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1. 发明申请

WO2013114127A1 Eye Massage Device 审中-公开
标题翻译：眼部按摩器
公开(公告)号：WO2013114127A1
公开(公告)日：2013-08-08
申请号：PCT/GB2013/050231
申请日：2013-02-01
申请人： SHARMA, Anant , SHARMA, Benjamin, Anand, Ruben , MOORE, Jonathan , LE MENTEC, Laurent , CONDE, Ginny
发明人： SHARMA, Anant , SHARMA, Benjamin, Anand, Ruben , MOORE, Jonathan , LE MENTEC, Laurent , CONDE, Ginny
IPC分类号： A61H7/00 , A61F9/00 , A61H23/02
CPC分类号： A61H5/00 , A61F9/00772 , A61H7/001 , A61H23/0245 , A61H2201/0157 , A61H2201/0207 , A61H2201/0228 , A61H2201/1253 , A61H2201/1692
摘要： A manual device for massaging one or both of the upper and lower lids of the eye, the device comprising: a body, composed of flexible resilient biocompatible material, wherein the body provides jaws or lips, wherein the lips are biased into a spaced relationship by the material of the body, and wherein each lip is adapted to engage either the upper or lower eyelid, such that movement of the lips causes movement of at least one eyelid with respect to the other. The devices can conveniently be used to manipulate the meibomian glands of the eye in an optimum orientation, for example for alleviating or treating dry eye.
摘要翻译：一种用于按摩眼睛的上盖和下盖中的一个或两个的手动装置，所述装置包括：主体，其由柔性弹性生物相容性材料构成，其中所述主体提供夹爪或唇部，其中所述唇缘被偏置成间隔开的关系身体的材料，并且其中每个唇部适于接合上眼睑或下眼睑，使得唇部的运动引起至少一个眼睑相对于另一眼的移动。该装置可以方便地用于以最佳方向操纵眼睛的睑板腺，例如用于缓解或治疗干眼症。

2. 发明申请

WO2011027119A1 COMBINATION MEDICAMENT 审中-公开
标题翻译：组合药物
公开(公告)号：WO2011027119A1
公开(公告)日：2011-03-10
申请号：PCT/GB2010/001668
申请日：2010-09-03
申请人： SHARMA, Anant , SHAH, Sunil
发明人： SHARMA, Anant
IPC分类号： A61K31/196 , A61K31/381 , A61K31/407 , A61K31/47 , A61K31/573 , A61K45/06 , A61P29/00 , A61P5/44
CPC分类号： A61K45/06 , A61K9/0048 , A61K31/196 , A61K31/381 , A61K31/407 , A61K31/47 , A61K31/573 , A61K2300/00
摘要： A medicament for treating inflammation of human or animal body tissues contains a steroid, typically a corticosteroid, in combination with a non-steroidal anti-inflammatory drug (NSAID), typically a cyclooxygenase (COX-1 or COX-2) inhibitor. The medicament is of a particular effectiveness in treating inflammation of and around the eyes, whether caused by infection, irritation or surgery. Further medicaments combine an NSAID with antihistamines or with mast cell stabilisers. The medicaments are particularly effective in topically-applicable form, although other forms of application should also show benefits.
摘要翻译：用于治疗人或动物体组织炎症的药物含有类固醇，通常为皮质类固醇，与非甾体抗炎药（NSAID），通常为环氧合酶（COX-1或COX-2）抑制剂组合。该药物在治疗眼睛周围和周围的炎症方面特别有效，无论是由感染，刺激或手术引起的。其他药物将NSAID与抗组胺药或肥大细胞稳定剂结合。药物在局部适用形式中特别有效，尽管其他形式的应用也应显示益处。

3. 发明申请

WO2012136969A2 OPHTHALMIC TREATMENTS 审中-公开
标题翻译：眼科治疗
公开(公告)号：WO2012136969A2
公开(公告)日：2012-10-11
申请号：PCT/GB2012/000330
申请日：2012-04-05
申请人： SHARMA, Anant
发明人： SHARMA, Anant
IPC分类号： A61L9/00
CPC分类号： A61K31/137 , A61K9/0048 , A61K9/06 , A61K9/08 , A61K31/135 , A61K31/4178 , A61K45/06 , A61K2300/00
摘要： Aqueous compositions suitable for topical administration to the human or animal eye contain at least one water-soluble polymeric ophthalmic lubricant, such as hyaluronate, carbomer gel or hypromellose, together with a water-soluble analgesic. The analgesic may be an opiod, particularly an opioid having an affinity for 5-HT receptors, such as tramadol. Typical tramadol levels would be in the range of 0.5% to 1.0% w /v. The aqueous compositions may for example be used as artificial tears, and as general ophthalmic lubricants for treating conditions such as dry eye or blepharitis. Further compositions combine ophthalmologically- active agents, such as pharmaceuticals, with opioids, such as tramadol in particular. These compositions may be used to treat the eye while reducing pain or discomfort that would normally be produced by administering these particular pharmaceuticals to the eye, and increasing the efficacy of the pharmaceuticals. Compositions are also disclosed, containing opioids with 5-HT receptor activity, which are of general use in alleviating pain in and around the eye.
摘要翻译：适于局部施用于人或动物眼睛的水性组合物含有至少一种水溶性聚合物眼用润滑剂，例如透明质酸盐，卡波姆凝胶或羟丙甲纤维素，以及水溶性镇痛剂。止痛剂可以是阿片类药物，特别是对5-HT受体具有亲和力的阿片样物质，如曲马多。典型的曲马多水平将在0.5％至1.0％w / v的范围内。水性组合物可以例如用作人造泪液，以及用作治疗诸如干眼症或睑炎的病症的一般眼用润滑剂。其它组合物将眼科活性剂如药物与阿片样物质组合，特别是曲马多组合。这些组合物可用于治疗眼睛，同时减少通常通过将这些特定药物施用于眼睛产生的疼痛或不适，并增加药物的功效。还公开了含有具有5-HT受体活性的阿片样物质的组合物，其通常用于缓解眼睛中和眼睛周围的疼痛。

4. 发明申请

WO2009077736A3 A MEDICAMENT COMPRISING A PARASYMPATHETIC AGONIST AND A SYMPATHETIC ANTAGONIST OR A SYMPATHETIC AGONIST 审中-公开
公开(公告)号：WO2009077736A3
公开(公告)日：2009-06-25
申请号：PCT/GB2008/004129
申请日：2008-12-15
申请人： SHARMA, Anant
发明人： SHARMA, Anant
IPC分类号： A61K31/138 , A61K31/4178 , A61K31/496 , A61K31/498 , A61K31/385 , A61K31/4168 , A61P27/02
摘要： A medicament for topical administration to a human or animal eye comprises at least two pharmacologically active agents. One of the active agents is a parasympathetic agonist, such as pilocarpine, and the other active agent is either a sympathetic antagonist such as dapiprazole or thymoxamine, or a sympathetic agonist such as brimonidine or iopidine. The medicament is preferably in the form of a liquid composition, such as eye drops, or a gel or ointment and may comprise a slow-release composition. The medicament acts to improve visual acuity for a period of several hours, and may be beneficial in cases of presbyopia, myopia, hypermetropia, astigmatism and/or impaired night vision.

5. 发明申请

WO2022101648A1 OPHTHALMOLOGICAL DEVICE AND INSTRUMENT 审中-公开
公开(公告)号：WO2022101648A1
公开(公告)日：2022-05-19
申请号：PCT/GB2021/052963
申请日：2021-11-16
申请人： SHARMA, Anant
发明人： SHARMA, Anant
IPC分类号： A61F9/007
摘要： The invention relates to an ophthalmological device for performing eye surgery, particularly cataract surgery including hydro-dissection and / or hydro-dilation. The invention concerns an ophthalmological device optionally integrated with a hydrodissection cannula or lens injector i.e. the device can be fitted over the instrument when desired or the invention can incorporate the instrument itself i.e. an ophthalmological device including an integrated cannula and/or injector. The ophthalmological device disclosed herein comprises an elongate flexible sleeve for making a peripheral seal with ocular layer(s), the sleeve being adapted to surround a majority of a cannula, optionally integrated therewith, to define an elongate annular space between the sleeve and the cannula, wherein the sleeve comprises at least one distal ly located fluidic entry point and at least one proximally located fluidic exit point, spatially distanced along a length of the sleeve from the entry point. The invention therefore effectively permits intraocular pressure to be managed since intraocular fluid in the eye can access the annular space of the device at the distal end, pass through the device via the length of the annular space and be emitted therefrom.

6. 发明申请

WO2018178658A1 INTRAOCULAR DEVICES AND METHODS 审中-公开
公开(公告)号：WO2018178658A1
公开(公告)日：2018-10-04
申请号：PCT/GB2018/050806
申请日：2018-03-28
申请人： SHARMA, Anant
发明人： SHARMA, Anant
IPC分类号： A61F9/007 , A61F9/00
CPC分类号： A61F9/007 , A61F9/0017 , A61F9/00781 , A61F2210/0057 , A61F2230/0069 , A61F2250/0059 , A61F2250/0064
摘要： The present application relates to intraocular devices (1) and their use in surgical techniques, as well as the novel surgical methodology achieved from their use. The device (1) acts as an intra-ocular pressure (IOP) balance mechanism during surgery, but also postoperatively, by allowing the eye to inflate if over drainage occurs.

7. 发明申请

WO2016083767A2 EPITHELIAL TREATMENT 审中-公开
标题翻译：上海治疗
公开(公告)号：WO2016083767A2
公开(公告)日：2016-06-02
申请号：PCT/GB2015/000305
申请日：2015-11-24
申请人： SHARMA, Anant
发明人： SHARMA, Anant
CPC分类号： A61K35/14 , A61F9/00 , A61K8/983 , A61K9/0014 , A61K9/0048 , A61K9/006 , A61K35/60 , A61K38/014 , A61K38/017 , A61K47/36 , A61K47/38 , A61Q11/00
摘要： Products are described for treating epithelial tissues of the human or animal body including liquid compositions containing whole blood, or parts of blood including blood plasma, blood serum, blood platelets and growth factors derivable from blood. Other compositions disclosed include solid reservoirs of collagen or amniotic membrane into which whole blood or parts of blood have been absorbed. Methods of treatment using these compositions are described, in particular for treatment of ophthalmic disorders such as dry-eye and oral disorders such as dry mouth. A range of devices (1, 11, 31, 41, 51, 61, 71, 81, 91, 101) are described for sampling, mixing, storing and/or applying blood and compositions containing blood and parts of blood.
摘要翻译：描述了用于治疗人或动物体的上皮组织的产品，包括含有全血或包括血浆，血清，血小板和可从血液衍生的生长因子的血液的部分的液体组合物。所公开的其它组合物包括已经吸收了全血或部分血液的胶原或羊膜的固体储存器。描述了使用这些组合物的治疗方法，特别是用于治疗眼部疾病如干眼症和口腔疾病如口干的方法。描述了一系列装置（1,11,31,41,51,61,71,81,91,101），用于取样，混合，储存和/或施用含有血液和血液的血液和组合物。

8. 发明申请

WO2013150277A1 OPHTHALMIC THERAPY 审中-公开
标题翻译： OPHTHALMIC治疗
公开(公告)号：WO2013150277A1
公开(公告)日：2013-10-10
申请号：PCT/GB2013/050824
申请日：2013-03-28
申请人： SHARMA, Anant
发明人： SHARMA, Anant
IPC分类号： A61K31/135 , A61K9/00 , A61K45/06 , A61K9/08
CPC分类号： A61K9/0048 , A61K31/135 , A61K47/32 , A61K47/36 , A61K47/38
摘要： The invention provides methods of treating redness in the eye of a subject, or increasing whiteness of the eye of a subject, comprising the use of Tramadol or related compounds. Also provided are compounds and compositions for this use, and use of compounds for such methods.
摘要翻译：本发明提供了治疗受试者眼睛发红或增加受试者眼睛白度的方法，包括使用曲马多或相关化合物。还提供了用于此用途的化合物和组合物，以及化合物用于此类方法的用途。

9. 发明申请

WO2006095178A1 MEDICAMENT AND TREATMENT FOR HERPES SIMPLEX 审中-公开
标题翻译：治疗药物和治疗方法简单
公开(公告)号：WO2006095178A1
公开(公告)日：2006-09-14
申请号：PCT/GB2006/000845
申请日：2006-03-10
申请人： SHARMA, Anant
发明人： SHARMA, Anant
IPC分类号： A61K31/343 , A61K31/475 , A61K31/165 , A61P31/22
CPC分类号： A61K31/343 , A61K31/165 , A61K31/475
摘要： A medicament for use in the treatment of viral infections, such as herpes simplex, that are transmitted anterogradely through the nervous system. Viruses, such as herpes simplex, may lie asymptomatically dormant or latent in nerve cell bodies of the CNS, but when reactivated, by whatever cause, are transported anterogradely along nerve cell axons to a surface of the body, where symptoms of the infection arise. A common form of herpes simplex infection lies dormant or latent in the trigeminal nerve ganglion until reactivated by stress, premenstrual tension or a range of other triggers. The herpes simplex virus (HSV) typically travels along trigeminal nerve axons to the lips, where it leads to symptoms such as cold sores. Herpes simplex infections may also take a more serious form in which the virus travels along nerve cells to the area of the eye socket. Here, HSV may cause symptoms such as ulceration of the cornea, with a potential serious effect on a patient's vision. The active ingredient of the medicament is an alkaloid such as colchicine, vinblastine, vincristine, a cytochalasin or derivaties thereof.
摘要翻译：用于治疗病毒性感染例如单纯疱疹的药物，其通过神经系统顺行传播。诸如单纯疱疹病毒的病毒可能无症状地在CNS的神经细胞体中休眠或潜伏，但是当任何原因重新激活时，沿着神经细胞轴突逐渐运输到感染症状出现的身体表面。单纯疱疹感染的常见形式在三叉神经神经节休眠或潜伏，直到由应激，经前张力或其他触发因素重新激活。单纯疱疹病毒（HSV）通常沿着三叉神经轴突行进到嘴唇，导致诸如冷疮等症状。单纯疱疹感染也可能采取更严重的形式，其中病毒沿着神经细胞传播到眼窝的区域。在这里，HSV可能引起角膜溃疡等症状，对患者的视力有潜在的严重影响。药物的活性成分是生物碱如秋水仙碱，长春花碱，长春新碱，细胞松弛素或其衍生物。

10. 发明申请

WO2010029292A1 IRRADIATION APPARATUS AND TREATMENT 审中-公开
标题翻译：辐射装置和处理
公开(公告)号：WO2010029292A1
公开(公告)日：2010-03-18
申请号：PCT/GB2009/002158
申请日：2009-09-09
申请人： SHARMA, Anant
发明人： SHARMA, Anant
IPC分类号： A61N5/06 , A61L2/10
CPC分类号： A61L2/0047 , A61N5/0603 , A61N5/0616 , A61N5/0624 , A61N2005/0612 , A61N2005/063 , A61N2005/0642 , A61N2005/0644 , A61N2005/0651 , A61N2005/0661
摘要： Infections of body tissues, particularly of the eye or of wounds, are treated by brief low- intensity irradiation with ultraviolet radiation in the UVC band. A suitable treatment device contains a light-emitting diode producing UVC radiation at a wavelength of about 265nm, at a power output of 5mW, directed on to a zone of tissue about 4mm in diameter. An optical aiming system indicates the zone of tissue to be irradiated. Irradiation for periods as brief as 1 second has been found effective, which equates to a dose of 4mJ/cm 2 delivered to the tissue. Longer periods and higher intensities may be used for more resistant infections. Such irradiation may be delivered endoscopically to treat internal infections or to prevent infection during surgery. The device may be hand held or mounted to an ophthalmic slit lamp or other support.
摘要翻译：身体组织，特别是眼睛或伤口的感染，通过紫外线辐射在UVC带中的短暂的低强度照射来治疗。合适的治疗装置包含发射二极管，其以约265nm的波长产生UVC辐射，功率输出为5mW，指向直径约4mm的组织区域。光学瞄准系统指示要照射的组织的区域。已经发现短暂1秒的照射是有效的，其等同于递送至组织的4mJ / cm 2的剂量。更长的时间和更高的强度可用于更多的耐药性感染。这种照射可以内窥镜递送以治疗内部感染或防止手术期间的感染。该装置可以是手持的或安装到眼科裂隙灯或其它支架上。

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