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1. 发明申请

WO2015181330A1 METHOD FOR ALL CANCER CATEGORY DETERMINATION BY MEANS OF METHYLATION PROFILING 审中-公开
标题翻译：通过甲基化方法确定所有癌症类别的方法
公开(公告)号：WO2015181330A1
公开(公告)日：2015-12-03
申请号：PCT/EP2015/061906
申请日：2015-05-28
申请人： SYVÄNEN, Ann-Christine , NORDLUND, Jessica , BÄCKLIN, Christofer , GUSTAFSSON, Mats , LÖNNERHOLM, Gudmar
发明人： SYVÄNEN, Ann-Christine , NORDLUND, Jessica , BÄCKLIN, Christofer , GUSTAFSSON, Mats , LÖNNERHOLM, Gudmar
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886
摘要： A method for determining whether a patient belongs to a specific cancer category is disclosed, which method comprises, in a sample from said patient, performing an analysis to determine the DNA methylation level in a group of predetermined CpG sites; said group of predetermined CpG sites comprising in the range of 7- 50 CpG sites, and said group of predetermined CpG sites being associated with a specific cancer category, wherein the output of said analysis is a patient methylation profile comprising a patient-specific methylation level for each CpG site in said group of predetermined CpG sites, and wherein said specific cancer category is characterised by a cancer category methylation profile comprising a cancer category specific methylation level for each CpG site in said group of predetermined CpG sites, said method further comprising the step of comparing said patient methylation profile with said cancer category methylation profile, wherein said patient belongs to said specific cancer category if said patient methylation profile corresponds to said cancer category methylation profile.
摘要翻译：公开了一种用于确定患者属于特定癌症类别的方法，该方法包括在来自所述患者的样品中进行分析以确定一组预定CpG位点中的DNA甲基化水平; 所述组的预定CpG位点包含7-50个CpG位点，并且所述预定CpG位点组与特定癌症类别相关联，其中所述分析的输出是包括患者特异性甲基化水平的患者甲基化谱对于所述预定CpG位点组中的每个CpG位点，并且其中所述特定癌症类别的特征在于包含所述预定CpG位点组中每个CpG位点的癌症类别特异性甲基化水平的癌症类别甲基化谱，所述方法还包括将所述患者甲基化谱与所述癌症类别甲基化谱进行比较的步骤，其中如果所述患者甲基化谱对应于所述癌症类别甲基化谱，则所述患者属于所述特定癌症类别。

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