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1. 发明申请

WO2007102019A1 THE USE OF BUPROPION METABOLITES FOR THE TREATMENT OF INFLAMMATORY DISORDERS 审中-公开
标题翻译：使用支架代谢物治疗炎症性疾病
公开(公告)号：WO2007102019A1
公开(公告)日：2007-09-13
申请号：PCT/GB2007/000868
申请日：2007-03-09
申请人： SOSEI R & D LTD. , BREW, John , BANNISTER, Robin, Mark , BAXTER, Andrew, Douglas
发明人： BREW, John , BANNISTER, Robin, Mark , BAXTER, Andrew, Douglas
IPC分类号： A61K31/135 , A61P29/00
CPC分类号： A61K31/135
摘要： Compounds that may be used for the treatment or prevention of a condition associated with T-cell proliferation or that is mediated by pro-inflammatory cytokines are of formula (I) or a salt thereof.
摘要翻译：可用于治疗或预防与T细胞增殖相关的或由促炎细胞因子介导的病症的化合物是式（I）或其盐。

2. 发明申请

WO2007102008A1 THE USE OF BETA-AMINOALCOHOLS IN THE TREATMENT OF INFLAMMATORY DISORDERS AND PAIN 审中-公开
标题翻译：氨基甲醇在治疗炎症性疾病和疼痛中的应用
公开(公告)号：WO2007102008A1
公开(公告)日：2007-09-13
申请号：PCT/GB2007/000816
申请日：2007-03-09
申请人： SOSEI R & D LTD. , BREW, John , BAXTER, Andrew, Douglas , BANNISTER, Robin, Mark
发明人： BREW, John , BAXTER, Andrew, Douglas , BANNISTER, Robin, Mark
IPC分类号： A61K31/137 , A61P29/00 , A61P19/00 , A61P11/00 , A61P11/06 , A61P1/00 , A61P17/06 , A61P17/00 , A61P1/02 , A61P37/00 , A61P27/00 , A61P27/04
CPC分类号： A61K31/137
摘要： A compound for therapeutic use, of the formula (I), wherein R 1 is aryl or heteroaryl optionally substituted with R 5 ; R 2 is H, alkyl or CH 2 OH or forms part of a ring with R 4 ; R 3 is H, alkyl or CH 2 OH or forms part of a ring with R 4 ; R 4 is H, alkyl or (when forming part of a ring with R 2 or R 3 ) CH 2 ; and R 5 is alkyl, CF 3 , OH, Oalkyl, OCOalkyl, CONH 2 , CN, halogen, NH 2 , NO 2 , NHCHO, NHCONH 2 , NHSO 2 Me, CONH 2 , or SOMe; or a salt thereof.
摘要翻译：用于治疗用途的式（I）化合物，其中R 1为任选被R 5取代的芳基或杂芳基; R 2是H，烷基或CH 2 OH或形成具有R 4的环的一部分; R 3是H，烷基或CH 2 OH或形成具有R 4的环的一部分; R 4是H，烷基或（当形成具有R 2或R 3或R 3或R 3的基团的一部分时）CH 2 >; 和R 5是烷基，CF 3，OH，O烷基，OCO烷基，CONH 2，CN，卤素，NH 2， NH 2，NH 2 H 2，NHSO 2 Me，CONH 2 N或SOMe; 或其盐。

3. 发明申请

WO2007003896A1 THE TREATMENT OF INFLAMMATORY DISORDERS AND PAIN 审中-公开
标题翻译：治疗炎症性疾病和疼痛
公开(公告)号：WO2007003896A1
公开(公告)日：2007-01-11
申请号：PCT/GB2006/002413
申请日：2006-06-30
申请人： SOSEI R & D LTD. , BAXTER, Andrew, Douglas , LYNE, Michael, Harvey , BANNISTER, Robin, Mark , LASTERRA, Elena
发明人： BAXTER, Andrew, Douglas , LYNE, Michael, Harvey , BANNISTER, Robin, Mark , LASTERRA, Elena
IPC分类号： C07C215/10 , A61K31/133 , A61P19/00
CPC分类号： C07C215/68 , A61K31/133 , C07C215/30
摘要： A compound that is useful for the treatment or prevention of a condition such as pain, that is associated with T-cell proliferation or that is mediated by pro- and/or anti-inflammatory cytokines, is of formula (I) wherein R 1 is aryl or heteroaryl optionally substituted with R 5 ; R 2 is H, alkyl or CH 2 OH and can be part of a ring with R 4 ; R 3 is H, alkyl or CH 2 OH and can be part of a ring with R 4 ; R 4 is H or alkyl or CH 2 (when forming part of a ring with R 2 or R 3 ); and R 5 is alkyl, CF 3 , OH, Oalkyl, OCOalkyl, CONH 2 , CN, F, Cl, Br, I, NH 2 , NO 2 , NHCHO, NHCONH 2 , NHSO 2 alkyl, CONH 2 , SOMe, CH 2 OH or OCONalkyl 2 ; or a salt thereof.
摘要翻译：可用于治疗或预防与由T细胞增殖相关或由促炎和/或抗炎细胞因子介导的疼痛等症状的化合物具有式（I），其中R _{1是任选被R 5取代的芳基或杂芳基; R 2是H，烷基或CH 2 OH，并且可以是具有R 4的环的一部分; R 3是H，烷基或CH 2 OH，并且可以是具有R 4的环的一部分; R 4是H或烷基或CH 2（当形成具有R 2或R 3的环的一部分时））; 和R 5是烷基，CF 3，OH，O烷基，OCO烷基，CONH 2，CN，F，Cl，Br，I，NH NH 2，NH 2 H 2，NHSO 2烷基，CONH 2 N 2，N 2， >，SOMe，CH 2 OH或OCON烷基2}

4. 发明申请

WO2005041963A1 THE USE OF NON-OPIATES FOR THE POTENTATION OF OPIATES 审中-公开
标题翻译：使用不透明度进行评估
公开(公告)号：WO2005041963A1
公开(公告)日：2005-05-12
申请号：PCT/GB2004/004446
申请日：2004-10-21
申请人： ARAKIS LTD. , BREW, John , BANNISTER, Robin, Mark , BAXTER, Andrew, Douglas , ROTHAUL, Alan , LYNE, Michael, Harvey
发明人： BREW, John , BANNISTER, Robin, Mark , BAXTER, Andrew, Douglas , ROTHAUL, Alan , LYNE, Michael, Harvey
IPC分类号： A61K31/445
CPC分类号： A61K31/445 , A61K31/135 , A61K31/137 , A61K31/165 , A61K31/381 , A61K31/395 , A61K31/485 , A61K31/5513 , A61K2300/00
摘要： A non-opioid analgesic is used for the treatment of intermittent or episodic pain experienced by a patient undergoing chronic pain treatment with an opioid analgesic.
摘要翻译：非阿片类镇痛药用于治疗由阿片类镇痛药进行慢性疼痛治疗的患者经历的间歇性或间歇性疼痛。

5. 发明申请

WO2004006903A1 THE TREATMENT OF EMESIS 审中-公开
标题翻译：治疗EMESIS
公开(公告)号：WO2004006903A1
公开(公告)日：2004-01-22
申请号：PCT/GB2003/003002
申请日：2003-07-11
申请人： ARAKIS LTD. , LYNE, Michael, Harvey , BREW, John , BANNISTER, Robin, Mark , BAXTER, Andrew, Douglas
发明人： LYNE, Michael, Harvey , BREW, John , BANNISTER, Robin, Mark , BAXTER, Andrew, Douglas
IPC分类号： A61K31/137
CPC分类号： A61K31/137
摘要： A single enantiomer of venlafaxine is used to treat nausea, dizziness, blurred vision or emesis.
摘要翻译：文拉法辛的单一对映异构体用于治疗恶心，眩晕，视力模糊或呕吐。

6. 发明申请

WO2003092689A1 THE TREATMENT OF PAIN WITH IFENDROPIL 审中-公开
标题翻译：用IFENDROPIL治疗疼痛
公开(公告)号：WO2003092689A1
公开(公告)日：2003-11-13
申请号：PCT/GB2003/001906
申请日：2003-05-06
申请人： ARAKIS LTD. , BREW, John , BANNISTER, Robin, Mark , BAXTER, Andrew, Douglas , ROTHAUL, Alan , LYNE, Michael, Harvey
发明人： BREW, John , BANNISTER, Robin, Mark , BAXTER, Andrew, Douglas , ROTHAUL, Alan , LYNE, Michael, Harvey
IPC分类号： A61K31/445
CPC分类号： A61K31/445 , A61K9/0043
摘要： Ifenprodil is useful for the treatment of pain, e.g. on administration intranasally or by another route that avoids first-pass metabolism.
摘要翻译： Ifenprodil可用于治疗疼痛，例如在鼻内给药或通过避免首次代谢的另一种途径。

7. 发明申请

WO2005041964A1 THE USE OF IFENPRODRIL IN THE TREATMENT OF PAIN 审中-公开
标题翻译：使用芬太尼治疗疼痛
公开(公告)号：WO2005041964A1
公开(公告)日：2005-05-12
申请号：PCT/GB2004/004459
申请日：2004-10-21
申请人： ARAKIS LTD. , BREW, John , BANNISTER, Robin, Mark , BAXTER, Andrew, Douglas , ROTHAUL, Alan , LYNE, Michael, Harvey
发明人： BREW, John , BANNISTER, Robin, Mark , BAXTER, Andrew, Douglas , ROTHAUL, Alan , LYNE, Michael, Harvey
IPC分类号： A61K31/445
CPC分类号： A61K31/445
摘要： Ifenprodil is useful for the treatment of pain.
摘要翻译： Ifenprodil可用于治疗疼痛。

8. 发明申请

WO2006095187A1 BENZOXAZOCINES AND THEIR THERAPEUTIC USE 审中-公开
标题翻译：苯并噻唑及其治疗用途
公开(公告)号：WO2006095187A1
公开(公告)日：2006-09-14
申请号：PCT/GB2006/000858
申请日：2006-03-10
申请人： SOSEI R & D LTD. , BAXTER, Andrew, Douglas
发明人： BAXTER, Andrew, Douglas
IPC分类号： C07D267/22 , A61K31/395 , A61P25/04
CPC分类号： C07D267/22
摘要： A compound selected from (1 S )-8-cyano-5-methyl-1-(3-methoxy)phenyl-1,3,4,6-tetrahydro-5H-benz[f]-2,5- oxazocine; (1 R )-8-cyano-5-methyl-1-(3-methoxy)phenyl-1,3,4,6-tetrahydro-5H-benz[f]-2,5- oxazocine; (1 S )-8-cyclopropyl-5-methyl-1-(3-methoxy)phenyl-1,3,4,6-tetrahydro-5H-benz[f]- 2,5-oxazocine; (1 S )-8-cyclopropyl-5-methyl-1-(3-methoxy)phenyl-1,3,4,6-tetrahydro-5H-benz[f]-2,5-oxazocine; (1 S )-5-methyl-1-(3-methoxy)phenyl-1 ,3,4,6-tetrahydro-5H-benz[f]-2,5- oxazocine-8-carboxamide; (1 R )-5-methyl-1-(3-methoxy)phenyl-1,3,4,6-tetrahydro-5H-benz[f]-2,5- oxazocine-8-carboxamide; and the salts thereof. These compounds have therapeutic utility.
摘要翻译：选自（1S）-8-氰基-5-甲基-1-（3-甲氧基）苯基-1,3,4,6-四氢-5H-苯并[f] -2,5-恶唑辛的化合物; （1R）-8-氰基-5-甲基-1-（3-甲氧基）苯基-1,3,4,6-四氢-5H-苯并[f] -2,5-恶唑辛; （1S）-8-环丙基-5-甲基-1-（3-甲氧基）苯基-1,3,4,6-四氢-5H-苯并[f] -2,5-恶唑辛; （1S）-8-环丙基-5-甲基-1-（3-甲氧基）苯基-1,3,4,6-四氢-5H-苯并[f] -2,5-恶唑辛; （1S）-5-甲基-1-（3-甲氧基）苯基-1,3,4,6-四氢-5H-苯并[f] -2,5-恶唑烷-8-甲酰胺; （1R）-5-甲基-1-（3-甲氧基）苯基-1,3,4,6-四氢-5H-苯并[f] -2,5-恶唑烷-8-甲酰胺; 及其盐。这些化合物具有治疗作用。

9. 发明申请

WO2007102011A1 THE USE OF BETA-AMINOALCOHOLS FOR THE TREATMENT OF INFLAMMATORY DISORDERS AND PAIN 审中-公开
标题翻译：用于治疗炎症性疾病和疼痛的β-氨基醇的用途
公开(公告)号：WO2007102011A1
公开(公告)日：2007-09-13
申请号：PCT/GB2007/000821
申请日：2007-03-09
申请人： SOSEI R & D LTD. , BAXTER, Andrew, Douglas
发明人： BAXTER, Andrew, Douglas
IPC分类号： A61K31/4458 , A61P11/06 , A61P17/00 , A61P1/00 , A61P19/00 , A61P19/02 , A61P29/00 , A61P1/02 , A61P13/12 , A61P37/00
CPC分类号： A61K31/4458
摘要： Compounds that may be used for the treatment or prevention of a condition associated with T-cell proliferation or that is mediated by pro-inflammatory cytokines are of formula (I): wherein at least one of R1 , R2 or R3 is not H and each is independently H, alkyl, CF 3 , CONH 2 , CN, halogen, NH 2 , NO 2 , NHCHO, NHCONH 2 , NHSO 2 alkyl, SOMe, SO 2 NH 2 , Salkyl, or CH 2 S0 2 alkyl; and R 4 is H or alkyl; or a salt thereof.
摘要翻译：可用于治疗或预防与T细胞增殖相关的或由促炎细胞因子介导的病症的化合物具有式（I）：其中R 1，R 2或R 3中的至少一个不是H，且每个独立地是H，烷基，CF 3，CONH 2，CN，卤素，NH 2，NO 2， NHCHO，NHCONH 2，NHSO 2烷基，SOMe，SO 2 NH 2，S烷基或CH _{2 S0 _{2 烷基; 并且R 4是H或烷基; 或其盐。}}

10. 发明申请

WO2006100453A1 GLYCOPYRRONIUM SALTS AND THEIR THERAPEUTIC USE 审中-公开
标题翻译：甘油盐及其治疗用途
公开(公告)号：WO2006100453A1
公开(公告)日：2006-09-28
申请号：PCT/GB2006/000995
申请日：2006-03-20
申请人： SOSEI R & D LTD. , BAXTER, Andrew, Douglas
发明人： BAXTER, Andrew, Douglas
IPC分类号： C07D207/12 , A61K31/40 , A61P11/00
CPC分类号： C07D207/12
摘要： A glycopyrronium salt such as glycopyrronium iodide has a lower glass transition temperature than glycopyrronium bromide. It is therefore more suitable for formulation.
摘要翻译：格列吡嗪鎓盐如碘化丙锭具有比格列吡嗪溴化物更低的玻璃化转变温度。因此更适合配制。

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