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1. 发明申请

WO2010076559A3 MOLTEN SALT TREATMENT SYSTEM AND PROCESS 审中-公开
公开(公告)号：WO2010076559A3
公开(公告)日：2010-07-08
申请号：PCT/GB2009/002964
申请日：2009-12-29
申请人： TATE & LYLE TECHNOLOGY LIMITED , WILEY, James, Edwin , AKERS, William , SKELDING, William, R.
发明人： WILEY, James, Edwin , AKERS, William , SKELDING, William, R.
IPC分类号： B01J10/00 , B01D47/00 , A62D3/32
摘要： A molten salt treatment system and process can include one or more tubular conduits flowably connected to a molten salt reactor, the tubular conduit containing concentrically within it a pipe or a shaft separated by an annular space therebetween, and one or more gas sources connected to feed gas into the annular space. The system may include a scrubbing device flowably connected to a molten salt reactor off-gas outlet to receive an off-gas, a first heating device configured to heat the effluent from the scrubbing device, and a filtering device flowably connected to receive the effluent from the heating device. An overflow conduit may be flowably connected to a molten salt reactor overflow outlet to receive molten salt therefrom and discharge the molten salt to a salt recovery vessel, and a blower or other gas mover may be connected to the molten salt reactor and the recovery vessel to prevent backflow of cold gases through the overflow outlet to the molten salt reactor.

2. 发明申请

WO2009118532A1 METHOD FOR THE PRODUCTION OF SUCRALOSE 审中-公开
标题翻译：用于生产枯草芽孢杆菌的方法
公开(公告)号：WO2009118532A1
公开(公告)日：2009-10-01
申请号：PCT/GB2009/000807
申请日：2009-03-26
申请人： TATE & LYLE TECHNOLOGY LIMITED , KERR, John , DENTEL, David, A. , LEINHOS, Duane, A. , WILEY, James, Edwin
发明人： KERR, John , DENTEL, David, A. , LEINHOS, Duane, A. , WILEY, James, Edwin
IPC分类号： C07H5/02
CPC分类号： C07H5/02 , C07H1/00
摘要： The present invention provides a method for producing sucralose from a feed stream comprising a sucrose-6-acylate in a reaction vehicle, wherein said method comprises: (i) reacting the sucrose-6-acylate with a chlorinating agent in order to chlorinate the 4, 1' and 6' positions of the sucrose-6-acylate; (ii) quenching the product stream of (i) with an aqueous solution of a base to provide a sucralose-6-acylate and the chloride salt of said base, wherein the concentration of the aqueous solution of the base is sufficiently high such that at least a portion of the chloride salt of the base is formed as a precipitate; (iii) either: deacylating the sucralose-6-acylate by treating the product stream of (ii) with a base and thereafter removing precipitated salt to provide a product stream comprising sucralose; or: removing precipitated salt from the product stream of (ii) and thereafter deacylating the sucralose-6-acylate by treating with a base to provide a product stream comprising sucralose; and (iv) isolating sucralose from the product stream of (iii).
摘要翻译：本发明提供了在反应载体中从包含蔗糖-6-酰化物的进料流中制备三氯半乳蔗糖的方法，其中所述方法包括：（i）使蔗糖-6-酰化物与氯化剂反应以使4 ，蔗糖-6-酰化物的1'和6'位; （ii）用碱的水溶液淬灭（i）的产物流，得到三氯半乳蔗糖-6-酰化物和所述碱的氯化物盐，其中碱的水溶液的浓度足够高，使得在至少一部分碱的氯化物盐形成沉淀物; （iii）：通过用碱处理（ii）的产物流，然后除去沉淀的盐以提供包含三氯蔗糖的产物流，使三氯蔗糖-6-酰化物脱酰化; 或者：从（ii）的产物流中除去沉淀的盐，然后通过用碱处理使三氯蔗糖-6-酰化物脱酰，得到包含三氯蔗糖的产物流; 和（iv）从（iii）的产物流中分离三氯半乳蔗糖。

3. 发明申请

WO2010151489A1 PURIFICATION OF TERTIARY FORMAMIDE CONTAMINATED WITH TERTIARY ACETAMIDE 审中-公开
标题翻译：纯化用苛性乙酰胺污染的腐殖酸
公开(公告)号：WO2010151489A1
公开(公告)日：2010-12-29
申请号：PCT/US2010/039142
申请日：2010-06-18
申请人： TATE & LYLE TECHNOLOGY LIMITED , WILEY, James, Edwin , JABER, Mohamad, R.
发明人： WILEY, James, Edwin , JABER, Mohamad, R.
IPC分类号： C07C231/24 , C07C233/03 , C07C233/05 , C07H1/06 , C07H5/02
CPC分类号： C07C231/24 , C07H1/06 , C07H5/02 , C07C233/03
摘要： A chlorinating agent such as a chloroiminium species is used to remove or neutralize tertiary acetamide present as a contaminant in a tertiary formamide solvent. Tertiary formamide solvent purified or treated in this manner can be used as a reaction vehicle for the chlorination of sucrose-6-acylates, thereby improving the yields of the desired sucralose-6-acylate (an intermediate in the production of sucralose).
摘要翻译：使用氯化剂如氯亚胺鎓物质来除去或中和作为叔甲酰胺溶剂中的污染物存在的叔乙酰胺。以这种方式纯化或处理的叔甲酰胺溶剂可用作蔗糖-6-酰化物氯化反应载体，从而提高所需三氯半乳蔗糖-6-酰化物（三氯蔗糖生产中的中间体）的产率。

4. 发明申请

WO2010112813A1 PROCESS FOR REMOVING DIMETHYLAMINE 审中-公开
标题翻译：去除二甲胺的方法
公开(公告)号：WO2010112813A1
公开(公告)日：2010-10-07
申请号：PCT/GB2010/000554
申请日：2010-03-24
申请人： TATE & LYLE TECHNOLOGY LIMITED , KERR, John , JANSEN, Robert , BAIADA, Anthony , LEINHOS, Duane , WILEY, James, Edwin
发明人： KERR, John , JANSEN, Robert , BAIADA, Anthony , LEINHOS, Duane , WILEY, James, Edwin
IPC分类号： C07H5/02
CPC分类号： C07H5/02
摘要： A process for removing dimethylamine (DMA) before and/or during and/or after deacylation in a reaction vessel of a feed stream comprising a sucralose-6-acylate resulting from the chlorination of a sucrose-6-acylate in the presence of dimethyl formamide (DMF), wherein the deacylation is conducted at a first set of conditions of temperature, pH and pressure, the process comprising: (a) providing a side stream loop from and to the reaction vessel; (b) adjusting the conditions of one or more of temperature, pH, and pressure in the loop, and setting the flow rate through the loop, to remove DMA while minimising carbohydrate degradation.
摘要翻译：在二甲基甲酰胺存在下，在包含由蔗糖-6-酰化物氯化得到的三氯半氯蔗糖-6-酰化物的进料流的反应容器中脱酰基之前和/或之前和/或之后除去二甲胺（DMA）的方法（DMF），其中所述脱酰基在温度，pH和压力的第一组条件下进行，所述方法包括：（a）从反应容器提供侧流回路; （b）调节循环中的一个或多个温度，pH和压力的条件，并设定流过循环的流速，以除去DMA同时使碳水化合物降解最小化。

5. 发明申请

WO2009087362A2 METHOD FOR THE PRODUCTION OF SUCRALOSE 审中-公开
标题翻译：用于生产枯草芽孢杆菌的方法
公开(公告)号：WO2009087362A2
公开(公告)日：2009-07-16
申请号：PCT/GB2009/000006
申请日：2009-01-02
申请人： TATE & LYLE TECHNOLOGY LIMITED , BAIADA, Anthony , CAMBORIEUX, Sebastien , JANSEN, Robert , KERR, John , LEINHOS, Duane , MAFFEZONI, Carlo , WALKER, Gordon , WILEY, James, Edwin
发明人： BAIADA, Anthony , CAMBORIEUX, Sebastien , JANSEN, Robert , KERR, John , LEINHOS, Duane , MAFFEZONI, Carlo , WALKER, Gordon , WILEY, James, Edwin
CPC分类号： C07H1/06 , C07H5/02
摘要： The present invention provides a method for producing sucralose from a feed stream resulting from the chlorination of a sucrose-6-acylate in a reaction vehicle, said feed stream comprising a sucralose-6-acylate, the reaction vehicle, water, and salts, said salts including one or more selected from the group consisting of alkali metal or alkaline earth metal chlorides and ammonium chloride, wherein said method comprises: (i) deacylation of the sucralose-6-acylate by treatment with a base to afford a product stream comprising sucralose; (ii) partial removal of water and, optionally, reaction vehicle from the product stream of (i) in order to cause precipitation of the salts from the product stream; (iii) removal of the precipitated salts from the product stream of (ii); and (iv) isolation of sucralose from the product stream of (iii).
摘要翻译：本发明提供了由反应载体中的蔗糖-6-酰化物氯化得到的进料流中生产三氯半乳蔗糖的方法，所述进料流包含三氯半乳蔗糖-6-酰化物，反应载体，水和盐，所述方法包括选自碱金属或碱土金属氯化物和氯化铵中的一种或多种的盐，其中所述方法包括：（i）通过用碱处理来脱羧三氯半乳蔗糖-6-酰化物，得到包含三氯蔗糖的产物流 ; （ii）从（i）的产物流中部分除去水和任选的反应载体，以便使产物流中的盐沉淀; （iii）从（ii）的产物流中除去沉淀的盐; 和（iv）从（iii）的产物流中分离三氯半乳蔗糖。

6. 发明申请

WO2009137193A3 EFFECT OF CARBOHYDRATE CONCENTRATION ON SUCRALOSE EXTRACTION EFFICIENCY 审中-公开
公开(公告)号：WO2009137193A3
公开(公告)日：2009-11-12
申请号：PCT/US2009/039102
申请日：2009-04-01
申请人： TATE & LYLE TECHNOLOGY LTD , MICINSKI, Edward , WILEY, James, Edwin
发明人： MICINSKI, Edward , WILEY, James, Edwin
IPC分类号： C07H1/06 , C07H5/02
摘要： A process for the purification of aqueous feed streams containing sucralose comprises: a) extracting an aqueous feed stream comprising sucralose with a first organic solvent and producing a first organic extract and a first aqueous extract, in which the organic solvent is immiscible with water, and a portion of the sucralose passes into the first organic extract; b) optionally extracting the first organic extract with an aqueous solvent to produce a second organic extract and a second aqueous extract, in which the sucralose preferentially passes into the second aqueous extract, and in which the second aqueous extract is recycled to step a); c) concentrating the first aqueous extract to form a concentrated aqueous feed stream; and d) extracting the concentrated aqueous feed stream with a second organic solvent and producing a third organic extract and a third aqueous extract, in which the second organic solvent is immiscible with water, and in which the sucralose preferentially passes into the third organic extract. A process for the purification of aqueous feed streams containing sucralose-6- esters comprises the steps of: a) providing an aqueous feed stream comprising a carbohydrate selected from the group consisting of sucralose 6-esters, and mixtures thereof with sucralose; b) concentrating the aqueous feed stream to form a concentrated aqueous feed stream; and c) extracting the concentrated aqueous feed stream with an organic solvent and producing an organic extract and an aqueous extract, in which the organic solvent is immiscible with water, and in which the carbohydrate preferentially passes into the organic extract.

7. 发明申请

WO2011045566A1 LOW TEMPERATURE, SINGLE SOLVENT PROCESS FOR THE PRODUCTION OF SUCROSE-6-ESTER 审中-公开
标题翻译：低温，单溶剂工艺，用于生产苏木糖6-ESTER
公开(公告)号：WO2011045566A1
公开(公告)日：2011-04-21
申请号：PCT/GB2010/001904
申请日：2010-10-12
申请人： TATE & LYLE PUBLIC LIMITED COMPANY , MICINSKI, Edward , COLEMAN, David , WILEY, James, Edwin
发明人： MICINSKI, Edward , COLEMAN, David , WILEY, James, Edwin
IPC分类号： C07H13/04 , C07H13/06
CPC分类号： C07H13/04 , C07F7/2232 , C07F7/2244 , C07F7/2256 , C07H13/06 , C07H13/08
摘要： A method for the preparation of a sucrose-6-ester is disclosed. In a first step of the method, sucrose in a polar aprotic solvent is reacted with an organotin-based acylation promoter. The water of reaction is removed at a temperature that does not exceed about 800C. In one aspect, the water is removed by distillation of part of the polar aprotic solvent at reduced pressure. In a second step, a carboxylic acid anhydride is added. In one aspect, the resulting reaction mixture is maintained at a temperature of 1O0C or less for a period of time sufficient to produce a sucrose-6-ester. The sucrose-6-ester can be converted to sucralose.
摘要翻译：公开了制备蔗糖-6-酯的方法。在该方法的第一步中，将极性非质子溶剂中的蔗糖与基于有机锡的酰化促进剂反应。反应水在不超过约80℃的温度下除去。在一个方面，通过在减压下蒸馏部分极性非质子溶剂除去水。在第二步中，加入羧酸酐。一方面，将所得反应混合物保持在10℃或更低的温度下足以产生蔗糖-6-酯的时间。蔗糖-6-酯可以转化成三氯蔗糖。

8. 发明申请

WO2009146052A3 CRYSTALLIZATION OF SUCRALOSE FROM SUCRALOSE-CONTAINING FEED STREAMS 审中-公开
公开(公告)号：WO2009146052A3
公开(公告)日：2009-12-03
申请号：PCT/US2009/039063
申请日：2009-04-01
申请人： TATE & LYLE TECHNOLOGY LTD , MICINSKI, Edward , WILEY, James, Edwin , LEINHOS, Duane, A. , HUBER, Mark, R.
发明人： MICINSKI, Edward , WILEY, James, Edwin , LEINHOS, Duane, A. , HUBER, Mark, R.
IPC分类号： C07H1/06 , C07H5/02
摘要： A process for the purification of sucralose in sucralose-containing feed streams is disclosed. The process includes multiple liquid-liquid extraction steps; optionally, a concentration step; multiple crystallization steps; optionally, a chromatography step; and various recycle steps.

9. 发明申请

WO2009117317A1 REMOVAL OF ACIDS FROM TERTIARY AMIDE SOLVENTS 审中-公开
标题翻译：从初级固体溶剂中除去酸
公开(公告)号：WO2009117317A1
公开(公告)日：2009-09-24
申请号：PCT/US2009/037079
申请日：2009-03-13
申请人： TATE & LYLE TECHNOLOGY LTD , KERR, John , JANSEN, Robert , ISAAC, Christian, J. , WILEY, James, Edwin , LEINHOS, Duane, A.
发明人： KERR, John , JANSEN, Robert , ISAAC, Christian, J. , WILEY, James, Edwin , LEINHOS, Duane, A.
IPC分类号： B01D11/04 , C07C231/24 , C07H1/06 , C07C233/03
CPC分类号： C07C231/24 , B01D11/0426 , B01D11/0446 , B01D11/0476 , B01D11/0492 , C07H1/06 , C07H5/02 , C07H13/04 , C07C233/03
摘要： A method of removing a carboxylic acid from a liquid that contains a tertiary amide solvent includes a step of contacting the liquid with an extraction medium comprising an amine. The amine is immiscible with both water and the tertiary amide solvent, and the contacting step forms a de-acidified phase containing the tertiary amide solvent and a phase containing the extraction medium and the carboxylic acid. Both the liquid that contains the tertiary amide solvent and the de-acidified phase may also contain a sucrose-6-acylate.
摘要翻译：从含有叔酰胺溶剂的液体中除去羧酸的方法包括使液体与包含胺的萃取介质接触的步骤。胺与水和叔酰胺溶剂不混溶，接触步骤形成含有叔酰胺溶剂的脱酸相和含有萃取介质和羧酸的相。含有叔酰胺溶剂和脱酸相的液体也可以含有蔗糖-6-酰化物。

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