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1. 发明申请

WO2018089830A1 EFFICIENT AND SCALABLE SYNTHESES OF NICOTINOYL RIBOSIDES AND REDUCED NICOTINOYL RIBOSIDES, MODIFIED DERIVATIVES THEREOF, PHOSPHORYLATED ANALOGS THEREOF, ADENYLYL DINUCLEOTIDE CONJUGATES THEREOF, AND NOVEL CRYSTALLINE FORMS THEREOF 审中-公开
标题翻译：烟酰基核苷和降低的烟酰基核糖核苷及其修饰衍生物的有效和可缩合的合成，其磷酸化类似物，其烯丙基DIN核苷酸结合物及其新型结晶形式
公开(公告)号：WO2018089830A1
公开(公告)日：2018-05-17
申请号：PCT/US2017/061154
申请日：2017-11-10
申请人： THE QUEEN'S UNIVERSITY OF BELFAST , CHROMADEX INC.
发明人： MIGAUD, Marie, Eugenie , REDPATH, Philip , CROSSEY, Kerri , CUNNINGHAM, Richard , ERICKSON, Aron , NYGAARD, Richard , STORJOHANN, Amanda
IPC分类号： A61K31/455 , A61K31/706 , C07H1/00 , C07H19/048
摘要： The present disclosure provides methods of making nicotinoyl riboside compounds or derivatives of formula (I): wherein X", Z 1 , Z 2 , n, R 1 , R 2 , R 3 , R 4 , R 5 , R 6, , R 7 , and R 8 are described herein, reduced analogs thereof, modified derivatives thereof, phosphorylated analogs thereof, and adenylyl dinucleotide conjugates thereof, or salts, solvates, or prodrugs thereof; and novel crystalline forms thereof.
摘要翻译：本公开提供了制备烟酰基核糖核苷化合物或式（I）的衍生物的方法：其中X 1，Z 1，Z 2，Z 3， n，R 1，R 2，R 3，R 4，R 5，R 5，R 4，R 4，R 5，本文描述了R 6，R 7，R 8和R 8，其还原类似物，修饰的衍生物其磷酸化类似物和腺苷酸二核苷酸缀合物，或其盐，溶剂化物或前药; 及其新颖的结晶形式。

2. 发明申请

WO2017161165A1 B-VITAMIN AND AMINO ACID CONJUGATES OF NICOTINOYL RIBOSIDES AND REDUCED NICOTINOYL RIBOSIDES, DERIVATIVES THEREOF, AND METHODS OF PREPARATION THEREOF 审中-公开
标题翻译：烟酰胺核糖核苷和还原的烟酰基核糖核苷的B-维生素和氨基酸的偶联物，其衍生物及其制备方法
公开(公告)号：WO2017161165A1
公开(公告)日：2017-09-21
申请号：PCT/US2017/022779
申请日：2017-03-16
申请人： CHROMADEX INC. , THE QUEEN'S UNIVERSITY OF BELFAST
发明人： MIGAUD, Marie, Eugenie , REDPATH, Philip , CROSSEY, Kerri , CUNNINGHAM, Richard , DELLINGER, Ryan , RHONEMUS, Troy , VENKATARAMAN, Sylesh , NETTLES, Brian
IPC分类号： A01N43/40 , A61K31/44
摘要： The present disclosure provides nicotinate/nicotinamide riboside compounds or derivatives of formula (I): wherein X - , Z 1 Z 2 , n, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , and R 8 are described herein, reduced analogs thereof, and synthetic processes for the preparation thereof.
摘要翻译：本公开提供了烟酸酯/烟酰胺核糖核苷化合物或式（I）的衍生物：其中X 1，Z 1 Z Z 2 n，R 1，R 2，R 3，R 4，R 5，R 4，R 4，R 4，R 4，本文描述了R 5，R 6，R 7和R 8，它们的还原类似物，以及用于准备。

3. 发明申请

WO2016196941A1 SELECTIVE SOLVENT FREE PHOSPHORYLATION 审中-公开
标题翻译：选择性溶剂免费磷化
公开(公告)号：WO2016196941A1
公开(公告)日：2016-12-08
申请号：PCT/US2016/035729
申请日：2016-06-03
申请人： CHROMADEX, INC. , THE QUEEN'S UNIVERSITY OF BELFAST
发明人： MIGAUD, Marie Eugenie , REDPATH, Philip , CROSSEY, Kerri , CUNNINGHAM, Richard , RHONEMUS, Troy , VENKATARAMAN, Sylesh
IPC分类号： A01N43/40 , A61K31/44
CPC分类号： C07H19/048 , C07F9/582 , C07F9/65583 , C07F9/65616 , C07H1/04 , C07H19/04 , C07H19/20
摘要： A synthetic process is provided for the preparation of phosphorylated analogs of nicotinamide riboside ("NR") having the formula (I), or salts thereof, and reduced or modified derivatives thereof, having the formula (II), wherein X - , Y 1 , Y 2 , Z 1 , Z 2 , n, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , and R 7 are as defined herein. The present disclosure also relates to the preparation of phosphorylated analogs of nicotinic acid riboside ("NAR") having the formula (I), or salts thereof, and reduced or modified derivatives thereof, having the formula (II). Generally solvent-free conditions are employed using appropriate mechano-chemical techniques as described. (I) (II)
摘要翻译：提供了一种合成方法，用于制备具有式（I）的烟酰胺核苷（“NR”）或其盐以及具有式（II）的还原或修饰的衍生物的磷酸化类似物，其中X，Y 1， Y2，Z1，Z2，n，R1，R2，R3，R4，R5，R6和R7如本文所定义。本公开还涉及具有式（I）的烟酸核糖苷（“NAR”）的磷酸化类似物或其盐以及具有式（II）的还原或修饰的衍生物的制备。一般使用无溶剂条件，使用所述的适当的机械化学技术。（一）（二）

4. 发明申请

WO2016149395A1 NICOTINIC ACID RIBOSIDE OR NICOTINAMIDE RIBOSIDE COMPOSITIONS, REDUCED DERIVATIVES THEREOF, AND THE USE THEREOF 审中-公开
标题翻译：非甾体类抗坏血酸或尼罗替尼组合物，其减少的衍生物及其用途
公开(公告)号：WO2016149395A1
公开(公告)日：2016-09-22
申请号：PCT/US2016/022682
申请日：2016-03-16
申请人： CHROMADEX INC. , THE QUEEN'S UNIVERSITY OF BELFAST
发明人： DELLINGER, Ryan , MIGAUD, Marie, Eugenie , REDPATH, Philip , RHONEMUS, Troy , CUNNINGHAM, Richard
IPC分类号： C07H19/048 , A61K31/706
CPC分类号： C07H19/048 , A61K8/675 , A61Q19/00 , A61Q19/004 , A61Q19/007 , A61Q19/08
摘要： Derivatives of nicotinic acid riboside (NAR), nicotinamide riboside (NR), and reduced NAR and NR, including 1-(2', 3', 5'-triacetyl-beta-D-ribofuranosyl)-1,4-dihydronicotinic acid (4a), and compositions containing the same and/or reduced derivative forms of nicotinamide riboside including 1-(2',3',5'-triacetyl-beta-D-ribofuranosyl)-1,4-nicotinamide (2), are provided for use in the care of treatment of skin and skin conditions. In some embodiments, the invention relates to pharmaceutical compositions and cosmetic compositions containing one or more NR, NAR, NRH, or NARH derivatives, or prodrugs or salts thereof. In further embodiments, the invention relates to methods of using one or more NR, NAR, NRH, or NARH derivatives, or prodrugs, solvates, or salts thereof, to promote the increase of intracellular levels of nicotinamide adenine dinucleotide (NAD+) in cells and tissues for improving cell and tissue survival and overall cell and tissue health.
摘要翻译：烟碱苷（NAR）衍生物，烟酰胺核苷（NR）和还原的NAR和NR，包括1-（2'，3'，5'-三乙酰基-β-D-呋喃核糖基）-1,4-二氢烟酸提供了含有相同和/或还原的衍生物形式的包括1-（2'，3'，5'-三乙酰基-β-D-呋喃核糖基）-1,4-烟酰胺（2）的烟酰胺核苷的组合物用于护理皮肤和皮肤状况的治疗。在一些实施方案中，本发明涉及含有一种或多种NR，NAR，NRH或NARH衍生物或其前药或盐的药物组合物和化妆品组合物。在进一步的实施方案中，本发明涉及使用一种或多种NR，NAR，NRH或NARH衍生物或其前药，溶剂合物或其盐来促进细胞中烟酰胺腺嘌呤二核苷酸（NAD +）的细胞内水平的增加的方法，以及用于改善细胞和组织存活的组织以及整个细胞和组织的健康。

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