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1. 发明申请

WO2007067829A3 DRUG DELIVERY SYSTEMS 审中-公开
公开(公告)号：WO2007067829A3
公开(公告)日：2007-06-14
申请号：PCT/US2006/060266
申请日：2006-10-26
申请人： SMALDONE, Gerald, C.
发明人： SMALDONE, Gerald, C.
IPC分类号： A62B18/02
摘要： A pressurized drug delivery system includes a source of HELIOX; a nebulizer device operatively and fluidly connected to the source of HELIOX; and a face mask fluidly connected to the source of HELIOX for delivering a nebulizer charge to a patient. The face mask is constructed and includes a venting feature such that less than a predetermined quantity of the nebulizer charge is deposited in eye regions of the patient.

2. 发明申请

WO2002094361A1 FACE MASKS FOR USE IN PRESSURIZED DRUG DELIVERY SYSTEMS 审中-公开
标题翻译：用于加压药物输送系统的面罩
公开(公告)号：WO2002094361A1
公开(公告)日：2002-11-28
申请号：PCT/US2002/015852
申请日：2002-05-17
申请人： SMALDONE, Gerald, C.
发明人： SMALDONE, Gerald, C.
IPC分类号： A61M16/06
CPC分类号： A61M16/06 , A61M15/00
摘要： Face masks (170) for use in pressurized drug delivery applications, such as aerosol drug delivery systems, and a method of reducing aerosol deposition in the region of the eyes are presented. The face masks according to the various embodiments disclosed herein contain features (150) that reduce the inertia of the aerosolized drug in perinasal ares. This results in a reduction in the amount of aerosolized that is deposited in the region of the eyes by inertial impaction, while at the same time, the features (150) are constructed to maintain the flow of the aerosolized drug into the face mask so that the aerosolized drug is effectively delivered to the respiratory system of the patient.
摘要翻译：提出了用于加压药物递送应用的口罩（170），例如气雾剂药物递送系统，以及减少眼睛区域中的气溶胶沉积的方法。根据本文公开的各种实施方案的面罩包含减少鼻腔中雾化药物的惯性的特征（150）。这导致通过惯性冲击而沉积在眼睛区域中的雾化量减少，而同时，特征（150）被构造成保持雾化的药物流入面罩，使得雾化药物被有效地输送到患者的呼吸系统。

3. 发明申请

WO2005041820A2 FACE MASKS FOR USE IN PRESSURIZED DRUG DELIVERY SYSTEMS 审中-公开
标题翻译：用于加压药物输送系统的面罩
公开(公告)号：WO2005041820A2
公开(公告)日：2005-05-12
申请号：PCT/US2004/036435
申请日：2004-10-29
申请人： SMALDONE, Gerald, C.
发明人： SMALDONE, Gerald, C.
IPC分类号： A61F
CPC分类号： A61M16/06 , A61M11/00 , A61M15/00 , A61M16/0616
摘要： Face masks for use in pressurized drug delivery applications, such as aerosol drug delivery systems, and a method of reducing aerosol deposition in the region of the eyes are presented. The face masks according to the various embodiments disclosed herein contain features that reduce the inertia of the aerosolized drug in perinasal areas. This results in a reduction in the amount of aerosolized drug that is deposited in the region of the eyes by inertial impaction, while at the same time, the features are constructed to maintain the flow of the aerosolized drug into the face mask so that the aerosolized drug is effectively delivered to the respiratory system of the patient.
摘要翻译：提出了用于加压药物递送应用的口罩，例如气雾剂药物递送系统，以及减少眼睛区域气溶胶沉积的方法。根据本文公开的各种实施方案的面罩包含降低鼻膜区域中气雾化药物的惯性的特征。这导致通过惯性冲击而沉积在眼睛区域中的气雾化药物的量减少，同时构建特征以保持雾化药物流入面罩，使得气雾化的药物有效输送到患者的呼吸系统。

4. 发明申请

WO2004071368A3 METHODS, DEVICES AND FORMULATIONS FOR TARGETED ENDOBRONCHIAL THERAPY 审中-公开
公开(公告)号：WO2004071368A3
公开(公告)日：2004-08-26
申请号：PCT/US2003/014708
申请日：2003-05-07
申请人： THE STATE UNIVERSITY OF NEW YORK AT STONY BROOK , SMALDONE, Gerald, C. , PALMER, Lucy, B
发明人： SMALDONE, Gerald, C. , PALMER, Lucy, B
IPC分类号： A61M16/00
摘要： The present invention provides an improved means of treating tracheobronchitis, bronchiectasis and pneumonia in the nosocomial patient, preferably with aerosolized anti gram-positive and anti-gram negative antibiotics administered in combination or in seriatim in reliably sufficient amounts for therapeutic effect. In one aspect, the invention assures this result when aerosol is delivered into the ventilator circuit. In one embodiment the result is achieved mechanically. In another embodiment, the result is achieved by aerosol formulation. In another aspect, the invention assures the result when aerosol is delivered directly to the airways distal of the ventilator circuit. The treatment means eliminates the dosage variability that ventilator systems engender when aerosols are introduced via the ventilator circuit. The treatment means also concentrates the therapeutic agent specifically at affected sites in the lung such that therapeutic levels of administrated drug are achieved without significant systemic exposure of the patient to the drug. The invention further provides a dose control device to govern this specialized regimen.

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