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1. 发明申请

WO2004003195A1 TRYPTOPHAN AS A FUNCTIONAL REPLACEMENT FOR ADP-RIBOSE-ARGININE IN RECOMBINANT PROTEINS 审中-公开
标题翻译： TRYPTOPHAN作为ADP-RIBOSE-ARGININE在重组蛋白中的功能替代
公开(公告)号：WO2004003195A1
公开(公告)日：2004-01-08
申请号：PCT/US2003/020498
申请日：2003-06-27
申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA,as represented by THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES , UNIVERSITY OF MASSACHUSETTS MEDICAL CENTER , MOSS, Joel , STEVENS, Linda , BOURGEOIS, Christelle , BORTELL, Rita
发明人： MOSS, Joel , STEVENS, Linda , BOURGEOIS, Christelle , BORTELL, Rita
IPC分类号： C12N9/24
CPC分类号： A61K38/1709 , C07H21/04 , C07K1/107 , C07K14/4723 , C12N9/1077 , C12P21/02
摘要： A method is disclosed for producing a polypeptide with a modified activity or stability, by replacing an arginine residue capable of being ADP-ribosylated with a tryptophan or a phenylalanine. In one embodiment, compositions are provided that include polypeptides, such as alpha defensin, with arginine-to-tryptophan or arginine-to-phenylalanine substitutions, where the arginine residue is capable of being ADP-ribosylated. In another embodiment, methods are disclosed for modifying an immune response in a subject.
摘要翻译：公开了通过用色氨酸或苯丙氨酸替代能够进行ADP-核糖基化的精氨酸残基来生产具有改变的活性或稳定性的多肽的方法。在一个实施方案中，提供了包括多肽，例如α-防御素与精氨酸对色氨酸或精氨酸 - 苯丙氨酸取代的组合物，其中精氨酸残基能够被ADP-核糖基化。在另一个实施方案中，公开了用于修饰受试者的免疫应答的方法。

2. 发明申请

WO2011031713A3 METHOD FOR THE TREATMENT OF PULMONARY DISEASE AND METHOD OF PRODUCING PROTEINS OF USE THEREIN 审中-公开
公开(公告)号：WO2011031713A3
公开(公告)日：2011-03-17
申请号：PCT/US2010/048068
申请日：2010-09-08
申请人： THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , MOSS, Joel , STEVENS, Linda , LEVINE, Rodney, L.
发明人： MOSS, Joel , STEVENS, Linda , LEVINE, Rodney, L.
IPC分类号： A61K38/16 , A61K38/17 , A61P11/06 , A61P11/00
摘要： Disclosed herein are methods of treating a subject with pulmonary disease including administering to the subject a therapeutically effective amount of a polypeptide including at least one arginine residue susceptible to ADP-ribosylation and nicotinamide adenine dinucleotide (NAD). In some embodiments, the polypeptide and/or NAD is administered via inhalation. Also disclosed is a pharmaceutical composition including at least one polypeptide (such as HNP-I) and NAD. The disclosure also provides in vitro methods of producing a polypeptide with altered activity, including contacting the polypeptide with NAD and an arginine- specific mono-ADP-ribosyltransferase (for example, ARTl) to produce a polypeptide including at least one ADP-ribosylated arginine residue, incubating the ADP-ribosylated polypeptide under conditions sufficient for conversion of at least one ADP-ribosylated arginine residue to ornithine, and isolating the ornithine- containing polypeptide. Methods of treating a subject with pulmonary disease including administering to the subject a therapeutically effective amount of a modified polypeptide (such as HNP-I) including at least one ornithine residue in place of an arginine residue are also disclosed.

3. 发明申请

WO2011031713A8 METHOD FOR THE TREATMENT OF PULMONARY DISEASE AND METHOD OF PRODUCING PROTEINS OF USE THEREIN 审中-公开
公开(公告)号：WO2011031713A8
公开(公告)日：2011-03-17
申请号：PCT/US2010/048068
申请日：2010-09-08
申请人： THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , MOSS, Joel , STEVENS, Linda , LEVINE, Rodney, L.
发明人： MOSS, Joel , STEVENS, Linda , LEVINE, Rodney, L.
IPC分类号： A61K38/16 , A61K38/17 , A61P11/06 , A61P11/00
摘要： Disclosed herein are methods of treating a subject with pulmonary disease including administering to the subject a therapeutically effective amount of a polypeptide including at least one arginine residue susceptible to ADP-ribosylation and nicotinamide adenine dinucleotide (NAD). In some embodiments, the polypeptide and/or NAD is administered via inhalation. Also disclosed is a pharmaceutical composition including at least one polypeptide (such as HNP-I) and NAD. The disclosure also provides in vitro methods of producing a polypeptide with altered activity, including contacting the polypeptide with NAD and an arginine- specific mono-ADP-ribosyltransferase (for example, ARTl) to produce a polypeptide including at least one ADP-ribosylated arginine residue, incubating the ADP-ribosylated polypeptide under conditions sufficient for conversion of at least one ADP-ribosylated arginine residue to ornithine, and isolating the ornithine- containing polypeptide. Methods of treating a subject with pulmonary disease including administering to the subject a therapeutically effective amount of a modified polypeptide (such as HNP-I) including at least one ornithine residue in place of an arginine residue are also disclosed.

4. 发明申请

WO2011031713A2 METHOD FOR THE TREATMENT OF PULMONARY DISEASE AND METHOD OF PRODUCING PROTEINS OF USE THEREIN 审中-公开
标题翻译：治疗肺部疾病的方法和生产其中使用的蛋白质的方法
公开(公告)号：WO2011031713A2
公开(公告)日：2011-03-17
申请号：PCT/US2010/048068
申请日：2010-09-08
申请人： THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVI , MOSS, Joel , STEVENS, Linda , LEVINE, Rodney, L.
发明人： MOSS, Joel , STEVENS, Linda , LEVINE, Rodney, L.
IPC分类号： A61K38/16 , A61K38/17 , A61P11/06 , A61P11/00
CPC分类号： C07K14/4712 , A61K31/7084 , A61K38/16 , A61K38/17 , A61K38/1729 , A61K38/45 , C07K14/47 , C12Y204/0203
摘要： Disclosed herein are methods of treating a subject with pulmonary disease including administering to the subject a therapeutically effective amount of a polypeptide including at least one arginine residue susceptible to ADP-ribosylation and nicotinamide adenine dinucleotide (NAD). In some embodiments, the polypeptide and/or NAD is administered via inhalation. Also disclosed is a pharmaceutical composition including at least one polypeptide (such as HNP-I) and NAD. The disclosure also provides in vitro methods of producing a polypeptide with altered activity, including contacting the polypeptide with NAD and an arginine- specific mono-ADP-ribosyltransferase (for example, ARTl) to produce a polypeptide including at least one ADP-ribosylated arginine residue, incubating the ADP-ribosylated polypeptide under conditions sufficient for conversion of at least one ADP-ribosylated arginine residue to ornithine, and isolating the ornithine- containing polypeptide. Methods of treating a subject with pulmonary disease including administering to the subject a therapeutically effective amount of a modified polypeptide (such as HNP-I) including at least one ornithine residue in place of an arginine residue are also disclosed.
摘要翻译：本文公开了治疗患有肺病的受试者的方法，所述方法包括向所述受试者施用治疗有效量的包含至少一个对ADP-核糖基化和烟酰胺腺嘌呤二核苷酸（NAD）敏感的精氨酸残基的多肽。在一些实施方案中，通过吸入施用多肽和/或NAD。还公开了包含至少一种多肽（例如HNP-1）和NAD的药物组合物。本公开还提供了产生具有改变的活性的多肽的体外方法，包括使所述多肽与NAD和精氨酸特异性单ADP-核糖基转移酶（例如ART1）接触以产生包含至少一个ADP-核糖基化精氨酸残基在足以将至少一个ADP-核糖化精氨酸残基转化为鸟氨酸的条件下温育ADP-核糖化多肽，并分离含鸟氨酸多肽。还公开了治疗患有肺病的受试者的方法，包括给受试者施用治疗有效量的包含至少一个鸟氨酸残基代替精氨酸残基的修饰多肽（例如HNP-1）。

5. 发明申请

WO2009074808A1 SYPHILIS DETECTION REAGENT 审中-公开
标题翻译： SYPHILIS检测试剂
公开(公告)号：WO2009074808A1
公开(公告)日：2009-06-18
申请号：PCT/GB2008/004106
申请日：2008-12-11
申请人： LAB 21 LIMITED , GOODWIN, Christian, John , AHMADI, Daniel, David , STEVENS, Linda
发明人： GOODWIN, Christian, John , AHMADI, Daniel, David , STEVENS, Linda
IPC分类号： C07K14/20 , G01N33/571
CPC分类号： C07K14/20 , A61K38/00 , G01N33/571 , G01N2333/20 , G01N2469/20
摘要： An isolated Treponema pallidum protein for use in an assay to detect the presence of Treponema pallidum in a sample, characterised in that the protein is reduced and/or denatured. Also disclosed is a reduced and/or denatured T. pallidum protein conjugate, methods of making a reduced and/or denatured T. pallidum protein and T. pallidum protein conjugates, use of same, a kit comprising same for the detection of T. pallidum in a sample, and a method of detecting T. pallidum in a sample.
摘要翻译：用于检测样品中梅毒螺旋体存在的测定中的分离的梅毒螺旋体苍白球蛋白，其特征在于蛋白质被还原和/或变性。还公开了还原和/或变性的苍白球蛋白缀合物，制备还原和/或变性T的方法。苍白球蛋白和苍白球蛋白缀合物，使用它们，用于检测样品中苍白曲霉的试剂盒，以及检测样品中苍白霉的方法。

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