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1. 发明申请

WO2010041892A3 NOVEL APPLICATION OF AIMP1 POLYPEPTIDE 审中-公开
标题翻译： AIMP1多肽的新应用
公开(公告)号：WO2010041892A3
公开(公告)日：2010-08-19
申请号：PCT/KR2009005778
申请日：2009-10-09
申请人： SNU R&DB FOUNDATION , KIM SUNGHOON , HAN JUNG MIN
发明人： KIM SUNGHOON , HAN JUNG MIN
IPC分类号： C07K16/18
CPC分类号： G01N33/564 , G01N2800/102
摘要： The present invention relates to a novel application of AIMP1 polypeptide and more specifically to a composition for diagnosis of rheumatoid arthritis including an antibody against AIMP1; a diagnostic kit including same; and a method for diagnosis of rheumatoid arthritis comprising a step wherein a specimen is obtained from an object and a step wherein the AIMP1 polypeptide included in said specimen is detected; and to an antibody against the AIMP1 polypeptide for the diagnosis of rheumatoid arthritis. The present invention provides a composition for diagnosis of rheumatoid arthritis as a novel diagnosis marker for rheumatoid arthritis, a diagnostic kit including the same and a method of rheumatoid arthritis diagnosis comprising a step wherein a specimen is obtained from a subject and a step wherein the AIMP1 polypeptide included in said specimen is detected; and the antibody against the AIMP1 polypeptide for the diagnosis of rheumatoid arthritis. The composition, diagnosis kit, diagnosis method and the antibody against the AIMP1 polypeptide of the present invention enable rheumatoid arthritis to be readily diagnosed from the specimen of a patient, and thus may be used for early diagnosis and confirmation of rheumatoid arthritis.
摘要翻译：本发明涉及AIMP1多肽的新应用，更具体地涉及用于诊断类风湿性关节炎的组合物，包括抗AIMP1抗体; 包括其的诊断试剂盒; 以及用于诊断类风湿性关节炎的方法，包括从物体获得样本的步骤和其中检测到包含在所述样本中的AIMP1多肽的步骤; 以及针对AIMP1多肽的抗体用于诊断类风湿性关节炎。本发明提供了一种用于诊断类风湿性关节炎的组合物，作为类风湿性关节炎的新型诊断标记物，包括其的诊断试剂盒和类风湿性关节炎诊断方法，其包括从受试者获得样品的步骤和其中AIMP1 检测包含在所述样品中的多肽; 和针对AIMP1多肽的抗体用于诊断类风湿性关节炎。本发明的组合物，诊断试剂盒，诊断方法和针对AIMP1多肽的抗体使得类风湿性关节炎能够从患者标本容易地诊断出来，因此可用于类风湿性关节炎的早期诊断和确认。

2. 发明申请

WO2010041892A2 NOVEL APPLICATION OF AIMP1 POLYPEPTIDE 审中-公开
公开(公告)号：WO2010041892A2
公开(公告)日：2010-04-15
申请号：PCT/KR2009005778
申请日：2009-10-09
申请人： SNU R&DB FOUNDATION , KIM SUNGHOON , HAN JUNG MIN
发明人： KIM SUNGHOON , HAN JUNG MIN
IPC分类号： C07K16/18
CPC分类号： G01N33/564 , G01N2800/102
摘要： The present invention relates to a novel application of AIMP1 polypeptide and more specifically to a composition for diagnosis of rheumatoid arthritis including an antibody against AIMP1; a diagnostic kit including same; and a method for diagnosis of rheumatoid arthritis comprising a step wherein a specimen is obtained from an object and a step wherein the AIMP1 polypeptide included in said specimen is detected; and to an antibody against the AIMP1 polypeptide for the diagnosis of rheumatoid arthritis. The present invention provides a composition for diagnosis of rheumatoid arthritis as a novel diagnosis marker for rheumatoid arthritis, a diagnostic kit including the same and a method of rheumatoid arthritis diagnosis comprising a step wherein a specimen is obtained from a subject and a step wherein the AIMP1 polypeptide included in said specimen is detected; and the antibody against the AIMP1 polypeptide for the diagnosis of rheumatoid arthritis. The composition, diagnosis kit, diagnosis method and the antibody against the AIMP1 polypeptide of the present invention enable rheumatoid arthritis to be readily diagnosed from the specimen of a patient, and thus may be used for early diagnosis and confirmation of rheumatoid arthritis.

3. 发明申请

WO2011053090A3 NOVEL 2, 4-PYRIMIDINE DERIVATIVES AND USE THEREOF 审中-公开
标题翻译：新的2,4-嘧啶衍生物及其用途
公开(公告)号：WO2011053090A3
公开(公告)日：2011-11-03
申请号：PCT/KR2010007656
申请日：2010-11-02
申请人： SNU R&DB FOUNDATION , KOREA RES INST CHEM TECH , KIM SUNGHOON , HAN JUNG MIN , KIM HYEONG RAE , JEON DONG JU , SONG JONG HWAN , PARK KYUNG EUN
发明人： KIM SUNGHOON , HAN JUNG MIN , KIM HYEONG RAE , JEON DONG JU , SONG JONG HWAN , PARK KYUNG EUN
IPC分类号： C07D401/12 , A61K31/513 , A61P29/00
CPC分类号： C07D239/60 , C07D239/52 , C07D401/12
摘要： The present invention relates to novel 2, 4-pyrimidine derivatives and a use thereof, and more specifically, to pyrimidine derivatives which are effective for systemic lupus erythematosus, a composition for preventing and treating systemic lupus erythematosus comprising the same as an active ingredient and a method for screening the same. The present inventors found novel materials inhibiting surface translocation of gp96 by mimicking a function of AIMP1 which is a molecular anchor for an intracellular residence of gp96, and identified in vitro and in vivo activity of the materials for preventing and treating SLE by alleviating SLE plasma in autoimmune diseases. Therefore, the present invention provides a novel method for screening a therapeutic agent for SLE, and for preventing or treating SLE using the mechanism.
摘要翻译：本发明涉及新的2,4-嘧啶衍生物及其用途，更具体地涉及对系统性红斑狼疮有效的嘧啶衍生物，包含其作为活性成分的系统性红斑狼疮预防和治疗用组合物和筛选方法。本发明人通过模拟作为gp96细胞内驻留的分子锚的AIMP1的功能，发现抑制gp96表面移位的新型材料，并通过减轻SLE血浆中的SLE血浆来鉴定用于预防和治疗SLE的材料的体外和体内活性自身免疫性疾病。因此，本发明提供了一种用于筛选SLE治疗剂以及使用该机制预防或治疗SLE的新方法。

4. 发明申请

WO2013043012A3 NOVEL USE OF LEUCYL TRNA SYNTHETASE 审中-公开
标题翻译： LEUCYL TRNA SYNTHETASE的新用途
公开(公告)号：WO2013043012A3
公开(公告)日：2013-05-16
申请号：PCT/KR2012007656
申请日：2012-09-24
申请人： MEDICINAL BIOCONVERGENCE RES CT , KIM SUNGHOON , HAN JUNG MIN
发明人： KIM SUNGHOON , HAN JUNG MIN
IPC分类号： G01N33/15 , C12N15/113 , C12N15/63
CPC分类号： G01N33/573 , C12N15/1137 , C12N2310/14 , C12Y601/01004 , G01N33/574 , G01N2800/044
摘要： The present invention relates to novel use of leucyl tRNA synthetase and more particularly it relates a method of screening an agent for preventing or treating mTORCl mediated diseases by screening an test agent which inhibits binding ability of LRS to RagD or RagD GTPases and a method of reducing cell size compared to the control group comprising inhibiting expression of intracellular LRS. The method of the present invention provides novel method of regulating cell size and further the screening method of screening can be used in developing novel reagent for treatment of disease such as cancer.
摘要翻译：本发明涉及亮氨酸tRNA合成酶的新用途，更具体地说，涉及通过筛选抑制LRS对RagD或RagD GTP酶的结合能力的测试剂来筛选药物以预防或治疗mTORC1介导的疾病的方法，以及减少细胞大小与包含抑制细胞内LRS表达的对照组相比。本发明的方法提供了调节细胞大小的新方法，进一步的筛选方法可用于开发用于治疗诸如癌症的疾病的新型试剂。

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