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    • 1. 发明申请
    • SILVER/POLYDIGUANIDE COMPLEX, PREPARATION METHOD THEREOF, AND ANTIBACTERIAL COMPOSITION CONTAINING THE SAME AS AN ACTIVE INGREDIENT
    • 银/聚异氰酸酯复合物,其制备方法和含有其作为活性成分的抗菌组合物
    • WO2011046267A1
    • 2011-04-21
    • PCT/KR2010/000717
    • 2010-02-05
    • SNU R&DB FOUNDATIONSONG, Joon MyongPAL, Sukdeb
    • SONG, Joon MyongPAL, Sukdeb
    • A61K33/38A61K31/155A61P17/02A61P17/00C07F1/10
    • C07C279/265
    • The present invention relates to a silver/polydiguanide complex and derivatives thereof including silver and polydiguanide having at least two biguanide moieties, wherein the silver is stabilized in an oxidation state of an integer of 0 to 4, a mole ratio between the silver and the polydiguanide is 1: 1-4, an average particle diameter of the complex is micrometer or nanometer, and zeta potential of the complex is greater than or equal to zero, a preparation method thereof, and an antibacterial composition for burns or wounds treatment including the same as an active ingredient. A silver/polydiguanide complex according to the present invention is different from conventional silver/polydiguanide complexes in carbon, hydrogen, and nitrogen contents as well as in structure of silver and polydiguanide, and solubility, is a material that exhibits a very good antibacterial activity due to a much lower minimal inhibitory concentration (MIC) value by 10 to 100 folds or more compared to silver sulfadiazine which is a conventional therapeutic agent for burns, and may be usefully used as an antibacterial composition for burns or wounds treatment.
    • 本发明涉及银/聚二胍复合物及其衍生物,其包含具有至少两个双胍部分的银和聚二胍,其中银以0至4的整数的氧化态稳定,银和聚二胍的摩尔比 为1:1-4,络合物的平均粒径为微米或纳米,络合物的ζ电位为大于或等于零,其制备方法以及包含其的烧伤或伤口治疗用抗菌组合物 作为活性成分。 根据本发明的银/聚二胍复合物与碳,氢和氮含量以及银和聚二胍的结构中的常规银/聚二胍络合物不同,并且溶解度是表现出非常好的抗菌活性的材料 与作为常规烧伤治疗剂的磺胺嘧啶磺胺相比,低得多的最小抑制浓度(MIC)值为10〜100倍以上,并且可以有效地用作烧伤或伤口治疗的抗菌组合物。