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1. 发明申请

WO2011085128A1 HEDGEHOG INHIBITORS 审中-公开
标题翻译： HEDGEHOG抑制剂
公开(公告)号：WO2011085128A1
公开(公告)日：2011-07-14
申请号：PCT/US2011/020416
申请日：2011-01-06
申请人： SELEXAGEN THERAPEUTICS, INC. , VERNIER, Jean-Michel , MAY, John , O'CONNOR, Patrick , RIPKA, William , PINKERTON, Anthony , BOUNAUD, Pierre-Yves , HOPKINS, Stephanie
发明人： VERNIER, Jean-Michel , MAY, John , O'CONNOR, Patrick , RIPKA, William , PINKERTON, Anthony , BOUNAUD, Pierre-Yves , HOPKINS, Stephanie
IPC分类号： A01N43/78 , A61K31/425
CPC分类号： C07D277/28 , C07D263/32 , C07D277/24 , C07D277/30
摘要： Described herein are compounds, pharmaceutical compositions and methods for the inhibition of Hedgehog signaling. Said compounds, pharmaceutical compositions and methods have utility in the treatment of human and veterinary disease and disorders.
摘要翻译：本文描述了用于抑制Hedgehog信号传导的化合物，药物组合物和方法。所述化合物，药物组合物和方法可用于治疗人和兽医疾病和病症。

2. 发明申请

WO2011085261A1 HEDGEHOG INHIBITORS 审中-公开
标题翻译： HEDGEHOG抑制剂
公开(公告)号：WO2011085261A1
公开(公告)日：2011-07-14
申请号：PCT/US2011/020593
申请日：2011-01-07
申请人： SELEXAGEN THERAPEUTICS, INC. , VERNIER, Jean-Michel , MAY, John , O'CONNOR, Patrick , RIPKA, William , PINKERTON, Anthony
发明人： VERNIER, Jean-Michel , MAY, John , O'CONNOR, Patrick , RIPKA, William , PINKERTON, Anthony
IPC分类号： A01N43/78
CPC分类号： C07D277/28 , C07D263/32
摘要： Described herein are compounds, pharmaceutical compositions and methods for the inhibition of hedgehog signaling. Said compounds, pharmaceutical compositions and methods have utility in the treatment of human and veterinary disease and disorders.
摘要翻译：本文描述了用于抑制刺猬蛋白信号传导的化合物，药物组合物和方法。所述化合物，药物组合物和方法可用于治疗人和兽医疾病和病症。

3. 发明申请

WO2011085269A1 RAF KINASE INHIBITORS 审中-公开
标题翻译： RAF激酶抑制剂
公开(公告)号：WO2011085269A1
公开(公告)日：2011-07-14
申请号：PCT/US2011/020602
申请日：2011-01-07
申请人： SELEXAGEN THERAPEUTICS, INC. , VERNIER, Jean-Michel , O'CONNOR, Patrick , RIPKA, William , MATTHEWS, David , PINKERTON, Anthony , BOUNAUD, Pierre-Yves , HOPKINS, Stephanie
发明人： VERNIER, Jean-Michel , O'CONNOR, Patrick , RIPKA, William , MATTHEWS, David , PINKERTON, Anthony , BOUNAUD, Pierre-Yves , HOPKINS, Stephanie
IPC分类号： A01N57/00 , A61K31/675
CPC分类号： C07D401/04 , C07D471/04
摘要： Described herein are compounds, pharmaceutical compositions and methods for the inhibition of RAF kinae mediated signaling. Said compounds, pharmaceutical compositions and methods have utility in the treatment of human disease and disorders.
摘要翻译：本文描述了用于抑制RAF基因介导的信号传导的化合物，药物组合物和方法。所述化合物，药物组合物和方法可用于治疗人类疾病和病症。

4. 发明申请

WO2011038261A1 HETEROCYCLIC KINASE INHIBITORS 审中-公开
标题翻译：杂环激酶抑制剂
公开(公告)号：WO2011038261A1
公开(公告)日：2011-03-31
申请号：PCT/US2010/050248
申请日：2010-09-24
申请人： SELEXAGEN THERAPEUTICS, INC. , VERNIER, Jean-Michel , O'CONNOR, Patrick , RIPKE, William , MATTHEWS, David , PINKERTON, Anthony
发明人： VERNIER, Jean-Michel , O'CONNOR, Patrick , RIPKE, William , MATTHEWS, David , PINKERTON, Anthony
IPC分类号： A01N43/52 , A61K31/40 , A61K31/415
CPC分类号： C07D401/04 , C07D401/14 , C07D471/04 , C07D487/04
摘要： Described herein are compounds, pharmaceutical compositions and methods for the inhibition of kinase signaling mediated by the kinases A-RAF, B-RAF,C-RAF, p38, or GSK3β.. Said compounds, pharmaceutical compositions and methods have utility in the treatment of human disease and disorders.
摘要翻译：本文描述了用于抑制由激酶A-RAF，B-RAF，C-RAF，p38或GSK3β介导的激酶信号传导的化合物，药物组合物和方法。所述化合物，药物组合物和方法可用于治疗人类疾病和疾病。

5. 发明申请

WO2010129620A1 IMIDAZO [ 1, 2 -A] PYRIDIN-2 -YL-PHENYL DERIVATIVES TO BE USED IN CANCER TREATMENT 审中-公开
标题翻译：用于癌症治疗的咪达唑[1,2-P]吡啶-2-基苯胺衍生物
公开(公告)号：WO2010129620A1
公开(公告)日：2010-11-11
申请号：PCT/US2010/033636
申请日：2010-05-04
申请人： ALLA CHEM, LLC , KHVAT, Alexander , TKACHENKO, Sergey , OKUN, Ilya , ROGOVOY, Borys V. , SAVCHUK, Nikolay , MAY, John , O'CONNOR, Patrick , RIPKA, William , VERNIER, Jean-Michel , MATTHEWS, David
发明人： KHVAT, Alexander , TKACHENKO, Sergey , OKUN, Ilya , ROGOVOY, Borys V. , SAVCHUK, Nikolay , MAY, John , O'CONNOR, Patrick , RIPKA, William , VERNIER, Jean-Michel , MATTHEWS, David
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
CPC分类号： C07D471/04
摘要： Described herein are compounds, pharmaceutical compositions and methods for the inhibition of Hedgehog signaling. Said compounds, pharmaceutical compositions and methods have utility in the treatment of human and veterinary diseases and disorders.
摘要翻译：本文描述了用于抑制Hedgehog信号传导的化合物，药物组合物和方法。所述化合物，药物组合物和方法可用于治疗人和兽医疾病和病症。

6. 发明申请

WO2012125981A2 RAF KINASE INHIBITORS 审中-公开
标题翻译： RAF激酶抑制剂
公开(公告)号：WO2012125981A2
公开(公告)日：2012-09-20
申请号：PCT/US2012/029547
申请日：2012-03-16
申请人： SELEXAGEN THERAPEUTICS, INC. , VERNIER, Jean-michel , HOPKINS, Stephanie , BOUNAUD, Pierre-Yves , O'CONNOR, Patrick , MATTHEWS, David , BENDER, Steve
发明人： VERNIER, Jean-michel , HOPKINS, Stephanie , BOUNAUD, Pierre-Yves , O'CONNOR, Patrick , MATTHEWS, David , BENDER, Steve
IPC分类号： C07D417/04 , C07D417/14 , C07D401/04 , C07D403/04 , A61K31/427 , A61P35/00
CPC分类号： C07D417/14 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D417/04 , C07D471/04
摘要： Described herein are compounds, pharmaceutical compositions and methods for the inhibition of RAF kinae mediated signaling. Said compounds, pharmaceutical compositions and methods have utility in the treatment of human disease and disorders.
摘要翻译：本文描述了用于抑制RAF基因介导的信号传导的化合物，药物组合物和方法。所述化合物，药物组合物和方法可用于治疗人类疾病和病症。

7. 发明申请

WO2014047330A1 NOVEL RAF KINASE INHIBITORS 审中-公开
标题翻译：新型RAF激酶抑制剂
公开(公告)号：WO2014047330A1
公开(公告)日：2014-03-27
申请号：PCT/US2013/060686
申请日：2013-09-19
申请人： VERNIER, Jean-Michel , O'CONNOR, Patrick , MATTHEWS, David , BOUNAUD, Pierre-Yves , HOPKINS, Stephanie
发明人： VERNIER, Jean-Michel , O'CONNOR, Patrick , MATTHEWS, David , BOUNAUD, Pierre-Yves , HOPKINS, Stephanie
IPC分类号： A61K31/415
CPC分类号： C07D401/04 , C07D403/04 , C07D417/04
摘要： Described herein are compounds, pharmaceutical compositions and methods for the inhibition of RAF kinae mediated signaling. Said compounds, pharmaceutical compositions and methods have utility in the treatment of human disease and disorders.
摘要翻译：本文描述了用于抑制RAF基因介导的信号传导的化合物，药物组合物和方法。所述化合物，药物组合物和方法可用于治疗人类疾病和病症。

8. 发明申请

WO2011018778A1 INTRAMEDULLARY NAILS FOR LONG BONE FRACTURE SETTING 审中-公开
标题翻译：用于长骨骨折设置的内固定钉
公开(公告)号：WO2011018778A1
公开(公告)日：2011-02-17
申请号：PCT/IE2010/000047
申请日：2010-08-12
申请人： CORK INSTITUTE OF TECHNOLOGY , DOHERTY, William , O'CONNOR, Patrick , HARTY, James , DAILEY, Hannah , DALY, Charles , O'DRISCOLL, Olive
发明人： DOHERTY, William , O'CONNOR, Patrick , HARTY, James , DAILEY, Hannah , DALY, Charles , O'DRISCOLL, Olive
IPC分类号： A61B17/72
CPC分类号： A61B17/725 , A61B17/7225 , A61B17/7241
摘要： An intramedullary nail has a proximal part for engagement with a proximal bone fragment and a distal part for engagement with a distal bone fragment. A motion assembly interconnects the parts and allows limited axial relative motion of the proximal and distal parts. This limited axial motion provides micromotion and in some embodiments also dynamisation. The nail may comprise a stem (7) for fastening to one bone fragment and an insert (30) within the stem for fastening to the other bone fragment, the insert being adapted to guide insertion of a bone screw through the stem and to prevent relative rotation of the distal and proximal bone fragments. The motion assembly may include spring bias and/or damping means (33) between the parts, possibly including one or more Belleville washers.
摘要翻译：髓内钉具有近端部分，用于与近端骨片段和用于与远侧骨片段接合的远端部分接合。运动组件互连部件并允许近端和远端部分的有限的轴向相对运动。这种有限的轴向运动提供微动作，并且在一些实施例中也是动态化。指甲可以包括用于紧固到一个骨碎片的杆（7）和杆内的插入件（30），用于紧固到另一个骨碎片，插入件适于引导骨螺钉穿过杆的插入并防止相对远端和近端骨碎片的旋转。运动组件可以包括在部件之间的弹簧偏压和/或阻尼装置（33），可能包括一个或多个Belleville垫圈。

9. 发明申请

WO2012156959A1 A FLUID REMOVAL AND DELIVERY APPARATUS 审中-公开
标题翻译：液体去除和输送装置
公开(公告)号：WO2012156959A1
公开(公告)日：2012-11-22
申请号：PCT/IE2012/000022
申请日：2012-05-16
申请人： CORK INSTITUTE OF TECHNOLOGY , VAUGHAN, John , O'DRISCOLL, Olive , O'CONNOR, Patrick
发明人： VAUGHAN, John , O'DRISCOLL, Olive , O'CONNOR, Patrick
IPC分类号： A61M1/00 , A61F11/00
CPC分类号： A61M1/0064 , A61F11/002 , A61M1/0039 , A61M1/0062 , A61M1/0084 , A61M2205/27 , A61M2210/0668
摘要： An apparatus (100) can be connected to an otoscope (500) and used to aspirate the middle ear and to deliver a medicament in the one operation. It can be operated by a single hand, allowing stabilisation of the patient's head during the procedure. The extent of vacuum application and of drug delivery is fully under user control both in terms of volume and duration. Aided by the otoscope (500), and operation of a lever (110) by the second finger extends the lumen (140) which will perforate the tympanic membrane (ear drum). Once the tympanic membrane is punctured, the user will press a vacuum push button (111) which allows fluid to be aspirated from the middle ear through the lumen (140). The extent of vacuum and its duration can be controlled because the clinician can control the movement of the button (111) between the extreme positions. The user will then press a lever (112) to administer a prescribed dose of drug into the middle ear. Again, the extent of medicament flow and its duration can be controlled because the clinician can control the movement of the lever (112) between the extreme positions. The extension mechanism lever (110) is then released.
摘要翻译：设备（100）可连接到耳镜（500）并用于吸入中耳并在一次手术中输送药物。它可以通过单手操作，从而在手术过程中稳定患者的头部。在体积和持续时间方面，真空应用和药物输送的程度完全由用户控制。通过耳镜（500）辅助，并且通过第二手指操作杆（110）延伸将使鼓膜（耳鼓）穿孔的内腔（140）。一旦鼓膜被刺穿，用户将按下真空按钮（111），其允许流体从中耳通过内腔（140）吸出。可以控制真空度及其持续时间，因为临床医生可以控制按钮（111）在极限位置之间的移动。然后用户将按压杆（112）将规定剂量的药物施用于中耳。再次，可以控制药物流动的程度及其持续时间，因为临床医生可以控制杠杆（112）在极限位置之间的移动。延伸机构杆（110）然后被释放。

10. 发明申请

WO2011000050A1 ROTARY DEVICE 审中-公开
标题翻译：旋转装置
公开(公告)号：WO2011000050A1
公开(公告)日：2011-01-06
申请号：PCT/AU2010/000840
申请日：2010-07-01
申请人： LUMBERJACK PTY LTD , O'CONNOR, Patrick
发明人： O'CONNOR, Patrick
IPC分类号： F01C1/18 , F04C2/18 , F04C18/18
CPC分类号： F01C1/18 , F01B13/067 , F01C1/084
摘要： A rotary device is described for use in a rotary engine, or a compressor, or turbine, the rotary device comprising two rotors disposed adjacent each other and rotatable about substantially parallel axes of rotation. Each of the rotors has protrusions extending therefrom at regular intervals about the circumference of each to define an open portion of a sealable compression chamber between adjacent protrusions. Each protrusion has two side surfaces and a projecting end surface, wherein the meeting point between each side surface and the projecting end surface defines a tip. The two rotors are arranged such that upon contra rotation of the rotors, a protrusion of one of the rotors engages between a pair of protrusions on the other rotor, and the tips of the engaging rotor are in constant sealing contact with the opposing side surfaces of the pair of protrusions for a predetermined period of time. During the predetermined period of time, a sealed chamber is formed and the volume of the chamber is reduced to a predetermined level by the contra rotation.
摘要翻译：描述了用于旋转发动机或压缩机或涡轮机中的旋转装置，该旋转装置包括彼此相邻设置并可大致平行的旋转轴线旋转的两个转子。每个转子具有从其周围以规则的间隔延伸的突起，每个圆周围绕相邻的突起之间限定可密封的压缩室的开口部分。每个突起具有两个侧表面和一个突出端表面，其中每个侧表面与突出端表面之间的汇合点限定一个尖端。两个转子被布置成使得当转子反转时，一个转子的突起接合在另一个转子上的一对突起之间，并且接合转子的末端与相对的侧表面保持恒定的密封接触该一对突起预定的时间段。在预定时间期间，形成密封室，并且通过反向旋转将室的体积减小到预定水平。

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