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1. 发明申请

WO2017081542A2 COMPUTATIONAL MICROSCOPES AND METHODS FOR GENERATING AN IMAGE UNDER DIFFERENT ILLUMINATION CONDITIONS 审中-公开
标题翻译：计算显微镜及不同照明条件下生成图像的方法
公开(公告)号：WO2017081542A2
公开(公告)日：2017-05-18
申请号：PCT/IB2016/001725
申请日：2016-11-10
申请人： SCOPIO LAB LTD.
发明人： SMALL, Eran , LESHEM, Ben , MADAR, Ittay , NAAMAN, Erez , HAYUT, Itai
IPC分类号： G02B21/06 , G02B21/36 , G02B27/10 , G02B27/58 , G02B21/14
CPC分类号： G02B21/245
摘要： Systems and methods are disclosed for constructing an image of a sample using a plurality of images acquired under multiple illumination conditions. In one implementation, a microscope may include an image capture device, an illumination assembly, and a controller. The controller may cause the illumination assembly to illuminate the sample at a series of different illumination conditions. The controller may further acquire from image capture device a plurality of images of the sample, wherein the plurality of images includes at least one image for each illumination condition. The controller may also determine, from the at least one image, image data of the sample for each illumination condition. The controller may further generate, from the determined image data for each illumination condition and in a non-iterative process, a reconstructed image of the sample. The reconstructed image may have a second image resolution higher than the first image resolution.
摘要翻译：公开了使用在多个照明条件下获取的多个图像来构建样本的图像的系统和方法。在一个实施方式中，显微镜可以包括图像捕获装置，照明组件和控制器。控制器可以使照明组件在一系列不同的照明条件下照射样本。控制器还可以从图像捕获装置获取样本的多个图像，其中多个图像针对每个照明条件包括至少一个图像。控制器还可以从至少一个图像确定每个照明条件的样本的图像数据。控制器可以进一步从确定的每个照明条件的图像数据和非迭代过程中生成样本的重建图像。重建图像可能具有高于第一图像分辨率的第二图像分辨率。

2. 发明申请

WO2017081541A1 MICROSCOPE HAVING A REFRACTIVE INDEX MATCHING MATERIAL 审中-公开
标题翻译：具有折射率匹配材料的显微镜
公开(公告)号：WO2017081541A1
公开(公告)日：2017-05-18
申请号：PCT/IB2016/001715
申请日：2016-11-10
申请人： SCOPIO LAB LTD.
发明人： LESHEM, Ben , SMALL, Eran , MADAR, Ittay , NAAMAN, Erez , HAYUT, Itai
IPC分类号： G02B21/06 , G02B21/36 , G02B27/10 , G02B27/58
CPC分类号： G02B21/367 , G02B21/06 , G02B27/1066 , G02B27/58
摘要： A microscope includes an illumination assembly configured to illuminate a sample under two or more different illumination conditions, at least one image capture device configured to capture image information associated with the sample at each of the two or more different illumination conditions, at least one processing device programmed to generate an image of the sample based on a combination of image information captured at each of the two or more different illumination conditions, and at least one refractive index matching material between the illumination assembly and the sample. The refractive index matching material is different from a medium between the at least one image capture device and the sample.
摘要翻译：显微镜包括照明组件，该照明组件被配置为在两个或更多个不同的照明条件下照射样本，至少一个图像捕获设备被配置成捕获与在两个或更多个不同的照明条件中的每一个处的样本相关联的图像信息照明条件;至少一个处理装置，其被编程为基于在所述两个或更多个不同照明条件中的每一个处捕获的图像信息的组合来生成所述样本的图像;以及所述照明组件和所述样本之间的至少一种折射率匹配材料。折射率匹配材料不同于至少一个图像捕获装置和样品之间的介质。

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