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1. 发明申请

WO2006128172A3 METHOD FOR TREATING B CELL REGULATED AUTOIMMUNE DISORDERS 审中-公开
标题翻译：用于治疗B细胞调节性自身免疫疾病的方法
公开(公告)号：WO2006128172A3
公开(公告)日：2008-04-17
申请号：PCT/US2006020908
申请日：2006-05-26
申请人： SYNTA PHARMACEUTICALS CORP , FOLEY KEVIN , BERTIN JOHN , GRANT ETHAN P
发明人： FOLEY KEVIN , BERTIN JOHN , GRANT ETHAN P
IPC分类号： A61K31/506 , A61K31/53
CPC分类号： A61K31/5377 , A61K31/506 , A61K31/53 , C12Q1/6883 , C12Q2600/106 , G01N33/5308 , G01N2500/04
摘要： The invention relates to a method for treating B-cell regulated autoimmune disorders using compounds that modulate the activity of c-Rel.
摘要翻译：本发明涉及使用调节c-Rel活性的化合物治疗B细胞调节的自身免疫病症的方法。

2. 发明申请

WO2007100631A9 COMPOSITIONS AND METHODS FOR MODULATING CYTOKINE PRODUCTION 审中-公开
标题翻译：用于调节细胞因子生产的组合物和方法
公开(公告)号：WO2007100631A9
公开(公告)日：2007-11-01
申请号：PCT/US2007004669
申请日：2007-02-22
申请人： SYNTA PHARMACEUTICALS CORP , KIRSHNER JESSICA R , ZHANG MEI , BERTIN JOHN , GRANT ETHAN P , DU ZHENJIAN , JACOBSON ERIC
发明人： KIRSHNER JESSICA R , ZHANG MEI , BERTIN JOHN , GRANT ETHAN P , DU ZHENJIAN , JACOBSON ERIC
IPC分类号： G01N33/53
CPC分类号： G01N33/6875 , C12Q1/485 , G01N2500/10
摘要： The present invention is directed to methods for identifying compounds that inhibit the production of IL-12p40 and/or increase the production of IL-IO, and methods for treating or preventing diseases or disorders related to IL-12, IL-23, and IL-27 production.
摘要翻译：本发明涉及用于鉴定抑制IL-12p40产生和/或增加IL-10产生的化合物的方法，以及用于治疗或预防与IL-12，IL-23和IL相关的疾病或病症的方法 -27生产。

3. 发明申请

WO2006128129A2 METHOD FOR TREATING CANCER 审中-公开
标题翻译：治疗癌症的方法
公开(公告)号：WO2006128129A2
公开(公告)日：2006-11-30
申请号：PCT/US2006020821
申请日：2006-05-26
申请人： SYNTA PHARMACEUTICALS CORP , BERTIN JOHN , GRANT ETHAN P
发明人： BERTIN JOHN , GRANT ETHAN P
IPC分类号： A61K31/53
CPC分类号： A61K31/53
摘要： The invention relates to a method for treating cancers using compounds that modulate the activity of c-Rel.
摘要翻译：本发明涉及使用调节c-Rel活性的化合物治疗癌症的方法。

4. 发明申请

WO2007100631A3 COMPOSITIONS AND METHODS FOR MODULATING CYTOKINE PRODUCTION 审中-公开
标题翻译：用于调节细胞因子生产的组合物和方法
公开(公告)号：WO2007100631A3
公开(公告)日：2008-06-19
申请号：PCT/US2007004669
申请日：2007-02-22
申请人： SYNTA PHARMACEUTICALS CORP , KIRSHNER JESSICA R , ZHANG MEI , BERTIN JOHN , GRANT ETHAN P , DU ZHENJIAN , JACOBSON ERIC
发明人： KIRSHNER JESSICA R , ZHANG MEI , BERTIN JOHN , GRANT ETHAN P , DU ZHENJIAN , JACOBSON ERIC
IPC分类号： C12Q1/00
CPC分类号： G01N33/6875 , C12Q1/485 , G01N2500/10
摘要： The present invention is directed to methods for identifying compounds that inhibit the production of IL-12p40 and/or increase the production of IL-IO, and methods for treating or preventing diseases or disorders related to IL-12, IL-23, and IL-27 production.
摘要翻译：本发明涉及用于鉴定抑制IL-12p40产生和/或增加IL-10产生的化合物的方法，以及用于治疗或预防与IL-12，IL-23和IL相关的疾病或病症的方法 -27生产。

5. 发明申请

WO03044160A3 NOVEL MOLECULES OF THE CARD RELATED PROTEIN FAMILY AND USES THEREOF 审中-公开
标题翻译：卡片相关蛋白家族的新分子及其用途
公开(公告)号：WO03044160A3
公开(公告)日：2003-09-12
申请号：PCT/US0225856
申请日：2002-08-14
申请人： MILLENIUM PHARMACEUTICALS INC , UNIV JEFFERSON , BERTIN JOHN , ALNEMRI EMAD S
发明人： BERTIN JOHN , ALNEMRI EMAD S
IPC分类号： A61K38/00 , C07K14/47 , C12Q1/68 , G01N33/53
CPC分类号： C07K14/4702 , A61K38/00
摘要： CARD-7 and CARD-8 polypeptides, proteins, and nucleic acid molecules disclosed. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：公开了CARD-7和CARD-8多肽，蛋白质和核酸分子。还提供了利用本发明组合物的诊断，筛选和治疗方法。

6. 发明申请

WO0130813A9 NOVEL MOLECULES OF THE CARD-RELATED PROTEIN FAMILY AND USES THEREOF 审中-公开
标题翻译：相关蛋白家族的新分子及其用途
公开(公告)号：WO0130813A9
公开(公告)日：2002-07-04
申请号：PCT/US0029796
申请日：2000-10-27
申请人： MILLENNIUM PHARM INC , BERTIN JOHN
发明人： BERTIN JOHN
IPC分类号： A61K38/00 , C07K14/47 , C07K14/00
CPC分类号： C07K14/4702 , A61K38/00
摘要： Novel CARD-7 and CARD-8 polypeptides, proteins, and nucleic acid molecules are disclosed. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：公开了新的CARD-7和CARD-8多肽，蛋白质和核酸分子。还提供利用本发明组合物的诊断，筛选和治疗方法。

7. 发明申请

WO0157185A2 NOVEL MOLECULES OF THE CARD-RELATED PROTEIN FAMILY AND USES THEREOF 审中-公开
标题翻译：相关蛋白家族的新分子及其用途
公开(公告)号：WO0157185A2
公开(公告)日：2001-08-09
申请号：PCT/US0103401
申请日：2001-02-02
申请人： MILLENNIUM PHARM INC , BERTIN JOHN
发明人： BERTIN JOHN
IPC分类号： C07K14/47 , C12N
CPC分类号： C07K14/4702
摘要： Novel CARD-13 or CARD-15 polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated CARD-13 or CARD-15 fusion proteins, the invention further provides CARD-13 or CARD-15 fusion proteins, antigenic peptides and anti-CARD-13 or anti-CARD-15 antibodies. The invention also provides CARD-13 or CARD-15 nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a CARD-13 or CARD-15 gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：公开了新型CARD-13或CARD-15多肽，蛋白质和核酸分子。除了分离的CARD-13或CARD-15融合蛋白之外，本发明还提供CARD-13或CARD-15融合蛋白，抗原肽和抗CARD-13或抗CARD-15抗体。本发明还提供CARD-13或CARD-15核酸分子，含有本发明的核酸分子的重组表达载体，已经引入了表达载体的宿主细胞和非人转基因动物，其中CARD-13或 CARD-15基因已被引入或破坏。还提供利用本发明组合物的诊断，筛选和治疗方法。

8. 发明申请

WO03097684A8 CARD-4 MOLECULES AND USES THEREOF 审中-公开
标题翻译： CARD-4分子及其用途
公开(公告)号：WO03097684A8
公开(公告)日：2004-04-29
申请号：PCT/IB0302597
申请日：2003-05-22
申请人： PASTEUR INSTITUT , BERTIN JOHN , PHILPOTT DANA , SANSONETTI PHILIPPE , GIRARDIN STEPHEN
发明人： BERTIN JOHN , PHILPOTT DANA , SANSONETTI PHILIPPE , GIRARDIN STEPHEN
IPC分类号： C07K14/47 , A01K67/027 , A61K35/00
CPC分类号： C07K14/4702 , A01K2217/05
摘要： The invention provides methods of using CARD-4 molecules to screen for modulators of LPS-induced cell signaling pathways. Also included are CARD-4 deficient mice, methods of modulating LPS-induced cell signaling pathways, and methods of treating or preventing bacterial infections.
摘要翻译：本发明提供了使用CARD-4分子来筛选LPS诱导的细胞信号传导途径的调节剂的方法。还包括CARD-4缺陷型小鼠，调节LPS诱导的细胞信号传导途径的方法以及治疗或预防细菌感染的方法。

9. 发明申请

WO02085939A8 NOVEL MOLECULES OF THE CARD-RELATED PROTEIN FAMILY AND USES THEREOF 审中-公开
标题翻译：相关蛋白家族的新分子及其用途
公开(公告)号：WO02085939A8
公开(公告)日：2002-12-12
申请号：PCT/US0213009
申请日：2002-04-24
申请人： MILLENNIUM PHARM INC , BERTIN JOHN
发明人： BERTIN JOHN
IPC分类号： A61K38/00 , C07K14/47 , C12N15/12 , C07K7/08 , C07K16/18 , C12N1/00 , C12N5/00 , C12N5/06 , C12P21/02 , C12Q1/37 , C12Q1/68 , G01N33/53 , G01N33/566 , G01N33/68
CPC分类号： C12N9/1205 , A61K38/00 , C07K14/4702 , C07K14/4747 , C12N9/6475
摘要： Novel CARD-12 polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated CARD-12 proteins, the invention further provides CARD-12, fusion proteins, antigenic peptides and anti-CARD-12 antibodies. The invention also provides CARD-12 nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a CARD-12 gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：公开了新型CARD-12多肽，蛋白质和核酸分子。除了分离的CARD-12蛋白之外，本发明还提供CARD-12，融合蛋白，抗原肽和抗CARD-12抗体。本发明还提供CARD-12核酸分子，含有本发明的核酸分子的重组表达载体，已经引入了表达载体的宿主细胞和其中引入了CARD-12基因的非人转基因动物，或破坏。还提供利用本发明组合物的诊断，筛选和治疗方法。

10. 发明申请

WO0159065A9 NOVEL MOLECULES OF THE CARD-RELATED PROTEIN FAMILY AND USES THEREOF 审中-公开
标题翻译：相关蛋白家族的新分子及其用途
公开(公告)号：WO0159065A9
公开(公告)日：2002-10-31
申请号：PCT/US0102087
申请日：2001-01-22
申请人： MILLENNIUM PHARM INC , BERTIN JOHN
发明人： BERTIN JOHN
IPC分类号： A61K38/00 , C07K14/47 , C07K14/00 , C07H21/00 , C07H21/02 , C07K16/00 , C12Q1/68
CPC分类号： C07K14/4747 , A61K38/00
摘要： Novel CARD-14 polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated CARD-14 proteins, the invention further provides CARD-14 fusion proteins, antigenic peptides and anti-CARD-14 antibodies. The invention also provides CARD-14 nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a CARD-14 gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：公开了新的CARD-14多肽，蛋白质和核酸分子。除了分离的CARD-14蛋白之外，本发明还提供CARD-14融合蛋白，抗原肽和抗CARD-14抗体。本发明还提供CARD-14核酸分子，含有本发明的核酸分子的重组表达载体，已经引入了表达载体的宿主细胞和其中引入了CARD-14基因的非人转基因动物，或破坏。还提供利用本发明组合物的诊断，筛选和治疗方法。

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