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1. 发明申请

WO2012137225A1 SUBSTITUTED METHYLFORMYL REAGENTS AND METHOD OF USING SAME TO MODIFY PHYSICOCHEMICAL AND/OR PHARMACOKINETIC PROPERTIES OF COMPOUNDS 审中-公开
标题翻译：取代的甲基试剂及其使用方法来改变化合物的化学和/或药物动力学性质
公开(公告)号：WO2012137225A1
公开(公告)日：2012-10-11
申请号：PCT/IN2012/000248
申请日：2012-04-09
申请人： SPHAERA PHARMA PVT. LTD , DUGAR, Sundeep , MAHAJAN, Dinesh , HOLLINGER PETER, Frank
发明人： DUGAR, Sundeep , MAHAJAN, Dinesh , HOLLINGER PETER, Frank
IPC分类号： A01N35/00 , A01N35/02 , A61K31/11
CPC分类号： C07D495/14 , C07D213/80 , C07D213/803 , C07D213/81 , C07D213/82 , C07D295/20 , C07D305/14 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D471/04 , C07D487/04 , C07D487/22 , C07D491/147 , C07D491/22
摘要： The present invention relates to the synthesis and application of novel chiral/ achiral substituted methyl formyl reagents to modify pharmaceutical agents and/or biologically active substances to modify the physicochemical, biological and/or pharmacokinetic properties of the resulting compounds from the unmodified original agent.
摘要翻译：本发明涉及新型手性/非手性取代的甲酰甲基试剂的合成和应用，以修饰药物和/或生物活性物质，以改变未经修饰的原始药剂所得化合物的物理化学，生物学和/或药代动力学性质。

2. 发明申请

WO2012101652A2 A NOVEL PROCESS FOR SYNTHESIS OF POLYPHENOLS 审中-公开
标题翻译：一种合成聚苯乙烯的新方法
公开(公告)号：WO2012101652A2
公开(公告)日：2012-08-02
申请号：PCT/IN2012/000052
申请日：2012-01-24
申请人： SPHAERA PHARMA PVT. LTD , DUGAR, Sundeep , MAHAJAN, Dinesh , GIANNOUSIS, Pantelis, Peter , SINGH, Vijay , KAPOOR, Kamal Kishore
发明人： DUGAR, Sundeep , MAHAJAN, Dinesh , GIANNOUSIS, Pantelis, Peter , SINGH, Vijay , KAPOOR, Kamal Kishore
IPC分类号： C07D311/30
CPC分类号： C07D311/74 , C07D311/30
摘要： The present invention provides synthetic processes for preparing racemic and/or optically pure epicatechin, epigallocatechin and related polyphenols as such or as their variously functionalized derivatives.
摘要翻译：本发明提供用于制备外消旋和/或光学纯的表儿茶素，表没食子儿茶素和相关多酚本身或其各种官能化衍生物的合成方法。

3. 发明申请

WO2012101654A2 NOVEL TRIAZINE COMPOUNDS 审中-公开
标题翻译：新颖的化合物
公开(公告)号：WO2012101654A2
公开(公告)日：2012-08-02
申请号：PCT/IN2012/000055
申请日：2012-01-25
申请人： SPHAERA PHARMA PVT. LTD , DUGAR, Sundeep , MAHAJAN, Dinesh , DEOKAR, Rhushikesh, Chandraban , HOLLINGER, Frank, Peter , KAPOOR, Kamal, Kishore
发明人： DUGAR, Sundeep , MAHAJAN, Dinesh , DEOKAR, Rhushikesh, Chandraban , HOLLINGER, Frank, Peter , KAPOOR, Kamal, Kishore
IPC分类号： C07D413/02
CPC分类号： C07D413/14 , C07D401/14 , C07D403/14 , C07D413/04 , C07D417/14 , C07D471/04 , C07D491/107 , C07D498/08
摘要： The present invention relates to novel triazine compounds of formula (1), methods of their preparation, pharmaceutical compositions containing these compounds and the use of these compounds to treat proliferative disorders such as tumors and cancers and also other conditions and disorders related to or associated with dysregulation of PI3 Kinases, PI3 Kinase pathway, mTOR and/ or the mTOR pathway.
摘要翻译：本发明涉及式（1）的新型三嗪化合物，其制备方法，含有这些化合物的药物组合物以及这些化合物用于治疗增殖性疾病如肿瘤和癌症的用途，以及与其相关或与之相关的其他病症和障碍 PI3激酶，PI3激酶途径，mTOR和/或mTOR途径的调节异常。

4. 发明申请

WO2013022846A2 FLAVONOID COMPOUNDS 审中-公开
标题翻译： FLAVONOID化合物
公开(公告)号：WO2013022846A2
公开(公告)日：2013-02-14
申请号：PCT/US2012/049767
申请日：2012-08-06
申请人： CARDERO THERAPEUTICS, INC. , BECKER, Cyrus, K. , SCHREINER, George, F. , DUGAR, Sundeep , MAHAJAN, Dinesh
发明人： BECKER, Cyrus, K. , SCHREINER, George, F. , DUGAR, Sundeep , MAHAJAN, Dinesh
CPC分类号： C07D311/62 , A61K31/353 , A61K31/496 , C07D405/10
摘要： The present invention relates to compounds, compositions, and methods for treatment of conditions related to mitochondrial function. In various aspects, the present invention comprises administering one or more epicatechin derivatives in an amount effective to stimulate mitochondrial function in cells. The compounds, compositions, and methods described herein provide for reducing infarct size in the heart following permanent ischemia or ischemia/reperfusion event or method for delaying, attenuating or preventing adverse cardiac remodeling, and can assist in prevention of impaired mitochondria biogenesis and thus prevention of the consequences of impaired mitochondrial biogenesis in various diseases and conditions, as well as provide for the active therapy of mitochondrial depletion that may have already occurred.
摘要翻译：本发明涉及用于治疗与线粒体功能相关的病症的化合物，组合物和方法。在各个方面，本发明包括施用一种或多种有效刺激细胞中线粒体功能的表儿茶素衍生物。本文所述的化合物，组合物和方法提供在永久缺血或缺血/再灌注事件或心脏延迟，减弱或预防不良心脏重塑后的心脏中降低梗死面积，并可有助于预防线粒体生物发生受损，从而预防在各种疾病和病症中受损的线粒体生物发生的后果，以及可能已经发生的线粒体消耗的主动治疗。

5. 发明申请

WO2014055938A1 NOVEL COMPOUNDS, THEIR PREPARATION AND THEIR USES 审中-公开
标题翻译：新化合物，其制备及其用途
公开(公告)号：WO2014055938A1
公开(公告)日：2014-04-10
申请号：PCT/US2013/063560
申请日：2013-10-04
申请人： INHIBIKASE THERAPEUTICS, INC. , SPHAERA PHARMA PTE. LTD. , DEOKAR, Rhushikesh, Chandrabhan , DUGAR, Sundeep , MAHAJAN, Dinesh , WERNER, Milton, Henry
发明人： DEOKAR, Rhushikesh, Chandrabhan , DUGAR, Sundeep , MAHAJAN, Dinesh , WERNER, Milton, Henry
IPC分类号： C07D401/14 , A61K31/506 , A61P35/00 , A61P31/12
CPC分类号： A61K31/506 , A61K31/095 , A61K31/5377 , A61K45/06 , C07C309/04 , C07D401/04 , Y02A50/475
摘要： Novel compounds and their synthesis are described. Methods for using these compounds in the prevention or treatment of cancer, a bacterial infection or a viral infection in a subject are also described.
摘要翻译：描述了新型化合物及其合成。还描述了使用这些化合物预防或治疗受试者中的癌症，细菌感染或病毒感染的方法。

6. 发明申请

WO2017221269A1 UTILITY OF (+) EPICATECHIN AND THEIR ANALOGS 审中-公开
标题翻译：（+）天冬酰胺及其类似物的用途
公开(公告)号：WO2017221269A1
公开(公告)日：2017-12-28
申请号：PCT/IN2017/050252
申请日：2017-06-21
申请人： SPHAERA PHARMA PVT. LTD.,
发明人： DUGAR, Sundeep , SCHREINER, Frederic, George
IPC分类号： C07H17/06 , A61K31/00 , C07D311/74 , C07D311/62 , C07D311/64
摘要： The present invention pertains to the enhanced activity of (+) epicatechin over (-) epicatechin. The present invention is related to novel analogs of (+) epicatechin of the formula (I), which enhances the pharmacokinetics and therefore the pharmacodynamics of (+) epicatechin. The present invention is related to analogs of (+) epicatechin of the formula (I). The general structure of the analogs of the present invention may be represented by Formula (I): Formula (I) wherein A and B are independently OR1 and C and D are independently OH; wherein R1 is independentlyC1 to C10 lower straight or branched chain acyclic or cyclic alkyl, or is selected from the group comprising, hydroxy butyric acid, dichloroacetic acid; phenyl butyric acid; valproic acid.
摘要翻译：本发明涉及（+）表儿茶酸对（ - ）表儿茶素的增强的活性。本发明涉及式（I）的（+）表儿茶素的新类似物，其增强（+）表儿茶素的药代动力学并因此提高其药效学。本发明涉及式（I）的（+）表儿茶素的类似物。本发明类似物的一般结构可由式（I）表示：式（I）其中A和B独立地为OR 1且C和D独立地为OH; 其中R 1独立地为C 1至C 10低级直链或支链无环或环状烷基，或选自羟基丁酸，二氯乙酸; 苯基丁酸; 丙戊酸。

7. 发明申请

WO2014054058A3 NOVEL COMPOUNDS, THEIR SYNTHESIS AND THEIR USES 审中-公开
公开(公告)号：WO2014054058A3
公开(公告)日：2014-04-10
申请号：PCT/IN2013/000607
申请日：2013-10-07
申请人： SPHAERA PHARMA PVT. LTD.
发明人： DUGAR, Sundeep , HOLLINGER, Frank, Peter , MAHAJAN, Dinesh , DEOKAR, Rhushikesh, Chandrabhan
IPC分类号： A61K31/4425
摘要： The present invention discloses novel chemical compounds obtained by causing a covalent attachment of a modifying agent of the structure provided for formula 1, to a functional group or a heteroatom of a heterocyclic ring system in chemical compound with improved chemical and biological properties. Wherein: Y is DRUG-CO; DRUG -OCO; DRUG-NRCO, and X is selected from.

8. 发明申请

WO2015181837A3 NOVEL COMPOUNDS AS ANTI-TUBERCULAR AGENTS 审中-公开
标题翻译：新型化合物作为抗结核药物
公开(公告)号：WO2015181837A3
公开(公告)日：2015-12-03
申请号：PCT/IN2015/000226
申请日：2015-06-01
申请人： SPHAERA PHARMA PVT. LTD. , DRUG DISCOVERY RESEARCH CENTRE
发明人： DUGAR, Sundeep , MAHAJAN, Dinesh , RAI, Santosh Kumar , RAO, Kanury , SINGH, Varshneya
IPC分类号： A61K31/00 , A61P31/06 , A61K31/06
摘要： The present invention relates to novel compounds of formula (1): The present invention also discloses compounds of formula (1) along with other pharmaceutical acceptable excipients and use of the compounds as anti-tubercular agents.
摘要翻译：本发明涉及式（1）的新化合物：本发明还公开了式（1）的化合物以及其他药学上可接受的赋形剂以及这些化合物作为抗结核药的用途。 / p>

9. 发明申请

WO2014162320A2 NOVEL ANALOGUES OF EPICATECHIN AND RELATED POLYPHENOLS 审中-公开
标题翻译：新霉素及相关多酚的类似物
公开(公告)号：WO2014162320A2
公开(公告)日：2014-10-09
申请号：PCT/IN2014/000213
申请日：2014-04-04
申请人： SPHAERA PHARMA PVT. LTD.
发明人： DUGAR, Sundeep , MAHAJAN, Dinesh , RAI, Kumar, Santosh , SINGH, Sarbjit , PATIL, Ishwar, Rakesh
CPC分类号： C07D311/62 , A23L33/10 , C07C45/71 , C07C45/72 , C07D311/54 , C07D311/60 , C07D405/12
摘要： The present invention provides novel analogues of epicatechin and related polyphenols, their variously functionalized derivatives, process for preparation of the same, composition comprising these compounds and their method of use.
摘要翻译：本发明提供了表儿茶素和相关多酚的新类似物，它们的各种官能化衍生物，其制备方法，包含这些化合物的组合物及其使用方法。

10. 发明申请

WO2018083713A1 COMPOSITION COMPRISING COMBINATION OF EPICATECHIN AND ANTI-CANCER COMPOUND 审中-公开
标题翻译：包含抗惊厥药和抗癌化合物组合的组合物
公开(公告)号：WO2018083713A1
公开(公告)日：2018-05-11
申请号：PCT/IN2017/050506
申请日：2017-11-01
申请人： SPHAERA PHARMA PVT. LTD.
发明人： DUGAR, Sundeep
IPC分类号： C07D311/00 , A61K36/00
摘要： The present invention discloses a novel, stable and synergistic combination of epicatechin with anti-cancer compounds. The present invention also discloses a composition comprising the novel combination of epicatechin with anti-cancer compounds along with other pharmaceutically acceptable excipients.
摘要翻译：本发明公开了表儿茶素与抗癌化合物的新颖，稳定且协同的组合。本发明还公开了包含表儿茶素与抗癌化合物以及其它药学上可接受的赋形剂的新组合的组合物。

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