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1. 发明申请

WO2023057181A1 COMPOSITION FOR PREVENTING OR TREATING AUTOIMMUNE DISEASES 审中-公开
公开(公告)号：WO2023057181A1
公开(公告)日：2023-04-13
申请号：PCT/EP2022/075461
申请日：2022-09-13
申请人： STATENS SERUM INSTITUT
发明人： CHRISTENSEN, Dennis , DIETRICH, Jes , PEDERSEN, Gabriel , WØRZNER, Katharina
IPC分类号： A61K39/39 , A61K39/00 , A61K2039/55511 , A61K2039/55555 , A61K2039/577 , A61K39/0008
摘要： The present invention relates to a composition for preventing or treating autoimmune diseases. In particular the present invention relates to a composition that prevents or treats the disease by specifically targeting the immune cells responsible for the autoimmune reaction. Thus one aspect relates to a composition comprising DDA and TDB or MMG, retinoic acid or analogues thereof, and at least one autoimmune antigen for use in prevention or treatment of autoimmune diseases.

2. 发明申请

WO2021209562A1 LIPOSOMAL COMPOSITION FOR PREVENTING OR EARLY TREATMENT OF PATHOGENIC INFECTION 审中-公开
公开(公告)号：WO2021209562A1
公开(公告)日：2021-10-21
申请号：PCT/EP2021/059807
申请日：2021-04-15
申请人： STATENS SERUM INSTITUT
发明人： FOLLMANN, Frank , ANDERSEN, Peter , DIETRICH, Jes , CHRISTENSEN, Dennis
IPC分类号： A61K9/00 , A61P31/16 , A61P31/04 , A61P11/06 , A61P5/48 , A61K9/127 , A61K39/39
摘要： The present invention relates to a liposomal composition for use as a medicament. In particular, the present invention relates to a liposomal composition for use in prevention or early treatment of pathogenic infection. More specifically, the liposomal composition is used for prevention, or early treatment, of pathogenic infection in the respiratory tract, preferably by nasal or pulmonary administration.

3. 发明申请

WO2010121618A1 A TUBERCULOSIS TB VACCINE TO PREVENT REACTIVATION 审中-公开
标题翻译： TUBERCULOSIS TB疫苗防止反应
公开(公告)号：WO2010121618A1
公开(公告)日：2010-10-28
申请号：PCT/DK2010/000054
申请日：2010-04-23
申请人： STATENS SERUM INSTITUT , DIETRICH, Jes , ANDERSEN, Peter , LUNDBERG, Carina, Vingsbo , HOANG, Truc, Thi, Kim, Than
发明人： DIETRICH, Jes , ANDERSEN, Peter , LUNDBERG, Carina, Vingsbo , HOANG, Truc, Thi, Kim, Than
IPC分类号： A61K39/04 , A61P11/00 , C07K14/35 , C07K19/00
CPC分类号： C07K14/35 , A61K39/04 , A61K2039/545
摘要： The present invention discloses a vaccine or immunogenic composition that can be administred to latently infected individuals to prevent reactivation of latent tuberculosis infection caused by species of the tuberculosis complex microorganisms ( Mycobacterium tuberculosis., M.bovis, M.africanum ), The invention is base on a number of M. tuberculosis derived proteins and protein fragments which are constitutively expressed in different stages of the infection. The invention is directed to the use of these polypeptides, immunologically active fragments thereof and the genes encoding them for immunological compositions such as vaccines.
摘要翻译：本发明公开了一种疫苗或免疫原性组合物，其可被用于潜伏感染的个体以防止由结核分枝杆菌复合微生物（结核分枝杆菌，M.bovis，M.africanum）的种类引起的潜在结核感染的再活化，本发明是碱在许多结核分枝杆菌衍生的蛋白质和在感染的不同阶段组成型表达的蛋白质片段。本发明涉及这些多肽，其免疫活性片段和编码它们的免疫组合物如疫苗的基因的用途。

4. 发明申请

WO2008000261A2 EXPANDING THE T CELL REPERTOIRE TO INCLUDE SUBDOMINANT EPITOPES BY VACCINATION WITH ANTIGENS DELIVERED AS PROTEIN FRAGMENTS OR PEPTIDE COCKTAILS 审中-公开
标题翻译：通过用作为蛋白质片段或肽蛋白质递送的抗原进行疫苗扩增细胞代谢物来包含亚群体外周血单核细胞
公开(公告)号：WO2008000261A2
公开(公告)日：2008-01-03
申请号：PCT/DK2007/000312
申请日：2007-06-26
申请人： STATENS SERUM INSTITUT , AAGAARD, Claus , DIETRICH, Jes , ANDERSEN, Peter
发明人： AAGAARD, Claus , DIETRICH, Jes , ANDERSEN, Peter
IPC分类号： A61K39/00 , A61K39/02
CPC分类号： A61K39/00 , A61K39/04 , A61K2039/55511 , A61K2039/5555 , Y02A50/412
摘要： The present invention teaches a convenient way of inducing a broad recognition of dominant and subdominant responses to epitopes of any given antigen of importance for prophylaxis or treatment of a chronic disease by immunizing with pools of overlapping fragments (synthetic peptides e.g. 10-30 mers with 2-20 aa overlap) of the desired antigen in appropriate adjuvants. The T cell repertoire is primed to include not only the immunodominant epitope recognized when the intact molecule is used for immunization and induced by the chronic infection itself, but induce a much broader and balanced response to a number of the subdominant epitopes as well. The resulting T-cell response to subdominant epitopes is important for protection against chronic diseases that on their own induces a response focused only towards immunodominant epitopes. The major advantage of the present invention is that it requires no prior knowledge of the precise localisation and identity of the subdominant epitopes and their recognition in a human population, but expands the T-cell repertoire and thereby the total number of epitopes recognized by specific T cells primed by vaccination from a few immunodominant epitopes to multiple of epitopes of vaccine relevance. For chronic disease controlled by humoral immunity the T helper cell response primed by the peptide mix may conveniently be boosted by the full size protein for maximum induction of an antibody response as well.
摘要翻译：本发明教导了一种方便的方法，通过用重叠片段的集合（例如10-30个细胞与2个（例如10-30个细胞）免疫）来诱导对预防或治疗慢性疾病具有重要意义的任何给定抗原的表位的显性和亚显性反应的广泛认识 -20 aa重叠）所需抗原在适当的佐剂中。引导T细胞谱不仅包括当完整分子用于免疫并由慢性感染本身诱导时识别的免疫显性表位，而且还诱导对多个亚显性表位的更广泛和平衡的响应。所产生的对亚显性抗原决定簇的T细胞应答对于防止慢性疾病是重要的，所述慢性疾病本身诱导仅针对免疫显性表位的反应。本发明的主要优点在于，它不需要在人群中亚显性表位的精确定位和鉴定的先验知识，而且扩展了T细胞谱，从而扩展了特定T识别的表位总数通过从少数免疫显性表位接种到多种疫苗相关表位的疫苗引发的细胞。对于通过体液免疫控制的慢性疾病，通过肽混合物引发的T辅助细胞应答可以方便地由全尺寸蛋白质加强以最大限度地诱导抗体应答。

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