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1. 发明申请

WO2017196995A1 METHOD AND SYSTEM FOR PIXEL SUPER-RESOLUTION OF MULTIPLEXED HOLOGRAPHIC COLOR IMAGES 审中-公开
标题翻译：用于像素超分辨率复合全息彩色图像的方法和系统
公开(公告)号：WO2017196995A1
公开(公告)日：2017-11-16
申请号：PCT/US2017/031984
申请日：2017-05-10
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： OZCAN, Aydogan , WU, Yichen , ZHANG, Yibo , LUO, Wei
IPC分类号： G03H1/04
摘要： A method of generating a color image of a sample includes obtaining a plurality of low resolution holographic images of the sample using a color image sensor, the sample illuminated simultaneously by light from three or more distinct colors, wherein the illuminated sample casts sample holograms on the image sensor and wherein the plurality of low resolution holographic images are obtained by relative x, y, and z directional shifts between sample holograms and the image sensor. Pixel super-resolved holograms of the sample are generated at each of the three or more distinct colors. De-multiplexed holograms are generated from the pixel super-resolved holograms. Phase information is retrieved from the de-multiplexed holograms using a phase retrieval algorithm to obtain complex holograms. The complex hologram for the three or more distinct colors is digitally combined and back-propagated to a sample plane to generate the color image.
摘要翻译：产生样本的彩色图像的方法包括使用彩色图像传感器获得样本的多个低分辨率全息图像，样本由来自三种或更多种不同颜色的光同时照射，其中照射样本在图像传感器上投射样本全息图，并且其中通过样本全息图和图像传感器之间的相对x，y和z方向位移来获得多个低分辨率全息图像。样品的像素超分辨全息图在三种或更多种不同颜色中的每一种上产生。解复用全息图由像素超分辨全息图生成。使用相位检索算法从解复用全息图中检索相位信息以获得复杂的全息图。用于三种或更多种不同颜色的复合全息图被数字组合并且向后传播到样本平面以生成彩色图像。

2. 发明申请

WO2020082030A1 DEVICE AND METHOD FOR MOTILITY-BASED LABEL-FREE DETECTION OF MOTILE OBJECTS IN A FLUID SAMPLE 审中-公开
公开(公告)号：WO2020082030A1
公开(公告)日：2020-04-23
申请号：PCT/US2019/057073
申请日：2019-10-18
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： OZCAN, Aydogan , ZHANG, Yibo , KOYDEMIR, Hatice Ceylan
IPC分类号： G01N33/487 , G01B11/24 , G01N15/14 , G03H1/04 , G03H1/08
摘要： Systems and methods for detecting motile objects (e.g., parasites) in a fluid sample by utilizing locomotion of the parasites as a specific biomarker and endogenous contrast mechanism. The imaging platform includes one or more substantially optically transparent sample holders. The imaging platform has a moveable scanning head containing light source(s) and corresponding image sensor(s) associated with the light source(s). The light source(s) are directed at a respective sample holder containing a sample and the respective image sensor(s) are positioned below a respective sample holder to capture time-varying holographic speckle patterns of the sample. The image sensor(s). A computing device is configured to receive time-varying holographic speckle pattern image sequences obtained by the image sensor(s). The computing device generates a 3D contrast map of motile objects within the sample use deep learning-based classifier software to identify the motile objects.

3. 发明申请

WO2021003369A1 MAGNETICALLY MODULATED COMPUTATIONAL CYTOMETER AND METHODS OF USE 审中-公开
公开(公告)号：WO2021003369A1
公开(公告)日：2021-01-07
申请号：PCT/US2020/040664
申请日：2020-07-02
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： OZCAN, Aydogan , RAY, Aniruddha , ZHANG, Yibo , DI CARLO, Dino
IPC分类号： G01N15/10 , B01D35/06 , B03C1/005 , B03C1/02 , B03C1/32
摘要： A computational cytometer operates using magnetically modulated lensless speckle imaging, which introduces oscillatory motion to magnetic bead-conjugated rare cells of interest through a periodic magnetic force and uses lensless time-resolved holographic speckle imaging to rapidly detect the target cells in three-dimensions (3D). Detection specificity is further enhanced through a deep learning-based classifier that is based on a densely connected pseudo-3D convolutional neural network (P3D CNN), which automatically detects rare cells of interest based on their spatio-temporal features under a controlled magnetic force. This compact, cost-effective and high-throughput computational cytometer can be used for rare cell detection and quantification in bodily fluids for a variety of biomedical applications.

4. 发明申请

WO2017205530A1 WIDE-FIELD IMAGING OF BIREFRINGENT CRYSTALS AND OTHER MATERIALS USING LENS-FREE POLARIZED MICROSCOPE 审中-公开
标题翻译：使用无透镜偏振显微镜进行双折射晶体和其他材料的宽视场成像
公开(公告)号：WO2017205530A1
公开(公告)日：2017-11-30
申请号：PCT/US2017/034311
申请日：2017-05-24
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： OZCAN, Aydogan , ZHANG, Yibo , LEE, Seung Yoon , FITZGERALD, John D.
IPC分类号： G01B9/021 , G03H1/26 , H01L27/146 , H04N1/028
CPC分类号： G03H1/0465 , G03H1/0005 , G03H1/0443 , G03H1/0866 , G03H2001/005 , G03H2001/0447 , G03H2001/0471 , G03H2001/2655 , G03H2001/267 , G03H2222/31 , G03H2223/22 , G03H2223/52 , G03H2226/02 , G03H2226/11 , G03H2227/03 , G06T3/4053 , G06T5/50 , G06T2207/10056 , G06T2207/20224 , G06T2207/30004 , H04N1/028 , H04N5/23232
摘要： A method of imaging a sample having birefringent crystals (or other materials) using a lens-free polarized microscopy device includes illuminating the sample contained on a sample holder with circularly polarized partially coherent or coherent light and capturing lower resolution holographic images of the birefringent crystals with an image sensor. A polarization analyzer unit made from a λ/4 retarder and a linear polarizer is positioned between the sample holder and the image sensor. The lower resolution holographic images are obtained with the polarization analyzer unit in two different orientations (e.g. ~90 orientations). Phase-retrieved, higher resolution images of the birefringent crystals at the different orientations are obtained using the lower resolution holographic images. A differential image is generated from the respective phase-retrieved, higher resolution images. An object support mask is applied to identify the birefringent crystals which can then be pseudo-colored.
摘要翻译：使用无透镜偏振显微镜装置对具有双折射晶体（或其他材料）的样本进行成像的方法包括用圆偏振部分相干或相干光照射包含在样本架上的样本并捕获较低用图像传感器分辨双折射晶体的高分辨率全息图像。由λ/ 4延迟器和线偏振器制成的偏振分析器单元位于样品架和图像传感器之间。偏振分析仪单元在两个不同的取向（例如〜90°取向）下获得较低分辨率的全息图像。使用较低分辨率的全息图像获得相位恢复的，在不同取向处的双折射晶体的更高分辨率图像。从各个相位检索的较高分辨率图像生成差分图像。应用对象支撑掩模来识别双折射晶体，然后可以伪色。

5. 发明申请

WO2017196885A1 METHOD AND DEVICE FOR HIGH-RESOLUTION COLOR IMAGING USING MERGED IMAGES FROM HOLOGRAPHIC AND LENS-BASED DEVICES 审中-公开
标题翻译：使用来自全息和基于镜头的装置的合成图像进行高分辨率彩色成像的方法和装置
公开(公告)号：WO2017196885A1
公开(公告)日：2017-11-16
申请号：PCT/US2017/031813
申请日：2017-05-09
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： OZCAN, Aydogan , ZHANG, Yibo , WU, Yichen
IPC分类号： G02B21/00 , G03H1/02 , G03H1/04 , G03H1/08 , G03H1/22 , G06T5/50
摘要： Methods and systems for generating a high-color-fidelity and high-resolution color image of a sample are disclosed; which fuses or merges a holographic image acquired at a single wavelength with a color-calibrated image taken by a low-magnification lens-based microscope using a wavelet transform based colorization method. A holographic microscope is used to obtain holographic images which are used to computationally reconstruct a high-resolution mono-color holographic image of the sample. A lens-based microscope is used to obtain low resolution color images. A discrete wavelet transform (DWT) is used to generate a final image that merges the low-resolution components from the lens-based color image and the high-resolution components from the high-resolution mono-color holographic image.
摘要翻译：公开了用于生成样本的高色彩逼真度和高分辨率彩色图像的方法和系统; 其使用基于小波变换的彩色化方法将在单个波长处获取的全息图像与由基于低倍率透镜的显微镜拍摄的色彩校准图像融合或合并。全息显微镜用于获取全息图像，用于计算重建样本的高分辨率单色全息图像。基于镜头的显微镜用于获取低分辨率的彩色图像。使用离散小波变换（DWT）来生成最终图像，该图像合并来自基于镜头的彩色图像的低分辨率分量和来自高分辨率单色全息图像的高分辨率分量。

6. 发明申请

WO2016019324A2 DEVICE AND METHOD FOR ITERATIVE PHASE RECOVERY BASED ON PIXEL SUPER-RESOLVED ON-CHIP HOLOGRAPHY 审中-公开
标题翻译：基于像素超分辨率片上自旋的迭代相恢复的装置和方法
公开(公告)号：WO2016019324A2
公开(公告)日：2016-02-04
申请号：PCT/US2015/043266
申请日：2015-07-31
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： OZCAN, Aydogan , GREENBAUM, Alon , ZHANG, Yibo , FEIZI, Alborz , LUO, Wei
IPC分类号： G03H1/04 , G03H1/00
CPC分类号： G03H1/0005 , G01N15/1429 , G01N15/1434 , G01N15/1475 , G01N2015/1006 , G01N2015/144 , G01N2015/1445 , G01N2015/1454 , G03H1/0443 , G03H1/0866 , G03H1/0891 , G03H2001/005 , G03H2001/0447 , G03H2001/0454 , G03H2001/046 , G03H2001/0816 , G03H2001/0883 , G03H2001/2655 , G03H2210/42 , G03H2226/02 , G03H2227/03 , H04N5/2256 , H04N5/23238
摘要： A method for lens-free imaging of a sample or objects within the sample uses multi-height iterative phase retrieval and rotational field transformations to perform wide FOV imaging of pathology samples with clinically comparable image quality to a benchtop lens-based microscope. The solution of the transport-of-intensity (TIE) equation is used as an initial guess in the phase recovery process to speed the image recovery process. The holographically reconstructed image can be digitally focused at any depth within the object FOV (after image capture) without the need for any focus adjustment, and is also digitally corrected for artifacts arising from uncontrolled tilting and height variations between the sample and sensor planes. In an alternative embodiment, a synthetic aperture approach is used with multi-angle iterative phase retrieval to perform wide FOV imaging of pathology samples and increase the effective numerical aperture of the image.
摘要翻译：用于样品或样品的透镜自由成像的方法使用多重迭代相位检索和旋转场转换来对具有临床上可比较的图像质量的病理样本进行宽的FOV成像到基于台式透镜的显微镜。传输强度（TIE）方程的解决方案用作相位恢复过程中的初始猜测，以加速图像恢复过程。全息重构的图像可以在物体FOV（图像捕获之后）中的任何深度进行数字聚焦，而不需要任何焦点调整，并且还可以对由样品和传感器平面之间的不受控制的倾斜和高度变化引起的伪影进行数字校正。在替代实施例中，使用合成孔径方法进行多角度迭代相位检索以对病理样本进行宽FOV成像并增加图像的有效数值孔径。

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