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1. 发明申请

WO1991008224A1 IM PEPTIDES 审中-公开
公开(公告)号：WO1991008224A1
公开(公告)日：1991-06-13
申请号：PCT/AU1990000564
申请日：1990-11-23
申请人： THE COUNCIL OF THE QUEENSLAND INSTITUTE OF ... , SCULLEY, Tom, Brian , MOSS, Denis, James
发明人： THE COUNCIL OF THE QUEENSLAND INSTITUTE OF ...
IPC分类号： C07K07/06
CPC分类号： C07K14/005 , A61K39/00 , C12N2710/16222 , Y10S435/975 , Y10S436/812
摘要： The invention is directed to the diagnosis and treatment of herpes virus related diseases. By noting within the Epstein-Barr virus (EBV) open reading frames (ORFs) transcribed late in the viral cycle for which a translation product may or may not have been established, and synthesizing one or more polypeptides each of which includes at least one segment, each segment comprising at least part of the amino acid sequence identified in that ORF, a specific and reliable diagnostic test for, and treatment of, infectious mononucleosis and related diseases is possible. The preferred amino acid sequences for these segments include NSPKNG, KNGSNQ, SNQLVI, AHARDK, RDKAGA, VMAMIL, SEPRPR and PSRTPS. These sequences can be further combined to provide polypeptides with at least one segment comprising sequences selected from AHARDKAGAVMAMIL, ASLNSPKNGSNQLVI, ELESEPRPRPSRTPS, QAMKKIEDKVRKSVD, SRSRGREAKKVQISD, LIKASLRKDRKLYAE, VSFSKTRRAIRESRA, CNYSAGEEDDQYHAN, RPHRRPVSKRPTHKP, EITQEENRGEQRLGH, GALRARLDRPRPTAQ, NSPKNGSNQAHARDKSEPRPR, NSPKNGSNQRDKAGASEPRPR, NSPKNGSNQSEPRPRKNGSNQ, NSPKNGSNQLVISEPRPRPSRTPS, NSPKNGSNQLVIPSRTPS and NSPKNGSNQAHARDKAGASEPRPR.
摘要翻译：本发明涉及疱疹病毒相关疾病的诊断和治疗。通过在爱泼斯坦 - 巴尔病毒（EBV）内注意到翻译产物可能已经建立或可能不被建立的病毒循环的晚期转录的开放阅读框（ORFs），并合成一个或多个多肽，每个多肽包括至少一个片段，每个片段包含在该ORF中鉴定的氨基酸序列的至少一部分，感染性单核细胞增多症和相关疾病的具体可靠的诊断测试和治疗是有可能的。这些片段的优选氨基酸序列包括NSPKNG，KNGSNQ，SNQLVI，AHARDK，RDKAGA，VMAMIL，SEPRPR和PSRTPS。这些序列可以被进一步结合以提供多肽与至少一个区段包括从AHARDKAGAVMAMIL，ASLNSPKNGSNQLVI，ELESEPRPRPSRTPS，QAMKKIEDKVRKSVD，SRSRGREAKKVQISD，LIKASLRKDRKLYAE，VSFSKTRRAIRESRA，CNYSAGEEDDQYHAN，RPHRRPVSKRPTHKP，EITQEENRGEQRLGH，GALRARLDRPRPTAQ，NSPKNGSNQAHARDKSEPRPR，NSPKNGSNQRDKAGASEPRPR，NSPKNGSNQSEPRPRKNGSNQ，NSPKNGSNQLVISEPRPRPSRTPS，NSPKNGSNQLVIPSRTPS和选择的序列 NSPKNGSNQAHARDKAGASEPRPR。

2. 发明申请

WO1993011157A1 MALARIAL VACCINE AND PEPTIDES COMPRISING HUMAN T-CELL EPITOPE OF CIRCUMSPOROZOITE PROTEIN OF P.VIVAX 审中-公开
标题翻译：包含P.VIVAX的环磷酰胺蛋白质的人T细胞外源的疟原菌和肽
公开(公告)号：WO1993011157A1
公开(公告)日：1993-06-10
申请号：PCT/AU1992000639
申请日：1992-11-27
申请人： THE COUNCIL OF THE QUEENSLAND INSTITUTE OF ... , GOOD, Michael , BILSBOROUGH, Janine
发明人： THE COUNCIL OF THE QUEENSLAND INSTITUTE OF ...
IPC分类号： C07K07/08
CPC分类号： C07K14/445 , A61K39/00 , Y02A50/412 , Y02A50/58
摘要： The present invention relates generally to a malarial vaccine and peptides useful for same. More particularly, the present invention is directed to a peptide comprising a human T-cell epitope of the circumsporozoite protein of Plasmodium vivax or parts, fragments, derivatives, homologues or analogues thereof. The present invention further provides antibodies to such a peptide and to their use in a diagnostic assay for infection by P.vivax.
摘要翻译：本发明一般涉及疟疾疫苗和可用于其的肽。更具体地，本发明涉及包含间日疟原虫的环子孢子蛋白的人T细胞表位的肽或其部分，片段，衍生物，同系物或类似物的肽。本发明还提供了针对这种肽的抗体及其在用于P.vivax感染的诊断测定中的用途。

3. 发明申请

WO1993021220A1 SYNTHETIC PEPTIDES USEFUL IN A VACCINE AGAINST AND IN THE DIAGNOSIS OF STREPTOCOCCAL INFECTION 审中-公开
标题翻译：合成肽在抗真菌药物中的应用和对结肠感染的诊断
公开(公告)号：WO1993021220A1
公开(公告)日：1993-10-28
申请号：PCT/AU1993000131
申请日：1993-03-30
申请人： THE COUNCIL OF THE QUEENSLAND INSTITUTE OF ... , GOOD, Michael, Francis , PRUKSAKORN, Sumalee;
发明人： THE COUNCIL OF THE QUEENSLAND INSTITUTE OF ...
IPC分类号： C07K07/08
CPC分类号： C07K14/315 , A61K39/00
摘要： The present invention provides a synthetic peptide comprising at least on B cell epitope from the carboxyterminus of M protein of Group A ss-hemolitic streptococci wherein an antibody reactive to the B cell epitope is only minimally reactive to human heart tissue. The synthetic peptide may also contain a T cell epitope. The present invention further comtemplates a vaccine comprising the synthetic peptide and a method for vaccinating human subjects against streptococcal infection.
摘要翻译：本发明提供了一种合成肽，其至少包含来自A组β-半胱氨酸链球菌的M蛋白的羧基末端的至少B细胞表位，其中与B细胞表位反应的抗体仅对人心脏组织具有极低的反应性。合成肽还可以含有T细胞表位。本发明还包括一种包含合成肽的疫苗和一种针对链球菌感染接种人类受试者的方法。

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