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1. 发明申请

WO2004101150A1 MULTI-WELL ASSAY PLATES 审中-公开
标题翻译：多层测试板
公开(公告)号：WO2004101150A1
公开(公告)日：2004-11-25
申请号：PCT/AU2004/000638
申请日：2004-05-14
申请人： THE AUSTRALIAN NATIONAL UNIVERSITY , BOSWELL, Rod , CHARLES, Christine , RAMDUTT, Devin , DOS REMEDIOS, Cris , BILEK, Marcela , MCKENZIE, David
发明人： BOSWELL, Rod , CHARLES, Christine , RAMDUTT, Devin , DOS REMEDIOS, Cris , BILEK, Marcela , MCKENZIE, David
IPC分类号： B01L3/00
CPC分类号： B01L3/5085 , B01L2200/12 , B01L2300/0819
摘要： A method for manufacturing a multi-well assay plate (2) for use in analysing biological and chemical samples including the steps of plasma etching a plurality of wells (6) in a substantially planar surface (8) of a substrate (4), and forming at least one surface in each well (6) chemically attractive to one or more selected target species.
摘要翻译：一种制造用于分析生物和化学样品的多孔测定板（2）的方法，包括在衬底（4）的基本上平坦的表面（8）中等离子体蚀刻多个孔（6）的步骤，以及在每个孔（6）中形成至少一个表面，对一个或多个选定的靶物种具有化学吸引力。

2. 发明申请

WO2005081592A1 AN APPARATUS FOR PLASMA TREATMENT 审中-公开
标题翻译：血浆治疗装置
公开(公告)号：WO2005081592A1
公开(公告)日：2005-09-01
申请号：PCT/AU2005/000227
申请日：2005-02-21
申请人： THE UNIVERSITY OF SYDNEY , YIN, Yongbai , BILEK, Marcela , MCKENZIE, David , IMENES, Anne, Gerd
发明人： YIN, Yongbai , BILEK, Marcela , MCKENZIE, David , IMENES, Anne, Gerd
IPC分类号： H05H01/02
CPC分类号： H01J37/32752 , H05H1/46
摘要： The present invention provides an apparatus (10) for plasma treatment of a substrate surface (16). The apparatus comprises a plasma source (12) for generating a plasma and a plasma-control electrode (14). The apparatus further comprises a drive means for effecting a relative movement between the plasma-control electrode (14) and the plasma source (12) or of the plasma-control electrode (14) and the plasma source (12) relative to the substrate (16). The plasma-control electrode (14) is located adjacent the substrate (16) to facilitate treatment of the substrate surface (16) in a controlled manner.
摘要翻译：本发明提供一种用于等离子体处理基板表面（16）的装置（10）。该装置包括用于产生等离子体的等离子体源（12）和等离子体控制电极（14）。该装置还包括用于在等离子体控制电极（14）和等离子体源（12）或等离子体控制电极（14）和等离子体源（12）之间相对于衬底进行相对运动的驱动装置 16）。等离子体控制电极（14）位于衬底（16）附近，以便以受控的方式处理衬底表面（16）。

3. 发明申请

WO2012174596A1 IMPLANTABLE DEVICE WITH PLASMA POLYMER SURFACE 审中-公开
标题翻译：具有等离子体聚合物表面的可植入装置
公开(公告)号：WO2012174596A1
公开(公告)日：2012-12-27
申请号：PCT/AU2012/000714
申请日：2012-06-21
申请人： THE UNIVERSITY OF SYDNEY , YIN, Yongbai , BILEK, Marcela , MCKENZIE, David
发明人： YIN, Yongbai , BILEK, Marcela , MCKENZIE, David
IPC分类号： A61L27/34 , A61L27/40
CPC分类号： A61L31/022 , A61F2/82 , A61F2240/001 , A61L17/145 , A61L27/34 , A61L27/50 , A61L27/54 , A61L31/10 , A61L31/14 , A61L31/16 , A61L2420/04 , A61L2420/08 , A61L2430/02 , C08L49/00
摘要： A deformable implantable medical device such as a stent comprising metallic, polymer and/or composite substrate having a columnar structured plasma polymer surface capable of binding functional biological molecules. The polymer surface can be bound to the substrate through a mixed or graded interface formed by a co-deposition process where a substrate material is deposited with carbon containing species while gradually reducing the substrate material proportion and increasing the carbon containing species proportion. The device is able to undergo deformation without substantial delamination of the plasma polymer surface.
摘要翻译：一种可变形可植入医疗装置，例如包括金属，聚合物和/或复合衬底的支架，其具有能够结合功能性生物分子的柱状结构化等离子体聚合物表面。聚合物表面可以通过由共沉积工艺形成的混合或分级界面结合到基底上，其中衬底材料沉积有含碳物质，同时逐渐降低基底材料比例并增加含碳物质比例。该装置能够经受变形而没有等离子体聚合物表面的实质分层。

4. 发明申请

WO2009015420A1 BIOLOGICAL FUNCTIONALISATION OF SUBSTRATES 审中-公开
标题翻译：基材的生物功能化
公开(公告)号：WO2009015420A1
公开(公告)日：2009-02-05
申请号：PCT/AU2008/001085
申请日：2008-07-25
申请人： THE UNIVERSITY OF SYDNEY , BILEK, Marcela , MCKENZIE, David , YIN, Yongbai
发明人： BILEK, Marcela , MCKENZIE, David , YIN, Yongbai
IPC分类号： C08J7/12 , A61L27/54 , A61L31/18 , A61L17/04 , A61L29/16 , C08F8/00
CPC分类号： A61L27/34 , A61L27/042 , A61L27/54 , A61L2300/252 , A61L2300/254 , A61L2300/606 , A61L2400/18 , B05D1/62 , G01N33/54306 , G01N2333/908 , Y10T442/30
摘要： The invention relates to an activated metallic, semiconductor, polymer, composite and/or ceramic substrate, the substrate being bound through a mixed or graded interface to a hydrophilic polymer surface that is activated to enable direct covalent binding to a functional biological molecule, the polymer surface comprising a sub-surface that includes a plurality of cross-linked regions, as well as to such activated substrates that have been functionalised with a biological molecule and to devices comprising such functionalised substrates. Such substrates can be produced by a method comprising steps of: a. exposing a surface of the substrate to any or more of (i) to (iii): (i) plasma ion implantation with carbon containing species; (ii) co-deposition under conditions in which substrate material is deposited with carbon containing species while gradually reducing substrate material proportion and increasing carbon containing species proportion; (iii) deposition of a plasma polymer surface layer with energetic ion bombardment; incubating the surface treated according to step (a) with a desired biological molecule.
摘要翻译：本发明涉及活化的金属，半导体，聚合物，复合材料和/或陶瓷基材，所述基材通过混合或分级界面结合到亲水性聚合物表面，所述界面被活化以实现与功能性生物分子的直接共价结合，所述聚合物表面，其包括包含多个交联区域的子表面，以及已经用生物分子官能化的这种活化的底物和包含这种官能化底物的装置。这样的基材可以通过包括以下步骤的方法制备：a。（i）至（iii）中的任何一种或多种：（i）用含碳物质进行等离子体离子注入; （ii）在使含有碳的物质沉积衬底材料的条件下共沉积，同时逐渐降低衬底材料比例并增加含碳物质比例; （iii）用能量离子轰击沉积等离子体聚合物表面层; 将根据步骤（a）处理的表面与所需的生物分子一起孵育。

5. 发明申请

WO2007104107A1 ACTIVATED POLYMERS BINDING BIOLOGICAL MOLECULES 审中-公开
标题翻译：活化聚合物结合生物分子
公开(公告)号：WO2007104107A1
公开(公告)日：2007-09-20
申请号：PCT/AU2007/000321
申请日：2007-03-15
申请人： THE UNIVERSITY OF SYDNEY , BILEK, Marcela , MCKENZIE, David , NOSWORTHY, Niel
发明人： BILEK, Marcela , MCKENZIE, David , NOSWORTHY, Niel
IPC分类号： C08J7/12 , A61L29/16 , A61L17/14 , A61L27/54 , A61L31/16 , C08F8/00 , C08G2/30
CPC分类号： C08G61/02 , A61L17/005 , A61L24/0015 , A61L27/54 , A61L31/16 , A61L2300/214 , A61L2300/22 , A61L2300/23 , A61L2300/25 , A61L2300/252 , A61L2300/254 , A61L2300/256 , A61L2300/258 , C08J7/12 , C08L65/00
摘要： The present invention relates to activated polymer substrates capable of binding functional biological molecules, to polymer substrates comprising bound and functional biological molecules, to devices comprising such substrates and to methods of producing them.
摘要翻译：本发明涉及能够结合功能性生物分子的活化聚合物底物，包含结合和功能性生物分子的聚合物底物，包括这种底物的装置及其生产方法。

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