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1. 发明申请

WO2011104621A1 SURFACTANT COMPOSITION 审中-公开
标题翻译：表面活性剂组合物
公开(公告)号：WO2011104621A1
公开(公告)日：2011-09-01
申请号：PCT/IB2011/000394
申请日：2011-02-25
申请人： STELLENBOSCH UNIVERSITY , SMITH, Johan , VAN ZYL, Johann, Martin , VAN DER BIJL, Pieter , HAWTREY, Arthur, Owen
发明人： SMITH, Johan , VAN ZYL, Johann, Martin , VAN DER BIJL, Pieter , HAWTREY, Arthur, Owen
IPC分类号： A61K38/16 , A61K31/683 , A61P11/00
CPC分类号： A61K31/683 , A61K9/0082 , A61K38/02 , A61K38/16
摘要： The invention describes a composition comprising a lipidaceous carrier and a peptide complex formed from poly-L-lysine or a salt thereof; and either poly- L-glutamic acid or poly-L-aspartic acid, or a salt thereof. The composition can be used to prevent or treat a condition related to pulmonary surfactant dysfunction or deficiency, such as hyaline membrane disease (HMD), respiratory distress syndrome (RDS), hydrocarbon poisoning, near-drowning, HIV/AIDS-related lung diseases, adult respiratory distress syndrome (ARDS) or acue lung injury (ALI), asthma, tuberculosis (TB) or severe acute respiratory syndrome (SARS). Alternatively, the composition can be used to increase the permeability of a pharmaceutical compound or composition across a membrane of a subject or to act as a carrier. The poly-L-lysine or salt thereof is longer than the poly-L-glutamic acid or poly-L-aspartic acid so that the complex that forms has a charge-neutralised region and a positively- charged region. The charge-neutralised region of the peptide complex interacts with the lipidaceous carrier, while the positively-charged region interacts with an aqueous and/or polar environment.
摘要翻译：本发明描述了一种包含脂质载体和由聚-L-赖氨酸或其盐形成的肽复合物的组合物; 和聚-L-谷氨酸或聚-L-天冬氨酸或其盐。该组合物可用于预防或治疗与肺表面活性物质功能障碍或缺陷有关的病症，如透明膜疾病（HMD），呼吸窘迫综合征（RDS），碳氢化合物中毒，近溺水，艾滋病毒/艾滋病相关肺部疾病，成人呼吸窘迫综合征（ARDS）或脊髓损伤（ALI），哮喘，结核病（TB）或严重急性呼吸综合征（SARS）。或者，组合物可以用于增加药物化合物或组合物穿过受试者的膜或作为载体的渗透性。聚-L-赖氨酸或其盐比聚-L-谷氨酸或聚-L-天冬氨酸长，使得形成的络合物具有电荷中和区域和带正电荷区域。肽络合物的电荷中和区域与脂质载体相互作用，而带正电荷的区域与水性和/或极性环境相互作用。

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