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1. 发明申请

WO2005113483A2 LEVALBUTEROL HYDROCHLORIDE POLYMORPH A 审中-公开
标题翻译：百草枯氢氯化物聚合物
公开(公告)号：WO2005113483A2
公开(公告)日：2005-12-01
申请号：PCT/US2005018149
申请日：2005-05-20
申请人： TEVA PHARM FINE CHEMICALS SRL , TEVA PHARMA , MERLI VALERIANO , MANTOVANI SILVIA , BIANCHI STEFANO , DAVERIO PAOLA , SPREAFICO ANGELO , ARONHIME JUDITH , KOVACSNE-MEZEI ADRIENNE
发明人： MERLI VALERIANO , MANTOVANI SILVIA , BIANCHI STEFANO , DAVERIO PAOLA , SPREAFICO ANGELO , ARONHIME JUDITH , KOVACSNE-MEZEI ADRIENNE
IPC分类号： A61K31/135 , A61K31/137 , A61K31/195 , A61K31/24 , A61P11/00 , C07C213/10 , C07C215/60 , C07C217/48 , C07C227/34 , C07C229/00 , C07C229/38
CPC分类号： C07C229/38 , C07C215/60 , C07C217/48 , C07C227/34
摘要： The invention is directed to processes for making levalbuterol HC1 Polymorph A from by suspending or forming a first slurry of (R)-SLB(D)-DBTA in at least a first organic solvent, adding HC1 to the suspension or slurry of the solid (R)-SLB.D-DBTA until the (R)-SLB.D-DBTA forms levalbuterol HC1 Polymorph A, and isolating the levalbuterol HC1 Polymorph A.
摘要翻译：本发明涉及通过在至少第一有机溶剂中悬浮或形成（R）-SLB（D）-DBTA的第一浆料来制备左美沙普特醇HCl多晶型物A的方法，向固体的悬浮液或浆液中加入HCl R）-SLB.D-DBTA，直到（R）-SLB.D-DBTA形成左美沙芬醇HC1多晶型A，并分离左美沙芬醇HC1多晶型物A.

2. 发明申请

WO2006020348A3 POLYMORPHS OF ATOMOXETINE HYDROCHLORIDE 审中-公开
标题翻译：氨基丁基氢氯化物的聚合物
公开(公告)号：WO2006020348A3
公开(公告)日：2006-06-08
申请号：PCT/US2005026008
申请日：2005-07-21
申请人： TEVA PHARM FINE CHEMICALS SRL , TEVA PHARMA , ARONHIME JUDITH , BIANCHI STEFANO , CASTELLI EUGENIO , DAVERIO PAOLA , MANTOVANI SILVIA , KOVACSNE-MEZEI ADRIENNE
发明人： ARONHIME JUDITH , BIANCHI STEFANO , CASTELLI EUGENIO , DAVERIO PAOLA , MANTOVANI SILVIA , KOVACSNE-MEZEI ADRIENNE
IPC分类号： C07C217/48 , C07C213/10
CPC分类号： C07C217/48
摘要： The present invention provides novel crystalline polymorph forms of atomoxetine hydrochloride denominated Forms B and C and methods for their preparation, as well as methods for the preparation of Form A. The present invention provides pharmaceutical compositions that comprise atomoxetine hydrochloride Form B, Form C, or mixtures thereof that can be used to treat attention deficit/ hyperactivity disorder.
摘要翻译：本发明提供了以盐酸阿托西汀形式B和C的新型结晶多晶型形式及其制备方法，以及制备形式A的方法。本发明提供药物组合物，其包含盐酸阿托莫西汀B型，C型或可用于治疗注意力缺陷/多动障碍的混合物。

3. 发明申请

WO2006004976A3 PROCESS FOR THE PREPARATION OF ATOMOXETINE HYDROCHLORIDE 审中-公开
标题翻译：制备盐酸原膜羟素的方法
公开(公告)号：WO2006004976A3
公开(公告)日：2006-02-16
申请号：PCT/US2005023419
申请日：2005-06-28
申请人： TEVA PHARM FINE CHEMICALS SRL , TEVA PHARMA , CASTELLI EUGENIO , LO MONACO GIUSEPPE , MANTOVANI SILVIA , DAVERIO PAOLA , RIVA PAOLA , VAILATI ALESSANDRA , BIANCHI STEFANO
发明人： CASTELLI EUGENIO , LO MONACO GIUSEPPE , MANTOVANI SILVIA , DAVERIO PAOLA , RIVA PAOLA , VAILATI ALESSANDRA , BIANCHI STEFANO
IPC分类号： C07C213/06 , C07C213/10 , C07C217/48
CPC分类号： C07C217/16 , C07B2200/07 , C07C213/06 , C07C213/08 , C07C217/48
摘要： The present invention provides improved processes for the preparation of atomoxetine hydrochloride under reaction conditions that improve reaction yields and facilitate commercial synthesis. In particular, the invention is directed to the synthesis of atomoxetine HC1 by adding HCl to a mixture of (R)-(-)-tomoxetine (S)-(+)mandelate with an organic solvent, with or without a base and water.
摘要翻译：本发明提供了在提高反应收率和促进商业合成的反应条件下制备阿托莫西汀盐酸盐的改进方法。特别地，本发明涉及通过将HCl加入（R） - （ - ） - 托莫西汀（S） - （+）扁桃酸酯与有机溶剂的混合物中，伴有或不伴有碱和水来合成阿托莫西汀盐酸盐。

4. 发明申请

WO2006004977A3 PROCESS FOR THE OPTICAL RESOLUTION AND RECYCLING OF TOMOXETINE 审中-公开
标题翻译： TOMOXETINE的光学分辨率和再循环方法
公开(公告)号：WO2006004977A3
公开(公告)日：2006-04-13
申请号：PCT/US2005023421
申请日：2005-06-28
申请人： TEVA PHARM FINE CHEMICALS SRL , TEVA PHARMA , CASTELLI EUGENIO , LO MONACO GIUSEPPE , MANTOVANI SILVIA , DAVERIO PAOLA , RIVA PAOLO , VAILATI ALESSANDRA , BIANCHI STEFANO
发明人： CASTELLI EUGENIO , LO MONACO GIUSEPPE , MANTOVANI SILVIA , DAVERIO PAOLA , RIVA PAOLO , VAILATI ALESSANDRA , BIANCHI STEFANO
IPC分类号： C07C213/06 , C07C213/10 , C07C217/48
CPC分类号： C07C217/16 , C07B2200/07 , C07C213/06 , C07C213/08 , C07C217/48
摘要： The present invention provides a process for the optical resolution of racemic tomoxetine under reaction conditions that improve reaction yields and optical purity. The invention also provides an epimerization process for the (S)-(+) enantiomer. The invention further provides the conversion of the enantiomer obtained from the optical resolution into atomoxetine or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明提供了在提高反应产率和光学纯度的反应条件下旋光拆分外消旋托莫西汀的方法。本发明还提供了（S） - （+）对映异构体的差向异构化方法。本发明还提供了由光学拆分得到的对映异构体向托莫西汀或其药学上可接受的盐的转化。

5. 发明申请

WO2012101232A3 CLAMP ASSEMBLY FOR PIPE-LAYING VESSEL AND METHOD OF LAYING A PIPELINE 审中-公开
标题翻译：管道船用夹具和铺设管道的方法
公开(公告)号：WO2012101232A3
公开(公告)日：2012-09-27
申请号：PCT/EP2012051270
申请日：2012-01-26
申请人： SAIPEM SPA , BAYLOT MICHEL PIERRE ARMAND , HAJERI YANN , ARDAVANIS KIMON TULLIO , BIANCHI STEFANO
发明人： BAYLOT MICHEL PIERRE ARMAND , HAJERI YANN , ARDAVANIS KIMON TULLIO , BIANCHI STEFANO
IPC分类号： F16L1/20 , F16L1/19
CPC分类号： F16L1/19 , F16L1/207
摘要： A pipe-laying vessel 100 including a pipe-laying tower 300 extending upwardly from the vessel, the vessel comprising a welding station 500 for joining a new pipestring to an end of the pipeline held by the tower, a clamp assembly 800 on the tower for engaging a pipestring with a lower end adjacent to the end of the pipeline held by the tower and with the pipestring extending upwardly from its lower end alongside the tower, wherein the clamp assembly 800 comprises a pipestring clamp that serves both the function of a transfer clamp for transferring the pipestring from a position 408 alongside the tower but displaced from the pipe-laying path to a position approximately aligned with the pipe-laying path 303, and the function of a line-up clamp for lining up the pipestring with the end of the pipeline.
摘要翻译：一种管道铺设容器100，包括从容器向上延伸的管道铺设塔300，该容器包括用于将新的管道连接到由塔架保持的管道的端部的焊接站500，塔上的夹具组件800 将管道连接到与由塔架保持的管道的端部相邻的下端，并且管道从其下端沿着塔架向上延伸，其中夹具组件800包括管道夹具，其用于转移夹具的功能用于将管道从位于塔架旁边的位置408转移出来，但是从管道铺设路径移动到与管道铺设路径303大致对准的位置，以及用于排列管道的排列夹具的功能，管道。

6. 发明申请

WO2012101233A2 PIPE-LAYING VESSEL AND METHOD OF LAYING A PIPELINE 审中-公开
标题翻译：管道管和铺设管道的方法
公开(公告)号：WO2012101233A2
公开(公告)日：2012-08-02
申请号：PCT/EP2012051271
申请日：2012-01-26
申请人： SAIPEM SPA , BIANCHI STEFANO , ARDAVANIS KIMON TULLIO , BAYLOT MICHEL PIERRE ARMAND , HAJERI YANN
发明人： BIANCHI STEFANO , ARDAVANIS KIMON TULLIO , BAYLOT MICHEL PIERRE ARMAND , HAJERI YANN
IPC分类号： F16L1/19
CPC分类号： F16L1/19 , F16L1/20
摘要： A pipe-laying vessel (100) including a pipe-laying tower (300) extending upwardly from the vessel, the tower comprising a first lower section (310) extending upwardly from a proximal end to a distal end above the main deck (103) of the vessel, and a second upper section (311) movably mounted on the first lower section, and the tower having a first pipe-laying configuration for laying pipeline P in which the upper section is positioned above the lower section and pipe is passed from the upper section to the lower section when, in use, it is being laid, and a second stowed configuration in which the second upper section is moved relative to the lower section and the overall height of the tower is reduced.
摘要翻译：一种管道敷设容器（100），包括从容器向上延伸的管道铺设塔（300），塔架包括从主甲板（103）上方的近端向远端向上延伸的第一下部（310）以及可移动地安装在所述第一下部上的第二上部部分（311），所述塔架具有用于铺设管道P的第一管道铺设构造，其中所述上部部分位于所述下部部分的上方，并且所述管道从在使用中被放置的下部的上部，以及第二上部相对于下部移动的第二收纳构造，并且塔的整体高度减小。

7. 发明申请

WO2008107186A8 UNDERSEA PIPE-LAYING 审中-公开
标题翻译：地下管线
公开(公告)号：WO2008107186A8
公开(公告)日：2009-10-01
申请号：PCT/EP2008001789
申请日：2008-03-06
申请人： SAIPEM SPA , BIANCHI STEFANO
发明人： BIANCHI STEFANO
IPC分类号： B63B35/03 , B63B35/04 , F16L1/20
CPC分类号： B63B35/03
摘要： A monohull vessel for laying a pipeline includes tensioners (13) disposed along a Pipelaying path (P). The pipelaying path (P) includes an upstream portion that is substantially horizontal and at least 10 m above the centre of rolling (R) of the vessel and, towards a stern end of the vessel hull, a downstream portion that is downwardly inclined and, in use, enters the water at a location inboard of the stern end of the vessel hull (1).
摘要翻译：用于铺设管道的单体船容器包括沿着Pipelaying路径（P）设置的张紧器（13）。管道铺设路径（P）包括基本上水平的并且比容器的滚动中心（R）至少10m的上游部分，并且朝向容器船体的尾端延伸向下倾斜的下游部分，在使用中，在船体（1）的尾端的内侧的位置进入水中。

8. 发明申请

WO0005525A3 UNDERWATER PIPE-LAYING VESSELS AND METHODS 审中-公开
标题翻译：水下管道船舶和方法
公开(公告)号：WO0005525A3
公开(公告)日：2000-05-04
申请号：PCT/EP9905201
申请日：1999-07-21
申请人： SAIPEM SPA , GIOVANNINI UMBERTO , SIGNAROLDI TERESIO , BIANCHI STEFANO
发明人： GIOVANNINI UMBERTO , SIGNAROLDI TERESIO , BIANCHI STEFANO
IPC分类号： B63B35/03 , F16L1/19 , F16L1/20 , F16L1/16 , F16L1/23 , F16L1/235
CPC分类号： B63B35/03 , B63B1/107 , F16L1/19
摘要： A pipe-laying vessel comprises: means (2) for propelling the vessel during pipe-laying; means for assembling sections of pipe generally horizontally on the vessel to form longer lengths; a tower (14) at the bow of the vessel, with respect to an intended direction of movement, pivotally mounted so that it can be angled forwards towards the top; means (29) for raising a length of pipe fromthe deck to a position aligned with the tower; means (21, 23) for joining such a length of pipe to a pipeline being laid; tensioners (20) arranged to grip such a pipeline and to lower it into the water while maintaining a desired tension in the pipeline; one or more clamps (18) arranged to grip the pipeline below the tensioners; and a lower ramp (17) provided with rollers and arranged to guide the pipeline as it leaves the vessel.
摘要翻译：管道铺设船包括：用于在铺管期间推进船舶的装置（2）; 用于将管道的部分大致水平地组装在容器上以形成更长的长度的装置; 相对于预期的运动方向，在容器的弓处的塔（14）枢转地安装，使得其可以朝着顶部向前成角度; 用于将管道从甲板升高到与塔架对准的位置的装置（29）; 用于将这种长度的管道连接到正在铺设的管道的装置（21,23）; 张紧器（20）布置成夹持这样的管道并将其降低到水中，同时保持管道中期望的张力; 一个或多个夹具（18）布置成夹持在张紧器下面的管道; 和设置有辊的下坡道（17），并布置成当管道离开船舶时引导管道。

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