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1. 发明申请

WO2018069871A2 ANTI-KRAS BINDING PROTEINS 审中-公开
标题翻译：抗KRAS结合蛋白
公开(公告)号：WO2018069871A2
公开(公告)日：2018-04-19
申请号：PCT/IB2017/056334
申请日：2017-10-12
申请人： SORRENTO THERAPEUTICS, INC. , ZHOU, Heyue , KIM, Min Soo
发明人： ZHOU, Heyue , KIM, Min Soo
IPC分类号： A61K39/395 , C07K16/30
摘要： The present disclosure provides anti-KRAS antibodies, and antigen-binding fragments thereof. In certain embodiments, the anti-KRAS antibodies or fragments thereof, are used for the treatment of cancer.
摘要翻译：本公开提供了抗KRAS抗体及其抗原结合片段。在某些实施方案中，抗KRAS抗体或其片段用于治疗癌症。

2. 发明申请

WO2018069871A3 ANTI-KRAS BINDING PROTEINS 审中-公开
公开(公告)号：WO2018069871A3
公开(公告)日：2018-04-19
申请号：PCT/IB2017/056334
申请日：2017-10-12
申请人： SORRENTO THERAPEUTICS, INC. , ZHOU, Heyue , KIM, Min Soo
发明人： ZHOU, Heyue , KIM, Min Soo
IPC分类号： A61K45/06 , C07K14/82 , A61K39/00
摘要： The present disclosure provides anti-KRAS antibodies, and antigen-binding fragments thereof. In certain embodiments, the anti-KRAS antibodies or fragments thereof, are used for the treatment of cancer.

3. 发明申请

WO2011130305A2 METHOD FOR DISPLAYING ANTIBODIES 审中-公开
标题翻译：显示抗体的方法
公开(公告)号：WO2011130305A2
公开(公告)日：2011-10-20
申请号：PCT/US2011/032159
申请日：2011-04-12
申请人： SORRENTO THERAPEUTICS INC. , JI, Henry , ZHOU, Heyue , ZHANG, Yanliang , RODI, Charles
发明人： JI, Henry , ZHOU, Heyue , ZHANG, Yanliang , RODI, Charles
IPC分类号： C12P21/00
CPC分类号： C07K16/00 , C07K2317/515 , C07K2317/55 , C07K2317/622
摘要： There is disclosed vector designs, constructs and approaches to construct antibody libraries that display antibodies, such as full-length immunoglobulins, single chain antibody (SCA) scFv, or Fab on the host cell surface. There is also disclosed screening approaches to isolate desired antibody binders from above mentioned antibody libraries for selective antibody targets.
摘要翻译：已经公开了构建在宿主细胞表面上显示抗体的抗体文库的载体设计，构建体和方法，例如全长免疫球蛋白，单链抗体（SCA）scFv或Fab。还公开了从上述选择性抗体靶标的抗体文库中分离所需抗体结合物的筛选方法。

4. 发明申请

WO2017132562A8 ANTIGEN BINDING PROTEINS THAT BIND PD-L1 审中-公开
标题翻译：抗原结合蛋白结合PD-L1
公开(公告)号：WO2017132562A8
公开(公告)日：2017-08-03
申请号：PCT/US2017/015429
申请日：2017-01-27
申请人： ZHOU, Heyue
发明人： ZHOU, Heyue
IPC分类号： C12P21/08 , A61K39/00
摘要： There is disclosed anti-PD-L1 IgG class antibodies that have an improved ability to be manufactured at higher yields. More specifically, there is disclosed human antibodies that bind PD-L1, PD-L1-binding fragments that can be manufactured at higher yields.
摘要翻译：公开了具有改善的以更高产量制造的能力的抗PD-L1IgG类抗体。更具体地说，公开了能够以更高产量制造的结合PD-L1的PD-L1结合片段的人抗体。

5. 发明申请

WO2017132562A1 ANTIGEN BINDING PROTEINS THAT BIND PD-L1 审中-公开
标题翻译：抗原结合蛋白结合PD-L1
公开(公告)号：WO2017132562A1
公开(公告)日：2017-08-03
申请号：PCT/US2017/015429
申请日：2017-01-27
申请人： ZHOU, Heyue
发明人： ZHOU, Heyue
IPC分类号： C12P21/08 , A61K39/00
CPC分类号： C07K16/2803 , C07K16/2827 , C07K16/30 , C07K2317/21 , C07K2317/51 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/92
摘要： There is disclosed anti-PD-L1 IgG class antibodies that have an improved ability to be manufactured at higher yields. More specifically, there is disclosed human antibodies that bind PD-L1, PD-L1 -binding fragments that can be manufactured at higher yields.
摘要翻译：公开了具有改善的以更高产量制造的能力的抗PD-L1IgG类抗体。更具体地说，公开了能够以更高产量制备的结合PD-L1，PD-L1-结合片段的人抗体。

6. 发明申请

WO2021226249A1 NEUTRALIZING ANTIBODIES THAT BIND THE SARS-COV-2 S PROTEIN 审中-公开
公开(公告)号：WO2021226249A1
公开(公告)日：2021-11-11
申请号：PCT/US2021/030909
申请日：2021-05-05
申请人： SORRENTO THERAPEUTICS, INC.
发明人： ZHOU, Heyue , CAO, Xia , LU, Lucy , YAN, Ying , ZHANG, Yanliang , JI, Henry Hongjun , ALLEN, Robert
IPC分类号： C07K16/10 , C07K14/165 , A61P31/12
摘要： The present disclosure provides antigen-binding proteins, such as fully human antibodies, that specifically bind the spike (S) protein of the SARS-CoV-2 coronavirus and uses thereof. In various embodiments, the anti-spike protein antibodies are neutralizing antibodies that prevent binding of the SARS-CoV-2 coronavirus to a target cell expressing the ACE2 protein. Included are anti-spike protein antibodies, antibody fragments, and single-chain antibodies, as well as pharmaceutical compositions that include such antibodies and antibody fragments. Also provided herein are nucleic acids and recombinant expression vectors that encode the anti-spike protein antibodies and antibody fragments disclosed herein and transgenic cells transected with such nucleic acids and expression vectors. Further provided are methods for preparing and using such anti-spike protein antibodies. Methods for using the anti-spike protein antibodies include methods of treating or preventing infection with a coronavirus, such as the SARS-CoV-2 coronavirus, by administering an antibody or antibody fragment as disclosed herein.

7. 发明申请

WO2021202904A1 ENGINEERED ANTIBODIES THAT BIND LAGS 审中-公开
公开(公告)号：WO2021202904A1
公开(公告)日：2021-10-07
申请号：PCT/US2021/025423
申请日：2021-04-01
申请人： SORRENTO THERAPEUTICS, INC.
发明人： BRESSON, Damien , KIM, Min Soo , ZHOU, Heyue , GRAY, John Dixon , SWANSON, Barbara A. , SINGH, Alok , KERWIN, Lisa Diane
IPC分类号： A61K39/395 , C07K16/28 , C07K16/46 , C12N15/13
摘要： The present disclosure provides fully human anti-LAG3 IgG class antibodies engineered to have amino acid sequence in their heavy chain variable region and/or light chain variable region to improve antigen binding, cell binding, T cell activation and cytokine release capabilities.

8. 发明申请

WO2016145139A1 ANTIBODY THERAPEUTICS THAT BIND PSMA 审中-公开
标题翻译：抗体治疗药物
公开(公告)号：WO2016145139A1
公开(公告)日：2016-09-15
申请号：PCT/US2016/021672
申请日：2016-03-10
申请人： SORRENTO THERAPEUTICS, INC.
发明人： GROS, Edwige , ZHOU, Heyue
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K16/40 , A61K39/39558 , A61K47/6803 , A61K47/6829 , A61K47/6869 , A61K2039/505 , C07K16/3069 , C07K2317/21 , C07K2317/55 , C07K2317/56 , C07K2317/73 , C07K2317/92
摘要： There is disclosed compositions and methods relating to or derived from anti-PSMA antibodies. More specifically, there is disclosed fully human antibodies that bind PSMA, PSMA-antibody binding fragments and derivatives of such antibodies, and PSMA-binding polypeptides comprising such fragments. Further still, there is disclosed nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating a disease. There is further disclosed targeted therapies for treatment of prostate cancer having the disclosed anti-PSMA antibodies and fragments thereof targeting the therapeutic agent or cell.
摘要翻译：公开了与抗PSMA抗体有关或衍生自抗PSMA抗体的组合物和方法。更具体地，公开了结合PSMA，PSMA-抗体结合片段和此类抗体的衍生物的完全人抗体，以及包含此类片段的PSMA结合多肽。此外，还公开了编码这种抗体，抗体片段和衍生物和多肽的核酸，包含这种多核苷酸的细胞，制备此类抗体的方法，抗体片段和衍生物和多肽，以及使用这种抗体，抗体片段和衍生物和多肽的方法，包括治疗疾病的方法。进一步公开了用于治疗具有所公开的抗PSMA抗体及其靶向治疗剂或细胞的片段的前列腺癌的靶向治疗。

9. 发明申请

WO2015160858A2 ANTIGEN BINDING PROTEINS THAT BIND WISP1 审中-公开
标题翻译：抗原结合蛋白，结合WISP1
公开(公告)号：WO2015160858A2
公开(公告)日：2015-10-22
申请号：PCT/US2015/025829
申请日：2015-04-14
申请人： SORRENTO THERAPEUTICS, INC.
发明人： ZHOU, Heyue , KAUFMANN, Gunnar, F.
IPC分类号： A61K39/395
CPC分类号： A61K39/39558 , A61K39/3955 , C07K16/22 , C07K16/30 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/92
摘要： There is disclosed compositions and methods relating to or derived from anti-WISPl antibodies. More specifically, there is disclosed fully human antibodies that bind WISP1, WISP1 -binding fragments and derivatives of such antibodies, and WISP1 -binding polypeptides comprising such fragments. Further still, there is disclosed nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating or diagnosing subjects having WISP1 related disorders or conditions. There is also disclosed a method for treating or preventing various cancers or inflammatory diseases and various diseases of the heart, bone/joints or lung.
摘要翻译：公开了涉及或衍生自抗WISP1抗体的组合物和方法。更具体而言，公开了结合WISP1的完全人抗体，WISP1结合片段和此类抗体的衍生物，以及包含此类片段的WISP1结合多肽。此外，还公开了编码此类抗体的核酸，抗体片段和衍生物和多肽，包含此类多核苷酸的细胞，制备此类抗体的方法，抗体片段和衍生物和多肽，以及使用此类抗体，抗体片段和衍生物和多肽包括治疗或诊断具有WISP1相关病症或病症的受试者的方法。还公开了用于治疗或预防各种癌症或炎性疾病以及心脏，骨/关节或肺的各种疾病的方法。

10. 发明申请

WO2013192596A2 ANTIGEN BINDING PROTEINS THAT BIND CCR2 审中-公开
标题翻译：抗体结合蛋白CCR2
公开(公告)号：WO2013192596A2
公开(公告)日：2013-12-27
申请号：PCT/US2013/047192
申请日：2013-06-21
申请人： SORRENTO THERAPEUTICS INC.
发明人： HUANG, Dingqiu , SWANSON, Barbara, A. , ZHOU, Heyue , LU, Guodi
IPC分类号： C07K16/28
CPC分类号： C07K16/2866 , A61K2039/505 , C07K16/3015 , C07K16/3023 , C07K16/303 , C07K16/3038 , C07K16/3069 , C07K2317/21 , C07K2317/33 , C07K2317/55 , C07K2317/622 , C07K2317/76 , C07K2317/92
摘要： There is disclosed compositions and methods relating to or derived from anti-CCR2 antibodies. More specifically, there is disclosed fully human antibodies that bind CCR2, CCR2 -binding fragments and derivatives of such antibodies, and CCR2 -binding polypeptides comprising such fragments. Further still, there is disclosed nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating or diagnosing subjects having CCR2 related disorders or conditions.
摘要翻译：公开了与抗CCR2抗体相关或衍生自抗CCR2抗体的组合物和方法。更具体地，公开了结合CCR2，CCR2结合片段和此类抗体的衍生物的完全人抗体以及包含此类片段的CCR2结合多肽。此外，还公开了编码这种抗体，抗体片段和衍生物和多肽的核酸，包含这种多核苷酸的细胞，制备此类抗体的方法，抗体片段和衍生物和多肽，以及使用这些抗体，抗体片段和衍生物和多肽的方法包括治疗或诊断具有CCR2相关疾病或病症的受试者的方法。

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