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1. 发明申请

WO2017223498A1 METHOD AND PROCESS FOR QUANTITATIVE EVALUATION OF PHARMACOKINETICS, THERAPEUTIC EFFECTS AND SAFETY OF DELIVERY OF DRUG COMPOUNDS TO THE INNER EAR FOR TREATMENT OF AUDITORY DISEASES 审中-公开
标题翻译：药物动力学定量评估的方法和过程，药物化合物向耳内递送用于治疗听力疾病的治疗效果和安全性
公开(公告)号：WO2017223498A1
公开(公告)日：2017-12-28
申请号：PCT/US2017/039090
申请日：2017-06-23
申请人： THE CHARLES STARK DRAPER LABORATORY INC. , MASSACHUSETTS EYE AND EAR INFIRMARY , MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： BORENSTEIN, Jeffrey T. , PARARAS, Erin , KIM, Ernest S. , TANDON, Vishal , AYOOB, Andrew , MCKENNA, Michael , SEWELL, William , PEPPI, Marcello , WEINBERG, Marc , LANGER, Robert
IPC分类号： A61K31/498 , A61K47/10 , A61K9/00 , A61P27/16
摘要： The present disclosure provides compositions and methods for treating an auditory disease in a subject in need thereof comprising administering an effective amount of a gel-based precursor that includes an inner ear-specific therapeutic compound directly into the cochlea of the subject.
摘要翻译：本公开内容提供了用于治疗有需要的受试者中的听觉疾病的组合物和方法，其包括将有效量的包含内耳特异性治疗化合物的基于凝胶的前体直接施用到耳蜗中的主题。

2. 发明申请

WO2018049076A2 SILICON CARBIDE ELECTROMECHANICAL STRUCTURE, DEVICES AND METHOD 审中-公开
标题翻译：碳化硅机电结构，器件和方法
公开(公告)号：WO2018049076A2
公开(公告)日：2018-03-15
申请号：PCT/US2017/050557
申请日：2017-09-07
申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by THE SECRETARY OF THE NAVY , THE CHARLES STARK DRAPER LABORATORY, INC.
发明人： KUB, Francis, J. , HOBART, Karl, D. , IMHOFF, Eugene, A. , MYERS-WARD, Rachael, L. , COOK, Eugene , BERNSTEIN, Jonathan , WEINBERG, Marc
摘要： Electromechanical device structures are provided, as well as methods for forming them. The device structures incorporate at least a first and second substrate separated by an interface material layer, where the first substrate comprises an anchor material structure and at least one suspended material structure, optionally a spring material structure, and optionally an electrostatic sense electrode. The device structures may be formed by methods that include providing an interface material layer on one or both of the first and second substrates, bonding the interface materials to the opposing first or second substrate or to the other interface material layer, followed by forming the suspended material structure by etching.
摘要翻译：提供了机电装置结构以及用于形成它们的方法。装置结构至少包括由界面材料层分开的第一和第二衬底，其中第一衬底包括锚固材料结构和至少一个悬浮材料结构，可选地弹簧材料结构以及可选的静电感测电极。器件结构可以通过以下方法形成，该方法包括在第一和第二衬底中的一个或两个上提供界面材料层，将界面材料结合到相对的第一或第二衬底或其他界面材料层，接着形成悬置材料结构通过蚀刻。

3. 发明申请

WO2018049076A3 SILICON CARBIDE ELECTROMECHANICAL STRUCTURE, DEVICES AND METHOD 审中-公开
公开(公告)号：WO2018049076A3
公开(公告)日：2018-03-15
申请号：PCT/US2017/050557
申请日：2017-09-07
申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by THE SECRETARY OF THE NAVY , THE CHARLES STARK DRAPER LABORATORY, INC.
发明人： KUB, Francis, J. , HOBART, Karl, D. , IMHOFF, Eugene, A. , MYERS-WARD, Rachael, L. , COOK, Eugene , BERNSTEIN, Jonathan , WEINBERG, Marc
IPC分类号： B32B9/00 , B81B7/02
摘要： Electromechanical device structures are provided, as well as methods for forming them. The device structures incorporate at least a first and second substrate separated by an interface material layer, where the first substrate comprises an anchor material structure and at least one suspended material structure, optionally a spring material structure, and optionally an electrostatic sense electrode. The device structures may be formed by methods that include providing an interface material layer on one or both of the first and second substrates, bonding the interface materials to the opposing first or second substrate or to the other interface material layer, followed by forming the suspended material structure by etching.

4. 发明申请

WO2013112310A2 MEMS VIBRATION ISOLATION SYSTEM AND METHOD 审中-公开
标题翻译： MEMS振动隔离系统及方法
公开(公告)号：WO2013112310A2
公开(公告)日：2013-08-01
申请号：PCT/US2013/021408
申请日：2013-01-14
申请人： THE CHARLES STARK DRAPER LABORATORY, INC.
发明人： BERNSTEIN, Jonathan , WEINBERG, Marc
IPC分类号： B81B7/00
CPC分类号： B81B7/0016
摘要： A microelectromechanical vibration isolation system includes a microelectromechanical structure having a plurality of fin apertures etched therethrough, and a plurality of fins each disposed within a respective one of the plurality of fin apertures and spaced apart from the microelectromechanical structure so as to define a fluid gap therebetween. The fluid gap is configured to provide squeeze film damping of vibrations imparted upon the microelectromechanical structure in at least two dimensions. The system further includes a frame surrounding the microelectromechanical structure, and a plurality of springs each coupled to the microelectromechanical structure and to the frame. The plurality of springs is configured to support the microelectromechanical structure in relation to the frame.
摘要翻译：一种微机电振动隔离系统包括微机电结构，该微机电结构具有蚀刻穿过的多个鳍孔以及多个鳍片，每个鳍片设置在多个鳍孔中的相应的一个内，并与微机电结构以在其间限定流体间隙。该流体间隙被配置为在至少两个维度上为施加在微机电结构上的振动提供挤压膜阻尼。该系统还包括围绕微机电结构的框架和多个弹簧，每个弹簧联接到微机电结构和框架。多个弹簧构造成相对于框架支撑微机电结构。

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