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1. 发明申请

WO2005086836A3 ION CHANNEL MODULATORS 审中-公开
公开(公告)号：WO2005086836A3
公开(公告)日：2006-01-05
申请号：PCT/US2005007667
申请日：2005-03-07
申请人： SCION PHARMACEUTICALS INC , ZELLE ROBERT , GALULLO VINCENT P , BAKER CHRISTOPHER TODD , WILL PAUL , FRAZEE WILLIAM J , MAZDIYASNI HORMOZ , GUO JINSONG
发明人： ZELLE ROBERT , GALULLO VINCENT P , BAKER CHRISTOPHER TODD , WILL PAUL , FRAZEE WILLIAM J , MAZDIYASNI HORMOZ , GUO JINSONG
IPC分类号： C07D233/44 , C07D403/12
CPC分类号： C07D403/12 , C07D233/84 , C07D249/12 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/12
摘要： The invention relates to compounds, compositions comprising the compounds, and methods of using the compounds and compound compositions. The compounds, compositions, and methods described herein can be used for the therapeutic modulation of ion channel function, and treatment of disease and disease symptoms, particularly those mediated by certain calcium channel subtype targets.

2. 发明申请

WO2005086902A2 ION CHANNEL MODULATORS 审中-公开
公开(公告)号：WO2005086902A2
公开(公告)日：2005-09-22
申请号：PCT/US2005007913
申请日：2005-03-07
申请人： SCION PHARMACEUTICALS INC , ZELLE ROBERT , GALULLO VINCENT P
发明人： ZELLE ROBERT , GALULLO VINCENT P
CPC分类号： A61K31/4164 , A61K31/4178
摘要： The invention relates to compounds, compositions comprising the compounds, and methods of using the compounds and compound compositions. The compounds, compositions, and methods described herein can be used for the therapeutic modulation of ion channel function, and treatment of disease and disease symptoms, particularly those mediated by certain calcium channel subtype targets.

3. 发明申请

WO2005086892A3 ION CHANNEL MODULATORS 审中-公开
公开(公告)号：WO2005086892A3
公开(公告)日：2006-05-11
申请号：PCT/US2005007896
申请日：2005-03-07
申请人： SCION PHARMACEUTICALS INC , ZELLE ROBERT , GALULLO VINCENT P
发明人： ZELLE ROBERT , GALULLO VINCENT P
IPC分类号： A61K31/4164 , C07D233/04 , C07D233/42 , C07D401/12 , C07D403/12 , C07D413/12 , C07D417/12
CPC分类号： C07D233/42 , C07D233/84 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D413/12 , C07D417/06 , C07D417/12
摘要： The invention relates to compounds, compositions comprising the compounds, and methods of using the compounds and compound compositions. The compounds, compositions, and methods described herein can be used for the therapeutic modulation of ion channel function, and treatment of disease and disease symptoms, particularly those mediated by certain calcium channel subtype targets.

4. 发明申请

WO2005097112A3 ION CHANNEL MODULATORS 审中-公开
公开(公告)号：WO2005097112A3
公开(公告)日：2006-06-15
申请号：PCT/US2005007899
申请日：2005-03-07
申请人： SCION PHARMACEUTICALS INC , ZELLE ROBERT , GALULLO VINCENT P
发明人： ZELLE ROBERT , GALULLO VINCENT P
IPC分类号： A61K31/4196 , A61K31/4184 , C07D249/08 , C07D249/12 , C07D401/06 , C07D403/06 , C07D417/06
CPC分类号： C07D249/12 , C07D401/06 , C07D403/06 , C07D417/06
摘要： The invention relates to compounds, compositions comprising the compounds, and methods of using the compounds and compound compositions. The compounds, compositions, and methods described herein can be used for the therapeutic modulation of ion channel function, and treatment of disease and disease symptoms, particularly those mediated by certain calcium channel subtype targets.

5. 发明申请

WO2005086895A3 ION CHANNEL MODULATORS 审中-公开
标题翻译：离子通道调节剂
公开(公告)号：WO2005086895A3
公开(公告)日：2006-08-17
申请号：PCT/US2005007902
申请日：2005-03-07
申请人： WYETH CORP , ZELLE ROBERT , GALULLO VINCENT P , MAZDIYASNI HORMOZ
发明人： ZELLE ROBERT , GALULLO VINCENT P , MAZDIYASNI HORMOZ
IPC分类号： A61K31/4164 , A61K31/4166 , A61K31/4178 , C07D233/54 , C07D233/84 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/06 , C07D405/12 , C07D417/12 , C07D417/14
CPC分类号： C07D233/84 , A61K31/4164 , A61K31/4178 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/06 , C07D405/12 , C07D417/12 , C07D417/14
摘要： The invention relates to compounds, compositions comprising the compounds, and methods of using the compounds and compound compositions. The compounds, compositions, and methods described herein can be used for the therapeutic modulation of ion channel function, and treatment of disease and disease symptoms, particularly those mediated by certain calcium channel subtype targets.
摘要翻译：本发明涉及化合物，包含所述化合物的组合物，以及使用所述化合物和化合物组合物的方法。本文所述的化合物，组合物和方法可用于离子通道功能的治疗性调节，以及治疗疾病和疾病症状，特别是由某些钙通道亚型靶标介导的疾病和疾病症状。

6. 发明申请

WO2004072615A3 METHODS FOR IDENTIFYING ION CHANNEL MODULATORS 审中-公开
标题翻译：识别离子通道调制器的方法
公开(公告)号：WO2004072615A3
公开(公告)日：2007-05-31
申请号：PCT/US2004003780
申请日：2004-02-09
申请人： SCION PHARMACEUTICALS INC , ZELLE ROBERT , FRIDEN PHILLIP
发明人： ZELLE ROBERT , FRIDEN PHILLIP
IPC分类号： G01N33/53 , G01N20060101 , G01N33/68
CPC分类号： G01N33/6872
摘要： The methods described herein relate to the identification of ion channel modulators.
摘要翻译：本文所述的方法涉及离子通道调节剂的鉴定。

7. 发明申请

WO2004072255A3 METHODS OF TREATING DISEASE 审中-公开
标题翻译：治疗疾病的方法
公开(公告)号：WO2004072255A3
公开(公告)日：2004-11-25
申请号：PCT/US2004003779
申请日：2004-02-09
申请人： SCION PHARMACEUTICALS INC , ZELLE ROBERT
发明人： ZELLE ROBERT
IPC分类号： A61K31/155 , C12N20060101
CPC分类号： A61K31/155
摘要： The invention relates to substituted-guanidinyl compounds, compositions comprising the compounds, and methods of using the compounds and compound compositions. The compounds, compositions, and methods described herein can be used for the therapeutic modulation of ion channel function, and treatment of disease and disease symptoms, particularly those mediated by certain calcium channel subtype targets.
摘要翻译：本发明涉及取代的胍基化合物，包含所述化合物的组合物，以及使用所述化合物和化合物组合物的方法。本文所述的化合物，组合物和方法可用于离子通道功能的治疗性调节，以及治疗疾病和疾病症状，特别是由某些钙通道亚型靶标介导的疾病和疾病症状。

8. 发明申请

WO2004071433A3 METHODS OF TREATING DISEASE 审中-公开
公开(公告)号：WO2004071433A3
公开(公告)日：2004-11-25
申请号：PCT/US2004003635
申请日：2004-02-09
申请人： SCION PHARMACEUTICALS INC , ZELLE ROBERT
发明人： ZELLE ROBERT
IPC分类号： A61K20060101 , A61K31/155 , A61K31/44
CPC分类号： A61K31/155 , A61K31/44
摘要： The invention relates to substituted-guanidinyl compounds, compositions comprising the compounds, and methods of using the compounds and compound compositions. The compounds, compositions, and methods described herein can be used for the therapeutic modulation of ion channel function, and treatment of disease and disease symptoms, particularly those mediated by certain calcium channel subtype targets.

9. 发明申请

WO2007120621A2 NONEL 1,2,3,4-TETRAHYDROQUINOLINE DERIVATIVES 审中-公开
标题翻译： NONEL 1,2,3,4-四氢喹啉衍生物
公开(公告)号：WO2007120621A2
公开(公告)日：2007-10-25
申请号：PCT/US2007008781
申请日：2007-04-11
申请人： CONCERT PHARMACEUTICALS INC , TUNG ROGER , ZELLE ROBERT
发明人： TUNG ROGER , ZELLE ROBERT
IPC分类号： A61K31/4706
CPC分类号： C07D215/42 , Y10T436/10
摘要： The present invention relates to a novel derivative of Compound 1 selectively substituted with fluorine and/or deuterium and optionally further substituted with deuterium and 13 C elsewhere in the molecule. The compounds of this invention are cholesterol esterase transfer protein inhibitors and possess unique biopharmaceutical and pharmacokinetic properties compared to Compound 1. They may also be used to accurately determine the concentration of Compound 1 in biological fluids and tissues and to determine metabolic patterns of Compound 1 and its isotopologues. The invention further provides compositions comprising these compounds and methods of treating diseases and conditions that are responsive to inhibition of cholesterol esterase transfer protein, alone and in combination with additional agents.
摘要翻译：本发明涉及化合物1的新型衍生物，其选择性地被氟和/或氘取代并任选进一步被分子中其他地方的氘和13 C取代。本发明的化合物是胆固醇酯酶转移蛋白抑制剂，与化合物1相比具有独特的生物药物和药代动力学特性。它们还可用于准确测定化合物1在生物流体和组织中的浓度，并确定化合物1和其同位素学。本发明进一步提供了包含这些化合物的组合物以及治疗单独和与其它试剂组合对胆固醇酯酶转移蛋白的抑制有反应的疾病和病症的方法。

10. 发明申请

WO2008073461A3 ION CHANNEL MODULATORS 审中-公开
标题翻译：离子通道调制器
公开(公告)号：WO2008073461A3
公开(公告)日：2008-09-12
申请号：PCT/US2007025416
申请日：2007-12-11
申请人： WYETH CORP , GALULLO VINCENT , ZELLE ROBERT , MAZDIYASNI HORMOZ , BAKER CHRISTOPHER TODD , WILL PAUL , GUO JINSONG , FENSOME ANDREW , SOENEN DANIELLE , KERN JEFFREY CURTIS , MOORE WILLIAM JAY , MELENSKI EDWARD GEORGE , KAPLAN JUSTIN , SABATUCCI JOSEPH PETER
发明人： GALULLO VINCENT , ZELLE ROBERT , MAZDIYASNI HORMOZ , BAKER CHRISTOPHER TODD , WILL PAUL , GUO JINSONG , FENSOME ANDREW , SOENEN DANIELLE , KERN JEFFREY CURTIS , MOORE WILLIAM JAY , MELENSKI EDWARD GEORGE , KAPLAN JUSTIN , SABATUCCI JOSEPH PETER
IPC分类号： C07D207/34 , C07D233/90 , C07D249/04 , C07D277/56 , C07D307/68 , C07D307/71 , C07D333/70 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D417/12
CPC分类号： C07D417/12 , C07D207/34 , C07D233/90 , C07D249/04 , C07D277/56 , C07D307/68 , C07D307/71 , C07D333/70 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D417/14
摘要： The present teachings provide carboxylic amide compounds that can modulate the activity of ion channels in a mammal. The present teachings also provide processes for producing said compounds and their pharmaceutically acceptable salts, hydrates and esters, and methods of treating a pathological condition or disorder, or alleviating a symptom thereof, using said compounds including their pharmaceutically acceptable salts, hydrates and esters. The compounds can be useful in modulating ion channel activity including treating a variety of conditions associated with the abnormal modulation of one or more voltage-gated calcium channels.
摘要翻译：本发明提供可调节哺乳动物中离子通道活性的羧酰胺化合物。本教导还提供使用所述化合物，包括其药学上可接受的盐，水合物和酯来制备所述化合物及其药学上可接受的盐，水合物和酯的方法，以及治疗病理状况或病症或减轻其症状的方法。该化合物可用于调节离子通道活性，包括治疗与一个或多个电压门控钙通道的异常调节相关的多种病症。

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