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    • 3. 发明申请
    • NANOCHANNEL-BASED SENSOR SYSTEM FOR USE IN DETECTING CHEMICAL OR BIOLOGICAL SPECIES
    • 用于检测化学或生物物种的基于纳米通道的传感器系统
    • WO2008063901A1
    • 2008-05-29
    • PCT/US2007/084046
    • 2007-11-08
    • TRUSTEES OF BOSTON UNIVERSITYCHEN, YuWANG, XihuaKALINOWSKI, AgniezskaHONG, MiMOHANTY, PritirajERRAMILLI, Shyamsunder
    • CHEN, YuWANG, XihuaKALINOWSKI, AgniezskaHONG, MiMOHANTY, PritirajERRAMILLI, Shyamsunder
    • G01N27/414
    • G01N27/12B82Y15/00G01N27/4146
    • A sensor system for detecting a chemical or biological species includes a sensing element and a bias and measurement circuit. The sensing element includes nanochannels, each having an outer surface functionalized to chemically interact with the species to create a corresponding surface potential, and each having a sufficiently small cross section to exhibit a shift of a differential conductance characteristic into a negative bias operating region by a shift amount dependent on the surface potential. The bias and measurement circuit applies a bias voltage across two ends of the nanochannels sufficiently negative to achieve a desired dependence of the differential conductance on the surface potential, wherein the dependence has a steeply sloped region of high amplification substantially greater than a reference amplification at a zero-bias condition, thus achieving relatively high signal-to-noise ratio. The bias and measurement circuit converts the measured differential conductance into a signal indicative of presence or activity of the species of interest.
    • 用于检测化学或生物物种的传感器系统包括感测元件和偏置和测量电路。 感测元件包括纳米通道,每个纳米通道的外表面被官能化以与物质发生化学相互作用以产生相应的表面电位,并且每个具有足够小的横截面以显示差分电导特性转移到负偏压操作区域中 位移量取决于表面电位。 偏置和测量电路将纳米通道的两端的偏置电压充分地负给以实现差分电导对表面电势的期望的依赖性,其中依赖性具有高放大的急剧下降的区域,基本上大于在 零偏置条件,从而达到较高的信噪比。 偏置和测量电路将测量的差分电导转换为指示感兴趣物种的存在或活动的信号。