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1. 发明申请

WO2011026020A3 FREEZE INDICATORS WITH A CONTROLLED TEMPERATURE RESPONSE 审中-公开
标题翻译：具有受控温度响应的冷冻指示器
公开(公告)号：WO2011026020A3
公开(公告)日：2011-04-21
申请号：PCT/US2010047121
申请日：2010-08-30
申请人： TEMPTIME CORP , SMITH DAWN E , LENTZ CARL M , TAYLOR DENE H , OSUNGA YVONNE , HUFFMAN BRIAN
发明人： SMITH DAWN E , LENTZ CARL M , TAYLOR DENE H , OSUNGA YVONNE , HUFFMAN BRIAN
IPC分类号： G01K11/12 , G01K11/08 , G01K11/16 , G01K11/18
CPC分类号： G01K11/12 , G01K11/08 , G01K11/16 , G01K11/18
摘要： A freeze indicator can include an indicator dispersion having an aqueous liquid medium and organic material indicator particles dispersed in the aqueous liquid medium. The indicator dispersion can have an initial appearance before freezing and an irreversibly different appearance after freezing and can exhibit a freeze-onset temperature of about -1.9°C or higher. Some factors helpful to providing a relatively high freeze onset temperature are employment of a proteinaceous ice-nucleating agent, control of pH, use of a protein stabilizer and control of the ratio of protein stabilizer to ice-nucleating agent.
摘要翻译：冷冻指示器可以包括具有水性液体介质和分散在水性液体介质中的有机材料指示剂颗粒的指示剂分散体。指示剂分散体在冷冻之前可以具有初始外观并且在冷冻后具有不可逆的不同外观，并且可以表现出约-1.9℃或更高的冷冻起始温度。一些有助于提供相对高的冷冻起始温度的因素是使用蛋白质冰成核剂，控制pH值，使用蛋白质稳定剂和控制蛋白质稳定剂与冰成核剂的比例。

2. 发明申请

WO2011026020A4 FREEZE INDICATORS WITH A CONTROLLED TEMPERATURE RESPONSE 审中-公开
标题翻译：具有控制温度响应的冻结指示器
公开(公告)号：WO2011026020A4
公开(公告)日：2011-06-16
申请号：PCT/US2010047121
申请日：2010-08-30
申请人： TEMPTIME CORP , SMITH DAWN E , LENTZ CARL M , TAYLOR DENE H , OSUNGA YVONNE , HUFFMAN BRIAN
发明人： SMITH DAWN E , LENTZ CARL M , TAYLOR DENE H , OSUNGA YVONNE , HUFFMAN BRIAN
IPC分类号： G01K11/12 , G01K11/08 , G01K11/16 , G01K11/18
CPC分类号： G01K11/12 , G01K11/08 , G01K11/16 , G01K11/18
摘要： A freeze indicator can include an indicator dispersion having an aqueous liquid medium and organic material indicator particles dispersed in the aqueous liquid medium. The indicator dispersion can have an initial appearance before freezing and an irreversibly different appearance after freezing and can exhibit a freeze-onset temperature of about -1.9°C or higher. Some factors helpful to providing a relatively high freeze onset temperature are employment of a proteinaceous ice-nucleating agent, control of pH, use of a protein stabilizer and control of the ratio of protein stabilizer to ice-nucleating agent.
摘要翻译：冷冻指示剂可以包括具有水性液体介质的指示剂分散体和分散在水性液体介质中的有机材料指示剂颗粒。指示剂分散体在冷冻之前可以具有初始外观，并且在冷冻后具有不可逆的外观，并且可以显示约-1.9℃或更高的冷冻起始温度。有助于提供相对高的冷冻起始温度的一些因素是使用蛋白质冰成核剂，控制pH，使用蛋白质稳定剂和控制蛋白质稳定剂与冰核成核剂的比例。

3. 发明申请

WO2012044655A4 COLOR-CHANGING EMULSIONS FOR FREEZE INDICATORS 审中-公开
公开(公告)号：WO2012044655A4
公开(公告)日：2012-07-05
申请号：PCT/US2011053607
申请日：2011-09-28
申请人： TEMPTIME CORP , TAYLOR DENE H , LENTZ CARL M , SMITH DAWN E
发明人： TAYLOR DENE H , LENTZ CARL M , SMITH DAWN E
IPC分类号： G01K11/06
CPC分类号： G01K11/12 , G01K3/04 , G01K11/06
摘要： A color-changing emulsion for use in a freeze indicator can employ a dispersion medium, for example, an aqueous liquid, a first reactant phase and a second reactant phase, which two reactant phases can both be dispersed in the dispersion medium. The first reactant phase includes a hydrophobic liquid and a first reactant, for example, a color precursor such as a leuco dye. The second reactant phase can include a hydrophobic liquid, and includes, or can be, a second reactant, for example, a color developer such as a leuco dye developer. The first and second reactant phases can be essentially unmixed, and can be co-reactable to provide a color change. In response to a freezing temperature, the color-changing emulsion can coagulate and change color irreversibly. An intense color change can be obtained by using, for example, a suitable leuco dye precursor and developer.

4. 发明申请

WO2012044655A3 COLOR-CHANGING EMULSIONS FOR FREEZE INDICATORS 审中-公开
标题翻译：变色乳剂冻结指标
公开(公告)号：WO2012044655A3
公开(公告)日：2012-05-18
申请号：PCT/US2011053607
申请日：2011-09-28
申请人： TEMPTIME CORP , TAYLOR DENE H , LENTZ CARL M , SMITH DAWN E
发明人： TAYLOR DENE H , LENTZ CARL M , SMITH DAWN E
IPC分类号： G01K11/06
CPC分类号： G01K11/12 , G01K3/04 , G01K11/06
摘要： A color-changing emulsion for use in a freeze indicator can employ a dispersion medium, for example, an aqueous liquid, a first reactant phase and a second reactant phase, which two reactant phases can both be dispersed in the dispersion medium. The first reactant phase includes a hydrophobic liquid and a first reactant, for example, a color precursor such as a leuco dye. The second reactant phase can include a hydrophobic liquid, and includes, or can be, a second reactant, for example, a color developer such as a leuco dye developer. The first and second reactant phases can be essentially unmixed, and can be co-reactable to provide a color change. In response to a freezing temperature, the color-changing emulsion can coagulate and change color irreversibly. An intense color change can be obtained by using, for example, a suitable leuco dye precursor and developer.
摘要翻译：用于冷冻指示器的变色乳剂可以使用分散介质，例如水性液体，第一反应物相和第二反应物相，其中两种反应物相都可以分散在分散介质中。第一反应物相包括疏水性液体和第一反应物，例如颜色前体，例如无色染料。第二反应物相可以包括疏水液体，并且包括或可以是第二反应物，例如，诸如无色染料显影剂的彩色显影剂。第一和第二反应物相可以基本上不混合，并且可以共反应以提供颜色变化。响应于冷冻温度，变色乳剂可以凝结并不可逆地改变颜色。通过使用例如合适的无色染料前体和显影剂可以获得强烈的颜色变化。

5. 发明申请

WO2008027814A8 COLOR-RETAINING EXCESS-TEMPERATURE EXPOSURE INDICATOR 审中-公开
标题翻译：彩色保温温度曝光指示器
公开(公告)号：WO2008027814A8
公开(公告)日：2009-05-22
申请号：PCT/US2007076844
申请日：2007-08-27
申请人： TEMPTIME CORP , ABBASSI OMAR , PRUSIK THADDEUS , SMITH DAWN E
发明人： ABBASSI OMAR , PRUSIK THADDEUS , SMITH DAWN E
IPC分类号： G01K11/00
CPC分类号： G01K11/06 , G01K3/04
摘要： An excess temperature indicator can provide a visual indication of past exposure of perishable, maturing and other host products to an elevated temperature exceeding a threshold temperature. The indicator can have an upper layer provided with a viewing window and a wick attached to the upper layer. A reservoir of heat- fusible indicator material can be disposed in contact with the wick, to fuse and move along the wick changing the visual appearance of a first portion of the wick viewable through the window, in response to an excess temperature event. Also, the indicator can have a region of fused upper layer material attaching the wick to the upper layer. Optionally, a window seal can extend around the viewing window to prevent migration of the indicator material. The indicator can be employed to monitor vaccines, foods and other products providing an enduring visual signal of exposure to potentially damaging temperature conditions.
摘要翻译：过温度指示器可以提供易腐烂，成熟和其他主体产品过去暴露于超过阈值温度的高温的视觉指示。指示器可以具有设置有观察窗口的上层和附接到上层的灯芯。热容指示剂材料的储存器可以布置成与芯接触，以便熔化并沿着灯芯移动，以响应于过高的温度事件而改变可通过窗口观察的芯的第一部分的视觉外观。此外，指示器可以具有将芯连接到上层的熔融上层材料的区域。可选地，窗口密封件可以围绕观察窗口延伸以防止指示剂材料的迁移。该指标可用于监测疫苗，食品和其他产品，提供暴露于潜在有害温度条件的持久视觉信号。

6. 发明申请

WO2008027814A2 COLOR-RETAINING EXCESS-TEMPERATURE EXPOSURE INDICATOR 审中-公开
标题翻译：彩色保温温度曝光指示器
公开(公告)号：WO2008027814A2
公开(公告)日：2008-03-06
申请号：PCT/US2007076844
申请日：2007-08-27
申请人： TEMPTIME CORP , ABBASSI OMAR , PRUSIK THADDEUS , SMITH DAWN E
发明人： ABBASSI OMAR , PRUSIK THADDEUS , SMITH DAWN E
IPC分类号： G01K11/00 , G01K3/00
CPC分类号： G01K11/06 , G01K3/04
摘要： An excess temperature indicator can provide a visual indication of past exposure of perishable, maturing and other host products to an elevated temperature exceeding a threshold temperature. The indicator can have an upper layer provided with a viewing window and a wick attached to the upper layer. A reservoir of heat- fusible indicator material can be disposed in contact with the wick, to fuse and move along the wick changing the visual appearance of a first portion of the wick viewable through the window, in response to an excess temperature event. Also, the indicator can have a region of fused upper layer material attaching the wick to the upper layer. Optionally, a window seal can extend around the viewing window to prevent migration of the indicator material. The indicator can be employed to monitor vaccines, foods and other products providing an enduring visual signal of exposure to potentially damaging temperature conditions.
摘要翻译：过温度指示器可以提供易腐烂，成熟和其他主体产品过去暴露于超过阈值温度的高温的视觉指示。指示器可以具有设置有观察窗口的上层和附接到上层的灯芯。热容指示剂材料的储存器可以布置成与芯接触，以便熔化并沿着灯芯移动，以响应于过高的温度事件而改变可通过窗口观察的芯的第一部分的视觉外观。此外，指示器可以具有将芯连接到上层的熔融上层材料的区域。可选地，窗口密封件可以围绕观察窗口延伸以防止指示剂材料的迁移。该指标可用于监测疫苗，食品和其他产品，提供暴露于潜在有害温度条件的持久视觉信号。

7. 发明申请

WO2013170273A3 DUAL-FUNCTION HEAT INDICATOR AND METHOD OF MANUFACTURE 审中-公开
标题翻译：双功能热指示器及其制造方法
公开(公告)号：WO2013170273A3
公开(公告)日：2014-01-30
申请号：PCT/US2013040824
申请日：2013-05-13
申请人： TEMPTIME CORP
发明人： PRUSIK THADDEUS , SMITH DAWN E , TAYLOR DENE H , ARNOLD NINA
IPC分类号： G01K11/12
CPC分类号： G01N21/78 , G01K3/04 , G01K11/12 , G01N31/229
摘要： A dual-function heat indicator for monitoring two or more modes of heat exposure is described. A manufacturing process for the dual-function heat indicator is also described. Dual-function heat indicators as described may be useful for monitoring the exposure of host products, with which the dual-function heat indicators may be associated, to cumulative ambient heat exposure and to a peak ambient heat exposure, and for other purposes.
摘要翻译：描述了用于监测两种或多种热曝光模式的双功能热指示器。还描述了用于双功能热指示器的制造过程。如上所述的双功能热指示器可用于监测双功能热指示器可能与之相关的主机产品的暴露与累积的环境热暴露以及高峰环境热暴露以及其他目的。

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