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1. 发明申请

WO2011049289A3 POLYPEPTIDE OR FUSED PROTEIN THEREOF INHIBITING THE EXTRAVASATION OF WHITE BLOOD CELLS OR THE GROWTH AND/OR METASTASIS OF CANCER CELLS 审中-公开
标题翻译：多肽或融合蛋白抑制白血细胞的提取或癌细胞的生长和/或转移
公开(公告)号：WO2011049289A3
公开(公告)日：2011-07-14
申请号：PCT/KR2010005619
申请日：2010-08-24
申请人： SUPADELIXIR INC , HAHN JANG-HEE , LEE KYOUNG-JIN , LEE SUN-HEE , JU HYUN-MI
发明人： HAHN JANG-HEE , LEE KYOUNG-JIN , LEE SUN-HEE , JU HYUN-MI
IPC分类号： A61K38/16 , A61P35/00 , A61P35/04
CPC分类号： A61K38/16
摘要： The present invention relates to a polypeptide derived from a highly conserved region (HCR) I-III of an extracellular region of a CD99 and CD99 family such as CD99L2 and PBDX (or XG), which are a kind of transmembrane protein, or a fused protein thereof. The polypeptide or the fused protein thereof has an activating function of inhibiting the extravasation of white blood cells, or inhibiting the growth and/or metastasis of cancer cells. The present invention also provides a polynucleotide coding the polypeptide, a vector including same, and a transformant transformed by the vector. In addition, the present invention provides a pharmaceutical composition including the polypeptide or the fused protein thereof for preventing or treating inflammatory diseases. Further, the present invention provides a pharmaceutical composition including the polypeptide or the fused protein thereof inhibiting the growth and/or metastasis of cancer cells, i.e., a pharmaceutical composition for preventing or treating cancer.
摘要翻译：本发明涉及由CD99和CD99家族的细胞外区如CD99L2和PBDX（或XG）的高度保守区（HCR）I-III衍生的多肽，它是一种跨膜蛋白，或融合蛋白其蛋白质。多肽或其融合蛋白具有抑制白血球外渗或抑制癌细胞生长和/或转移的活化功能。本发明还提供编码所述多肽的多核苷酸，包含其的载体和由所述载体转化的转化体。另外，本发明提供了包含该多肽或其融合蛋白的药物组合物，用于预防或治疗炎性疾病。此外，本发明提供了包含抑制癌细胞生长和/或转移的多肽或其融合蛋白质的药物组合物，即用于预防或治疗癌症的药物组合物。

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