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1. 发明申请

WO1997039357A1 Wnt RECEPTOR COMPOSITIONS AND METHODS 审中-公开
标题翻译： Wnt受体组成和方法
公开(公告)号：WO1997039357A1
公开(公告)日：1997-10-23
申请号：PCT/US1997006049
申请日：1997-04-11
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY , JOHNS HOPKINS UNIVERSITY
发明人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY , JOHNS HOPKINS UNIVERSITY , BRINK, Marcel , SAMOS, Cindy, H. , WANG, Yansu , HSIEH, Jen-Chih , ANDREW, Deborah , NATHANS, Jeremy , NUSSE, Roel , BHANOT, Purnima
IPC分类号： G01N33/566
CPC分类号： C07K14/71 , C07K14/43581 , G01N33/74 , G01N2333/43573 , G01N2500/00
摘要： Wnt receptor compositions and methods of use are disclosed. In particular, methods using Wnt receptors, such as Dfz2, in screens for compounds which modulate the binding of a Wnt polypeptide to a Wnt receptor.
摘要翻译：公开了Wnt受体组合物和使用方法。特别地，使用Wnt受体（例如Dfz2）在筛选调节Wnt多肽与Wnt受体的结合的化合物的方法。

2. 发明申请

WO1998005060A1 MULTIZONE BAKE/CHILL THERMAL CYCLING MODULE 审中-公开
标题翻译：多功能烘烤/冷冻循环模块
公开(公告)号：WO1998005060A1
公开(公告)日：1998-02-05
申请号：PCT/US1997013568
申请日：1997-07-31
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
发明人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY , SCHAPER, Charles, D. , EL-AWADY, Khalid, A. , KAILATH, Thomas
IPC分类号： H01L21/00
CPC分类号： B01L7/52 , B01L7/54 , H01L21/67109
摘要： A thermal cycling module includes an array of thermoelectric devices (36) divided into multiple zones (A, B, C, D) independently controlled by corresponding variable power supplies (56, 58, 60, 62). The thermoelectric devices (36) provide localized, precise, and rapid control of both heating an cooling, while fluid from one of several fluid supplies (64, 66, 68) provides bulk heating or cooling via a fluid heat exchanger (38). Sensors (46, 48, 50, 52) provide feedback of temperature or other process parameters to a controller (54) which generates control signals for controlling the power supplies (56, 58, 60, 62), the fluid supplies (64, 66, 68), and fluid valves (70, 72) which control fluid flow through the heat exchanger (38).
摘要翻译：热循环模块包括分成多个区域（A，B，C，D）的热电装置（36）的阵列，其独立地由相应的可变电源（56,58,60,62）控制。热电装置（36）提供对加热冷却的局部的，精确的和快速的控制，而来自多个流体供应（64,66,68）之一的流体通过流体热交换器（38）提供大量加热或冷却。传感器（46,48,50,52）向控制器（54）提供温度或其他过程参数的反馈，控制器（54）产生用于控制电源（56,58,60,62），流体供应（64,66），68）和控制流过所述热交换器（38）的流体的流体阀（70,72）。

3. 发明申请

WO1997022349A1 METHODS FOR IN VIVO T CELL ACTIVATION BY ANTIGEN-PULSED DENDRITIC CELLS 审中-公开
标题翻译：抗原激活细胞激活血管内皮细胞的方法
公开(公告)号：WO1997022349A1
公开(公告)日：1997-06-26
申请号：PCT/US1996019954
申请日：1996-12-17
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
发明人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY , ENGLEMAN, Edgar, G. , LEVY, Ronald , HSU, Frank , BENIKE, Claudia
IPC分类号： A61K35/14
CPC分类号： G01N33/56988 , A61K39/0011 , A61K39/12 , A61K39/21 , A61K2039/5154 , C12N2740/16134 , G01N33/686
摘要： The present invention relates to methods of using isolated human dendritic cells to present exogenous antigens for the induction of immune responses in vivo. In particular, it relates to the isolation of dendritic cells from human blood, exposing the cells to lymphoma-derived immunoglobulins or to proteins derived from human immunodeficiency virus (HIV) as antigens, and infusing the antigen-pulsed dendritic cells into patients to induce and/or augment an antigen-specific immune response. The methods of the invention described herein have a wide range of applications, including, but not limited to, the clinical use of antigen-pulsed dendritic cells as vaccines and/or immunotherapeutics against cancer and infectious agents such as viruses.
摘要翻译：本发明涉及使用分离的人树突状细胞来呈递外源抗原以诱导体内免疫应答的方法。特别地，它涉及从人血液中分离树突状细胞，将细胞暴露于来自淋巴瘤的免疫球蛋白或衍生自人免疫缺陷病毒（HIV）的蛋白质作为抗原，并将抗原脉冲的树突细胞注入患者以诱导和 /或增加抗原特异性免疫应答。本文描述的本发明的方法具有广泛的应用，包括但不限于抗原脉冲的树突状细胞作为疫苗和/或针对癌症和感染因子如病毒的免疫治疗剂的临床应用。

4. 发明申请

WO1997018333A1 DISRUPTION OF EXPRESSION OF MULTIPLE ALLELES OF MAMMALIAN GENES 审中-公开
标题翻译：破坏MAMMALIAN基因多态性的表达
公开(公告)号：WO1997018333A1
公开(公告)日：1997-05-22
申请号：PCT/US1996018828
申请日：1996-11-15
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
发明人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY , LI, Limin , COHEN, Stanley, N.
IPC分类号： C12Q01/68
CPC分类号： G01N33/57415 , C07K14/4702 , C12N15/00 , C12Q1/68 , C12Q1/6886 , C12Q2600/118 , C12Q2600/136
摘要： Methods are provided for identifying a gene at a random chromosomal locus in the genome of a mammalian cell. The method involves inactivating one copy of the gene by integrating one DNA construct (knockout construct) in that gene copy. The knockout construct includes a positive selection marker region sequence and, in a 5' direction from the selection marker region sequence, a transcription initiation region sequence responsive to a transactivation factor, said transcription initiation region oriented for antisense RNA transcription in the direction away from the selection marker region sequence. The second copy of the gene is inactivated by transforming the cells with a second DNA construct (transactivation construct) containing a gene sequence for the transactivation factor which initiates antisense RNA transcription extending from the knockout construct into the chromosomal locus flanking the knockout construct at its 5' end. Inactivation of both gene copies may result in a change in cell phenotype distinguishable from the wild-type phenotype. Optionally, the wild-type phenotype can be regained by introducing a third construct that can inhibit antisense RNA transcription. A gene is provided associated with tumor susceptibility of mammalian cells, tsg 101.
摘要翻译：提供了用于鉴定哺乳动物细胞基因组中随机染色体基因座上的基因的方法。该方法包括通过在该基因拷贝中整合一个DNA构建体（敲除构建体）来使基因的一个拷贝失活。敲除构建体包括阳性选择标记区序列，并且在从选择标记区序列的5'方向上，对反式激活因子有反应的转录起始区序列，所述转录起始区在远离选择标记区序列。通过用包含反式激活因子的基因序列的第二个DNA构建体（反式激活构建体）转化细胞来灭活该基因的第二个拷贝，其启动从敲除构建体延伸到其敲除构建体侧翼的染色体基因座的5' ' 结束。两种基因拷贝的失活可导致与野生型表型区分开的细胞表型的变化。任选地，可以通过引入可抑制反义RNA转录的第三构建体来恢复野生型表型。提供与哺乳动物细胞tsg 101的肿瘤易感性相关的基因。

5. 发明申请

WO1996028120A1 APPARATUS AND METHOD FOR CORE BODY WARMING OF MAMMALS EXPERIENCING HYPOTHERMIA 审中-公开
标题翻译：用于经验丰富的妈妈的核心身体加热的装置和方法
公开(公告)号：WO1996028120A1
公开(公告)日：1996-09-19
申请号：PCT/US1996003231
申请日：1996-03-08
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
发明人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY , GRAHN, Dennis, A.
IPC分类号： A61F07/00
CPC分类号： A61F7/02 , A61B2017/306 , A61F2007/0029 , A61F2007/0039 , A61F2007/0054 , A61F2007/0088 , A61F2007/0239
摘要： The invention presents an apparatus and a method for core body warming of hypothermic mammals. The apparatus has an enclosing element (12) to be placed around a predetermined body portion of a mammal in a vacuum tight manner and a vacuum system (26) connected to the enclosing element (12) for generating and maintaining a predetermined negative pressure, preferably between -20 mm hg and -80 mm hg, inside the enclosing element (12). A heating unit (34) delivers a thermal energy while the vacuum system (26) is maintaining the predetermined negative pressure. The simultaneous application of thermal energy and negative pressure produces vasodilation, which promotes absorption of the thermal energy through the surface of the body portion. The circulatory system of the mammal naturally carries the thermal energy to the core body of the mammal.
摘要翻译：本发明提出了低体温哺乳动物的核心体温升高装置和方法。所述装置具有围绕所述哺乳动物的预定身体部分以真空密封的方式放置的封闭元件（12）和连接到所述封闭元件（12）的用于产生和保持预定负压的真空系统（26），优选地在-20mmh和-80mmh之间，在封闭元件（12）内。加热单元（34）在真空系统（26）保持预定的负压的同时传递热能。同时施加热能和负压产生血管舒张，其促进热能通过身体部分表面的吸收。哺乳动物的循环系统自然地携带热能到哺乳动物的核心。

6. 发明申请

WO1996022546A1 WIDE AREA DIFFERENTIAL GPS REFERENCE SYSTEM AND METHOD 审中-公开
标题翻译：广域差分GPS参考系和方法
公开(公告)号：WO1996022546A1
公开(公告)日：1996-07-25
申请号：PCT/US1996000672
申请日：1996-01-17
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
发明人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY , ENGE, Per, K. , WALTER, Todd, F. , CHAO, Yi-Chung
IPC分类号： G01S05/02
CPC分类号： G01S19/05 , G01S19/07
摘要： A GPS reference system and corresponding method utilizing a network of reference stations and a master station (Fig. 1). Each reference station (102) receives GPS signals from GPS satellites (106), it observes and computes in response a pseudo-range residual for each GPS satellite. The master station (108) is in communication with the reference stations to receive the computed pseudo-range residuals and comprises a pseudo-range residual synchronizer, an ephemeris and clock correction estimator for each GPS satellite observed by the reference stations and a transmitter. The pseudo-range residual synchronizer computes clock differences between the reference stations so as to synchronize them. Each ephemeris and clock correction estimator computes an ephemeris correction and a clock correction for the corresponding GPS satellite. The transmitter transmits to users the computed ephemeris and clock correction.
摘要翻译： GPS参考系和相应的方法，利用参考站和主站的网络（图1）。每个参考站（102）从GPS卫星（106）接收GPS信号，它响应地观察并计算每个GPS卫星的伪距离残差。主站（108）与参考站通信以接收所计算的伪距离残差，并且包括伪距余量同步器，由参考站和发射机观测的每个GPS卫星的星历和时钟校正估计器。伪距离剩余同步器计算参考站之间的时钟差，以便使它们同步。每个星历和时钟校正估计器计算相应GPS卫星的星历校正和时钟校正。发射机向用户发送计算的星历和时钟校正。

7. 发明申请

WO1996009791A2 FORWARD VIEWING ULTRASONIC IMAGING CATHETER 审中-公开
标题翻译：前瞻性超声波成像导管
公开(公告)号：WO1996009791A2
公开(公告)日：1996-04-04
申请号：PCT/US1995011656
申请日：1995-09-15
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
发明人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY , LIANG, David, H. , HU, Bob, S.
IPC分类号： A61B00/00
CPC分类号： A61B8/12 , A61B8/445 , A61B8/4461 , A61B8/4483 , A61B18/245 , G10K11/35
摘要： A simple forward viewing ultrasound catheter includes one or more transducers and an ultrasound mirror supported by a bearing in a sealed end of a catheter with a drive cable imparting relative motion to the transducer and mirror. The mirror directs ultrasound waves forward of the catheter. An optical fiber can be provided to direct a laser beam for ablation of atheroma while under guidance of simultaneous intravascular ultrasound.
摘要翻译：简单的前视超声导管包括一个或多个换能器和由导管的密封端中的轴承支撑的超声镜，其具有向换能器和反射镜赋予相对运动的驱动电缆。镜子将超声波引导到导管的前方。可以提供光纤以在同时进行血管内超声的引导下引导激光束以消融动脉粥样化。

8. 发明申请

WO1996005858A1 HAEMOPHILUS ADHERENCE AND PENETRATION PROTEINS 审中-公开
标题翻译： HAEMOPHILUS ADHERENCE和渗透蛋白
公开(公告)号：WO1996005858A1
公开(公告)日：1996-02-29
申请号：PCT/US1995010661
申请日：1995-08-16
申请人： WASHINGTON UNIVERSITY , THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
发明人： WASHINGTON UNIVERSITY , THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY , ST. GEME, Joseph, W., III , FALKOW, Stanley
IPC分类号： A61K39/00
CPC分类号： C12N9/52 , A61K38/00 , A61K39/00 , C07K14/285 , C07K16/1242
摘要： Haemophilus adhesion and penetration proteins, nucleic acids, vaccines and monoclonal antibodies are provided.
摘要翻译：提供嗜血杆菌粘附和穿透蛋白，核酸，疫苗和单克隆抗体。

9. 发明申请

WO1996000300A1 ANERGY GENES 审中-公开
标题翻译：神经根
公开(公告)号：WO1996000300A1
公开(公告)日：1996-01-04
申请号：PCT/US1995007958
申请日：1995-06-22
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
发明人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY , BLOOM, Debra , FATHMAN, Garrison
IPC分类号： C12Q01/68
CPC分类号： C07K14/4705 , C12Q1/68 , C12Q1/6876 , C12Q2600/158 , G01N33/56972 , Y10T436/143333
摘要： Methods and compositions are provided for identifying genes associated with induction of anergy in T-cells and the use of the nucleic acids or proteins as diagnostics for monitoring induction of tolerance for the presence of tolerized T-cells in a physiological sample, or elucidating the pathway to anergy or activation in T-cells. A cysteine string protein is found to indicate quiescent T-cells and is lost with anergic T-cells.
摘要翻译：提供了用于鉴定与T细胞中的无反应性诱导相关的基因的方法和组合，以及使用核酸或蛋白质作为诊断用于监测对生理样品中耐受性T细胞的存在的耐受性的诱导，或阐明该途径在T细胞中的无能或活化。发现半胱氨酸链蛋白表示静止的T细胞，并且与无能T细胞一起丢失。

10. 发明申请

WO1995020872A1 GENETIC ENGINEERING OF MOLLUSKS 审中-公开
标题翻译： MOLLUSKS遗传工程
公开(公告)号：WO1995020872A1
公开(公告)日：1995-08-10
申请号：PCT/US1995001477
申请日：1995-02-02
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY , MADSEN, Annamae, L. +lf , POWERS, Dennis, Alpha , GOMEZ-CHIARRI, Marta
发明人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY , MADSEN, Annamae, L. +lf , HEREFORD, Lynna, Madsen +di
IPC分类号： A01K61/00
CPC分类号： A01K67/0334 , A01K2217/05 , A01K2267/02 , C07K14/435 , C07K14/4716 , C12N15/8509
摘要： The present invention describes vectors and methods useful for the production of transgenic mollusks, in particular, transgenic abalone. The invention further describes transgenic mollusks having enhanced growth properties. In addition, the isolation and characterization of an abalone actin gene promoter region is disclosed.
摘要翻译：本发明描述了可用于生产转基因软体动物，特别是转基因鲍鱼的载体和方法。本发明还描述了具有增强生长特性的转基因软体动物。此外，公开了鲍鱼肌动蛋白基因启动子区域的分离和表征。

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