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1. 发明申请

WO02065104A2 METHOD AND APPARATUS FOR IN-SITU SPECTROSCOTPIC DETECTION AND ANALYSIS OF POLYMORPHIC MODIFICATIONS 审中-公开
标题翻译：用于现场光谱检测和多态性改性分析的方法和装置
公开(公告)号：WO02065104A2
公开(公告)日：2002-08-22
申请号：PCT/US0204263
申请日：2002-02-13
申请人： SMITHKLINE BEECHAM CORP , WALKER DWIGHT SHEROD , WILLIAMS WESLEY BRYANT
发明人： WALKER DWIGHT SHEROD , WILLIAMS WESLEY BRYANT
IPC分类号： G01N21/85 , G01N21/35
CPC分类号： G01N21/8507
摘要： An apparatus for in-situ detection of polymorphic transformations comprising a probe body having first flow passage means and a retainer member, a screen member having second flow passage means adapted to capture at least one crystal structure of the organic compound, a cap having third flow passage means and means for introducing into the third flow passage means, the cap including first engagement means adapted to engage the retainer member, radiation transmission means for transmitting an excitation light of a given wavelength to at least a first sample of the organic compound, an outlet tube having fourth flow passage means, and pump means for providing a first flow rate of the organic compound into and through the first, second, third and fourth flow passage means.
摘要翻译：一种用于原位检测多态转化的装置，包括具有第一流动通道装置和保持器构件的探针体，筛网构件，具有适于捕获有机化合物的至少一种晶体结构的第二流动通道装置，具有第三流动的盖用于引入第三流动通道装置的通道装置和装置，其包括适于接合保持构件的第一接合装置，用于将给定波长的激发光传递至至少第一有机化合物样品的辐射传递装置，具有第四流动通道装置的出口管和用于将有机化合物的第一流量提供到第一，第二，第三和第四流动通道装置中的泵装置。

2. 发明申请

WO03032020A2 REFRACTIVE INDEX PROBE APPARATUS AND SYSTEM 审中-公开
标题翻译：折射指数探测器和系统
公开(公告)号：WO03032020A2
公开(公告)日：2003-04-17
申请号：PCT/US0231470
申请日：2002-10-03
申请人： SMITHKLINE BEECHAM CORP , BARGER LEE ALLEN , PARTRIDGE JOHN JOSEPH , WALKER DWIGHT SHEROD
发明人： BARGER LEE ALLEN , PARTRIDGE JOHN JOSEPH , WALKER DWIGHT SHEROD
IPC分类号： G01N21/41 , G01N21/43 , G02B6/00 , G02B
CPC分类号： G01N21/431
摘要： A refractive index device (10) comprising a probe member (16) having a sensing region (24) and a length of optic fiber (40) having a refract region (44) and a reflecting surface (48) disposed proximate the distal end adapted to substantially redirect said light transmitted through the fiber, the fiber being substantially disposed in the probe member wherein the refract region (44) is disposed proximate the sensing region (24).
摘要翻译：包括具有感测区域（24）的探针构件（16）和具有折射区域（44）的光纤长度（40）的折射率装置（10）和邻近所述远端设置的反射表面（48）适于以基本上重新定向透射通过纤维的所述光，所述纤维基本上设置在所述探针构件中，其中所述折射区域（44）设置在所述感测区域（24）附近。

3. 发明申请

WO03013427A3 A METHOD FOR PREPARING FLUTICASONE DERIVATIVES 审中-公开
标题翻译：一种制备氟酮衍生物的方法
公开(公告)号：WO03013427A3
公开(公告)日：2003-10-16
申请号：PCT/US0224586
申请日：2002-08-01
申请人： SMITHKLINE BEECHAM CORP , PARTRIDGE JOHN JOSEPH , WALKER DWIGHT SHEROD
发明人： PARTRIDGE JOHN JOSEPH , WALKER DWIGHT SHEROD
IPC分类号： A61P11/00 , A61P11/02 , A61P11/06 , A61P17/06 , A61P19/02 , A61P27/14 , A61P37/08 , C07J31/00 , C07J9/00 , A61K31/46 , C07J41/00
CPC分类号： C07J31/006
摘要： A method for preparing 6alpha,9alpha-difluoro-17alpha-[(2-furanylcarbonyl)oxy]-11ss-hydroxy-16alpha-methyl-3-oxoandrosta-1,4-diene-17ss-carbothioicacid S-fluoromethyl ester from a thiocarboxylic acid by reacting the thiocarboxylic acid with a solution containing chlorofluoromethane and a mild base medium at a temperature in the range of -60° C to 90° C.
摘要翻译：从硫代羧酸制备6α，9α-二氟-17α - [（2-呋喃基羰基）氧基]-11β-羟基-16α-甲基-3-氧代雄甾-1,4-二烯-17β-硫代碳酸S-氟甲酯的方法通过在-60℃至90℃的温度下使硫代羧酸与含有氯氟甲烷和温和的碱性介质的溶液反应。

4. 发明申请

WO02059599A3 SYSTEM AND METHOD FOR IN VITRO ANALYSIS OF THERAPEUTIC AGENTS 审中-公开
标题翻译：用于治疗药物体内分析的系统和方法
公开(公告)号：WO02059599A3
公开(公告)日：2003-02-06
申请号：PCT/US0202223
申请日：2002-01-25
申请人： SMITHKLINE BEECHAM CORP , WALKER DWIGHT SHEROD , PATRICK MARK AUSTIN
发明人： WALKER DWIGHT SHEROD , PATRICK MARK AUSTIN
IPC分类号： G01N33/483 , G01N21/05 , G01N21/31 , G01N21/33 , G01N27/28 , G01N27/416 , G01N33/15 , G01N33/50 , G01N33/487
CPC分类号： G01N21/05 , G01N21/31
摘要： A system and method for in vitro analysis of therapeutic agents comprising a reservoir adapted to hold a therapeutic agent, a first flow cell having a first cell chamber adapted to receive at least a first sample of the therapeutic agent, a second flow cell having a second cell chamber adapted to receive at least a second sample of the therapeutic agent, the first flow cell having a first path length (be') and the second flow cell having a second path length (be"), the first path length being substantially equal to a sensitivity factor (f) x be", a membrane chamber having a biological cell membrane therein adapted to receive at least a third sample of the therapeutic agent, the membrane chamber being further adapted to detect the membrane potential of the biological cell membrane; and spectroscopic detection means for detecting the spectral characteristics of the first and second therapeutic agent samples.
摘要翻译：一种用于体外分析治疗剂的系统和方法，所述治疗剂包括适于保持治疗剂的储存器，具有适于接收所述治疗剂的至少第一样品的第一细胞室的第一流动池，具有第二流体池所述第一流动池具有第一路径长度（be'），所述第二流动池具有第二路径长度（be“），所述第一路径长度基本相等对于敏感性因子（f）x为“，具有其中适于接收至少第三样品的治疗剂的生物细胞膜的膜室，所述膜室还适于检测所述生物细胞膜的膜电位; 以及用于检测第一和第二治疗剂样品的光谱特性的光谱检测装置。

5. 发明申请

WO2008063938A3 METHOD AND SYSTEM FOR EVALUATING GASTROINTESTINAL MOTILITY 审中-公开
标题翻译：评价气体动力学的方法与系统
公开(公告)号：WO2008063938A3
公开(公告)日：2008-08-21
申请号：PCT/US2007084378
申请日：2007-11-12
申请人： SMITHKLINE BEECHAM CORP , WALKER DWIGHT SHEROD
发明人： WALKER DWIGHT SHEROD
IPC分类号： A61N1/18
CPC分类号： A61B7/008 , A61B5/42 , A61B5/6805 , A61B7/04
摘要： A system and method for evaluating gastrointestinal motility that can be effectively employed to acquire one or more signals associated with acoustic energy (i.e. sound) emanating from an abdominal region of a body and determine at least one gastrointestinal parameter based on the acoustic energy signal(s) is described. The gastrointestinal parameter can include a gastrointestinal event, including gastrointestinal mixing, emptying, contraction and propulsion, and gastrointestinal transit time.
摘要翻译：一种用于评估胃肠运动性的系统和方法，其可以有效地用于获取与从身体的腹部区域发出的声能（即声音）相关联的一个或多个信号，并基于声能信号确定至少一个胃肠参数）。胃肠道参数可以包括胃肠道事件，包括胃肠道混合，排空，收缩和推进，以及胃肠通过时间。

6. 发明申请

WO03032020A9 REFRACTIVE INDEX PROBE APPARATUS AND SYSTEM 审中-公开
标题翻译：折射指数探测器和系统
公开(公告)号：WO03032020A9
公开(公告)日：2004-05-06
申请号：PCT/US0231470
申请日：2002-10-03
申请人： SMITHKLINE BEECHAM CORP , BARGER LEE ALLEN , PARTRIDGE JOHN JOSEPH , WALKER DWIGHT SHEROD
发明人： BARGER LEE ALLEN , PARTRIDGE JOHN JOSEPH , WALKER DWIGHT SHEROD
IPC分类号： G01N21/41 , G01N21/43 , G02B6/00 , G01B9/00
CPC分类号： G01N21/431
摘要： A refractive index device (10) comprising a probe member (16) having a sensing region (24) and a length of optic fiber (40) having a refract region (44) and a reflecting surface (48) disposed proximate the distal end adapted to substantially redirect said light transmitted through the fiber, the fiber being substantially disposed in the probe member wherein the refract region (44) is disposed proximate the sensing region (24).
摘要翻译：包括具有感测区域（24）的探针构件（16）和具有折射区域（44）的光纤长度（40）的折射率装置（10）和邻近所述远端设置的反射表面（48）适于以基本上重新定向透射通过纤维的所述光，所述纤维基本上设置在所述探针构件中，其中所述折射区域（44）设置在所述感测区域（24）附近。

7. 发明申请

WO2007098392A3 METHOD AND SYSTEM FOR CHEMICAL SPECIFIC SPECTRAL ANALYSIS 审中-公开
标题翻译：化学光谱分析方法与系统
公开(公告)号：WO2007098392A3
公开(公告)日：2008-09-18
申请号：PCT/US2007062294
申请日：2007-02-16
申请人： GLAXO GROUP LTD , WALKER DWIGHT SHEROD
发明人： WALKER DWIGHT SHEROD
IPC分类号： G01J5/02
CPC分类号： G01N21/359 , G01N21/3563 , G01N21/3577
摘要： A method for chemical specific spectral analysis of a pharmaceutical composition (100) comprising the steps of transmitting light having a wavelength in the range of 800 - 2500 nm to a pharmaceutical composition, whereby the pharmaceutical composition interacts with the transmitted light, the interaction including the emission of a first light, directing the first light to a first multi-optical element (14) adapted to selectively pass a predetermined first fraction of the first light to pass there through, the first light fraction corresponding to the absorbance spectrum of an active contained in the pharmaceutical composition, and directing the first light fraction to a first NIR camera (16a) adapted to receive the first light fraction and provide a first NIR image of the pharmaceutical composition.
摘要翻译：一种用于药物组合物（100）的化学特异性光谱分析的方法，包括以下步骤：将波长在800-2500nm范围内的光透射到药物组合物，由此药物组合物与透射光相互作用，包括发射第一光，将第一光引导到适于选择性地通过第一光的预定第一部分以通过其中的第一多光学元件（14），与包含的活性物质的吸收光谱相对应的第一轻馏分并且将第一轻馏分引导到适于接收第一轻馏分并提供药物组合物的第一近红外图像的第一近红外照相机（16a）。

8. 发明申请

WO0129537A3 METHOD AND APPARATUS FOR MONITORING SOLID PHASE CHEMICAL REACTIONS 审中-公开
标题翻译：用于监测固体相化学反应的方法和装置
公开(公告)号：WO0129537A3
公开(公告)日：2001-11-29
申请号：PCT/US0028218
申请日：2000-10-12
申请人： GLAXO GROUP LTD , ANDERSON JOANNE ELIZABETH , TARCZYNSKI FRANK JOSEPH , WALKER DWIGHT SHEROD
发明人： ANDERSON JOANNE ELIZABETH , TARCZYNSKI FRANK JOSEPH , WALKER DWIGHT SHEROD
IPC分类号： G01N21/75 , B01J19/00 , C07B61/00 , C40B20/08 , C40B30/10 , C40B60/04 , C40B60/14 , G01N21/25 , G01N21/27 , G01N21/55 , G01N21/64
CPC分类号： G01N21/253 , B01J19/0046 , B01J2219/00313 , B01J2219/00315 , B01J2219/005 , B01J2219/00596 , B01J2219/00691 , B01J2219/00693 , B01J2219/00695 , B01J2219/00702 , B01J2219/0072 , C40B60/14 , G01N21/552
摘要： A method for monitoring a solid phase chemical reaction comprises the steps of: (a) providing a reaction mixture comprising a solid support and a reaction medium, (b) contacting an attenuated total reflection element to said reaction mixture; and then (c) monitoring the chemical reaction on the solid support through the attenuated total reflection element. The monitoring step is carried out by attenuated total reflection spectroscopy. An advantage of the invention is that the chemical reaction on the solid support may be directly monitored, rather than indirectly monitoring that chemical reaction by monitoring reaction constituents in the reaction medium.
摘要翻译：用于监测固相化学反应的方法包括以下步骤：（a）提供包含固体支持物和反应介质的反应混合物，（b）将减毒的全反射元件与所述反应混合物; 然后（c）通过衰减的全反射元件监测固体支持物上的化学反应。监测步骤由衰减全反射光谱法进行。本发明的一个优点是可以直接监测对固体支持物的化学反应，而不是通过监测反应介质中的反应组分来间接监测该化学反应。

9. 发明申请

WO2012078291A8 METHOD OF DETERMINING CLEANLINESS 审中-公开
标题翻译：确定清洁度的方法
公开(公告)号：WO2012078291A8
公开(公告)日：2013-04-18
申请号：PCT/US2011059849
申请日：2011-11-09
申请人： GLAXO GROUP LTD , CROWDER TIMOTHY M , DICKENS JASON E , ELY KEVIN J , WALKER DWIGHT SHEROD
发明人： CROWDER TIMOTHY M , DICKENS JASON E , ELY KEVIN J , WALKER DWIGHT SHEROD
IPC分类号： G01N21/03
CPC分类号： G01N21/64 , B08B1/00 , G01N21/25 , G01N21/65 , G01N21/76 , G01N33/00 , G01N2001/028 , G01N2201/0221
摘要： A method of determining cleanliness of a manufacturing area is disclosed. The method of determining cleanliness of a manufacturing area comprising swabbing at least one target area within the manufacturing area, placing the swab in a testing apparatus, analyzing for the presence of the at least one substance with the testing apparatus and determining in real time the cleanliness of the manufacturing area.
摘要翻译：公开了一种确定制造区域的清洁度的方法。确定制造区域的清洁度的方法，包括在制造区域内擦拭至少一个目标区域，将拭子放置在测试装置中，用测试装置分析至少一种物质的存在并实时确定清洁度的制造区域。

10. 发明申请

WO0181899A3 METHOD AND APPARATUS FOR IN-SITU SPECTROSCOPIC ANALYSIS 审中-公开
标题翻译：用于现场光谱分析的方法和装置
公开(公告)号：WO0181899A3
公开(公告)日：2002-03-28
申请号：PCT/US0113511
申请日：2001-04-26
申请人： GLAXO GROUP LTD , WALKER DWIGHT SHEROD , BARGER LEE A
发明人： WALKER DWIGHT SHEROD , BARGER LEE A
IPC分类号： G01N21/03 , G01N21/05
CPC分类号： G01N21/0303 , G01N21/05 , G01N2021/0346
摘要： A method and apparatus for in-situ spectroscopic analysis of a flowable material comprising a flow cell having a flow passage and means for introducing the flowable material into the flow passage, first probe means for transmitting a given wavelength of light into the flow passage, second probe means for detecting the emission light from the flowable material, and control means for providing the light to the first probe means and analyzing the emission light detected by the second probe means. The first and second probe means include optic means that project into a region of reasonable flow in the flow passage. The first and second probe means also have a path length in the range of 1 mu m to 10 mm.
摘要翻译：一种用于对可流动材料进行原位光谱分析的方法和装置，包括具有流动通道的流动池和用于将可流动材料引入流动通道的装置，用于将给定波长的光传输到流动通道中的第一探针装置，第二用于检测来自可流动材料的发射光的探测装置和用于将光提供给第一探测装置并分析由第二探测装置检测的发射光的控制装置。第一和第二探针装置包括投射到流动通道中合理流动区域的光学装置。第一和第二探针装置还具有在1μm至10mm范围内的路径长度。

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