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    • 3. 发明申请
    • PHARMACEUTICAL COMPOSITION FOR PREVENTING / TREATING TRPV1 ACTIVITY-RELATED AND INFLAMMATION-RELATED DISEASES OR CONDITIONS CONTAINING MAILLARD PEPTIDE SEPARATED FROM WELL-AGED TRADITIONAL SOY SAUCE AS ACTIVE INGREDIENT
    • 用于预防/治疗TRPV1活性相关和与炎症有关的疾病或病症的药物组合物,其含有分解自作为活性成分的传统大豆
    • WO2011056033A3
    • 2011-11-03
    • PCT/KR2010007845
    • 2010-11-08
    • KOREA FOOD RES INSTSNU R&DB FOUNDATIONRHYU MEE-RASONG AH-YOUNGKIM EUN-YOUNGOH SEOG BAELEE YOUNGJOOLIM WON CHUNG
    • RHYU MEE-RASONG AH-YOUNGKIM EUN-YOUNGOH SEOG BAELEE YOUNGJOOLIM WON CHUNG
    • A61K38/00A61P1/00A61P25/00A61P29/00
    • A61K38/168A61K36/47
    • The present invention relates to a pharmaceutical composition for preventing or treating TRPV1 activity-related or inflammation-related, diseases or conditions, containing a Maillard peptide separated from well-aged traditional soy sauce as an active ingredient. The Maillard peptide according to the present invention functions both as a TRPV1 agonist and a TRPV1 antagonist, and thus functions as a TRPV1 activity modulator. Therefore, the present Maillard peptide can be used as a pharmaceutical composition for preventing or treating TRPV1 activity-related diseases such as pain, neurological diseases, urgent defecation, inflammatory bowel disease, respiratory diseases, urinary incontinence, overactive bladder, neurogenic / allergic / inflammatory skin diseases, skin, eye or mucosal irritation, hyperacusis, tinnitus, vestibular hypersensitivity, heart disease, etc. In addition, the Maillard peptide of the present invention can inhibit COX-2 activity, and therefore can be effectively used as a pharmaceutical composition for preventing or treating inflammation-related diseases or conditions such as rheumatic fever, influenza, cold, throat pain, headaches, toothaches, sprains, neuralgia, synovitis, rheumatoid arthritis, degenerative arthropathies, gout, ankylosing spondylitis, psoriasis, dermatitis, etc.
    • 本发明涉及一种用于预防或治疗TRPV1活性相关或炎症相关疾病或病症的药物组合物,其含有与传统酱油作为有效成分分离的美拉德肽。 根据本发明的美拉德肽既作为TRPV1激动剂又作为TRPV1拮抗剂起作用,因此起到TRPV1活性调节剂的作用。 因此,本发明的美拉德肽可用作预防或治疗TRPV1活性相关疾病如疼痛,神经系统疾病,紧急排便,炎性肠病,呼吸系统疾病,尿失禁,膀胱过度活动,神经源性/过敏性/炎症性的药物组合物 皮肤疾病,皮肤,眼睛或粘膜刺激,腹胀,耳鸣,前庭超敏反应,心脏病等。另外,本发明的美拉德肽可以抑制COX-2活性,因此可以有效地用作药物组合物 预防或治疗炎症相关疾病或病症如风湿热,流感,感冒,咽喉痛,头痛,牙痛,扭伤,神经痛,滑膜炎,类风湿性关节炎,退行性关节病,痛风,强直性脊柱炎,牛皮癣,皮炎等。