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1. 发明申请

WO2022136961A1 METHOD FOR ANALYZING INDIVIDUAL CELLS OR PARTICULATES IN BLOOD USING FLUORESCENCE 审中-公开
公开(公告)号：WO2022136961A1
公开(公告)日：2022-06-30
申请号：PCT/IB2021/060168
申请日：2021-11-03
申请人： SEDICIDODICI S.R.L.
发明人： RUGGERI, Zaverio M. , VANERIO, Noemi , MAZZUCATO, Mario
IPC分类号： G01N33/49
摘要： The present invention relates to an apparatus which is usable for a method for evaluating the risk of thrombotic and hemorrhagic diseases linked to blood coagulation processes. In particular, the present invention relates to an apparatus (1) for analyzing the coagulation function of a subject's blood sample, comprising: - a cartridge (4) comprising a perfusion chamber (5) for the blood sample and a well (27) for mixing reagents and blood sample; - a unit (2) for acquiring fluorescence images of the blood sample; - a support member (3) for the cartridge (4), which is movable along a y axis between an access position by an operator and at least one digital image acquisition position; - a unit (6) for moving the reagents, i.e., the solutions of fluorescent probes and blood recalcification or the single reagent which brings them together, and the blood sample, which is movable along an x axis, orthogonal to said y axis and defining a horizontal plane with said y axis, and along a z axis orthogonal to the plane formed by said x, y axes; - a system (8) for pumping the blood sample through the perfusion chamber (5), the pumping system (8) comprising a syringe pump (20), wherein the relative movement between the cartridge (4) and the image acquisition unit (2) occurs with micrometric adjustment along said y axis and/or along said x axis.

2. 发明申请

WO2022136960A1 PERFUSION DEVICE FOR EVALUATING BLOOD PARAMETERS 审中-公开
公开(公告)号：WO2022136960A1
公开(公告)日：2022-06-30
申请号：PCT/IB2021/060167
申请日：2021-11-03
申请人： SEDICIDODICI S.R.L.
发明人： RUGGERI, Zaverio M. , MANZONI, Angelo , VANERIO, Noemi , MAZZUCATO, Mario
IPC分类号： A61B6/00 , A61J1/05 , G01N33/49 , G01N21/01 , B01L3/00
摘要： The present invention relates to a perfusion device for a method for evaluating the risk of thrombotic and hemorrhagic diseases linked to blood coagulation processes. In particular, the present invention relates to a cartridge (4) for conducting a dynamic "ex-vivo" evaluation method of the coagulation process in a subject's blood sample, comprising at least one perfusion chamber (105; 205; 305; 405, 405', 405"; 505), a well (27) for loading the blood sample and reagents, an inclined ascending microchannel (28) connecting the well (27) to a first end (105a, 205a, 305a, 405a, 505a) of the perfusion chamber (105; 205; 305; 405, 405', 405"; 505), and an inclined descending microchannel (29) placed at a second end (105b, 205b, 305b, 405b, 505b), wherein preferably at least one perfusion chamber (105; 205; 305; 405, 405', 405"; 505) comprises two half-channels (131, 132; 231, 232; 331, 332; 531, 532) of different width (d, D), placed in series or in parallel, or the cartridge (4) comprises at least two perfusion chambers (405, 405', 405") placed in parallel and wherein at least two of said perfusion chambers (405, 405', 405") have a different width (D, D', d").

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