMASTER, Christopher , HENNEBERRY, Annette , BAN, Fuqiang
发明人： WU, Fan , WEAVER, Donald , BARDEN, Chris , BYERS, David , MCMASTER, Christopher , HENNEBERRY, Annette , BAN, Fuqiang
IPC分类号： C07D409/02 , C07D409/04 , C12Q1/00 , A61P31/04 , A61P31/00 , A61K31/41
CPC分类号： C12Q1/18 , A61K31/41 , C07D409/04 , C07D409/14 , C07D495/14 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/481
摘要： The synthesis and activity of novel LpxA inhibitors is described, these inhibitors present antibacterial activity. The compounds were designed based on a receptor model developed using the crystal structure of LpxA and are arranged to have a favorable binding interaction at the active site of the enzyme. In particular, the compounds present the following formula (I) where V, W, X, Y and Z can be independently C, S, N or O and Pl, P2 and P3 are ligands to bind to the three points of the proposed pharmacophore model. They can be chosen from a variety of groups.
摘要翻译：描述了新型LpxA抑制剂的合成和活性，这些抑制剂具有抗菌活性。基于使用LpxA的晶体结构开发的受体模型设计化合物，并且被设置为在酶的活性位点具有有利的结合相互作用。特别地，化合物呈现下式（I）其中V，W，X，Y和Z可以独立地是C，S，N或O，并且P1，P2和P3是与所提出的药效基团的三个点结合的配体模型。他们可以从各种团体中选出。

4. 发明申请

WO2006040703A2 MULTI-BRANCH PARALLEL PROCESSING METHOD AND APPARATUS FOR IMPLEMENTING ITERATIVE COMPUTATIONS 审中-公开
标题翻译：多分支并行处理方法和实现迭代计算的装置
公开(公告)号：WO2006040703A2
公开(公告)日：2006-04-20
申请号：PCT/IB2005/053211
申请日：2005-09-29
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , SUN, Yanmeng , WU, Fan
发明人： SUN, Yanmeng , WU, Fan
IPC分类号： G06F17/15
CPC分类号： G06F17/12 , H04L25/03019 , H04L25/03082 , H04L2025/03535 , H04L2025/03611
摘要： The invention proposes a method for performing multi-branch parallel processing on the multiple received signals by using iterative algorithm, the multiple received signals having intrinsic correlation and corresponding to multiple groups of specific parameters respectively, the method comprising the steps of: (a) inputting each of the multiple groups of specific parameters and the same initial value respectively into multiple iterative computation branches; (b) performing iterative computation in each iterative computation branch according to a predefined processing function and the intrinsic correlation, to get the iteration result of each iterative computation branch, the iteration result respectively corresponding to the information of said multiple received signals; wherein each said iteration result is used for iterative computation of the subsequent received signals having intrinsic correlation with the iteration result in said multiple received signals.
摘要翻译：本发明提出了一种通过使用迭代算法对多个接收信号执行多分支并行处理的方法，所述多个接收信号具有固有的相关性并且分别对应于多个特定参数组，所述方法包括以下步骤：（a）输入多组具体参数和相同初始值分别分为多个迭代计算分支; （b）根据预定的处理函数和固有相关性在每个迭代计算分支中执行迭代计算，以获得每个迭代计算分支的迭代结果，迭代结果分别对应于所述多个接收信号的信息; 其中每个所述迭代结果用于与所述多个接收信号中的迭代结果具有固有相关性的后续接收信号的迭代计算。

5. 发明申请

WO2017096100A1 HETEROCYCLE COMPOUNDS AND USES THEREOF 审中-公开
标题翻译：杂环化合物及其用途
公开(公告)号：WO2017096100A1
公开(公告)日：2017-06-08
申请号：PCT/US2016/064507
申请日：2016-12-02
申请人： SHANGHAI AEON BIOTECH CO., LTD. , ZHAI, Haixiao , WU, Fan , WU, Zhanggui
发明人： ZHAI, Haixiao , WU, Fan , WU, Zhanggui
IPC分类号： C07D487/04 , H01L51/54
CPC分类号： C07D495/04
摘要： Compounds having the general formula (I) and pharmaceutical compositions that can be used as Bruton's Tyrosine Kinase (BTK), ITK, JAK3, and selective mutant epidermal growth factor receptor tyrosine kinase (EGFR-TK) inhibitor and their uses in the treatment of related diseases and disorders such as cancer.
摘要翻译：具有通式（I）的化合物和可用作布鲁顿酪氨酸激酶（BTK），ITK，JAK3和选择性突变表皮生长因子受体酪氨酸激酶（EGFR-TK）抑制剂的药物组合物及其在治疗相关疾病和疾病如癌症中的用途。

6. 发明申请

WO2021141974A2 COMBINATION CANCER THERAPY USING CHK INHIBITOR 审中-公开
公开(公告)号：WO2021141974A2
公开(公告)日：2021-07-15
申请号：PCT/US2021/012287
申请日：2021-01-06
申请人： WU, Fan
发明人： WU, Fan
IPC分类号： A61K31/404 , A61K31/405 , A61K31/4196 , A61K31/5025
摘要： Disclosed is the use of a checkpoint kinase (CHK) inhibitor in combination with i) an immunotherapeutic agent or a therapeutic agent targeting a cancer-promoting/sustaining molecule, and optionally ii) a chemotherapeutic agent such as gemcitabine, in cancer treatment.

7. 发明申请

WO2016054804A1 SUBSTITUTED PYRIMIDINES AS INHIBITORS OF HIF PROLYL HYDROXYLASE 审中-公开
标题翻译：作为HIF PROLYL羟基酶抑制剂的替代吡咯烷
公开(公告)号：WO2016054804A1
公开(公告)日：2016-04-14
申请号：PCT/CN2014/088318
申请日：2014-10-10
申请人： MERCK SHARP & DOHME CORP. , UJJAINWALLA, Fez , TAN, John Qiang , DANG, Qun , SINZ, Christopher J. , CRESPO, Alejandro , WANG, Ming , CHEN, Yili , CAI, Jiaqiang , WU, Fan , DU, Xiaoxing
发明人： UJJAINWALLA, Fez , TAN, John Qiang , DANG, Qun , SINZ, Christopher J. , CRESPO, Alejandro , WANG, Ming , CHEN, Yili , CAI, Jiaqiang , WU, Fan , DU, Xiaoxing
IPC分类号： C07D239/36 , C07D401/04 , C07D403/04 , C07D417/04 , A61K31/505 , A61K31/506 , A61K31/66 , A61P7/00
CPC分类号： C07D239/36 , C07D239/34 , C07D401/12 , C07D403/12 , C07D405/12
摘要： The present invention concerns compounds of Formula I that inhibit HIF prolyl hydroxylase, their use for enhancing endogenous production of erythropoietin, and for treating conditions associated with reduced endogenous production of erythropoietin such as anemia and like conditions, as well as pharmaceutical compositions comprising such a compound and a pharmaceutical carrier.
摘要翻译：本发明涉及抑制HIF脯氨酰羟化酶的式I化合物，其用于促进促红细胞生成素的内源性产生的用途，以及用于治疗与减少红细胞生成素的内源产生如贫血和类似病症相关的病症，以及包含这种化合物和药用载体。

8. 发明申请

WO2015127639A1 SYSTEMS AND METHODS FOR DETERMINING CONCENTRATION OF A COMPONENT IN A FLUID SAMPLE 审中-公开
标题翻译：用于确定流体样品中组分浓度的系统和方法
公开(公告)号：WO2015127639A1
公开(公告)日：2015-09-03
申请号：PCT/CN2014/072663
申请日：2014-02-28
申请人： EMPIRE TECHNOLOGY DEVELOPMENT LLC , WU, Fan
发明人： WU, Fan
IPC分类号： G01N21/51 , G01N1/38 , G01N35/10
CPC分类号： G01N21/82 , G01N15/06 , G01N21/51 , G01N33/5304 , G01N33/536 , G01N2015/0053 , G01N2015/0065 , G01N2015/0693
摘要： Systems and methods for determining concentration of a component of a fluid sample are described. The system includes a reaction vessel(30), a light source(60), a detection tube(70), and a mobile terminal(80), wherein the system is configured to determine the concentration of the component in the fluid sample based on characteristics of scattered light produced from the interaction of the component with a detection compound.
摘要翻译：描述了用于确定流体样品的组分浓度的系统和方法。该系统包括反应容器（30），光源（60），检测管（70）和移动终端（80），其中该系统构造成基于以下步骤确定流体样品中的组分的浓度：由组分与检测化合物的相互作用产生的散射光的特征。

9. 发明申请

WO2008128321A1 THERAPEUTIC PRO-ANTIBIOTIC AGENTS AND METHODS OF USE THEREOF 审中-公开
标题翻译：治疗性抗菌药物及其使用方法
公开(公告)号：WO2008128321A1
公开(公告)日：2008-10-30
申请号：PCT/CA2008/000632
申请日：2008-04-16
申请人： DENOVAMED INC. , BARDEN, Christopher, J. , HENNEBERRY, Annette, L. , BYERS, David M. , MCMASTER, Christopher, R. , WEAVER, Donald , WU, Fan
发明人： BARDEN, Christopher, J. , HENNEBERRY, Annette, L. , BYERS, David M. , MCMASTER, Christopher, R. , WEAVER, Donald , WU, Fan
IPC分类号： C07D409/04 , A61K31/41 , A61K31/427 , A61P29/00 , C07D417/14 , C07D207/337 , C07D307/54 , C07D333/24
CPC分类号： C07D417/14 , C07D409/04
摘要： The present invention provides for therapies characterized in part by co-administration or combination of antibiotic agents with medicinal compositions comprising as the pro-antibiotic active ingredient either a compound represented by a formula [I] or a pharmaceutically acceptable composite thereof; [wherein X represents oxygen, sulfur, NH, or N-alkyl; R 1 and R 2 represent hydrogen, tetrazole, or alkyltetrazole, respectively (with the restriction that if R 1 is not hydrogen, R 2 must be, and vice versa); R 3 represents e.g., benzyl, phenyl optionally substituted, biphenyl, napthyl, N-phenylcarboxamido, etc.; R 4 represents e.g. carboxylic acid, or its alkyl esters, or a bioisosteric equivalent thereof, etc.; R 5 represents e.g. hydrogen, carboxylic acid, etc.]in particular, medicine which is useful as therapeutic and/or protective drugs for infectious and/or inflammatory diseases. Other relevant compounds are also provided.
摘要翻译：本发明提供了一种治疗方法，其特征在于部分通过共同施用或组合抗生素与药物组合物组合，所述药物组合物包含作为前抗生素活性成分的由式[I]表示的化合物或其药学上可接受的复合物; [其中X表示氧，硫，NH或N-烷基; R 1和R 2分别代表氢，四唑或烷基四唑（限制如果R 1不是氢，R SUB > 2 必须，反之亦然）; R 3表示例如苄基，任选取代的苯基，联苯基，萘基，N-苯基甲酰胺基等; R 4表示例如。羧酸或其烷基酯，或其生物电子等同物等; R 5表示例如。氢，羧酸等]，特别是可用作感染性和/或炎性疾病的治疗和/或保护性药物的药物。还提供了其它相关化合物。

10. 发明申请

WO2021141980A1 COMBINATION CANCER THERAPY USING CHK INHIBITOR 审中-公开
公开(公告)号：WO2021141980A1
公开(公告)日：2021-07-15
申请号：PCT/US2021/012295
申请日：2021-01-06
申请人： WU, Fan , WU, Zhanggui
发明人： WU, Fan , WU, Zhanggui
IPC分类号： A61K31/404 , A61K31/405 , A61K31/4196
摘要： Disclosed is the use of a checkpoint kinase (CHK) inhibitor in combination with i) a poly(ADP)-ribose polymerase inhibitor, and optionally ii) a chemotherapeutic agent such as gemcitabine, in cancer treatment.

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