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1. 发明申请

WO2009131245A1 IMINOPYRIDINE DERIVATIVES AND USE THEREOF 审中-公开
标题翻译：亚氨基吡啶衍生物及其用途
公开(公告)号：WO2009131245A1
公开(公告)日：2009-10-29
申请号：PCT/JP2009/058434
申请日：2009-04-22
申请人： TAKEDA PHARMACEUTICAL COMPANY LIMITED , YOSHIDA, Masato , SAKAUCHI, Nobuki , SATO, Ayumu
发明人： YOSHIDA, Masato , SAKAUCHI, Nobuki , SATO, Ayumu
IPC分类号： C07D213/82 , A61K31/44 , A61P13/02
CPC分类号： C07D213/82
摘要： The present invention aims to provide an iminopyridine derivative compound having an α1D adrenergic receptor antagonistic action, which is useful as an agent for the prophylaxis or treatment of a lower urinary tract disease and the like.The present invention provides a compound represented by the formula wherein each symbol is as defined in the specification, or a salt thereof.
摘要翻译：本发明的目的在于提供具有a1D肾上腺素能受体拮抗作用的亚氨基吡啶衍生物化合物，其可用作预防或治疗下尿路疾病等。本发明提供下式表示的化合物，其中每个符号如说明书中所定义，或其盐。

2. 发明申请

WO2004017908A3 CALCIUM RECEPTOR MODULATING COMPOUND AND USE THEREOF 审中-公开
公开(公告)号：WO2004017908A3
公开(公告)日：2004-03-04
申请号：PCT/US2003/026317
申请日：2003-08-21
申请人： TAKEDA PHARMACEUTICAL COMPANY LIMITED , YASUMA, Tsuneo , MORI, Akira , KAWASE, Masahiro , KIMURA, Hiroyuki , YOSHIDA, Masato , GYORKOS, Albert, Charles , PRATT, Scott, Alan , CORRETTE, Christopher, Peter
发明人： YASUMA, Tsuneo , MORI, Akira , KAWASE, Masahiro , KIMURA, Hiroyuki , YOSHIDA, Masato , GYORKOS, Albert, Charles , PRATT, Scott, Alan , CORRETTE, Christopher, Peter
IPC分类号： C07D221/04
摘要： There is provided a calcium receptor modulator comprising a compound of the formula (I): wherein ring A is an optionally substituted 5- to 7- membered ring; ring B is an optionally substituted 5- to 7- membered heterocyclic ring; X 1 is CR 1 , CR 1 R 2 , N or NR 13 ; X 2 is N or NR 3 ; Y is C, CR 4 or N, Z is CR 5 , CR 5 R 6 , N or NR 7 ; Ar is an optionally substituted cyclic group; R is H, an optionally substituted hydrocarbon group, etc.; and --- is a single bond or a double bond; R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and R 13 are independently H, an optionally substituted hydrocarbon group; or a salt thereof or a prodrug thereof. Compounds of the formula (II) and (III): wherein ring A is an optionally substituted 5- to 7- membered ring; Q is C, CR 5 or N; R 8 , R 9 ,R 10 , R 11 and R 12 are independently, H, an optionally substituted hydrocarbon group, etc., or a salt thereof are also provided. Also specify X 1 , R 3 , R 1 , Y and X 3 in formula (II) and (III) as before.

3. 发明申请

WO2015068856A1 PYRAZOLE FOR THE TREATMENT AUTOIMMUNE DISORDERS 审中-公开
标题翻译：用于治疗自身免疫疾病的吡咯
公开(公告)号：WO2015068856A1
公开(公告)日：2015-05-14
申请号：PCT/JP2014/080005
申请日：2014-11-05
申请人： TAKEDA PHARMACEUTICAL COMPANY LIMITED
发明人： YOSHIDA, Masato , TAKAMI, Kazuaki , TOMINARI, Yusuke , SHIOKAWA, Zenyu , SHIBUYA, Akito , SASAKI, Yusuke , GIBSON, Tony , TAKAGI, Terufumi
IPC分类号： C07D401/14 , C07D413/14 , A61K31/4155 , C07D401/04 , C07D403/14 , C07D409/14 , C07D417/14 , C07D487/04 , C07D487/10 , A61P37/00
CPC分类号： C07D413/14 , A61K9/06 , A61K9/2018 , A61K9/2054 , A61K9/4858 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14 , C07D417/14 , C07D471/04 , C07D471/10 , C07D487/04 , C07D487/10 , C07D491/107 , C07D495/04
摘要： The present invention provides a heterocyclic compound having an IRAK-4 inhibitory action, which is useful for the prophylaxis or treatment of inflammatory disease, autoimmune disease, osteoarticular degenerative disease, neoplastic disease and the like, and a medicament containing thereof. The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.
摘要翻译：本发明提供了具有IRAK-4抑制作用的杂环化合物，其可用于预防或治疗炎症性疾病，自身免疫性疾病，骨关节炎性退行性疾病，肿瘤性疾病等，以及含有它们的药物。本发明涉及由式（I）表示的化合物：其中每个符号如说明书中所定义，或其盐。

4. 发明申请

WO2005035426A1 ESCALATOR AND SKIRT END STRUCTURE 审中-公开
标题翻译：自动化和结构结构
公开(公告)号：WO2005035426A1
公开(公告)日：2005-04-21
申请号：PCT/JP2004/015304
申请日：2004-10-08
申请人： TOSHIBA ELEVATOR KABUSHIKI KAISHA , YOSHIDA, Masato
发明人： YOSHIDA, Masato
IPC分类号： B66B29/04
CPC分类号： B66B29/04 , B66B27/00
摘要： There is provided an escalator having a skirt end portion which is improved in the visibility of an indicator, etc. and in the safety of the transport of passengers. The escalator, having a pair of balustrades disposed on both sides of traveling steps, includes: a balustrade end for turning back a handrail belt wound around on each said balustrade; a skirt end portion having a belt entrance port for the handrail belt; and an indicator for indicating the operating conditions of the escalator, wherein the front face of the skirt end portion includes an inclined surface at predetermined angles with a vertical plane and with the direction of passengers' riding from the entrance to the escalator, and the indicator is disposed such that its display face conforms to the inclination of the inclined surface.
摘要翻译：提供了具有裙部端部的自动扶梯，其提高了指示器的可视性等，并且在乘客的运输的安全性方面。自动扶梯具有设置在行进台阶两侧的一对栏杆，包括：用于转回围绕每个所述栏杆的扶手带的栏杆端; 裙部端部具有用于扶手带的带入口; 以及用于指示自动扶梯的操作条件的指示器，其中裙部端部的前表面包括具有垂直平面的预定角度的倾斜表面以及乘客从入口到自动扶梯的乘坐方向，并且指示器被布置成使得其显示面符合倾斜表面的倾斜度。

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