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    • 1. 发明申请
    • REDUCING COUPLING COEFFICIENT VARIATION IN COUPLERS
    • 降低耦合器中的耦合系数变化
    • WO2012016087A2
    • 2012-02-02
    • PCT/US2011/045799
    • 2011-07-28
    • SKYWORKS SOLUTIONS, INC.LI, YangZHU, XuanangHOANG, Dinhphuoc, V.ZHANG, GuohaoREISNER, RussPRIKHODKO, DmitriGUO, Jiunn-ShengSCOLES, Bradley, D.VIVEIROS, David
    • LI, YangZHU, XuanangHOANG, Dinhphuoc, V.ZHANG, GuohaoREISNER, RussPRIKHODKO, DmitriGUO, Jiunn-ShengSCOLES, Bradley, D.VIVEIROS, David
    • H01P5/04H01P5/08H01P5/12
    • H01P5/184H01P5/185H01P5/187Y10T29/49002Y10T29/49169Y10T29/49208
    • A number of couplers are presented that have high-directivity and low coupling coefficient variation. One such coupler includes a first trace associated with a first port and a second port. The first trace includes a first main arm, a first connecting trace connecting the first main arm to the second port, and a non-zero angle between the first main arm and the first connecting trace. Further, the coupler includes a second trace associated with a third port and a fourth port. The second trace includes a second main arm. Another such coupler includes a first trace with a first edge substantially parallel to a second edge and substantially equal in length to the second edge. The first trace includes a third edge substantially parallel to a fourth edge. The fourth edge is divided into three segments. The outer segments are a first distance from the third edge. The middle segment is a second distance from the third edge. Further, the coupler includes a second trace, which includes a first edge substantially parallel to a second edge and substantially equal in length to the second edge. The second trace includes a third edge substantially parallel to a fourth edge. The fourth edge is divided into three segments. The outer segments are a first distance from the third edge. The middle segment is a second distance from the third edge. Another such coupler includes a first trace associated with a first port and a second port. The first port is configured substantially as an input port and the second port is configured substantially as an output port. The coupler further includes a second trace associated with a third port and a fourth port. The third port is configured substantially as a coupled port and the fourth port is configured substantially as an isolated port. In addition, the coupler includes a first capacitor configured to introduce a discontinuity to induce a mismatch in the coupler.
    • 提出了许多具有高方向性和低耦合系数变化的耦合器。 一个这样的耦合器包括与第一端口和第二端口相关联的第一迹线。 第一轨迹包括第一主臂,将第一主臂连接到第二端口的第一连接迹线以及第一主臂和第一连接迹线之间的非零角度。 此外,耦合器包括与第三端口和第四端口相关联的第二迹线。 第二条曲线包括第二条主臂。 另一个这样的耦合器包括第一迹线,第一迹线具有基本上平行于第二边缘的第一边缘并且与第二边缘的长度基本相等。 第一迹线包括基本平行于第四边缘的第三边缘。 第四条边被分成三段。 外部分是距第三边缘的第一距离。 中间部分距第三边缘第二距离。 此外,耦合器包括第二迹线,该第二迹线包括基本上平行于第二边缘并且长度基本上与第二边缘相等的第一边缘。 第二轨迹包括基本平行于第四边缘的第三边缘。 第四条边被分成三段。 外部分是距第三边缘的第一距离。 中间部分距第三边缘第二距离。 另一个这样的耦合器包括与第一端口和第二端口相关联的第一迹线。 第一端口基本上被配置为输入端口,第二端口基本上被配置为输出端口。 该耦合器还包括与第三端口和第四端口相关联的第二迹线。 第三端口实质上配置为耦合端口,并且第四端口实质上配置为隔离端口。 此外,该耦合器包括第一电容器,该第一电容器被配置为引入不连续性以引起耦合器中的不匹配。
    • 7. 发明申请
    • A SHEET FORMING TOOL AND A METHOD FOR THE MANUFACTURE OF A CORRUGATED SHEET
    • 一种成型工具及其制造方法
    • WO2013010293A1
    • 2013-01-24
    • PCT/CN2011/001197
    • 2011-07-21
    • SULZER CHEMTECH AGCHIN, KimwahSHENG, XiaoleiLI, YangCHOTHUTSHANG, Lhoden
    • CHIN, KimwahSHENG, XiaoleiLI, YangCHOTHUTSHANG, Lhoden
    • B21D13/02B31F1/20B29C53/22B29C53/24
    • B21D13/02B21D13/10B29C53/24B31F1/247Y10T428/12354
    • A sheet forming tool (1) for the manufacture of a corrugated sheet has a lower tool element (40) and an upper tool element (50), each of the upper tool element and the lower tool element having a front side (23, 33, 41) and a rear side (25, 35, 42). The lower tool element (40) comprises a first base element (2, 4, 6, 8) and a first finger element (3, 5, 7, 9) projecting from said first base element (2, 4, 6, 8). The first finger element (3, 5, 7, 9) forms a first ridge (22, 24, 26, 28) for forming a corrugation peak in the sheet. The upper tool element (50) comprises a second base element (12, 14) and a second finger element (13, 15) projecting from said second base element (12, 14), the second finger element (13, 15) forming a second ridge (32, 34) for forming a corrugation trough in said sheet. The first ridge (22, 24, 26, 28) is arranged opposite to the second ridge (32, 34) and the first ridge (22, 24, 26, 28) is offset from the second ridge (32, 34) so as to allow for an engagement of the first finger element (3, 5, 7, 9) and the second finger element (13, 15) in an engaged position. Each of the first ridge (22, 24, 26, 28) and second ridge (32, 34) comprises a main portion (20) and an end portion (11, 21) and the angle β (36) between each of the first ridge (22, 24, 26, 28) and second ridge (32, 34) in the main portion (20) and the corresponding front side (23, 33, 41 ) is at least partly different from the angle between each of the first ridge (22, 24, 26, 28) and second ridge (32, 34) in the end portion (11, 21) and the corresponding front side and a space is provided between the first finger element (3, 5, 7, 9) and the neighbouring second finger element (13, 15) in the engaged position.
    • 用于制造波纹片的片材成形工具(1)具有下部工具元件(40)和上部工具元件(50),上部工具元件和下部工具元件中的每一个具有前侧(23,33 ,41)和后侧(25,35,42)。 下部工具元件(40)包括第一基座元件(2,4,6,8)和从所述第一基座元件(2,4,6,8)伸出的第一指状元件(3,5,7,9) 。 第一指状元件(3,5,7,9)形成用于在片材中形成波纹峰的第一脊(22,24,26,28)。 上部工具元件(50)包括第二基本元件(12,14)和从所述第二基础元件(12,14)突出的第二指状元件(13,15),所述第二指状元件(13,15)形成 用于在所述片材中形成波纹槽的第二脊部(32,34)。 第一脊(22,24,26,28)与第二脊(32,34)相对设置,第一脊(22,24,26,28)从第二脊(32,34)偏移,以便 以允许第一手指元件(3,5,7,9)和第二手指元件(13,15)接合在接合位置。 第一脊部(22,24,26,28)和第二脊部(32,34)中的每一个包括主要部分(20)和端部部分(11,21),并且第一脊部(22,24,26,28)和第二脊部 主部分(20)中的脊(22,24,26,28)和第二脊(32,34)与相应的前侧(23,33,41)之间的角度至少部分地不同于第一 在第一手指元件(3,5,7,9)之间设置有端部(11,21)中的脊部(22,24,26,28)和第二脊部(32,34)和相应的前侧以及空间, )和相邻的第二手指元件(13,15)处于接合位置。
    • 8. 发明申请
    • HUMAN FGF RECEPTOR AND β-KLOTHO BINDING PROTEINS
    • 人FGF受体和ß-KLOTHO结合蛋白
    • WO2011130417A2
    • 2011-10-20
    • PCT/US2011/032333
    • 2011-04-13
    • AMGEN INC.FACHINI, RogerFOLTZ, IanHAN, Seog JoonHARRIS, Susie MikiHU, Shaw-Fen SylviaKING, Chadwick TerenceLI, YangLU, JiMICHAELS, Mark LeoSUN, Jeonghoon
    • FACHINI, RogerFOLTZ, IanHAN, Seog JoonHARRIS, Susie MikiHU, Shaw-Fen SylviaKING, Chadwick TerenceLI, YangLU, JiMICHAELS, Mark LeoSUN, Jeonghoon
    • C07K16/28
    • A61K39/3955C07K16/2863C07K16/40C07K2317/21C07K2317/31C07K2317/32C07K2317/75C07K2317/92C07K2319/75
    • The present invention provides compositions and methods relating to or derived from antigen binding proteins and antigen binding protein-FGF21 fusions that specifically bind to β-Klotho, or β-Klotho and one or more of FGFR1c, FGFR2c, FGFR3c, and FGFR4. In some embodiments the antigen binding proteins and antigen binding protein-FGF21 fusions induce FGF21-like signaling. In some embodiments, an antigen binding protein or antigen binding protein-FGF21 fusion antigen binding component is a fully human, humanized, or chimeric antibody, binding fragments and derivatives of such antibodies, and polypeptides that specifically bind to β-Klotho, or β-Klotho and one or more of FGFR1c, FGFR2c, FGFR3c, and FGFR4. Other embodiments provide nucleic acids encoding such antigen binding proteins and antigen binding protein-FGF21 fusions, and fragments and derivatives thereof, and polypeptides, cells comprising such polynucleotides, methods of making such antigen binding proteins and antigen binding protein-FGF21 fusions, and fragments and derivatives thereof, and polypeptides, and methods of using such antigen binding proteins and antigen binding protein-FGF21 fusions, fragments and derivatives thereof, and polypeptides, including methods of treating or diagnosing subjects suffering from type 2 diabetes, obesity, NASH, metabolic syndrome and related disorders or conditions.
    • 本发明提供与抗原结合蛋白和特异性结合ß-Klotho或ß-Klotho以及FGFR1c,FGFR2c,FGFR3c和FGFR4中的一种或多种的抗原结合蛋白和抗原结合蛋白-FGF21融合物相关或衍生的组合物和方法。 在一些实施方案中,抗原结合蛋白和抗原结合蛋白FGF21融合物诱导FGF21样信号传导。 在一些实施方案中,抗原结合蛋白或抗原结合蛋白-FGF21融合抗原结合组分是完全人,人源化或嵌合抗体,这种抗体的结合片段和衍生物,以及特异性结合ß-Klotho或ß- Klotho和FGFR1c,FGFR2c,FGFR3c和FGFR4中的一种或多种。 其他实施方案提供编码这种抗原结合蛋白和抗原结合蛋白-FGF21融合体的核酸,及其片段和衍生物,以及多肽,包含这种多核苷酸的细胞,制备这种抗原结合蛋白的方法和抗原结合蛋白-FGF21融合物, 其衍生物和多肽,以及使用这种抗原结合蛋白和抗原结合蛋白-FGF21融合体,其片段和衍生物和多肽的方法,包括治疗或诊断患有2型糖尿病,肥胖症,NASH,代谢综合征和 相关疾病或病症。