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1. 发明申请

WO2015058163A3 HETEROMAROMATIC COMPOUNDS USEFUL FOR THE TREATMENT OF PROLFERATIVE DISEASES 审中-公开
标题翻译：用于治疗预防性疾病的异种化合物
公开(公告)号：WO2015058163A3
公开(公告)日：2015-06-11
申请号：PCT/US2014061264
申请日：2014-10-17
申请人： SYROS PHARMACEUTICALS INC , PARAZA PHARMA INC , CIBLAT STEPHANE , DEROY PATRICK , LEBLANC MELISSA , MARINEAU JASON J , MOORE JOEL , ROY STEPHANIE , SIDDIQUI M ARSHAD , SPROTT KEVIN , WINTER DANA K , KABRO ANZHELIKA , LEGER SERGE , MILLER TOM , SCHMIDT DARBY , BRADLEY MICHAEL
发明人： CIBLAT STEPHANE , DEROY PATRICK , LEBLANC MELISSA , MARINEAU JASON J , MOORE JOEL , ROY STEPHANIE , SIDDIQUI M ARSHAD , SPROTT KEVIN , WINTER DANA K , KABRO ANZHELIKA , LEGER SERGE , MILLER TOM , SCHMIDT DARBY , BRADLEY MICHAEL
IPC分类号： C07D401/14 , A61K31/506 , A61P35/02 , C07D401/04 , C07D403/04 , C07D403/14 , C07D413/04 , C07D413/14 , C07D417/04
CPC分类号： C07D401/14 , A61K31/506 , A61K31/5377 , A61K31/635 , A61K45/06 , C07D401/04 , C07D403/04 , C07D403/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D451/04
摘要： The present invention provides novel compounds of Formula (I) and Formula (II), and pharmaceutically acceptable salts, solvates, hydrates, tautomers, stereoisomers, isotopically labeled derivatives, and compositions thereof. Also provided are methods and kits involving the compounds or compositions for treating or preventing proliferative diseases (e.g., cancers (e.g.,leukemia, melanoma, multiple myeloma), benign neoplasms, angiogenesis, inflammatory diseases, autoinflammatory diseases, and autoimmune diseases) in a subject. Treatment of a subject with a proliferative disease using a compound or composition of the invention may inhibit the aberrant activity of a kinase, such as a cyclin-dependent kinase (CDK) (e.g., cyclin-dependent kinase 7 (CDK7)), and therefore, induce cellular apoptosis and/or inhibit transcription in the subject. (I)
摘要翻译：本发明提供式（I）和式（II）的新化合物及其药学上可接受的盐，溶剂合物，水合物，互变异构体，立体异构体，同位素标记的衍生物及其组合物。还提供了涉及用于治疗或预防受试者的增殖性疾病（例如，癌症（例如白血病，黑素瘤，多发性骨髓瘤），良性肿瘤，血管生成，炎性疾病，自身炎性疾病和自身免疫性疾病）的化合物或组合物的方法和试剂盒。使用本发明的化合物或组合物治疗具有增殖性疾病的受试者可以抑制激酶例如细胞周期蛋白依赖性激酶（CDK）（例如细胞周期蛋白依赖性激酶7（CDK7））的异常活性，因此，诱导受试者的细胞凋亡和/或抑制转录。（一世）

2. 发明申请

WO2015058126A8 HETEROAROMATIC COMPOUNDS USEFUL FOR THE TREATMENT OF PROLFERATIVE DISEASES 审中-公开
标题翻译：用于治疗预防性疾病的异种化合物
公开(公告)号：WO2015058126A8
公开(公告)日：2016-06-02
申请号：PCT/US2014061206
申请日：2014-10-17
申请人： SYROS PHARMACEUTICALS INC , DANA FARBER CANCER INST INC
发明人： CIBLAT STEPHANE , DEROY PATRICK , GRAY NATHANAEL , LEBLANC MELISSA , MARINEAU JASON J , MOORE JOEL , SPROTT KEVIN , ZHANG TINGHU , SIDDIQUI M ARSHAD , KABRO ANZHELIKA , LEGER SERGE , MILLER TOM , ROY STEPHANIE , SCHMIDT DARBY , WINTER DANA K , BRADLEY MICHAEL
IPC分类号： C07D401/14 , A61K31/506 , A61P35/02
CPC分类号： C07D401/14 , A61K31/506 , A61K45/06
摘要： The present invention provides novel compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, tautomers, stereoisomers, isotopically labeled derivatives, and compositions thereof. Also provided are methods and kits involving the compounds or compositions for treating or preventing proliferative diseases (e.g., cancers (e.g., leukemia, melanoma, multiple myeloma), benign neoplasms, angiogenesis, inflammatory diseases, autoinflammatory diseases, and autoimmune diseases) in a subject. Treatment of a subject with a proliferative disease using a compound or composition of the invention may inhibit the aberrant activity of a kinase, such as a cyclin-dependent kinase (CDK) (e.g., cyclin-dependent kinase 7 (CDK7)), and therefore, induce cellular apoptosis and/or inhibit transcription in the subject.
摘要翻译：本发明提供新的式（I）化合物及其药学上可接受的盐，溶剂合物，水合物，互变异构体，立体异构体，同位素标记的衍生物及其组合物。还提供了涉及用于治疗或预防受试者的增殖性疾病（例如，癌症（例如白血病，黑素瘤，多发性骨髓瘤），良性肿瘤，血管生成，炎性疾病，自身炎性疾病和自身免疫性疾病）的化合物或组合物的方法和试剂盒。使用本发明的化合物或组合物治疗具有增殖性疾病的受试者可以抑制激酶例如细胞周期蛋白依赖性激酶（CDK）（例如细胞周期蛋白依赖性激酶7（CDK7））的异常活性，因此，诱导受试者的细胞凋亡和/或抑制转录。

3. 发明申请

WO2015154039A8 INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) 审中-公开
标题翻译： CYPIN依赖性激酶7（CDK7）的抑制剂
公开(公告)号：WO2015154039A8
公开(公告)日：2016-10-27
申请号：PCT/US2015024358
申请日：2015-04-03
申请人： SYROS PHARMACEUTICALS INC
发明人： SPROTT KEVIN , MARINEAU JASON J , SCHMIDT DARBY , BRADLEY MICHAEL , CIBLAT STEPHANE , SIDDIQUI M ARSHAD , KABRO ANZHELIKA , LEBLANC MELISSA , LEGER SERGE , ROY STEPHANIE , WINTER DANA K , MILLER TOM , RIPKA AMY , LI DANSU
IPC分类号： C07D401/14 , A61K31/506 , A61P29/00 , A61P31/00 , A61P37/00 , C07D403/04 , C07D403/14 , C07D405/04 , C07D409/04 , C07D411/14 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04 , C07D487/04 , C07D487/10 , C07D498/10
CPC分类号： C07D487/10 , A61K31/506 , A61K31/5377 , A61K31/551 , A61K45/06 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D409/04 , C07D411/14 , C07D413/14 , C07D417/04 , C07D417/14 , C07D451/04 , C07D471/04 , C07D471/10 , C07D487/04 , C07D498/10
摘要： The present invention provides novel compounds of Formula (I) and Formula (II) and pharmaceutically acceptable salts, solvates, hydrates, tautomers, stereoisomers, isotopically labeled derivatives, and compositions thereof. Also provided are methods and kits involving the compounds or compositions for treating or preventing proliferative diseases (e.g., cancers (e.g., leukemia, melanoma, multiple myeloma), benign neoplasms, angiogenesis, inflammatory diseases, autoinflammatory diseases, and autoimmune diseases) in a subject. Treatment of a subject with a proliferative disease using a compound or composition of the invention may inhibit the aberrant activity of cyclin-dependent kinase 7 (CDK7), and therefore, induce cellular apoptosis and/or inhibit transcription in the subject.
摘要翻译：本发明提供新的式（I）和式（II）化合物及其药学上可接受的盐，溶剂合物，水合物，互变异构体，立体异构体，同位素标记的衍生物及其组合物。还提供了涉及用于治疗或预防受试者的增殖性疾病（例如，癌症（例如白血病，黑素瘤，多发性骨髓瘤），良性肿瘤，血管生成，炎性疾病，自身炎性疾病和自身免疫性疾病）的化合物或组合物的方法和试剂盒。使用本发明的化合物或组合物治疗具有增殖性疾病的受试者可以抑制细胞周期蛋白依赖性激酶7（CDK7）的异常活性，因此在受试者中诱导细胞凋亡和/或抑制转录。

4. 发明申请

WO2015154039A3 INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) 审中-公开
标题翻译： CYPIN依赖性激酶7（CDK7）的抑制剂
公开(公告)号：WO2015154039A3
公开(公告)日：2015-12-03
申请号：PCT/US2015024358
申请日：2015-04-03
申请人： SYROS PHARMACEUTICALS INC
发明人： SPROTT KEVIN , MARINEAU JASON J , SCHMIDT DARBY , BRADLEY MICHAEL , CIBLAT STEPHANE , SIDDIQUI M ARSHAD , KABRO ANZHELIKA , LEBLANC MELISSA , LEGER SERGE , ROY STEPHANIE , WINTER DANA K , MILLER TOM , RIPKA AMY , LI DANSU
IPC分类号： C07D401/14 , A61K31/506 , A61P29/00 , A61P31/00 , A61P37/00 , C07D403/04 , C07D403/14 , C07D405/04 , C07D409/04 , C07D411/14 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04 , C07D487/04 , C07D487/10 , C07D498/10
CPC分类号： C07D487/10 , A61K31/506 , A61K31/5377 , A61K31/551 , A61K45/06 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D409/04 , C07D411/14 , C07D413/14 , C07D417/04 , C07D417/14 , C07D451/04 , C07D471/04 , C07D471/10 , C07D487/04 , C07D498/10
摘要： The present invention provides novel compounds of Formula (I) and Formula (II) and pharmaceutically acceptable salts, solvates, hydrates, tautomers, stereoisomers, isotopically labeled derivatives, and compositions thereof. Also provided are methods and kits involving the compounds or compositions for treating or preventing proliferative diseases (e.g., cancers (e.g., leukemia, melanoma, multiple myeloma), benign neoplasms, angiogenesis, inflammatory diseases, autoinflammatory diseases, and autoimmune diseases) in a subject. Treatment of a subject with a proliferative disease using a compound or composition of the invention may inhibit the aberrant activity of cyclin-dependent kinase 7 (CDK7), and therefore, induce cellular apoptosis and/or inhibit transcription in the subject.
摘要翻译：本发明提供新的式（I）和式（II）化合物及其药学上可接受的盐，溶剂合物，水合物，互变异构体，立体异构体，同位素标记的衍生物及其组合物。还提供了涉及用于治疗或预防受试者的增殖性疾病（例如，癌症（例如白血病，黑素瘤，多发性骨髓瘤），良性肿瘤，血管生成，炎性疾病，自身炎性疾病和自身免疫性疾病）的化合物或组合物的方法和试剂盒。使用本发明的化合物或组合物治疗具有增殖性疾病的受试者可以抑制细胞周期蛋白依赖性激酶7（CDK7）的异常活性，因此在受试者中诱导细胞凋亡和/或抑制转录。

5. 发明申请

WO2008059240A3 ELECTROMAGNETIC TREATMENT OF CONTAMINATED MATERIALS 审中-公开
标题翻译：污染物质的电磁处理
公开(公告)号：WO2008059240A3
公开(公告)日：2009-03-05
申请号：PCT/GB2007004344
申请日：2007-11-14
申请人： UNIV NOTTINGHAM , ROBINSON JOHN , KINGDOM SAM , SNAPE COLIN , BRADLEY MICHAEL , BRADSHAW STEVEN
发明人： ROBINSON JOHN , KINGDOM SAM , SNAPE COLIN , BRADLEY MICHAEL , BRADSHAW STEVEN
IPC分类号： B09C1/06 , C01G1/00 , E21B21/06
CPC分类号： B09C1/005 , B09C1/06 , C10G1/04 , C10G2300/805 , E21B21/066
摘要： A method for separating a hydrocarbon content from a hydrocarbon contaminated matrix is disclosed. The method comprises controlling a water content of a feed material comprising the hydrocarbon contaminated matrix; continuously conveying the feed material into a treatment cavity (3), exposing the feed material in a treatment area (8) of the treatment cavity to microwave radiation arranged to cause rapid heating of at least a portion of the water content to form steam, wherein the rapid steam formation results in thermal desorption of at least a portion of the hydrocarbon content from the matrix; and continuously removing the treated matrix from the treatment cavity.
摘要翻译：公开了一种从碳氢化合物污染的基质中分离烃含量的方法。该方法包括控制包含烃污染的基质的进料的含水量; 将进料材料连续地输送到处理腔（3）中，将处理腔的处理区域（8）中的进料材料暴露于布置成使至少一部分水含量快速加热以形成蒸汽的微波辐射，其中快速蒸汽形成导致来自基质的烃含量的至少一部分的热解吸; 并从处理腔中连续地除去处理过的基质。

6. 发明申请

WO03017287A3 IMPROVEMENTS IN AND RELATING TO CONTAINMENT 审中-公开
标题翻译：与容器相关的改进
公开(公告)号：WO03017287A3
公开(公告)日：2003-05-01
申请号：PCT/GB0203823
申请日：2002-08-19
申请人： BNFL IP LTD , PARKER ROSS STRACHEN , BRADLEY MICHAEL
发明人： PARKER ROSS STRACHEN , BRADLEY MICHAEL
IPC分类号： G21C3/62 , G21F7/005
CPC分类号： G21C3/623 , G21F7/005 , Y02E30/38
摘要： A method of containing contaminating material, feed material handling apparatus and the use of feed material handling apparatus is provided with a view to minimising the possibilities for contaminating material spreading from a high contamination level environment to a low contamination level environment, the two environments being linked by a passage, at least part of the passage being filled with the feed material.
摘要翻译：提供一种容纳污染物质，给料处理装置和使用给料处理装置的方法，以使污染物质从高污染等级环境扩散到低污染等级环境的可能性最小化，两个环境相关联通过通道，通道的至少一部分填充有供给材料。

7. 发明申请

WO02093419A3 METHOD AND SYSTEM FOR DISPLAYING ANALYTICS ABOUT A WEBSITE AND ITS CONTENTS 审中-公开
标题翻译：用于显示关于网站及其内容的分析的方法和系统
公开(公告)号：WO02093419A3
公开(公告)日：2003-09-25
申请号：PCT/CA0200714
申请日：2002-05-16
申请人： BUYSTREAM INC , BRADLEY MICHAEL , RYAN SHANNON , WOODS RANDY
发明人： BRADLEY MICHAEL , RYAN SHANNON , WOODS RANDY
IPC分类号： G06F11/32 , G06F11/34 , G06F17/30 , G06Q30/02
CPC分类号： G06Q30/02 , G06F11/32 , G06F11/3419 , G06F11/3438 , G06F17/3089 , G06F2201/875
摘要： There is provided a method of displaying analytics about a website And its contents resident on a server computer. The method comprises the steps of: (a) causing a browser program to be opened on the server computer with a first display frame and a second display frame immediately adjacent said first display frame, wherein the first display frame comprises a page of the website; (b) marking the page displayed in the first display frame with a first identifier and creating an interface call to a report server; (c) retrieving a report file corresponding to the first identifier from the report server; (d) displaying the analytics in the report file in the second display frame; (e) after a pre-determined period of time, comparing the page displayed in the first display frame with the first identifier; and (f) if different, repeating the method from step (b) for the page displayed in the first display frame; or (g) if the same, resetting for a second of the pre-determined period of time and repeating the method from step (e).
摘要翻译：提供了一种显示关于网站的分析的方法及其驻留在服务器计算机上的内容。该方法包括以下步骤：（a）使服务器计算机上的第一显示框和紧邻所述第一显示框的第二显示框打开浏览器程序，其中第一显示框包括网页; （b）用第一标识符标记在第一显示帧中显示的页面，并创建到报告服务器的接口调用; （c）从所述报告服务器检索与所述第一标识符相对应的报告文件; （d）在第二显示帧中在报告文件中显示分析; （e）在预定的时间段之后，将在第一显示帧中显示的页面与第一标识符进行比较; 和（f）如果不同，则对于在第一显示帧中显示的页重复来自步骤（b）的方法; 或（g）如果相同，则重置预定时间段的第二个时间并重复步骤（e）中的方法。

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