专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2010003046A3 GABAPENTIN ENACARBIL SALTS AND PROCESSES FOR THEIR PREPARATION 审中-公开
标题翻译： GABAPENTIN ENACARBIL SALTS及其制备方法
公开(公告)号：WO2010003046A3
公开(公告)日：2010-02-25
申请号：PCT/US2009049490
申请日：2009-07-02
申请人： TEVA PHARMA , TEVA PHARMA , COHEN MEITAL , NIDDAM-HILDESHEIM VALERIE , PIRAN MAYTAL , BEN MOHA-LERMAN ELENA
发明人： COHEN MEITAL , NIDDAM-HILDESHEIM VALERIE , PIRAN MAYTAL , BEN MOHA-LERMAN ELENA
IPC分类号： C07C271/22 , A61K31/27 , A61P25/08
CPC分类号： C07C271/22 , C07C2601/14
摘要： The preparation and use of calcium, barium, magnesium and copper salts of gabapentin enacarbil are described.
摘要翻译：描述了加巴喷丁恩卡巴尔的钙，钡，镁和铜盐的制备和使用。

2. 发明申请

WO2010063002A3 PROCESSES FOR THE PREPARATION AND PURIFICATION OF GABAPENTIN ENACARBIL 审中-公开
标题翻译：加巴喷丁恩加贝尔的制备和纯化过程
公开(公告)号：WO2010063002A3
公开(公告)日：2010-11-04
申请号：PCT/US2009066006
申请日：2009-11-26
申请人： TEVA PHARMA , TEVA PHARMA , BEN-MOHA-LERMAN ELENA , NIDAM TAMAR , COHEN MEITAL , AVHAR-MAYDAN SHARON , BALANOV ANNA
发明人： BEN-MOHA-LERMAN ELENA , NIDAM TAMAR , COHEN MEITAL , AVHAR-MAYDAN SHARON , BALANOV ANNA
IPC分类号： C07C201/12 , C07C269/04 , C07C269/08 , C07C271/22
CPC分类号： C07C269/04 , C07C201/12 , C07C269/08 , C07C2601/14 , C07C205/43 , C07C271/22
摘要： Gabapentin enacarbil was prepared and purified from intermediates such as 1- haloalkyl carbamate or carbonate and diacid acetal skeleton. For example, a 1-haloalkyl carbonate or carbamate was prepared by combining a C1 to C 10 alcohol or C1 to C10 primary amine, a solvent selected from the group consisting of: acetonitrile, C3 to C7 ketone, C5 to C 10 ether, C2 to C7 ester, C5 to C 10 hydrocarbon and a combination thereof; a 1-haloalkyl halo formate of the following formula:(I) wherein each X is independently selected from Br, I, or Cl; R1 is alkyl or H; and a C6 to C21 tertiary amine.
摘要翻译：加巴喷丁enacarbil由中间体如1-卤代烷基氨基甲酸酯或碳酸酯和二酸缩醛骨架制备和纯化。例如，碳酸1-卤代烷基酯或氨基甲酸酯是通过将C1-C10醇或C1-C10伯胺，选自乙腈，C3-C7酮，C5-C10醚，C2 至C7酯，C5至C10烃及其组合; 具有下式的1-卤代烷基卤代甲酸酯：（I）其中每个X独立地选自Br，I或Cl; R1是烷基或H; 和C6至C21叔胺。

3. 发明申请

WO2010063002A2 PROCESSES FOR THE PREPARATION AND PURIFICATION OF GABAPENTIN ENACARBIL 审中-公开
标题翻译：加巴酚丁酯的制备和纯化方法
公开(公告)号：WO2010063002A2
公开(公告)日：2010-06-03
申请号：PCT/US2009066006
申请日：2009-11-26
申请人： TEVA PHARMA , TEVA PHARMA , BEN-MOHA-LERMAN ELENA , NIDAM TAMAR , COHEN MEITAL , AVHAR-MAYDAN SHARON , BALANOV ANNA
发明人： BEN-MOHA-LERMAN ELENA , NIDAM TAMAR , COHEN MEITAL , AVHAR-MAYDAN SHARON , BALANOV ANNA
IPC分类号： C07C201/12 , C07C269/04 , C07C269/08 , C07C271/22
CPC分类号： C07C269/04 , C07C201/12 , C07C269/08 , C07C2601/14 , C07C205/43 , C07C271/22
摘要： Gabapentin enacarbil was prepared and purified from intermediates such as 1- haloalkyl carbamate or carbonate and diacid acetal skeleton. For example, a 1-haloalkyl carbonate or carbamate was prepared by combining a C1 to C 10 alcohol or C1 to C10 primary amine, a solvent selected from the group consisting of: acetonitrile, C3 to C7 ketone, C5 to C 10 ether, C2 to C7 ester, C5 to C 10 hydrocarbon and a combination thereof; a 1-haloalkyl halo formate of the following formula:(I) wherein each X is independently selected from Br, I, or Cl; R1 is alkyl or H; and a C6 to C21 tertiary amine.
摘要翻译：从中间体例如1-卤代烷基氨基甲酸酯或碳酸酯和二酸缩醛骨架制备和纯化加巴喷丁恩卡巴尔。例如，通过将C1至C10醇或C1至C10伯胺，选自乙腈，C3至C7酮，C 5至C 10醚，C 2至C 10醇的溶剂组合，制备碳酸1-卤代烷基酯或氨基甲酸酯 C7酯，C5〜C10烃及其组合; 下式的1-卤代烷基卤甲酸酯：（I）其中每个X独立地选自Br，I或Cl; R1是烷基或H; 和C 6至C 21叔胺。

4. 发明申请

WO2011091142A3 CRYSTALLINE AND AMORPHOUS FORMS OF OLANZAPINE PAMOATE 审中-公开
标题翻译： OLANZAPINE PAMOATE的晶体和非晶形态
公开(公告)号：WO2011091142A3
公开(公告)日：2011-10-13
申请号：PCT/US2011021873
申请日：2011-01-20
申请人： TEVA PHARMA , TEVA PHARMA , RAFILOVICH MICHAL , COHEN MEITAL
发明人： RAFILOVICH MICHAL , COHEN MEITAL
IPC分类号： C07D495/04 , A61K31/5513 , A61P25/18
CPC分类号： C07D495/04
摘要： The present invention provides amorphous and crystalline forms of olanzapine pamoate, and processes for preparing them. The invention further provides a pharmaceutical composition comprising at least one of the described crystalline forms of olanzapine pamoate. This pharmaceutical composition may additionally comprise at least one pharmaceutically acceptable excipient. The present invention encompasses the use of at least one of the forms of olanzapine pamoate for the preparation of a formulation. The present invention further provides the use of at least one of the forms of olanzapine pamoate of the invention for the treatment of schizophrenia and manic episodes. In another embodiment, the invention provides a method of treating schizophrenia or manic episodes comprising administering a therapeutically effective amount of at least one of the forms of olanzapine pamoate of the invention described above or a therapeutic effective amount of at least one of the pharmaceutical compositions of the invention to a person suffering from schizophrenia or manic episodes.
摘要翻译：本发明提供无定形和结晶形式的奥氮平双羟萘酸钠及其制备方法。本发明进一步提供包含至少一种所述的奥氮平双羟萘酸盐的结晶形式的药物组合物。该药物组合物可另外包含至少一种药学上可接受的赋形剂。本发明包括至少一种形式的奥氮平双羟萘酸盐在制备制剂中的用途。本发明进一步提供了本发明的奥氮平双羟萘酸盐的至少一种形式用于治疗精神分裂症和躁狂发作的用途。在另一个实施方案中，本发明提供治疗精神分裂症或躁狂发作的方法，包括给予治疗有效量的至少一种上述本发明的奥氮平扑酸盐或治疗有效量的至少一种下列药物组合物：将发明发给患有精神分裂症或躁狂发作的人。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式