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1. 发明申请

WO2010005537A2 MULTI LUMEN HEAT EXCHANGER 审中-公开
标题翻译：多功能换热器
公开(公告)号：WO2010005537A2
公开(公告)日：2010-01-14
申请号：PCT/US2009/003947
申请日：2009-07-02
申请人： SMITHS MEDICAL ASD, INC. , JOHNSON, Michael , HUGHES, Gregory
发明人： JOHNSON, Michael , HUGHES, Gregory
IPC分类号： A61F7/12 , A61M5/44
CPC分类号： F28F9/0253 , A61M5/44 , A61M2205/366 , F28D7/106
摘要： A heat exchanger has a multi-lumen tubing having one end connected to a supply fitting and another end connected to a return fitting. The tubing has a central lumen, a middle lumen that surrounds the central lumen and an outer lumen that surrounds the middle lumen. The supply fitting has an inlet, an outlet and a proximal port wherethrough an infusate is input to the heat exchanger. The supply fitting is configured such that its inlet is connected to the central lumen, its outlet connected to the outer lumen, and its proximal port connected to the middle lumen of the tubing. The return fitting is configured to establish a through passage between the central lumen and the outer lumen of the tubing so that a heating fluid fed through the supply fitting to the central lumen is returned to the supply fitting by way of the outer lumen. The return fitting further has a distal port configured to connect to the central lumen of the tubing, so that the infusate fed to the proximal port of the supply fitting may be output from the distal port of the return fitting, after passing through the central lumen of the tubing. As the infusate traverses along the heat exchanger, it is heated by the heating fluid that flows along the central lumen, and also by the rerouted heating fluid that flows along the outer lumen of the tubing. The heat exchanger is fluidly coupled to a heater by its inlet and outlet so that the temperature of the heating fluid for warming the infusate is maintained at a predetermined temperature.
摘要翻译：热交换器具有多管管，其一端连接到供应配件，另一端连接到回流配件。管道具有中心腔，围绕中心腔的中间腔和围绕中腔的外腔。供应配件具有入口，出口和近端口，通过输入口输入到热交换器。供应配件被配置成使得其入口连接到中心腔，其出口连接到外腔，并且其近端口连接到管的中间腔。返回配件构造成在管道的中心腔和外腔之间建立通道，使得通过供应配件供应到中心腔的加热流体通过外腔返回到供应配件。返回配件还具有构造成连接到管道的中心管腔的远端口，使得输送到供应配件的近端口的输液管可以在通过中央管腔之后从返回配件的远端口输出的管道。当输入物沿着热交换器穿过时，其被沿着中心腔流动的加热流体以及沿着管道的外腔流动的被重新路由的加热流体加热。热交换器通过其入口和出口流体耦合到加热器，使得用于加热输液的加热流体的温度保持在预定温度。

2. 发明申请

WO2011087484A3 PEDIATRIC UNDERBODY BLANKET 审中-公开
公开(公告)号：WO2011087484A3
公开(公告)日：2011-07-21
申请号：PCT/US2010/003212
申请日：2010-12-20
申请人： SMITHS MEDICAL ASD, INC. , PIERRE, Joseph , STARR, Rachel , HUGHES, Gregory
发明人： PIERRE, Joseph , STARR, Rachel , HUGHES, Gregory
IPC分类号： A61F7/00 , A61F7/08 , A47C21/04
摘要： An underbody convective warming blanket that may be used by a pediatric or neonate patient includes a head portion configured with multiple substantially U-shaped channels each having a plurality of adjacent rows of apertures that circumscribe the head of the patient positioned on the blanket. The adjacent rows of apertures are configured on the upper layer of the blanket so as to be positioned at an orientation or angle relative to the base plane of the blanket or the head of the patient such that those apertures would substantially face the head of the patient when the blanket is inflated, so that the heated air output from the apertures is directed substantially towards the head of the patient to thereby effect an invisible dome of heated air that envelopes the head of the patient.

3. 发明申请

WO2010107472A2 HEAT EXCHANGER CONNECTOR ASSEMBLY 审中-公开
标题翻译：热交换器连接器总成
公开(公告)号：WO2010107472A2
公开(公告)日：2010-09-23
申请号：PCT/US2010/000719
申请日：2010-03-10
申请人： SMITHS MEDICAL ASD, INC. , ANDERSEN, Eric , BAKER, David , HUGHES, Gregory , O'SHEA, Liam , SEARLE, Gary
发明人： ANDERSEN, Eric , BAKER, David , HUGHES, Gregory , O'SHEA, Liam , SEARLE, Gary
IPC分类号： F28F9/26 , A61F7/00 , A61H39/06 , F28F9/00
CPC分类号： F28F9/0246 , A61M5/44 , A61M39/10 , A61M39/105 , A61M2039/1072 , Y10S604/905
摘要： A connector assembly for a heat exchanger has a fitting and a mount to which the fitting couples. The fitting has an elongate body having a proximal portion and a distal portion. At the proximal portion there is a crossbar, and at the distal portion there are an inlet and an outlet that protrude away from the body. Two wings extend from the body in a direction opposite to that of the inlet and outlet. There is formed on each of the wings a locking protrusion. The mount has a top portion where there is a groove dimensioned to accept the crossbar of the fitting. A longitudinal channel is formed orthogonal to the groove in the mount. Two sidewalls extend from the mount each for accepting a corresponding one of the wings, when the fitting is coupled to the mount. Apertures are provided at the sidewalls to engage the protrusion at the wings so that, once the fitting is coupled to the mount, it is secured thereto, until a force is exerted to compress the wings towards each other to disengage the protrusions from the apertures. To couple the fitting to the mount, a user first positions the crossbar of the fitting onto the groove of the mount, with the body of the fitting at an angle relative to the mount. With the crossbar resting on the groove, a pivot point is established between the fitting and the mount, so that the body of the fitting can be pivotally positioned within the channel of the mount. At that time the inlet and outlet of the fitting are mated to an output port and an input port, respectively, of the mount; and the protrusions at the wings of the fitting are engaged to the apertures at the sidewalls of the mount. An infusate line and a heat exchanger are connected to the proximal end and distal end, respectively, of the fitting.
摘要翻译：用于热交换器的连接器组件具有配件和配件相配合的安装件。配件具有细长体，其具有近端部分和远端部分。在近端部分处有横杆，并且在远侧部分处具有远离身体突出的入口和出口。两个翼沿着与入口和出口相反的方向从身体延伸。在每个翼上形成有锁定突起。安装座具有顶部，其中有一个凹槽的尺寸以接受配件的横杆。纵向通道形成为与安装件中的凹槽正交。当配件联接到安装座时，两个侧壁从每个安装件延伸以接收相应的一个翼。孔设置在侧壁处以与翼部处的突起接合，使得一旦接头联接到安装件上，其被固定到其上，直到施加力以将翼片朝向彼此压缩以使突起与孔分离。为了将配件联接到安装座，用户首先将配件的横杆定位在安装件的凹槽上，使配件的主体相对于安装座成一角度。在横杆搁置在凹槽上，在配件和安装件之间建立枢轴点，使得配件的主体可以枢转地定位在安装件的通道内。此时，配件的入口和出口分别与安装座的输出端口和输入端口配合; 并且配件的翼部处的突起接合到安装件的侧壁处的孔。输液管线和热交换器分别连接到配件的近端和远端。

4. 发明申请

WO2012024100A2 PROCESS FOR PREPARING AMINOCYCLOHEXYL ETHER COMPOUNDS 审中-公开
标题翻译：制备氨基甲基醚化合物的方法
公开(公告)号：WO2012024100A2
公开(公告)日：2012-02-23
申请号：PCT/US2011/046885
申请日：2011-08-08
申请人： MERCK SHARP & DOHME CORP. , LIMANTO, John , BEUTNER, Gregory, L. , YIN, Jingjun , KLAPARS, Artis , ASHLEY, Eric, R. , STROTMAN, Hallena, R. , TRUPPO, Matthew, D. , CHUNG, Cheol, K. , HUGHES, Gregory , LIU, Zhijian , GRAU, Brendan , JANEY, Jacob
发明人： LIMANTO, John , BEUTNER, Gregory, L. , YIN, Jingjun , KLAPARS, Artis , ASHLEY, Eric, R. , STROTMAN, Hallena, R. , TRUPPO, Matthew, D. , CHUNG, Cheol, K. , HUGHES, Gregory , LIU, Zhijian , GRAU, Brendan , JANEY, Jacob
IPC分类号： C07D207/12
CPC分类号： C07D207/12 , C07C217/52 , C07D207/416 , C12P17/10
摘要： The present invention relates to a process for preparing aminocyclohexyl ether compounds of Formula I: or the pharmaceutically acceptable salts and esters thereof. In particular, the instant invention is directed towards a process for preparing (1R,2R)-2-[(3R)-Hydroxypyrrolidinyl]-1-(3,4-dimethoxyphenethoxy)-cyclohexane as well as various intermediates.
摘要翻译：本发明涉及制备式I的氨基环己基醚化合物或其药学上可接受的盐和酯的方法。特别地，本发明涉及制备（1R，2R）-2 - [（3R） - 羟基吡咯烷基] -1-（3,4-二甲氧基苯乙氧基） - 环己烷以及各种中间体的方法。

5. 发明申请

WO2009143033A1 PROCESS FOR THE PREPARATION OF AN OREXIN RECEPTOR ANTAGONIST 审中-公开
标题翻译：制备OREXIN受体拮抗剂的方法
公开(公告)号：WO2009143033A1
公开(公告)日：2009-11-26
申请号：PCT/US2009/044284
申请日：2009-05-18
申请人： MERCK & CO., INC. , MERCK FROSST CANADA LTD. , CAMPEAU, Louis-charles , HUGHES, Gregory , GAUVREAU, Danny , GIRARDIN-RONDEAU, Melina , MELLON, Christophe , MOORE, Jeffrey, C. , O'SHEA, Paul , QUELLET, Stephane, G.
发明人： CAMPEAU, Louis-charles , HUGHES, Gregory , GAUVREAU, Danny , GIRARDIN-RONDEAU, Melina , MELLON, Christophe , MOORE, Jeffrey, C. , O'SHEA, Paul , QUELLET, Stephane, G.
IPC分类号： C07D401/12 , C07D401/14 , C07D233/96
CPC分类号： C07D401/14 , C07D233/96 , C07D401/12
摘要： The present invention is directed to processes for preparing a pyridyl piperidine compound which is an antagonist of orexin receptors, and which is useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved.
摘要翻译：本发明涉及制备食欲肽受体拮抗剂的吡啶基哌啶化合物的方法，其可用于治疗或预防涉及食欲素受体的神经和精神疾病及疾病。

6. 发明申请

WO2012024104A2 BIOCATALYSTS AND METHODS FOR THE SYNTHESIS OF (1R,2R)-2-(3,4-DIMETHOXYPHENETHOXY)CYCLOHEXANAMINE 审中-公开
标题翻译：生物催化剂和（1R，2R）-2-（3,4-二甲氧基苯氧基）环己胺合成方法
公开(公告)号：WO2012024104A2
公开(公告)日：2012-02-23
申请号：PCT/US2011/046932
申请日：2011-08-08
申请人： CODEXIS, INC. , CABIROL, Fabien, L. , GOHEL, Anupam , COLLIER, Steven, J. , LIANG, Jack , MOCK, Marissa , MUNDORFF, Emily , NOVICK, Scott , LIMANTO, John , SMITH, Derek , BEUTNER, Gregory , KLAPARS, Artis , ASHLEY, Eric , STROTMAN, Hallena , TRUPPO, Matthew , HUGHES, Gregory , GRAU, Brendan , JANEY, Jacob
发明人： CABIROL, Fabien, L. , GOHEL, Anupam , COLLIER, Steven, J. , LIANG, Jack , MOCK, Marissa , MUNDORFF, Emily , NOVICK, Scott , LIMANTO, John , SMITH, Derek , BEUTNER, Gregory , KLAPARS, Artis , ASHLEY, Eric , STROTMAN, Hallena , TRUPPO, Matthew , HUGHES, Gregory , GRAU, Brendan , JANEY, Jacob
IPC分类号： C12P13/00
CPC分类号： C12P13/001 , C12N9/1096
摘要： The disclosure provides transaminase polypeptides capable of converting the substrate, 2-(3,4-dimethoxyphenethoxy)cyclohexanone to the trans diastereomer product (1R,2R)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine in at least a 2:1 diastereomeric ratio relative to the cis diastereomer (1R,2S)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine. The disclosure also provides polynucleotides, vectors, host cells, and methods of making and using the transaminase polypeptides in processes for preparing (1R,2R)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine and its analogs, which can product compounds can be further used to prepare the aminocyclohexylether compound, (3R)-1-[(1R,2R)-2-[2-(3,4-dimethoxyphenyl)ethoxy]cyclohexyl]pyrrolidin-3-ol, which is an ion channel blocker.
摘要翻译：本公开提供能够将底物2-（3,4-二甲氧基苯乙氧基）环己酮转化成反式非对映异构体产物（1R，2R）-2-（3,4-二甲氧基苯乙氧基）环己胺的转氨酶多肽以相对于顺式非对映异构体（1R，2S）-2-（3,4-二甲氧基苯乙氧基）环己胺至少2:1的非对映异构体比例。本公开还提供了用于制备（1R，2R）-2-（3,4-二甲氧基苯乙氧基）环己胺及其类似物的方法中制备和使用转氨酶多肽的多核苷酸，载体，宿主细胞和方法，进一步用于制备作为离子通道阻断剂的氨基环己基醚化合物（3R）-1 - [（1R，2R）-2- [2-（3,4-二甲氧基苯基）乙氧基]环己基]吡咯烷-3-醇。

7. 发明申请

WO2010121382A1 PROCESS FOR MAKING INDOLE CYCLOPROPYL AMIDE DERIVATIVES 审中-公开
标题翻译：制备环丙基酰胺衍生物的方法
公开(公告)号：WO2010121382A1
公开(公告)日：2010-10-28
申请号：PCT/CA2010/000626
申请日：2010-04-21
申请人： MERCK FROSST CANADA LTD. , MOLINARO, Carmela , NADEAU, Christian , HUGHES, Gregory
发明人： MOLINARO, Carmela , NADEAU, Christian , HUGHES, Gregory
IPC分类号： C07D209/08
CPC分类号： C07D209/08
摘要： An efficient and economical process for synthesizing kilogram quantities of an indole cyclopropyl amide derivative of Formula (I), or a pharmaceutically acceptable salt thereof, is disclosed. The process comprises the coupling of indolecarboxylic acid derivative 4, or its diethylamine salt, with cyclopropylamine 6 or its methanesulfonic acid salt. Compound (I) is an EP4 antagonist useful for treating prostaglandin E mediated diseases such as acute and chronic pain, osteoarthritis and rheumatoid arthritis.
摘要翻译：公开了合成千克量的式（I）的吲哚环丙基酰胺衍生物或其药学上可接受的盐的有效和经济的方法。该方法包括将吲哚羧酸衍生物4或其二乙胺盐与环丙胺6或其甲磺酸盐偶合。化合物（I）是可用于治疗前列腺素E介导的疾病如急性和慢性疼痛，骨关节炎和类风湿性关节炎的EP4拮抗剂。

8. 发明申请

WO2012177527A1 IMMOBILIZED TRANSAMINASES AND PROCESS FOR MAKING AND USING IMMOBILIZED TRANSAMINASE 审中-公开
标题翻译：固定化的多胺和制备和使用固定化的转移酶的方法
公开(公告)号：WO2012177527A1
公开(公告)日：2012-12-27
申请号：PCT/US2012/042853
申请日：2012-06-18
申请人： MERCK SHARP & DOHME CORP. , TRUPPO, Matthew, D. , JANEY, Jacob, M. , HUGHES, Gregory
发明人： TRUPPO, Matthew, D. , JANEY, Jacob, M. , HUGHES, Gregory
IPC分类号： C07K14/00 , C12Q1/52
CPC分类号： C12N9/1096 , C12N11/08 , C12P13/001 , C12P17/182 , Y02P20/52
摘要： The invention is directed to immobilized transaminases and methods of making and using them.
摘要翻译：本发明涉及固定化的转氨酶及其制备和使用方法。

9. 发明申请

WO2011005477A1 TRANSAMINASE REACTIONS 审中-公开
标题翻译：衍生物反应
公开(公告)号：WO2011005477A1
公开(公告)日：2011-01-13
申请号：PCT/US2010/039343
申请日：2010-06-21
申请人： CODEXIS, INC. , HUGHES, Gregory , DEVINE, Paul, N. , FLEITZ, Fred, J. , GRAU, Brendon, T. , LIMANTO, John , SAVILE, Christopher , MUNDORFF, Emily
发明人： HUGHES, Gregory , DEVINE, Paul, N. , FLEITZ, Fred, J. , GRAU, Brendon, T. , LIMANTO, John , SAVILE, Christopher , MUNDORFF, Emily
IPC分类号： C12N9/10 , C12P1/00
CPC分类号： C12P17/10 , C12N9/1096 , C12P13/001 , C12P13/04 , C12P17/12 , C12P17/182 , C12Y206/01 , Y02P20/52
摘要： The present disclosure relates to methods of using transaminase polypeptides in the synthesis of chiral amines from prochiral ketones.
摘要翻译：本公开涉及在由前手性酮合成手性胺时使用转氨酶多肽的方法。

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