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1. 发明申请

WO2004033478A2 FATTY ACID MODIFIED FORMS OF GLUCOCORTICOIDS 审中-公开
标题翻译：脂肪酸改性葡萄糖苷形式
公开(公告)号：WO2004033478A2
公开(公告)日：2004-04-22
申请号：PCT/US2003/031923
申请日：2003-10-08
申请人： SEPRACOR INC. , CURRIE, Mark G. , JONES, Steven , ZEPP, Charles M.
发明人： CURRIE, Mark G. , JONES, Steven , ZEPP, Charles M.
IPC分类号： C07J5/00
CPC分类号： C07J5/00 , C07J5/0076 , C07J5/0092 , C07J71/0031 , Y10S514/826 , Y10S514/886
摘要： A genus of 11,21-dihydroxypregna-1,4-diene-3,20-diones is disclosed, in which the 21-hydroxy is esterified with C8 to C24 hydrocarbon or the residue of misoprostol. The compounds are useful for treating rhinitis and asthma, particularly by inhalation, and for treating inflammation, particularly by local or topical administration.
摘要翻译：公开了11,21-二羟基孕酮-1,4-二烯-3,20-二酮的一种，其中21-羟基被C 8〜C 24烃或米索前列醇的残基酯化。该化合物可用于治疗鼻炎和哮喘，特别是通过吸入治疗和治疗炎症，特别是通过局部或局部给药治疗炎症。

2. 发明申请

WO2012155114A1 PEPTIDES DERIVED FROM UROGUANYLIN AND THEIR USE IN GASTROINTESTINAL DISORDERS 审中-公开
标题翻译：从乌古兰林衍生的肽及其在胃肠疾病中的用途
公开(公告)号：WO2012155114A1
公开(公告)日：2012-11-15
申请号：PCT/US2012/037663
申请日：2012-05-11
申请人： IRONWOOD PHARMACEUTICALS, INC. , CURRIE, Mark G. , ZIMMER, Daniel P. , KESSLER, Marco
发明人： CURRIE, Mark G. , ZIMMER, Daniel P. , KESSLER, Marco
IPC分类号： C07K7/08 , A61K38/04
CPC分类号： C07K7/08 , A61K38/04
摘要： The present invention provides new uroguanylin derivatives that are useful for the treatment of gastrointestinal disorders. The present invention also provides compositions and methods of treating gastrointestinal disorders and pharmaceutical compositions for accomplishing the same. In some embodiments, these pharmaceutical compositions include oral dosage forms.
摘要翻译：本发明提供了可用于治疗胃肠道疾病的新的尿路鸟苷衍生物。本发明还提供了治疗胃肠疾病的组合物和方法以及用于实现其的药物组合物。在一些实施方案中，这些药物组合物包括口服剂型。

3. 发明申请

WO2007062168A3 METHODS AND COMPOSITIONS FOR THE TREATMENT OF GASTROINTESTINAL DISORDERS 审中-公开
公开(公告)号：WO2007062168A3
公开(公告)日：2007-05-31
申请号：PCT/US2006/045289
申请日：2006-11-22
申请人： MICROBIA, INC. , CURRIE, Mark G.
发明人： CURRIE, Mark G.
IPC分类号： C07H19/00 , C07F9/02
摘要： The present invention features compositions and related methods for treating IBS and other gastrointestinal disorders and conditions (e.g., gastrointestinal motility disorders, functional gastrointestinal disorders, gastroesophageal reflux disease (GERD), duodenogastric reflux, Crohn's disease, ulcerative colitis, Inflammatory bowel disease, functional heartburn, dyspepsia (including functional dyspepsia or nonulcer dyspepsia), gastroparesis employing. The methods and compositions employ guanosine 3', 5'-cyclic monophosphate pharmaceutically acceptable salt thereof.

4. 发明申请

WO2008124505A2 SOLUBLE GUANYLATE CYCLASE (SGC) MODULATORS FOR TREATMENT OF LIPID RELATED DISORDERS 审中-公开
标题翻译：用于治疗脂肪相关疾病的可溶性葡萄糖环化酶（SGC）调节剂
公开(公告)号：WO2008124505A2
公开(公告)日：2008-10-16
申请号：PCT/US2008/059272
申请日：2008-04-03
申请人： IRONWOOD PHARMACEUTICALS,INC. , CURRIE, Mark G. , ZIMMER, Daniel P.
发明人： CURRIE, Mark G. , ZIMMER, Daniel P.
IPC分类号： A61K31/04 , A61K31/21 , A61K31/34 , A61P9/00
CPC分类号： A61K31/34 , A61K31/04 , A61K31/165 , A61K31/192 , A61K31/21 , A61K31/40 , A61K31/407 , A61K31/5377 , A61K31/541
摘要： Disclosed herein are novel compositions and methods for treating or preventing a variety of disorders and conditions associated with lipid metabolism. The methods generally include administering to a patient in need thereof a therapeutically effective amount of a pharmaceutical composition comprising one or more sGC modulators alone or in combination with one or more lipid altering agents and/or PDE inhibitors.
摘要翻译：本文公开了用于治疗或预防与脂质代谢相关的多种病症和病症的新型组合物和方法。所述方法通常包括向有需要的患者施用治疗有效量的药物组合物，其包含单独一种或多种sGC调节剂或与一种或多种脂质改变剂和/或PDE抑制剂组合。

5. 发明申请

WO2008080092A3 METHOD FOR DYNÂMICALLY TESTING A PROGRAM WITH AN EDITOR DURING CONSTRUCTION 审中-公开
公开(公告)号：WO2008080092A3
公开(公告)日：2008-07-03
申请号：PCT/US2007/088624
申请日：2007-12-21
申请人： IRONWOOD PHARMACEUTICALS, INC. , CURRIE, Mark G.
发明人： CURRIE, Mark G.
IPC分类号： A61K9/00 , A61K31/195 , A61K31/27 , A61K31/341 , A61K31/4164 , A61K31/4184 , A61K31/426 , A61K31/4439 , A61K31/444 , A61K31/575 , A61K31/785 , A61K33/08 , A61K33/10 , A61P1/04 , A61K45/06
摘要： Disclosed herein are novel compositions for treating or preventing upper GI tract disorders and protecting stratified squamous epithelium against injury by a noxious substance. The pharmaceutical composition comprises at least one bile acid sequestrant, alone or in combination with at least one proton pump inhibitor, and optionally one or more agent chosen from antacids, histamine H2-receptor antagonists, -aminobutyricacid-b (GABA-B) agonists,, prodrugs of GABA-B agonists, and protease inhibitors.

6. 发明申请

WO2008019357A2 INDOLE COMPOUNDS 审中-公开
标题翻译： INDOLE化合物
公开(公告)号：WO2008019357A2
公开(公告)日：2008-02-14
申请号：PCT/US2007/075332
申请日：2007-08-07
申请人： MICROBIA, INC. , TALLEY, John Jeffrey , SPROTT, Kevin , PEARSON, James Philip , MILNE, G. Todd , SCHAIRER, Wayne , YANG, Jing Jing , KIM, Charles , BARDEN, Timothy , LUNDIGRAN, Regina , MERMERIAN, Ara , CURRIE, Mark G.
发明人： TALLEY, John Jeffrey , SPROTT, Kevin , PEARSON, James Philip , MILNE, G. Todd , SCHAIRER, Wayne , YANG, Jing Jing , KIM, Charles , BARDEN, Timothy , LUNDIGRAN, Regina , MERMERIAN, Ara , CURRIE, Mark G.
IPC分类号： A61K31/4439
CPC分类号： C07D209/18 , C07D209/22 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/14 , C07D413/06 , C07D413/14 , C07D417/14 , C07D498/04
摘要： Indole derivatives that are useful for treating pain, inflammation and other conditions are described. Certain of the compounds are benzyl derivatives and others are benzoyl derivatives. The compounds are substituted at least at the 3 position of the indole.
摘要翻译：描述了可用于治疗疼痛，炎症和其它病症的吲哚衍生物。某些化合物是苄基衍生物，而其它化合物是苯甲酰基衍生物。该化合物至少在吲哚的3位被取代。

7. 发明申请

WO2007146795A2 PHARMACEUTICAL FORMULATION FOR PARENTERAL ADMINISTRATION 审中-公开
标题翻译：医院管理的药物配方
公开(公告)号：WO2007146795A2
公开(公告)日：2007-12-21
申请号：PCT/US2007/070746
申请日：2007-06-08
申请人： MICROBIA, INC. , CURRIE, Mark G. , ZIMMER, Daniel P.
发明人： CURRIE, Mark G. , ZIMMER, Daniel P.
IPC分类号： A61K31/557
CPC分类号： A61K31/557 , A61K31/407 , A61K2300/00
摘要： Parenteral formulations comprising ketorolac, and a compound of formula II wherein R is hydrogen or lower alkyl. Such formulations are used for the treatment and prevention of pain.
摘要翻译：包含酮咯酸和式II化合物的肠胃外制剂，其中R是氢或低级烷基。这些制剂用于治疗和预防疼痛。

8. 发明申请

WO2008002971A2 METHODS AND COMPOSITIONS FOR THE TREATMENT OF GASTROINTESTINAL DISORDERS 审中-公开
标题翻译：治疗胃肠疾病的方法和组合物
公开(公告)号：WO2008002971A2
公开(公告)日：2008-01-03
申请号：PCT/US2007/072223
申请日：2007-06-27
申请人： MICROBIA, INC. , CURRIE, Mark G. , ZIMMER, Daniel P.
发明人： CURRIE, Mark G. , ZIMMER, Daniel P.
IPC分类号： A61K38/17
CPC分类号： C07K14/4705 , A61K38/00
摘要： Compositions and related methods for treating IBS and other gastrointestinal disorders and conditions (e.g., gastrointestinal motility disorders, functional gastrointestinal disorders, gastroesophageal reflux disease (GERD), duodenogastric reflux, Crohn's disease, ulcerative colitis, inflammatory bowel disease, functional heartburn, dyspepsia (including functional dyspepsia or nonulcer dyspepsia), gastroparesis, chronic intestinal pseudo-obstruction (or colonic pseudoobstruction), disorders and conditions associated with constipation, e.g., constipation associated with use of opiate pain killers, post-surgical constipation, and constipation associated with neuropathic disorders and disorders and conditions associated with excess fluid and/or salt retention as well as other conditions and disorders are described. The compositions feature polypeptides that activate the guanylate cyclase C (GC-C) receptor.
摘要翻译：用于治疗IBS和其他胃肠道疾病和病症的组合物和相关方法（例如，胃肠动力障碍，功能性胃肠道疾病，胃食管反流病（GERD），十二指肠胃反流，克罗恩病，溃疡性结肠炎，炎性肠病，功能性胃灼热，消化不良（包括功能性消化不良或非溃疡性消化不良），胃轻瘫，慢性肠假性梗阻（或结肠假性梗阻），与便秘相关的病症和病症，例如与使用阿片类止痛药相关的便秘，手术后便秘和与神经性疾病相关的便秘描述了与过量流体和/或盐保留以及其它条件和病症相关的疾病和病症。组合物特征在于激活鸟苷酸环化酶C（GC-C）受体的多肽。

9. 发明申请

WO2012155101A1 TREATMENTS FOR GASTROINTESTINAL DISORDERS 审中-公开
标题翻译：治疗胃肠疾病
公开(公告)号：WO2012155101A1
公开(公告)日：2012-11-15
申请号：PCT/US2012/037637
申请日：2012-05-11
申请人： IRONWOOD PHARMACEUTICALS, INC. , CURRIE, Mark G. , FRETZEN, Angelika , KESSLER, Marco , ZIMMER, Daniel P.
发明人： CURRIE, Mark G. , FRETZEN, Angelika , KESSLER, Marco , ZIMMER, Daniel P.
IPC分类号： A61K38/10 , A61P1/00 , A61P35/00
CPC分类号： C07K7/08 , A61K38/10 , A61K45/06
摘要： The present invention provides pharmaceutical compositions and methods of treating lower gastrointestinal disorders, including irritable bowel syndrome and constipation.
摘要翻译：本发明提供了药物组合物和治疗下胃肠道病症的方法，包括肠易激综合征和便秘。

10. 发明申请

WO2007101161A2 METHODS AND COMPOSITIONS FOR THE TREATMENT OF GASTROINTESTINAL DISORDERS 审中-公开
标题翻译：治疗胃肠疾病的方法和组合
公开(公告)号：WO2007101161A2
公开(公告)日：2007-09-07
申请号：PCT/US2007/062820
申请日：2007-02-26
申请人： MICROBIA, INC. , CURRIE, Mark G.
发明人： CURRIE, Mark G.
CPC分类号： A61K31/56 , A61K38/10 , C07K7/08 , A61K2300/00
摘要： Pharmaceutical compositions comprising certain peptides that are capable of activating the guanylate-cyclase C (GC-C) receptor are described as are the peptides and method for using the peptides and pharmaceutical compositions for treating gastrointestinal disorders and other disorder.
摘要翻译：描述了能够激活鸟苷酸环化酶C（GC-C）受体的某些肽的药物组合物是用于治疗胃肠道疾病和其它病症的肽和药物组合物的肽和方法。

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