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1. 发明申请

WO2007067943A2 ASSESSMENT OF ELECTRODE COUPLING FOR TISSUE ABLATION 审中-公开
公开(公告)号：WO2007067943A2
公开(公告)日：2007-06-14
申请号：PCT/US2006/061716
申请日：2006-12-06
申请人： ST. JUDE MEDICAL, ATRIAL FIBRILLATION DIVISION, INC. , PAUL, Saurav , CAO, Hong , BEHLE, Kedar, Ravindra , THAO, Chou
发明人： PAUL, Saurav , CAO, Hong , BEHLE, Kedar, Ravindra , THAO, Chou
IPC分类号： A61B18/18
CPC分类号： A61B18/1206 , A61B18/1492 , A61B34/20 , A61B2018/00303 , A61B2018/00357 , A61B2018/00577 , A61B2018/00642 , A61B2018/00666 , A61B2018/00702 , A61B2018/0075 , A61B2018/00755 , A61B2018/00869 , A61B2018/00875 , A61B2090/064 , A61B2090/065
摘要： An electrode catheter and a method for assessing electrode-tissue contact and coupling are disclosed. An exemplary electrode catheter comprises an electrode adapted to apply electrical energy. A measurement circuit is adapted to measure impedance between the electrode and ground as the electrode approaches a target tissue. A processor determines a contact and coupling condition for the target tissue based at least in part on reactance of the impedance measured by the measurement circuit. In another exemplary embodiment, the electrode catheter determines the contact and coupling condition based at least in part on a phase angle of the impedance.

2. 发明申请

WO2008083123A1 DESIGN OF ABLATION ELECTRODE WITH TACTILE SENSOR 审中-公开
标题翻译：消除电极与触觉传感器的设计
公开(公告)号：WO2008083123A1
公开(公告)日：2008-07-10
申请号：PCT/US2007/088729
申请日：2007-12-21
申请人： ST. JUDE MEDICAL, ATRIAL FIBRILLATION DIVISION, INC. , CAO, Hong , THAO, Chou , PAUL, Saurav
发明人： CAO, Hong , THAO, Chou , PAUL, Saurav
IPC分类号： A61B5/04
CPC分类号： A61B18/1492 , A61B5/6852 , A61B5/6885 , A61B2090/065
摘要： A catheter assembly for assessing contact between the catheter assembly and tissue is disclosed. The assembly includes a catheter shaft and a pressure sensitive conductive composite member whose electrical resistance varies with pressure applied to the catheter assembly. The assembly also includes at least one measurement terminal to permit the measurement of changes in the electrical characteristics of the pressure sensitive conductive composite member. The assembly may optionally include a measurement device to measure resistance, impedance and/or other electrical characteristics. The assembly may utilize a reference electrode secured to the patient's tissue, which permits the measurement device to measure changes between the reference electrode and the at least one measurement terminal. Optionally, the assembly may include a conductive outer layer. Also disclosed are sensor assemblies, contact sensor, methods of contact sensing, and methods of manufacturing relating to the use of pressure sensitive conductive composites.
摘要翻译：公开了一种用于评估导管组件和组织之间的接触的导管组件。组件包括导管轴和压力敏感的导电复合构件，其电阻随着施加到导管组件的压力而变化。组件还包括至少一个测量端子，以允许测量压敏导电复合构件的电特性的变化。组件可以可选地包括测量电阻，阻抗和/或其他电特性的测量装置。组件可以利用固定到患者组织的参考电极，其允许测量装置测量参考电极和至少一个测量终端之间的变化。可选地，组件可以包括导电外层。还公开了传感器组件，接触传感器，接触感测方法以及与使用压敏导电复合材料有关的制造方法。

3. 发明申请

WO2007070361A2 ASSESSMENT OF ELECTRODE COUPLING FOR TISSUE ABLATION 审中-公开
标题翻译：电器联合电击组织评估
公开(公告)号：WO2007070361A2
公开(公告)日：2007-06-21
申请号：PCT/US2006/046816
申请日：2006-12-06
申请人： ST. JUDE MEDICAL, ATRIAL FIBRILLATION DIVISION, INC. , PAUL, Saurav , CAO, Hong , THAO, Chou
发明人： PAUL, Saurav , CAO, Hong , THAO, Chou
IPC分类号： A61N1/378
CPC分类号： A61N1/40 , A61B2018/00357 , A61B2018/00875
摘要： An electrode catheter and a method for assessing electrode-tissue contact and coupling are disclosed. An exemplary electrode catheter comprises an electrode adapted to apply electrical energy. A measurement circuit is adapted to measure impedance between the electrode and ground as the electrode approaches a target tissue. A processor determines a contact and coupling condition for the target tissue based at least in part on reactance of the impedance measured by the measurement circuit. In another exemplary embodiment, the electrode catheter determines the contact and coupling condition based at least in part on a phase angle of the impedance.
摘要翻译：公开了电极导管和用于评估电极组织接触和耦合的方法。示例性电极导管包括适于施加电能的电极。测量电路适于在电极接近目标组织时测量电极和地面之间的阻抗。处理器至少部分地基于由测量电路测量的阻抗的电抗来确定目标组织的接触和耦合条件。在另一示例性实施例中，电极导管至少部分地基于阻抗的相位角确定接触和耦合条件。

4. 发明申请

WO2009082635A1 FLEXIBLE CONDUCTIVE POLYMER ELECTRODE AND METHOD FOR ABLATION 审中-公开
标题翻译：柔性导电聚合物电极和方法
公开(公告)号：WO2009082635A1
公开(公告)日：2009-07-02
申请号：PCT/US2008/086582
申请日：2008-12-12
申请人： ST. JUDE MEDICAL, ATRIAL FIBRILLATION DIVISION, INC. , PAUL, Saurav , CAO, Hong , THAO, Chou
发明人： PAUL, Saurav , CAO, Hong , THAO, Chou
IPC分类号： A61B18/18
CPC分类号： A61B18/1492 , A61B2018/00005 , A61B2018/00023 , A61B2018/00029 , A61B2018/00077 , A61B2018/00136 , A61B2018/00148 , A61B2018/00797 , A61B2018/00815 , A61B2018/00821
摘要： An electrode for ablation therapy includes a flexible conductive element for conducting electrical energy and a flexible conductive polymer member in electrically conductive contact with the conductive element. A catheter shaft (91) may be coupled to the conductive element (221) and/or the flexible conductive polymer member (222). The flexible conductive element (221) may be formed as a helical coil, a mesh coating or wrap, or any other suitable form, and may surround (wholly or partially) a flexible electrically insulative, and optionally thermally conductive, member (223). A heat sink (225) may be thermally coupled to at least one of the flexible conductive polymer member (221) and the flexible electrically insulative member (223). The flexible electrically insulative member (223) may include a passageway for coolant fluid to cool the electrode during ablation. The passageway may include at least one efflux hole (226) to permit coolant fluid to flow from the passageway, or may define a closed loop.
摘要翻译：用于消融治疗的电极包括用于传导电能的柔性导电元件和与导电元件导电接触的柔性导电聚合物构件。导管轴（91）可以联接到导电元件（221）和/或柔性导电聚合物构件（222）。柔性导电元件（221）可以形成为螺旋线圈，网状涂层或包裹物，或任何其它合适的形式，并且可以包围（全部或部分地）柔性电绝缘且任选地导热的构件（223）。散热器（225）可以热耦合到柔性导电聚合物构件（221）和柔性电绝缘构件（223）中的至少一个。柔性电绝缘构件（223）可以包括用于在消融期间冷却电极的冷却剂流体的通道。通道可以包括至少一个流出孔（226），以允许冷却剂流体从通道流出，或者可以限定闭环。

5. 发明申请

WO2008063195A1 ASSESSMENT OF ELECTRODE COUPLING FOR TISSUE ABLATION 审中-公开
标题翻译：电器联合电击组织评估
公开(公告)号：WO2008063195A1
公开(公告)日：2008-05-29
申请号：PCT/US2006/061717
申请日：2006-12-07
申请人： ST. JUDE MEDICAL, ATRIAL FIBRILLATION DIVISION, INC. , PAUL, Saurav , CAO, Hong , THAO, Chou
发明人： PAUL, Saurav , CAO, Hong , THAO, Chou
IPC分类号： A61B18/18 , A61B5/04 , A61B5/103 , A61B5/117
CPC分类号： A61B18/1492 , A61B2018/00869 , A61B2018/00875 , A61B2090/065
摘要： An electrode catheter and a method for assessing electrode-tissue contact and coupling are disclosed. An exemplary electrode catheter comprises an electrode adapted to apply electrical energy. A measurement circuit is adapted to measure impedance between the electrode and ground as the electrode approaches a target tissue. A processor determines a contact and coupling condition for the target tissue based at least in part on reactance of the impedance measured by the measurement circuit. In another exemplary embodiment, the electrode catheter determines the contact and coupling condition based at least in part on a phase angle of the impedance.
摘要翻译：公开了电极导管和用于评估电极组织接触和耦合的方法。示例性电极导管包括适于施加电能的电极。测量电路适于在电极接近目标组织时测量电极和地面之间的阻抗。处理器至少部分地基于由测量电路测量的阻抗的电抗来确定目标组织的接触和耦合条件。在另一示例性实施例中，电极导管至少部分地基于阻抗的相位角确定接触和耦合条件。

6. 发明申请

WO2007050960A2 SYSTEMS AND METHODS FOR ELECTRODE CONTACT ASSESSMENT 审中-公开
标题翻译：电极接触评估系统与方法
公开(公告)号：WO2007050960A2
公开(公告)日：2007-05-03
申请号：PCT/US2006/042119
申请日：2006-10-27
申请人： ST. JUDE MEDICAL, ATRIAL FIBRILLATION DIVISION, INC. , PAUL, Saurav , TEGG, Troy , THAO, Chou , CAO, Hong , PURYEAR, Harry , KUEHN, Fos , HEIMBECHER, Reed R.
发明人： PAUL, Saurav , TEGG, Troy , THAO, Chou , CAO, Hong , PURYEAR, Harry , KUEHN, Fos , HEIMBECHER, Reed R.
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B5/6852 , A61B5/6885 , A61B2090/065
摘要： Systems and methods are disclosed for assessing electrode-tissue contact for tissue ablation. An exemplary electrode contact sensing system comprises an electrode 10 housed within a distal portion of a catheter shaft 14. At least one electro-mechanical sensor 20 is operatively associated with the electrode 10 within the catheter shaft 14. The at least one electro-mechanical sensor 20 is responsive to movement of the electrode 10 by generating electrical signals corresponding to the amount of movement. The system may also include an output device electrically connected to the at least one electro-mechanical sensor 20. The output device receives the electrical signals for assessing a level of contact between the electrode 10 and a tissue 12.
摘要翻译：公开了用于评估用于组织消融的电极组织接触的系统和方法。示例性的电极接触感测系统包括容纳在导管轴14的远端部分内的电极10.至少一个电 - 机械传感器20与导管轴14内的电极10可操作地相关联。至少一个电 - 机械传感器 20通过产生对应于移动量的电信号来响应于电极10的运动。该系统还可以包括电连接到至少一个机电传感器20的输出装置。输出装置接收用于评估电极10和组织12之间的接触程度的电信号。

7. 发明申请

WO2007002004A3 ABLATION CATHETER WITH FLUID DISTRIBUTION STRUCTURES 审中-公开
公开(公告)号：WO2007002004A3
公开(公告)日：2007-01-04
申请号：PCT/US2006/023854
申请日：2006-06-19
申请人： ST. JUDE MEDICAL, ATRIAL FIBRILLATION DIVISION, INC. , CAO, Hong , THAO, Chou , BELHE, Kedar, Ravindra , PAUL, Saurav , STANGENES, Todd
发明人： CAO, Hong , THAO, Chou , BELHE, Kedar, Ravindra , PAUL, Saurav , STANGENES, Todd
IPC分类号： A61B18/04 , A61F7/00
摘要： An ablation catheter (22) has improved fluid distribution structures. An ablation section at a distal end (12) of the catheter (22) is designed to provide a more uniform fluid flow emanating from the catheter (22). By creating a uniform fluid flow, a more uniform tissue lesion results and the possibility of charring the tissue is reduced. A combination of mesh material (142) layers, porous materials (354), and dispersion channels or openings (346) are used to achieve the uniform flow. The amount of fluid used as a virtual electrode to ablate the tissue is greatly reduced with the present invention. Further, the catheter (22) may be used to create a single, uniform linear lesion by successive application of energy to adjacent portions of the ablation section, thus reducing the power required to create the desired lesion.

8. 发明申请

WO2008083122A2 PRESSURE-SENSITIVE CONDUCTIVE COMPOSITE ELECTRODE AND METHOD FOR ABLATION 审中-公开
标题翻译：压力敏感导电复合电极及其消除方法
公开(公告)号：WO2008083122A2
公开(公告)日：2008-07-10
申请号：PCT/US2007/088723
申请日：2007-12-21
申请人： ST. JUDE MEDICAL, ATRIAL FIBRILLATION DIVISION, INC. , PAUL, Saurav , BELHE, Kedar Ravindra , THAO, Chou , CAO, Hong
发明人： PAUL, Saurav , BELHE, Kedar Ravindra , THAO, Chou , CAO, Hong
IPC分类号： A61N7/00
CPC分类号： A61B18/1492 , A61B2018/00029 , A61B2018/00791 , A61B2018/1437 , A61B2090/064 , A61B2090/065 , A61B2218/002
摘要： The present invention is directed to ablation devices and methods utilizing pressure sensitive conductive composites, such as quantum tunneling composites, or other contact-sensitive, conductive polymers. The materials provide for electrodes and methods capable of differentiating between a soft and a hard push. The present invention thus provides an electrode for delivering selective electrical energy for ablation that may be varied based upon the pressure exerted on the surface area of the targeted tissue.
摘要翻译：本发明涉及使用压敏导电复合材料如量子隧道复合材料或其它接触敏感的导电聚合物的消融装置和方法。这些材料提供了能够区分软推和硬推的电极和方法。因此，本发明提供了一种用于输送用于消融的选择性电能的电极，其可以基于施加在目标组织的表面积上的压力而变化。

9. 发明申请

WO2008083108A2 FABRIC ELECTRODE HEAD 审中-公开
标题翻译：织物电极头
公开(公告)号：WO2008083108A2
公开(公告)日：2008-07-10
申请号：PCT/US2007/088668
申请日：2007-12-21
申请人： ST. JUDE MEDICAL, ATRIAL FIBRILLATION DIVISION, INC. , BELHE, Kedar Ravindra , PAUL, Saurav , THAO, Chou , CAO, Hong
发明人： PAUL, Saurav , THAO, Chou , CAO, Hong
IPC分类号： A61N1/05
CPC分类号： A61B18/14 , A61B18/16 , A61B2018/00577 , A61N1/0464 , A61N1/05
摘要： An electrode head (272) is disclosed that utilizes electrically conductive or dissipative fabric (278) to exchange electrical energy with tissue. This electrode head may be used for any appropriate application, such as a catheter electrode, a return electrode, or the like. Any appropriate function may be provided by this electrode head, such as tissue ablation, tissue mapping, or providing an electrical ground.
摘要翻译：公开了一种利用导电或耗散织物（278）与组织交换电能的电极头（272）。该电极头可以用于任何适当的应用，例如导管电极，返回电极等。该电极头可以提供任何适当的功能，例如组织消融，组织标测或提供电接地。

10. 发明申请

WO2008045956A2 TISSUE CONTACT AND THERMAL ASSESSMENT FOR BRUSH ELECTRODES 审中-公开
标题翻译：用于布丝电极的组织接触和热评估
公开(公告)号：WO2008045956A2
公开(公告)日：2008-04-17
申请号：PCT/US2007/080981
申请日：2007-10-10
申请人： ST. JUDE MEDICAL, ATRIAL FIBRILLATION DIVISION, INC. , THAO, Chou , CAO, Hong , PAUL, Saurav
发明人： THAO, Chou , CAO, Hong , PAUL, Saurav
IPC分类号： A61B18/18
CPC分类号： A61B18/14 , A61B18/1492 , A61B2018/00351 , A61B2018/143 , A61B2090/065
摘要： Systems and methods are disclosed for tissue contact and thermal assessment, e.g., for tissue ablation procedures. An exemplary brush electrode (10) comprises a plurality of flexible filaments (12) adapted to transfer electrical energy to a tissue. At least one piezoelectric sensor (20) is embedded among the plurality of flexible filaments (12). The at least one piezoelectric sensor (20) is responsive to contact stress of the flexible filaments (12) by generating electrical signals corresponding to the amount of contact stress. An output device is electrically connected to the at least one piezoelectric sensor (20). The output device receives the electrical signals for assessing tissue contact by the flexible filaments (12). The brush electrode (10) may further comprise a sensing device (251) mounted adjacent the at least one piezoelectric sensor (20), wherein the sensing device (251) is a pressure sensor, a thermistor, a thermocouple, or an ultrasound sensor.
摘要翻译：公开了用于组织接触和热评估的系统和方法，例如用于组织消融程序。示例性的刷电极（10）包括适于将电能传递到组织的多个柔性细丝（12）。至少一个压电传感器（20）嵌入在多个柔性细丝（12）中。至少一个压电传感器（20）通过产生对应于接触应力的量的电信号来响应柔性细丝（12）的接触应力。输出装置电连接到至少一个压电传感器（20）。输出装置接收用于评估柔性细丝（12）的组织接触的电信号。刷电极（10）还可以包括邻近至少一个压电传感器（20）安装的感测装置（251），其中感测装置（251）是压力传感器，热敏电阻，热电偶或超声传感器。

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