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2. 发明申请

WO2013082600A1 BIOSENSOR SYSTEMS AND RELATED METHODS FOR DETECTING ANALYTES IN AQUEOUS AND BIOLOGICAL ENVIRONMENTS 审中-公开
标题翻译：生物传感器系统和相关方法检测水分和生物环境中的分析
公开(公告)号：WO2013082600A1
公开(公告)日：2013-06-06
申请号：PCT/US2012/067609
申请日：2012-12-03
申请人： THE JOHNS HOPKINS UNIVERSITY
发明人： EVERETT, Allen Dale , KATZ, Howard , BESAR, Kalpana , HUANG, Weiguo
IPC分类号： G01N33/50 , G01N33/48 , G01N33/53 , G01N27/26
CPC分类号： G01N27/327 , A61B5/14507 , A61B5/14865 , C23C16/4486 , G01N27/4145
摘要： Disclosed herein are biosensor systems and related methods for detecting analytes in aqueous and biologic environments. A biosensor system for detecting binding of an analyte of interest may include a detector configured to detect a change in an electrical property on a surface thereof. The detector may be a FET. The system also may include a passive layer disposed on a top surface of the detector. Further, the system may include a hydrophobic layer disposed on the passive layer. The system also may include a receptor-attachment material configured for binding to an analyte. A receptor may bind to the analyte, and the receptor may be attached to the receptor-attachment material. The binding of the analyte to the receptor can cause the change of the electrical property at the surface. In response to the change for example, a current may change for indicating the binding of the analyte to the receptor.
摘要翻译：本文公开了用于在水和生物环境中检测分析物的生物传感器系统和相关方法。用于检测感兴趣分析物的结合的生物传感器系统可以包括检测器，其被配置为检测其表面上的电特性的变化。检测器可以是FET。该系统还可以包括设置在检测器的顶表面上的无源层。此外，该系统可以包括设置在被动层上的疏水层。该系统还可以包括配置用于结合分析物的受体 - 附着材料。受体可以结合分析物，并且受体可以连接到受体附着物质上。分析物与受体的结合可导致表面电性能的变化。响应于例如的变化，电流可能改变以指示分析物与受体的结合。

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