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1. 发明申请

WO2021119853A1 ADHESIVE DEVICE FOR BIOMEDICAL APPLICATIONS AND METHODS OF USE THEREOF 审中-公开
公开(公告)号：WO2021119853A1
公开(公告)日：2021-06-24
申请号：PCT/CA2020/051781
申请日：2020-12-21
申请人： THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO , SUNNYBROOK HEALTH SCIENCES CENTRE
发明人： SANTERRE, Paul , SONE, Eli , FLOROS, Michael , FIALKOV, Jeffrey , WHYNE, Cari
IPC分类号： C09J7/30 , A61L24/04 , C09J7/22 , A61B17/03 , A61F2/00 , C09J175/00
摘要： An adhesive device for biomedical applications is provided comprising a support and one or more water insoluble compounds of structure 1 wherein B is an oligomer derived from a polyester, polyether, polyalkylene glycol, polysilicone or polycarbonate with a MW

2. 发明申请

WO2014019083A1 BONE STABILIZATION DEVICE AND METHOD OF PRODUCTION 审中-公开
标题翻译：骨稳定装置及其生产方法
公开(公告)号：WO2014019083A1
公开(公告)日：2014-02-06
申请号：PCT/CA2013/050570
申请日：2013-07-22
申请人： SUNNYBROOK HEALTH SCIENCES CENTRE , THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO
发明人： WHYNE, Cari Marisa , PILLIAR, Robert M. , FIALKOV, Jeffrey Allan , SANTERRE, Paul , REGEV, Eran
IPC分类号： A61B17/68 , A61L31/12 , B32B13/12
CPC分类号： A61F2/28 , A61B17/688 , A61B17/80 , A61B2017/00004 , A61F2210/0004 , A61L31/026 , A61L31/088 , A61L31/10 , A61L31/127 , A61L31/128 , A61L31/14 , A61L31/146 , A61L31/148 , A61L2430/02 , B32B5/028 , B32B13/12 , B32B13/14 , B32B21/08 , B32B21/10 , B32B21/14 , B32B27/20 , B32B27/285 , B32B27/34 , B32B27/36 , B32B27/365 , B32B27/40 , B32B2260/021 , B32B2260/046 , B32B2262/105 , B32B2307/542 , B32B2307/7163 , C08L1/10 , C08L33/08 , C08L67/04
摘要： The present disclosure discloses a bone stabilization device (also referred to as a bone tape), which includes a composite flexible construct including a rigidifiable biocompatible sheet structure having first and second opposed surfaces. A biocompatible cement is located on the first surface. In use the composite flexible construct is applied to a bone with the cement contacted directly to the bone. The cement is made of a material that, once adhered to the bone, is curable to mechanically and/or ionically bond to the sheet structure and to chemically bond to the bone to achieve a permanent bond. The bone tape allows simultaneous alignment and stabilization of multiple articulated fragments for successful 3D reconstruction of shattered bones. Initial flexibility and translucency provided by the bone tape can facilitate the temporary stabilization and alignment adjustment of multiple fragments, prior to permanent rigid bonding.
摘要翻译：本公开公开了一种骨稳定装置（也称为骨胶带），其包括复合柔性构造，其包括具有第一和第二相对表面的可刚性化的生物相容性片结构。生物相容性水泥位于第一表面。在使用中，将复合柔性构造物施用于具有与骨直接接触的骨水泥的骨骼上。该水泥由一种材料制成，一旦粘附到骨上，它可固化成机械地和/或离子地结合到片状结构上，并化学地结合到骨上以实现永久的粘合。骨胶带允许同时对准和稳定多个关节碎片，以便成功地重建破碎的骨骼。由骨胶原提供的初始柔韧性和半透明度可以有助于在永久性刚性粘合之前对多个碎片的临时稳定和对准调整。

3. 发明申请

WO2021119855A1 WATER SOLUBLE BIOADHESIVES 审中-公开
公开(公告)号：WO2021119855A1
公开(公告)日：2021-06-24
申请号：PCT/CA2020/051784
申请日：2020-12-21
申请人： THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO
发明人： SANTERRE, Paul , SONE, Eli , FLOROS, Michael
IPC分类号： C09J175/08 , A61K47/34 , A61K9/00 , C09J167/00
摘要： A water soluble biocompatible adhesive is provided comprising one or more compounds of structure 1 wherein B is an oligomer derived from a polyether or polyalkylene glycol, with a MW

4. 发明申请

WO2017139868A1 BIODEGRADABLE SOFT TISSUE FILLER 审中-公开
标题翻译：可生物降解的软组织填充物
公开(公告)号：WO2017139868A1
公开(公告)日：2017-08-24
申请号：PCT/CA2017/000030
申请日：2017-02-16
申请人： THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO , UNIVERSITY HEALTH NETWORK
发明人： SANTERRE, Paul , SHARIFPOOR, Soror , LEONG, Liang, Wey
IPC分类号： A61L27/18 , A61L27/56
CPC分类号： A61L27/18 , A61L27/56 , A61L27/58 , A61L2400/06 , A61L2430/04 , C08L75/04
摘要： A soft tissue filler comprising a biodegradable amino-acid derived polycarbonate-urethanes and methods of repairing soft tissue defects are provided. The biodegradable soft tissue filler comprises a porous scaffold that is the reaction product of: a) a divinyl oligomer component that comprises a carbonate-derived divinyl oligomer that is the reaction product of a lysine-derived diisocyanate, a vinyl coupling agent, and a polycarbonate and, optionally, an ether-derived divinyl oligomer, wherein the ether-derived divinyl oligomer is the reaction product of a lysine-derived diisocyanate, a vinyl coupling agent, and an ether; b) at least one anionic monomer; and c) at least one hydrophobic monomer. The molar ratio of (a) : (b+c) is between about 1:≥21 and about 1:30, the soft tissue filler has a porosity of > 75 %; and a compressive moduli of between about 1 kPa and about 50 kPa.
摘要翻译：提供了包含可生物降解的氨基酸衍生的聚碳酸酯 - 氨基甲酸酯的软组织填充物以及修复软组织缺陷的方法。可生物降解的软组织填充物包括多孔支架，所述多孔支架是以下物质的反应产物：a）二乙烯基低聚物组分，其包含碳酸酯衍生的二乙烯基低聚物，其为赖氨酸衍生的二异氰酸酯，乙烯基偶联剂和聚碳酸酯以及任选地衍生自醚的二乙烯基低聚物，其中所述衍生自醚的二乙烯基低聚物是赖氨酸衍生的二异氰酸酯，乙烯基偶联剂和醚的反应产物; b）至少一种阴离子单体; 和c）至少一种疏水单体。（a）：（b + c）的摩尔比在约1:21和约1:30之间，软组织填充剂的孔隙率> 75％; 和在约1kPa和约50kPa之间的压缩模量。

5. 发明申请

WO2021119854A1 BIOCOMPATIBLE ADHESIVES AND METHODS OF MANUFACTURE THEREOF 审中-公开
公开(公告)号：WO2021119854A1
公开(公告)日：2021-06-24
申请号：PCT/CA2020/051782
申请日：2020-12-21
申请人： THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO
发明人： SONE, Eli , FLOROS, Michael , SANTERRE, Paul
IPC分类号： C09J175/00 , A61K47/34 , A61K49/00 , A61L24/04
摘要： A biocompatible adhesive is provided comprising one or more water insoluble compounds of structure (1) wherein B is an oligomer derived from a polyester, polyether, polyalkylene glycol, polysilicone or polycarbonate with a MW

6. 发明申请

WO2022261791A1 AMPHIPHILIC OLIGOMERS AND SELF-ASSEMBLING HYDROGELS FORMED THEREFROM 审中-公开
公开(公告)号：WO2022261791A1
公开(公告)日：2022-12-22
申请号：PCT/CA2022/050992
申请日：2022-06-20
申请人： THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO
发明人： SANTERRE, Paul , SONE, Eli , LAM, Angus Wen-tsung
IPC分类号： C08G18/40 , A61K9/00 , A61K9/48 , A61K47/18
摘要： Amphiphilic oligomers are provided that yield self-assembled, phase-separated hydrogels suitable for sustained release drug delivery. The oligomers are of formula (D-C-A-C)n-B or (D-C-B-C)n-A, where A represents a hydrophilic segment such as polyethylene glycol, B is a degradable hydrophobic segment such as polycaprolactone, C is a linking group comprising a urethane or urea linkage, D is a terminal catechol adhesive group capable of cross- linking, and n is 2 or 3. The oligomers are prepared by (i) reacting either one of a hydrophilic polyol or a hydrophobic polyol with a diisocyanate compound; (ii) reacting the product of step (i) with the other of the hydrophilic polyol and hydrophobic polyol; and (iii) reacting the product of step (ii) with a catechol derivative to form the terminal adhesive groups.

7. 发明申请

WO2016023102A1 BIOMATERIAL WITH REDUCED INFLAMMATORY RESPONSE 审中-公开
标题翻译：具有减少炎症反应的生物材料
公开(公告)号：WO2016023102A1
公开(公告)日：2016-02-18
申请号：PCT/CA2015/000461
申请日：2015-08-14
申请人： THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO
发明人： SANTERRE, Paul , BATTISON, Kyle
IPC分类号： C08F290/06 , A61K47/32 , A61K9/00 , C08L51/08
CPC分类号： A61L27/16 , A61K47/32 , A61L27/14 , A61L27/18 , A61L27/34 , A61L27/54 , A61L31/06 , A61L31/10 , A61L31/16 , A61L2400/18 , C08F220/06 , C08F220/18 , C08F283/008 , C08F220/14 , C08L75/04
摘要： Polar hydrophobic ionic materials and, in particular, polar hydrophobic ionic polyurethanes having a minimum ratio of hydrophobic and anionic components to the remainder of the polymer components are provided that exhibit reduced IgG Fab exposure.
摘要翻译：提供极性疏水性离子材料，特别是具有疏水和阴离子组分与聚合物组分剩余部分的最小比例的极性疏水性离子型聚氨酯，其显示减少的IgG Fab暴露。

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