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1. 发明申请

WO2007008657A3 HEPATITIS C VIRUS INHIBITORS 审中-公开
标题翻译：丙型肝炎病毒抑制剂
公开(公告)号：WO2007008657A3
公开(公告)日：2007-05-31
申请号：PCT/US2006026513
申请日：2006-07-10
申请人： SQUIBB BRISTOL MYERS CO , HEWAWASAM PIYASENA , DING MIN , SUN LI-QIANG , SCOLA PAUL MICHAEL
发明人： HEWAWASAM PIYASENA , DING MIN , SUN LI-QIANG , SCOLA PAUL MICHAEL
IPC分类号： C07K5/08 , A61K38/06 , C07D207/14 , C07D207/16
CPC分类号： C07K5/0808 , A61K38/00
摘要： The present disclosure relates to tripeptide compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.
摘要翻译：本公开涉及用于治疗丙型肝炎病毒（HCV）感染的三肽化合物，组合物和方法。还公开了含有这些化合物的药物组合物以及使用这些化合物治疗HCV感染的方法。

2. 发明申请

WO2007140200A3 CYCLOPROPYL FUSED INDOLOBENZAZEPINE HCV NS5B INHIBITORS 审中-公开
标题翻译： CYCLOPROPYL融合吲哚苯并吖庚因HCV NS5B抑制剂
公开(公告)号：WO2007140200A3
公开(公告)日：2008-02-14
申请号：PCT/US2007069526
申请日：2007-05-23
申请人： SQUIBB BRISTOL MYERS CO , GENTLES ROBERT G , DING MIN , HEWAWASAM PIYASENA
发明人： GENTLES ROBERT G , DING MIN , HEWAWASAM PIYASENA
IPC分类号： C07D487/04 , A61K31/55 , A61P31/12
CPC分类号： C07D487/04
摘要： The invention encompasses compounds of formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.
摘要翻译：本发明包括式I的化合物以及使用该化合物的组合物和方法。这些化合物对丙型肝炎病毒（HCV）具有活性，可用于治疗HCV感染者。

3. 发明申请

WO2010030538A3 COMPOUNDS FOR THE TREATMENT OF HEPATITIS C 审中-公开
标题翻译：治疗丙型肝炎的化合物
公开(公告)号：WO2010030538A3
公开(公告)日：2010-05-06
申请号：PCT/US2009055648
申请日：2009-09-02
申请人： SQUIBB BRISTOL MYERS CO , PRACITTO RICHARD , KADOW JOHN F , BENDER JOHN A , BENO BRETT R , GRANT-YOUNG KATHARINE A , HAN YING , HEWAWASAM PIYASENA , NICKEL ANDREW , PARCELLA KYLE E , YEUNG KAP-SUN , CHUPAK LOUIS S
发明人： PRACITTO RICHARD , KADOW JOHN F , BENDER JOHN A , BENO BRETT R , GRANT-YOUNG KATHARINE A , HAN YING , HEWAWASAM PIYASENA , NICKEL ANDREW , PARCELLA KYLE E , YEUNG KAP-SUN , CHUPAK LOUIS S
IPC分类号： C07D209/42 , A61K31/381 , A61K31/4741 , A61K31/4745 , A61P31/14 , C07D333/68 , C07D471/04 , C07D491/048
CPC分类号： C07D471/04 , C07D209/42 , C07D333/68 , C07D491/048
摘要： The disclosure provides compounds of formula I, II, III, IV, and V, including their salts, as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV.
摘要翻译：本公开提供了式I，II，III，IV和V化合物，包括它们的盐，以及使用这些化合物的组合物和方法。该化合物对丙型肝炎病毒（HCV）具有活性，并可用于治疗感染HCV的患者。

4. 发明申请

WO2015160641A3 COMPOUNDS USEFUL AS IMMUNOMODULATORS 审中-公开
标题翻译：化合物作为免疫调节剂有用
公开(公告)号：WO2015160641A3
公开(公告)日：2015-12-23
申请号：PCT/US2015025249
申请日：2015-04-10
申请人： SQUIBB BRISTOL MYERS CO
发明人： CHUPAK LOUIS S , DING MIN , MARTIN SCOTT W , ZHENG XIAOFAN , HEWAWASAM PIYASENA , CONNOLLY TIMOTHY P , XU NINGNING , YEUNG KAP-SUN , ZHU JULIANG , LANGLEY DAVID R , TENNEY DANIEL J , SCOLA PAUL MICHAEL
IPC分类号： C07C255/54 , C07D207/26 , C07D207/335 , C07D213/30 , C07D215/14 , C07D215/18 , C07D231/56 , C07D239/26 , C07D261/08 , C07D271/06 , C07D405/04
CPC分类号： C07D319/18 , A61K31/165 , A61K31/277 , A61K31/357 , A61K31/40 , A61K31/4015 , A61K31/416 , A61K31/4178 , A61K31/4245 , A61K31/427 , A61K31/4433 , A61K31/453 , A61K31/4545 , A61K31/47 , A61K31/472 , A61K31/496 , A61K31/505 , A61K31/5377 , A61K31/541 , A61K45/06 , C07C233/36 , C07C235/42 , C07C255/13 , C07C255/54 , C07C271/28 , C07C317/22 , C07D207/26 , C07D207/335 , C07D213/30 , C07D215/14 , C07D215/18 , C07D217/16 , C07D231/56 , C07D239/26 , C07D261/08 , C07D271/06 , C07D405/04 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , A61K2300/00
摘要： The present disclosure generally relates to inhibitors of the PD-l/PD- Ll protein/protein and CD80/PD-L1 protein/protein interactions useful as immunomodulators. Provided herein are compounds, compositions comprising such compounds, and methods of their use. The disclosure further pertains to pharmaceutical compositions comprising at least one compound according to the disclosure that are useful for the treatment of various diseases, including cancer and infectious diseases.
摘要翻译：本公开内容通常涉及用作免疫调节剂的PD-1 / PD-L1蛋白/蛋白质和CD80 / PD-L1蛋白/蛋白相互作用的抑制剂。本文提供的化合物，包含这些化合物的组合物及其使用方法。本公开还涉及包含至少一种根据本公开的化合物的药物组合物，其可用于治疗各种疾病，包括癌症和感染性疾病。

5. 发明申请

WO02066426A3 FLUORO OXINDOLE DERIVATIVES AS MODULATORS OF KCNQ POTASSIUM CHANNELS 审中-公开
标题翻译：氟尿嘧啶衍生物作为KCNQ钾通道调节剂
公开(公告)号：WO02066426A3
公开(公告)日：2002-11-21
申请号：PCT/US0204304
申请日：2002-02-14
申请人： SQUIBB BRISTOL MYERS CO
发明人： HEWAWASAM PIYASENA , DEXTRAZE PIERRE , GRIBKOFF VALENTIN K , KINNEY GENE G , DWORETZKY STEVEN I
IPC分类号： A61K31/404 , A61P25/06 , A61P43/00 , C07D209/34
CPC分类号： C07D209/34
摘要： There is provided novel 3-fluoro-3-phenyl oxindole derivatives of Formula I wherein R , R , R and R each are independently hydrogen, C1-4 alkyl, halogen, fluoromethyl, trifluoromethyl, phenyl, 4-methylphenyl or 4-trifluoromethylphenyl; R is C1-6 alkyl optionally substituted with one to three same or different groups selected from fluoro and chloro, provided R is not C1-6 alkyl when Y is O; Y is O or S; and R and R each are independently hydrogen, chloro, bromo or trifluoromethy; which are openers of the KCNQ potassium channels and are useful in the treatment of disorders which are responsive to the opening of the KCNQ potassium channels.
摘要翻译：提供了式I的新的3-氟-3-苯基羟吲哚衍生物，其中R 1，R 2，R 3和R 4各自独立地为氢，C 1-4烷基，卤素，氟甲基，三氟甲基，苯基，4-甲基苯基或4-三氟甲基苯基; R 5为任选被1-3个选自氟和氯的相同或不同基团取代的C 1-6烷基，条件是当Y为O时R 5不是C 1-6烷基; Y是O或S; 并且R 6和R 7各自独立地为氢，氯，溴或三氟甲基; 它们是KCNQ钾通道的开放剂，并且可用于治疗对KCNQ钾通道开放有反应的病症。

6. 发明申请

WO02072088A2 MODULATORS OF KCNQ POTASSIUM CHANNELS AND USE THEREOF IN TREATING MIGRAINE AND MECHANISTICALLY RELATED DISEASES 审中-公开
标题翻译： KCNQ钾通道的调节剂及其在治疗机体和机械相关疾病中的应用
公开(公告)号：WO02072088A2
公开(公告)日：2002-09-19
申请号：PCT/US0204374
申请日：2002-02-14
申请人： SQUIBB BRISTOL MYERS CO
发明人： DWORETZKY STEVEN , GRIBKOFF VALENTIN K , KINNEY GENE G , HEWAWASAM PIYASENA
IPC分类号： G01N33/50 , A61K31/404 , A61K31/506 , A61K45/00 , A61P25/06 , G01N33/15 , C07D209/34 , C07D239/42
CPC分类号： A61K31/404 , A61K31/506
摘要： Compounds which function as modulators, particularly, openers, of human KCNQ potassium channel proteins or polypeptides, particularly, central nervous system(CNS)-located KCNQ potassium channels, and heteromultimers thereof, and their use in the treatment of migraine are provided by the present invention. One novel type of potassium channel polypeptide openers provided by the present invention is the fluorooxindole compounds, described for the first time as therapeutics for the treatment of migraine by preventing the asynchronous firing of neurons. Other KCNQ potassium channel opener compounds that are also useful in the treatments of the invention include 2,4-disubstituted pyrimidine-5-carboxamide derivatives. One or more of the compounds according to the present invention may be utilized alone, in combination, or in conjunction with other treatment modalities for reducing, ameliorating and/or alleviating migraine or diseases similar to, or mechanistically related to, migraine, e.g., cluster headache.
摘要翻译：作为人KCNQ钾通道蛋白或多肽，特别是中枢神经系统（CNS）分配的KCNQ钾通道及其异源多肽的调节剂，特别是开放剂的化合物及其在治疗偏头痛中的用途由本发明提供发明。本发明提供的一种新型的钾通道多肽开放剂是氟氧吲哚化合物，首次作为通过防止神经元的异步烧制来治疗偏头痛的治疗剂。也可用于本发明处理的其它KCNQ钾通道开放剂化合物包括2,4-二取代的嘧啶-5-甲酰胺衍生物。根据本发明的一种或多种化合物可以单独使用，或与其它治疗方式联用，用于减少，改善和/或减轻与偏头痛相似或机械相关的偏头痛或类似疾病，例如，集群头痛。

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