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1. 发明申请

WO2006135894A1 COMPOSITIONS AND METHODS FOR TREATING INFLAMMATORY CONDITIONS 审中-公开
标题翻译：用于治疗炎症条件的组合物和方法
公开(公告)号：WO2006135894A1
公开(公告)日：2006-12-21
申请号：PCT/US2006/023022
申请日：2006-06-13
申请人： SIGNUM BIOSCIENCES, INC. , STOCK, Jeffry, B. , GORDON, Joel , STOCK, Maxwell , STOCK, Gregory
发明人： STOCK, Jeffry, B. , GORDON, Joel , STOCK, Maxwell , STOCK, Gregory
IPC分类号： C12Q1/48 , C07C319/00
CPC分类号： A61K31/198 , A61K8/46 , A61K31/20 , A61K45/06 , A61K2800/75 , A61K2800/782 , A61Q19/00 , C07C323/59
摘要： The present invention relates to compositions containing signal transduction modulator compounds, to methods for treating or preventing inflammation, or promoting healthy joints, using the compounds and to kits for the same.
摘要翻译：本发明涉及含有信号转导调节剂化合物的组合物，用于治疗或预防炎症或促进健康关节的方法，使用该化合物和用于其的试剂盒。

2. 发明申请

WO2009132051A1 COMPOUNDS, COMPOSITIONS AND METHODS FOR MAKING THE SAME 审中-公开
标题翻译：化合物，组合物及其制备方法
公开(公告)号：WO2009132051A1
公开(公告)日：2009-10-29
申请号：PCT/US2009/041321
申请日：2009-04-21
申请人： SIGNUM BIOSCIENCES, INC. , VORONKOV, Michael , VAFAI, Scott , STOCK, Maxwell , STOCK, Jeffry, B. , LI, Zhu , LEE, Seung-yub , GU, Haoming , SARNGADHARAN, Gopal
发明人： VORONKOV, Michael , VAFAI, Scott , STOCK, Maxwell , STOCK, Jeffry, B. , LI, Zhu , LEE, Seung-yub , GU, Haoming , SARNGADHARAN, Gopal
IPC分类号： A61K31/405
CPC分类号： A61K31/405
摘要： The present invention provides compounds and/or compositions that modulate PP2A methylation and/or activity and methods for preparing the same, which are useful for modulating the demethylation of PP2A, modulating the methylation of PP2 A and/or modulating the activity of PP2A.
摘要翻译：本发明提供调节PP2A甲基化和/或活性的化合物和/或组合物及其制备方法，其可用于调节PP2A的去甲基化，调节PP2A的甲基化和/或调节PP2A的活性。

3. 发明申请

WO2009073665A1 ACID MIMIC COMPOUNDS FOR THE INHIBITION OF ISOPRENYL-S-CYSTEINYL METHYLTRANSFERASE 审中-公开
标题翻译：用于抑制异丙基-β-半胱氨酸甲基转移酶的酸性模拟化合物
公开(公告)号：WO2009073665A1
公开(公告)日：2009-06-11
申请号：PCT/US2008/085274
申请日：2008-12-02
申请人： SIGNUM BIOSCIENCES, INC. , LEE, Seung-Yub , PEREZ, Eduardo , RAPOLE, Keshava , SARNGADHARAN, Gopal , STOCK, Gregory, B. , STOCK, Jeffry, B. , STOCK, Maxwell , VORONKOV, Michael , WOLANIN, Peter
发明人： LEE, Seung-Yub , PEREZ, Eduardo , RAPOLE, Keshava , SARNGADHARAN, Gopal , STOCK, Gregory, B. , STOCK, Jeffry, B. , STOCK, Maxwell , VORONKOV, Michael , WOLANIN, Peter
IPC分类号： A01N37/12 , A01N37/44 , A61K31/195
CPC分类号： C07D231/12 , C07C323/60 , C07D233/61 , C07D235/14 , C07D249/04 , C07D249/08 , C07D257/04
摘要： Among other things, the present invention provides novel compounds capable of effectively inhibiting inflammatory responses that are mediated by G-proteins or GPCRs in neutrophils, macrophages and platelets. In particular, compounds of the present invention act as inhibitors of edema, inhibitors of erythema and inhibitors of MPO (myeloperoxidase), pharmaceutical compositions containing the same compounds and the use thereof for the treatment of diseases that may benefit from edema, erythema and MPO inhibition, such as inflammation (acute or chronic), asthma, autoimmune diseases, and chronic obstructive pulmonary disease (COPD) (e.g., emphysema, chronic bronchitis and small airways disease, etc.), inflammatory responses of the immune system, skin diseases (e.g., reducing acute skin irritation for patients suffering from rosacea, atopic dermatitis, seborrheic dermatitis, psoriasis), irritable bowel syndrome (e.g., Chron's disease and ulcerative colitis, etc.), and central nervous system disorders (e.g., Parkinson's disease).
摘要翻译：除其他之外，本发明提供了能够有效地抑制由嗜中性粒细胞，巨噬细胞和血小板中的G-蛋白或GPCR介导的炎症反应的新型化合物。具体而言，本发明化合物用作水肿抑制剂，红斑抑制剂和MPO抑制剂（髓过氧化物酶），含有相同化合物的药物组合物及其用于治疗可受益于水肿，红斑和MPO抑制的疾病，例如炎症（急性或慢性），哮喘，自身免疫性疾病和慢性阻塞性肺病（COPD）（例如肺气肿，慢性支气管炎和小气道疾病等），免疫系统的炎症反应，皮肤病（例如，减轻患有红斑痤疮，特应性皮炎，脂溢性皮炎，银屑病的患者的急性皮肤刺激），肠易激综合征（例如克伦氏病和溃疡性结肠炎等）和中枢神经系统疾病（例如帕金森病） p>

4. 发明申请

WO2011060330A1 USE OF ANTI-BACTERIAL AGENTS FOR THE TREATMENT OF EPITHELIAL-RELATED CONDITIONS 审中-公开
标题翻译：使用抗细菌剂治疗上皮相关病症
公开(公告)号：WO2011060330A1
公开(公告)日：2011-05-19
申请号：PCT/US2010/056624
申请日：2010-11-12
申请人： SIGNUM BIOSCIENCES, INC. , STOCK, Jeffry, B. , STOCK, Maxwell
发明人： STOCK, Jeffry, B. , STOCK, Maxwell
IPC分类号： A01N37/18 , A61K31/165
CPC分类号： A61K38/05 , A61K9/0014 , A61K9/007 , A61K31/165 , A61K31/198 , A61K31/341 , A61K31/381 , A61K31/4045 , A61K31/5375 , Y02A50/478 , Y02A50/481
摘要： Disclosed herein are methods of inactivating and/or decolonizing bacteria on a surface. The present invention also discloses methods for treatment of epithelial conditions caused or aggravated by bacteria, such as acne vulgaris, in a subject in need thereof. The present invention additionally discloses inventive compounds and compositions that exhibit anti-bacterial and/or anti-inflammatory effects.
摘要翻译：本文公开了在表面上灭活和/或非殖民细菌的方法。本发明还公开了在有需要的受试者中治疗由细菌如寻常痤疮引起或加重的上皮状况的方法。本发明还公开了具有抗细菌和/或抗炎作用的本发明化合物和组合物。

5. 发明申请

WO2005123103A1 TOPICAL COMPOSITIONS AND METHODS FOR EPITHELIAL-RELATED CONDITIONS 审中-公开
标题翻译：用于上传相关条件的主题组合物和方法
公开(公告)号：WO2005123103A1
公开(公告)日：2005-12-29
申请号：PCT/US2005/020555
申请日：2005-06-13
申请人： SIGNUM BIOSCIENCES, INC. , STOCK, Jeffry B. , GORDON, Joel , STOCK, Maxwell , STOCK, Gregory
发明人： STOCK, Jeffry B. , GORDON, Joel , STOCK, Maxwell , STOCK, Gregory
IPC分类号： A61K38/00
CPC分类号： A61K31/198 , A61K8/447 , A61K8/46 , A61K8/4926 , A61K8/496 , A61K9/0014 , A61K2800/75 , A61Q5/006 , A61Q19/00 , A61Q19/007 , A61Q19/08
摘要： The present invention relates to pharmaceutical, cosmetic and cosmeceutical topical compositions containing polyisoprenyl-protein inhibitor compounds and methods useful in the promotion of healthy epithelium and the treatment of epithelial-related conditions.
摘要翻译：本发明涉及包含聚异戊二烯基蛋白抑制剂化合物的药物，化妆品和药妆外用组合物以及用于促进健康上皮和治疗上皮相关病症的方法。

6. 发明申请

WO2010090845A1 ANTI-INFLAMMATORY COMPLEXES 审中-公开
标题翻译：抗炎药物复合物
公开(公告)号：WO2010090845A1
公开(公告)日：2010-08-12
申请号：PCT/US2010/021544
申请日：2010-01-20
申请人： SIGNUM BIOSCIENCES, INC. , VORONKOV, Michael , STOCK, Jeffry, B. , STOCK, Maxwell , LEE, Seung-Yub , PEREZ, Eduardo , GORDON, Joel, S.
发明人： VORONKOV, Michael , STOCK, Jeffry, B. , STOCK, Maxwell , LEE, Seung-Yub , PEREZ, Eduardo , GORDON, Joel, S.
IPC分类号： C07C319/00
CPC分类号： C07C323/59 , A61K31/198 , C07D209/48 , Y02A50/478
摘要： Disclosed are certain complexes of AFC compounds and binding agents. Such complexes are useful, among other things, in the treatment of inflammatory diseases or disorders.
摘要翻译：公开了一些AFC化合物和结合剂的复合物。除了别的以外，这种复合物可用于治疗炎性疾病或病症。

7. 发明申请

WO2010056778A1 ISOPRENYL COMPOUNDS AND METHODS THEREOF 审中-公开
标题翻译：异丙苯化合物及其方法
公开(公告)号：WO2010056778A1
公开(公告)日：2010-05-20
申请号：PCT/US2009/064077
申请日：2009-11-11
申请人： SIGNUM BIOSCIENCES, INC. , STOCK, Jeffry, B. , STOCK, Maxwell , RAPOLE, Keshava , LEE, Seung-yub , VORONKOV, Michael , PEREZ, Eduardo , CHEN, Shuyi , CHEN, Jinglong , GORDON, Joel
发明人： STOCK, Jeffry, B. , STOCK, Maxwell , RAPOLE, Keshava , LEE, Seung-yub , VORONKOV, Michael , PEREZ, Eduardo , CHEN, Shuyi , CHEN, Jinglong , GORDON, Joel
IPC分类号： C07C57/02
CPC分类号： A61K31/197 , A61K9/0014 , C07C243/34 , C07C321/18 , C07C323/59 , C07C335/08 , C07C2601/02 , C07C2601/14 , C07D207/16 , C07D209/18 , C07D209/48 , C07D217/26 , C07D243/34 , C07D295/145 , C07D307/54 , C07D333/24
摘要： Among other things, the present invention provides novel isoprenyl compounds capable of effectively modulating inflammatory responses and pharmaceutical, cosmetic, cosmeceutical and topical compositions comprising these isoprenyl compounds. Anti-inflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with inflammation. Proinflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with suppression of inflammatory responses. Thus, the present invention also provides methods useful in the treatment or prevention of diseases or conditions associated with inflammation as well as methods useful in the treatment or prevention of diseases or conditions associated with suppression of inflammatory responses.
摘要翻译：除此之外，本发明提供能够有效调节炎症反应的新型异戊二烯基化合物和包含这些异戊二烯基化合物的药物，化妆品，药妆和局部组合物。本发明的抗炎化合物可用于治疗或预防与炎症相关的疾病或病症。本发明的促炎症化合物可用于治疗或预防与抑制炎性反应相关的疾病或病症。因此，本发明还提供了用于治疗或预防与炎症相关的疾病或病症的方法以及可用于治疗或预防与抑制炎性反应相关的疾病或病症的方法。

8. 发明申请

WO2009108713A2 TOPICAL COMPOSITIONS AND METHODS UTILIZING PEPTIDES CONTAINING LIPID-MODIFIED CYSTEINE-CONTAINING PEPTIDES 审中-公开
标题翻译：含有脂质修饰的含有CYP3的肽的肽的局部组合物和方法
公开(公告)号：WO2009108713A2
公开(公告)日：2009-09-03
申请号：PCT/US2009/035162
申请日：2009-02-25
申请人： SIGNUM BIOSCIENCES, INC. , LEE, Seung-Yub , PEREZ, Eduardo , SARNGADHARAN, Gopal , STOCK, Jeffry, B. , STOCK, Maxwell , VORONKOV, Michael , WOLANIN, Peter
发明人： LEE, Seung-Yub , PEREZ, Eduardo , SARNGADHARAN, Gopal , STOCK, Jeffry, B. , STOCK, Maxwell , VORONKOV, Michael , WOLANIN, Peter
IPC分类号： A61K38/16
CPC分类号： C07K1/1077 , A61K8/64 , A61K9/0014 , A61K9/006 , A61K9/127 , A61K9/7023 , A61Q19/007
摘要： Described are compositions for topical application to keratinous tissues or substrates such as skin, or mucosal surfaces. The composition may be used to treat a skin condition or disease. The composition comprises at least one polypeptide and/or lipidated peptide and a carrier.
摘要翻译：描述了用于局部施用于角质组织或底物如皮肤或粘膜表面的组合物。该组合物可用于治疗皮肤状况或疾病。该组合物包含至少一种多肽和/或脂化肽和载体。

9. 发明申请

WO2006084033A1 COMPOSITIONS AND METHODS FOR ENHANCING COGNITIVE FUNCTION 审中-公开
标题翻译：用于增强认知功能的组合物和方法
公开(公告)号：WO2006084033A1
公开(公告)日：2006-08-10
申请号：PCT/US2006/003686
申请日：2006-02-03
申请人： SIGNUM BIOSCIENCES, INC. , STOCK, Jeffry , STOCK, Maxwell , HAOMING, Gu , STOCK, Gregory, B. , LI, Zhu , WOLANIN, Peter, Michael
发明人： STOCK, Jeffry , STOCK, Maxwell , HAOMING, Gu , STOCK, Gregory, B. , LI, Zhu , WOLANIN, Peter, Michael
IPC分类号： A61K36/00
CPC分类号： A61K31/355 , A23F5/24 , A23F5/267 , A23G3/36 , A23G3/48 , A23G4/06 , A23G4/068 , A23L2/02 , A23L2/38 , A23L33/105 , A23L33/40 , A23V2002/00 , A61K36/16 , A61K36/185 , A61K36/258 , A61K36/28 , A61K36/38 , A61K36/55 , A61K36/74 , A61K36/81 , A61K36/82 , A61K36/87 , A61K36/8962 , A61K45/06 , A61K2300/00 , A23V2200/322 , A23V2250/21
摘要： The invention encompasses novel compositions containing a methylation modifying compound isolated from botanical raw materials, including a fruit of the genus Coffea , and microbial raw materials, methods of making such compositions, and methods of treating or preventing human disease using such compositions. The methylation modifying compound in botanical extracts of the present invention can dramatically increase the level of methylation of PP2A, thus increasing cognitive function, particularly in persons suffering from or prone to developing Alzheimer's disease.
摘要翻译：本发明包括含有从植物原料分离的甲基化修饰化合物的新型组合物，其包括咖啡属的果实，微生物原料，制备这种组合物的方法，以及使用这些组合物治疗或预防人类疾病的方法。本发明的植物提取物中的甲基化修饰化合物可以显着增加PP2A的甲基化水平，从而增加认知功能，特别是在患有或易于发生阿尔茨海默病的人中。

10. 发明申请

WO2003078448A1 MODULATION OF PROTEIN METHYLATION AND PHOSPHOPROTEIN PHOSPHATE 审中-公开
标题翻译：蛋白质甲基化和磷酸肌磷酸盐的调节
公开(公告)号：WO2003078448A1
公开(公告)日：2003-09-25
申请号：PCT/US2003/007658
申请日：2003-03-13
申请人： SIGNUM BIOSCIENCES, INC. , STOCK, Gregory , STOCK, Jeffry , STOCK, Maxwell , VAFAI, Scott
发明人： STOCK, Gregory , STOCK, Jeffry , STOCK, Maxwell , VAFAI, Scott
IPC分类号： C07H21/04
CPC分类号： G01N33/6896 , C12Q1/42 , C12Q1/48 , G01N2500/00
摘要： The invention relates to methylated proteins that control protein phosphorylation, particularly phosphoesterases, such as PP2A. It relates to screening methods for determining agents that affect methylation of these proteins and thus also modulate the level of phosphorylation of phosphoproteins. It relates as well to the agents and to compositions comprising the agents. In a particular aspect in this regard the invention relates to agents that alter PP2A methylation and that thereby affect phosphorylation of phosphoproteins that play an important role in health or disease, such as the tau protein which is implicated in the etiology of Alzheimer's Disease. The invention further relates to diagnostic methods based on protein methylation levels, to compositions comprising agents for affecting methylation of proteins and for controlling the phosphate complement of phosphoproteins. Additionally, the invention relates to methods for administering the agents and compositions to affect methylation of proteins physiologically and to modulate the phosphate complement of phosphoproteins. Examples in this regard include agents and compositions that affect physiological activity of PP2A and alter the phosphate complement of phosphoproteins that are altered in disease.
摘要翻译：本发明涉及控制蛋白磷酸化的甲基化蛋白质，特别是磷酸酯酶，例如PP2A。它涉及用于确定影响这些蛋白质甲基化的试剂的筛选方法，因此也调节磷酸化蛋白的磷酸化水平。它还涉及试剂和包含试剂的组合物。在这方面的一个特定方面，本发明涉及改变PP2A甲基化并因此影响在健康或疾病中起重要作用的磷蛋白的磷酸化的试剂，例如与阿尔茨海默病病因有关的tau蛋白。本发明进一步涉及基于蛋白质甲基化水平的诊断方法，包括影响蛋白质甲基化和控制磷酸蛋白磷酸化补体的试剂的组合物。此外，本发明涉及用于施用影响蛋白质生理学上的甲基化并调节磷酸蛋白的磷酸盐补体的试剂和组合物的方法。在这方面的实例包括影响PP2A的生理活性并改变在疾病中改变的磷酸化蛋白的磷酸盐补体的药剂和组合物。

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