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1. 发明申请

WO2008060347A1 SIMULTANEOUS ASPIRATOR AND DISPENSER FOR MULTIWELL PLATES AND SIMILAR DEVICES 审中-公开
标题翻译：同时用于多层板和类似设备的辅助器和分配器
公开(公告)号：WO2008060347A1
公开(公告)日：2008-05-22
申请号：PCT/US2007/019566
申请日：2007-09-07
申请人： SRU BIOSYSTEMS, INC. , LAING, Lance, G. , SMITH, Timothy, F. , GERSTENMAIER, John , JOGIKALMATH, Gangadhar
发明人： LAING, Lance, G. , SMITH, Timothy, F. , GERSTENMAIER, John , JOGIKALMATH, Gangadhar
IPC分类号： G01N35/00
CPC分类号： G01N35/1074 , G01N35/1011
摘要： A device for simultaneously dispensing a solution containing a sample to a test device and aspirating the sample from the device. In one embodiment the device is hand-held and includes a control mechanism, e.g., button for activating the dispensing and aspiration of the sample. The testing device may take the form of a multi-well plate with a plurality of wells arranged in rows and columns, with the bottom of the wells formed as a photonic crystal biosensor.. The device can be configured with dispense and aspirate manifolds and associated dispense and aspirate ports which are positioned in all the wells along a row or column of wells so as to simultaneously aspirate and dispense solution to all the wells in a row or column of the multi-well plate.
摘要翻译：一种用于将含有样品的溶液同时分配到测试装置并从该装置抽吸样品的装置。在一个实施例中，该装置是手持式的并且包括控制机构，例如用于激活样品的分配和抽吸的按钮。测试装置可以采用具有排列成行和列的多个孔的多孔板的形式，阱的底部形成为光子晶体生物传感器。该装置可以配置有分配和抽吸歧管并且相关联分配和抽吸位于沿着一列或多列井的所有井中的端口，以便同时吸取并分配溶液到多孔板的一列或多列中的所有孔。

2. 发明申请

WO2007019024A3 GRATING-BASED SENSOR COMBINING LABEL-FREE BINDING DETECTION AND FLUORESCENCE AMPLIFICATION AND READOUT SYSTEM FOR SENSOR 审中-公开
公开(公告)号：WO2007019024A3
公开(公告)日：2007-02-15
申请号：PCT/US2006/028473
申请日：2006-07-20
申请人： SRU BIOSYSTEMS, INC. , SCHULZ, Stephen, C. , CUNNINGHAM, Brian, T. , LAING, Lance, G. , LI, Peter, Y. , BINDER, Brant , JOGIKALMATH, Gangadhar , BORSODY, Alex
发明人： SCHULZ, Stephen, C. , CUNNINGHAM, Brian, T. , LAING, Lance, G. , LI, Peter, Y. , BINDER, Brant , JOGIKALMATH, Gangadhar , BORSODY, Alex
IPC分类号： G01N21/55 , G01N21/64
摘要： A grating-based sensor is disclosed that has a grating structure constructed and designed for both evanescent resonance (ER) fluorescence detection and label-free detection applications. Some embodiments are disclosed which are optimized for ER detection in an air mode, in which the sample is dry. Other embodiments are optimized for ER detection in liquid mode, in which the sample is suspended in liquid medium such as water. One and two-dimensional gratings are also disclosed, including gratings characterized by unit cells with central posts, central holes, and two-level, two-dimensional gratings. A readout system for such sensors is also disclosed. One embodiment includes a first light source optimized for collecting label -free detection data, a second light source optimized for collecting ER fluorescence amplification data, and at least one detector. In one embodiment, the detector is an imaging system and includes a CCD camera for collecting both ER and label-free data. In other embodiments, the at least one detector takes the form of a spectrometer for collection of label-free data and a photomultiplier for collecting ER data. In other embodiments, a single light source such as a tunable laser or broad band light source is used.

3. 发明申请

WO2008156560A1 GRATING-BASED SENSOR COMBINING LABEL-FREE BINDING DETECTION AND FLUORESCENCE AMPLIFICATION AND READOUT SYSTEM FOR SENSOR 审中-公开
标题翻译：基于GRATING的传感器组合无标签绑定检测和荧光放大和读取传感器系统
公开(公告)号：WO2008156560A1
公开(公告)日：2008-12-24
申请号：PCT/US2008/007031
申请日：2008-06-03
申请人： SRU BIOSYSTEMS, INC. , CUNNINGHAM, Brian, T. , LI, Peter, Y. , LAING, Lance, G. , JOGIKALMATH, Gangadhar , BINDER, Brant
发明人： CUNNINGHAM, Brian, T. , LI, Peter, Y. , LAING, Lance, G. , JOGIKALMATH, Gangadhar , BINDER, Brant
IPC分类号： G01N21/47 , G01N21/55 , G01N21/64
CPC分类号： G01N21/6452 , G01N21/648 , G01N21/76 , G01N21/7743 , G01N33/54373 , G01N33/6872 , Y10S436/805
摘要： A grating-based sensor is disclosed that has a grating structure constructed and designed for both evanescent resonance (ER) fluorescence detection and label-free detection applications. One and two-dimensional gratings are also disclosed, including gratings characterized by unit cells with central posts, central holes, and two-level, two-dimensional gratings. A readout system for such sensors is also disclosed. Various applications for the biosensors are described, including cell-based assays for assessing the effect of drug compounds, proteins, peptides and other materials on cell function. A biosensor embodiment optimized for a luminescent response at two different wavelengths is also described. Such luminescent response could be produced by fluorescence (either native or from an attached fluorophore), phosphorescence, chemi-luminescence, or other luminescence technology. Two different luminescence technologies could be combined on the same biosensor chip.
摘要翻译：公开了一种光栅传感器，其具有构造和设计用于ev逝共振（ER）荧光检测和无标签检测应用的光栅结构。还公开了一维和二维光栅，包括以具有中心柱，中心孔和两层二维光栅的单元电池为特征的光栅。还公开了一种用于这种传感器的读出系统。描述了用于生物传感器的各种应用，包括用于评估药物化合物，蛋白质，肽和其他材料对细胞功能的影响的基于细胞的测定。还描述了针对两个不同波长的发光响应进行了优化的生物传感器实施例。这种发光反应可以通过荧光（天然的或来自附着的荧光团），磷光，化学发光或其他发光技术产生。两种不同的发光技术可以组合在相同的生物传感器芯片上。

4. 发明申请

WO2009009718A1 METHODS OF IDENTIFYING MODULATORS OF ION CHANNELS 审中-公开
标题翻译：识别离子通道调节剂的方法
公开(公告)号：WO2009009718A1
公开(公告)日：2009-01-15
申请号：PCT/US2008/069752
申请日：2008-07-11
申请人： SRU BIOSYSTEMS, INC. , BINDER, Brant , LAING, Lance, G.
发明人： BINDER, Brant , LAING, Lance, G.
IPC分类号： G01N33/53
CPC分类号： G01N33/6872 , G01N33/54373
摘要： The invention provides methods for identifying modulators of ion channels without the use of recombinant cell lines over-expressing the ion channel proteins or the use of detection labels.
摘要翻译：本发明提供用于鉴定离子通道调节剂的方法，而不使用过表达离子通道蛋白的重组细胞系或检测标记的使用。

5. 发明申请

WO2009149285A1 DETECTION OF PROMISCUOUS SMALL SUBMICROMETER AGGREGATES 审中-公开
标题翻译：检测致病小细胞集落体
公开(公告)号：WO2009149285A1
公开(公告)日：2009-12-10
申请号：PCT/US2009/046298
申请日：2009-06-04
申请人： SRU BIOSYSTEMS, INC. , LAING, Lance, G.
发明人： LAING, Lance, G.
IPC分类号： G03C5/02 , G01N21/00
CPC分类号： G01N21/78 , G01N21/253 , G01N21/7743 , G01N33/54373 , G01N2021/7773 , G01N2021/7776
摘要： The invention provides methods for the detection of aggregating molecules that are capable of promiscuous or non-specific binding to proteins in a time efficient manner without the use of labels.
摘要翻译：本发明提供了用于检测能够以时间有效的方式混合或非特异性结合蛋白质的聚集分子的方法，而不使用标记。

6. 发明申请

WO2010132890A1 DETECTION OF CHANGES IN CELL POPULATIONS AND MIXED CELL POPULATIONS 审中-公开
标题翻译：检测细胞群体和混合细胞群体的变化
公开(公告)号：WO2010132890A1
公开(公告)日：2010-11-18
申请号：PCT/US2010/035152
申请日：2010-05-17
申请人： SRU BIOSYSTEMS, INC , SHAMAH, Steven , LAING, Lance, G. , YUZHAKOV, Alexander , WAGNER, Rick , ABODEELY, Marla , ROCKNEY, Bennet , SCHULZ, Stephen, C. , PADALIA, Zinkal , GETMAN, Michael , SANDBERG, Eric
发明人： SHAMAH, Steven , LAING, Lance, G. , YUZHAKOV, Alexander , WAGNER, Rick , ABODEELY, Marla , ROCKNEY, Bennet , SCHULZ, Stephen, C. , PADALIA, Zinkal , GETMAN, Michael , SANDBERG, Eric
IPC分类号： G01N33/543 , G01N33/566 , G01N33/50
CPC分类号： G01N33/54373 , G01N21/7743 , G01N33/5044 , G01N33/5064 , G01N33/5073
摘要： The invention provides methods of label-free detection of changes in cell populations and mixed cell populations.
摘要翻译：本发明提供了无标记检测细胞群体和混合细胞群体变化的方法。

7. 发明申请

WO2003062786A2 BIOSENSOR FOR SMALL MOLECULE ANALYTES 审中-公开
标题翻译：生物传感器用于小分子分析
公开(公告)号：WO2003062786A2
公开(公告)日：2003-07-31
申请号：PCT/US2002/026105
申请日：2002-08-15
申请人： REGENESIS , LAING, Lance, G.
发明人： LAING, Lance, G.
IPC分类号： G01N
CPC分类号： C12Q1/6825 , C12Q2565/628 , C12Q2565/525 , C12Q2522/101
摘要： A biosensor device for detecting small molecules analytes is provided. The device employs a first class of molecules, e.g., protein that binds to both the analyte and a second class of molecules, e.g., nucleic acid. The binding of the protein to the analyte and nucleic acid can be mutually exclusive, and the presence of analyte in a sample results in a detectable displacement of protein from nucleic acid. Alternatively, binding of the protein to the nucleic acid can depend on the presence of analyte in the sample. In a specific embodiment, either the protein or nucleic acid is immobilized on a solid phase support. An arsenic detection system is exemplified. An ArsR binding sequence from the E. coli ars operon is immobilized on a gold-plated surface. ArsR protein binds to the DNA in the absence of arsenic, and is released in the presence of sodium arsenate or phenylarsine oxide. Protein release results in a change in surface plasmon resonance, and the magnitude or kinetics of the change indicate the concentration of arsenic.
摘要翻译：提供了用于检测小分子分析物的生物传感器装置。该装置采用第一类分子，例如结合分析物和第二类分子（例如核酸）的蛋白质。蛋白质与分析物和核酸的结合可以相互排斥，并且样品中分析物的存在导致蛋白质从核酸的可检测位移。或者，蛋白质与核酸的结合可以取决于样品中分析物的存在。在一个具体实施方案中，将蛋白质或核酸固定在固相载体上。示例了砷检测系统。来自大肠杆菌ars操纵子的ArsR结合序列被固定在镀金表面上。 ArsR蛋白在不存在砷的情况下与DNA结合，并在砷酸钠或氧化胂的存在下释放。蛋白质释放导致表面等离子体共振的变化，并且变化的大小或动力学指示砷的浓度。

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