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1. 发明申请

WO2005004946A1 MEDICAL DEVICES AND METHODS FOR INHIBITING SMOOTH MUSCLE CELL PROLIFERATION 审中-公开
标题翻译：用于抑制平滑肌细胞增殖的医学装置和方法
公开(公告)号：WO2005004946A1
公开(公告)日：2005-01-20
申请号：PCT/US2004/021079
申请日：2004-06-30
申请人： SCIMED LIFE SYSTEMS, INC. , HERRMANN, Robert, A. , BARRY, James, J. , KAMATH, Kalpana, R.
发明人： HERRMANN, Robert, A. , BARRY, James, J. , KAMATH, Kalpana, R.
IPC分类号： A61L31/18
CPC分类号： A61L31/10 , A61L31/16 , A61L2300/416
摘要： The present invention relates generally to medical devices, preferably a stent, comprising an amount of one or more therapeutic agents, preferably paclitaxel, useful for preventing or treating a disease or condition associated with cell proliferation and/or migration. In particular, the invention relates to medical devices that is capable of releasing a cytostatic amount of paclitaxel that is effective to arrest smooth muscle cells in their G1/S phase without killing the cells. The medical devices can also release paclitaxel at a predetermined rate. Methods of making and using the medical devices are also provided.
摘要翻译：本发明一般涉及可用于预防或治疗与细胞增殖和/或迁移相关的疾病或病症的量的一种或多种治疗剂，优选紫杉醇的医疗装置，优选支架。特别地，本发明涉及能够释放细胞抑制量的紫杉醇的医疗装置，其有效地在G1 / S期抑制平滑肌细胞而不杀死细胞。医疗装置也可以以预定的速率释放紫杉醇。还提供了制造和使用医疗装置的方法。

2. 发明申请

WO2004006942A1 METHOD FOR SUSTAINING DIRECT CELL DELIVERY 审中-公开
标题翻译：用于维持直接单元交付的方法
公开(公告)号：WO2004006942A1
公开(公告)日：2004-01-22
申请号：PCT/US2003/021421
申请日：2003-07-09
申请人： SCIMED LIFE SYSTEMS, INC.
发明人： PALASIS, Maria , BARRY, James, J. , ROSENTHAL, Arthur
IPC分类号： A61K35/12
CPC分类号： A61K47/32 , A61K9/0019 , A61K35/12 , A61K47/34 , A61K47/36
摘要： The present invention provides a method of sustaining direct delivery of cells into a target area. The method generally includes delivering cells to a target area. Specifically, the cells are introduced through an introduction site of a target area and delivered to the target area. The method further includes depositing at the introduction site, a plug member that contains a therapeutic agent generally acts to increase intracellular coupling between the grafted cells and the target area. The plug member also acts to seal the introduction site to inhibit cells from leaking from the introduction site into surrounding areas of the body.
摘要翻译：本发明提供一种维持将细胞直接递送到目标区域中的方法。该方法通常包括将细胞递送到目标区域。具体地，通过目标区域的引入位点引入单元并将其输送到目标区域。该方法还包括在引入位置沉积含有治疗剂的栓塞构件通常用于增加移植细胞与靶区域之间的胞内偶联。插塞构件还用于密封引入部位以抑制细胞从引入部位泄漏到身体的周围区域。

3. 发明申请

WO2002087651A1 METHOD AND SYSTEM FOR DELIVERY OF COATED IMPLANTS 审中-公开
标题翻译：用于输送涂层植入物的方法和系统
公开(公告)号：WO2002087651A1
公开(公告)日：2002-11-07
申请号：PCT/US2002/008649
申请日：2002-03-22
申请人： SCIMED LIFE SYSTEMS, INC.
发明人： BARRY, James, J. , GILLIGAN, Sean
IPC分类号： A61L29/08
CPC分类号： A61F2/82 , A61F2210/0004 , A61F2250/0067 , A61L29/085 , A61L29/14
摘要： Method and system for delivery of coated implants is provided. One embodiment encompasses a coated implant delivery system. This system includes an implant delivery device having a first end, a second end, and an inner lumen, wherein the first end has a releasable implant retention region with an accessible surface having a coated implant adhesion-resistant treatment. In another embodiment a method of deploying a coated releasable implant at a target site of a vessel using an implant delivery system is provided. This method includes inserting a portion of an implant delivery device having a releasable implant into the vessel, advancing the implant delivery device to the target site, deploying the releasable implant from the delivery device, and withdrawing the inserted portion of the implant delivery device from the vessel. The implant delivery device in this embodiment has a releasable implant retention region with an accessible surface having a coated implant adhesion-resistant treatment and wherein the releasable implant has a first coating that faces the accessible surface of the releasable implant retention region.
摘要翻译：提供了用于递送涂覆植入物的方法和系统。一个实施方案包括涂覆的植入物递送系统。该系统包括具有第一端，第二端和内腔的植入物递送装置，其中第一端具有可释放的植入物保持区域，其具有可涂覆的植入物耐粘附处理的可接近表面。在另一个实施方案中，提供了使用植入物递送系统在容器的靶位点部署涂覆的可释放植入物的方法。该方法包括将具有可释放植入物的植入物递送装置的一部分插入到容器中，将植入物递送装置推进到目标部位，将可释放植入物从输送装置展开，以及将植入物递送装置的插入部分从船只。该实施例中的植入物递送装置具有可释放的植入物保留区域，其具有可涂覆的植入物耐粘附处理的可触及表面，并且其中可释放植入物具有面向可释放植入物保留区域的可接近表面的第一涂层。

4. 发明申请

WO2003035135A1 OPTIMIZED DOSING FOR DRUG COATED STENTS 审中-公开
标题翻译：用于药物涂层的优化剂量
公开(公告)号：WO2003035135A1
公开(公告)日：2003-05-01
申请号：PCT/US2002/030193
申请日：2002-09-24
申请人： SCIMED LIFE SYSTEMS, INC.
发明人： BARRY, James, J. , KAMATH, Kalpana, R.
IPC分类号： A61L31/16
CPC分类号： A61L31/16
摘要： The inventors have found that both the drug dose and drug release profiles are significant factors for the safety and efficacy of drug coated stents. The inventors have identified optimum dosing and release kinetics for drug coated stents. In particular, the inventors have determined dosing and release kinetics that permit the delivery of the lowest effective drug dosage, thus enhancing patient safety and minimizing any side effects from the drug.
摘要翻译：本发明人已经发现药物剂量和药物释放曲线都是药物涂层支架的安全性和有效性的重要因素。本发明人确定了药物涂层支架的最佳剂量和释放动力学。特别地，本发明人已经确定了允许递送最低有效药物剂量的剂量和释放动力学，从而增强患者的安全性并使药物的任何副作用最小化。

5. 发明申请

WO2003008005A2 CATHETER AND IMPLANTS FOR THE DELIVERY OF THERAPEUTIC AGENTS TO TISSUES 审中-公开
标题翻译：输送治疗药物到组织的导管和植入物
公开(公告)号：WO2003008005A2
公开(公告)日：2003-01-30
申请号：PCT/US2001/042994
申请日：2001-11-07
申请人： SCIMED LIFE SYSTEMS, INC.
发明人： PALASIS, Maria , BARRY, James, J. , ELLIS, Louis , HENDRICKSON, Gary, L. , HARRISON, Kent, D. , WANG, Lixiao
IPC分类号： A61L27/00
CPC分类号： A61L29/16 , A61L2300/258 , A61L2300/414 , A61L2300/416 , A61L2300/64 , A61M25/0084 , A61M37/0069 , A61M2025/0089
摘要： A catheter is provided for delivering implants including therapeutic agents to tissues. The catheter is advancable intra-luminally to place the implants. In one embodiment, the implants include a liquid carrier and therapeutic agent for infusion into the tissue. In another embodiment, a solid carrier includes the therapeutic agent. In yet another embodiment, the implant is formed in situ.
摘要翻译：提供了用于将包括治疗剂的植入物输送到组织的导管。导管在内部发光前进以放置植入物。在一个实施例中，植入物包括用于输注到组织中的液体载体和治疗剂。在另一个实施方案中，固体载体包含治疗剂。在又一个实施例中，植入物就地形成。

6. 发明申请

WO2006053159A2 MEDICAL DEVICE FOR DELIVERING BIOLOGICALLY ACTIVE MATERIAL 审中-公开
标题翻译：提供生物活性物质的医疗设备
公开(公告)号：WO2006053159A2
公开(公告)日：2006-05-18
申请号：PCT/US2005/040822
申请日：2005-11-08
申请人： BOSTON SCIENTIFIC SCIMED, INC. , ROSENTHAL, Arthur , BARRY, James, J. , MILLER, Matthew
发明人： ROSENTHAL, Arthur , BARRY, James, J. , MILLER, Matthew
IPC分类号： A61L27/00 , A61F2/00 , A61F2/90 , A61K31/337 , A61K31/436 , A61K31/517 , A61K31/573 , A61K38/00
CPC分类号： A61F2/90 , A61F2/91 , A61F2/915 , A61F2002/91525 , A61F2002/91533 , A61F2002/91575 , A61F2250/0014 , A61F2250/0067 , A61L31/16 , A61L31/18 , A61L2300/00
摘要： This invention relates generally to medical devices, such as stents, for delivering a biologically active material to a desired location within the body of a patient. In particular, the invention relates generally to a medical device for delivering a biologically active material to a surface of a body lumen. More particularly, the invention is directed to a medical device comprising two opposing end sections, each having a surface, and a middle portion. The middle portion comprises a plurality of struts and the two opposing end sections comprises non-structural elements. The end sections of the surface either (1) contain a greater amount of a biologically active material per unit length of the surface or (2) have a greater capacity per unit length to contain such material than the middle section of the surface than the middle section. The struts and the non-structural elements comprise biologically active material to the body tissue of a patient by inserting this medical device into the body of the patient. Still further, the invention is directed to a method of treating a body lumen surface by preventing or treating restenosis or hyperplasia, using the system of the invention. Still further, the invention is directed to a stent having a sidewall which comprises a middle section, a first end section and a second end section. The stent also comprises a band comprising a biologically active material. The band is connected to the first end section and/or second end section of the stent.
摘要翻译：本发明一般涉及用于将生物活性物质递送至患者体内期望位置的医疗装置，例如支架。具体而言，本发明总体上涉及用于将生物活性物质递送至体腔表面的医疗装置。更具体地说，本发明涉及一种医疗装置，其包括两个相对的端部部分，每个端部部分具有表面和中间部分。中间部分包括多个支柱，并且两个相对的端部部分包括非结构元件。表面的末端部分（1）每单位长度的表面包含更大量的生物活性材料或者（2）每单位长度具有更大的容量以容纳除表面的中间部分之外的材料比中间部分部分。通过将该医疗装置插入患者体内，支柱和非结构元件包括生物活性物质到患者的身体组织。另外，本发明涉及使用本发明的系统通过预防或治疗再狭窄或增生来治疗体腔表面的方法。更进一步，本发明涉及一种具有侧壁的支架，该侧壁包括中间部分，第一末端部分和第二末端部分。支架还包含含有生物活性物质的带。带被连接到支架的第一端部和/或第二端部。

7. 发明申请

WO2006006963A2 AEROSOL DELIVERY SYSTEMS AND METHODS 审中-公开
标题翻译：航空运输系统和方法
公开(公告)号：WO2006006963A2
公开(公告)日：2006-01-19
申请号：PCT/US2005/011086
申请日：2005-04-01
申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES, CENTERS FOR DISEASE CONTROL AND PREVENTION , CREARE INCORPORATED , PAPANIA, Mark, J. , BARRY, James, J. , BAGLEY, Mark, C. , ELKOUH, Nabil, A. , KNAUS, Darin , TRABKA, Robert
发明人： PAPANIA, Mark, J. , BARRY, James, J. , BAGLEY, Mark, C. , ELKOUH, Nabil, A. , KNAUS, Darin , TRABKA, Robert
IPC分类号： A61M11/00
CPC分类号： B05B17/0638 , A61M15/0033 , A61M15/0065 , A61M15/0085 , A61M2205/07 , A61M2205/3306 , A61M2205/825 , B05B12/008 , B05B12/082 , B05B17/0623 , B05B17/0676
摘要： Methods and systems for aerosol delivery of agents to a patient are described herein. The present system can be used to administer various types of agents, such as a vaccine or other types of pharmaceutical substances. Certain embodiments of the present system utilize an actuator coupled to a disposable aerosolizing element that aerosolizes an agent for delivery to a patient when acted upon by the actuator. The aerosolizing element prevents the agent from contacting the actuator and other non-disposable components of the system so that little or no cleaning or maintenance is required. The present system also can include an aerosolization rate monitor that monitors the rate at which an agent is being aerosolized and provides feedback to the user to ensure that the proper dose is being administered.
摘要翻译：本文描述了将药剂气雾剂递送至患者的方法和系统。本系统可用于施用各种类型的试剂，例如疫苗或其他类型的药物。本系统的某些实施例利用联接到一次性雾化元件的致动器，其在由致动器作用时使药剂雾化以递送给患者。雾化元件防止试剂与系统的致动器和其他非一次性部件接触，从而不需要或不需要清洁或维护。本系统还可以包括气雾化速率监测器，其监测试剂被雾化的速率，并向使用者提供反馈以确保施用适当的剂量。

8. 发明申请

WO2004069303A2 FLUID EJECTION SYSTEM 审中-公开
标题翻译：流体喷射系统
公开(公告)号：WO2004069303A2
公开(公告)日：2004-08-19
申请号：PCT/US2004/002884
申请日：2004-02-02
申请人： CREARE INC. , BARRY, James, J. , BAGLEY, Mark, C. , BURGHARDT, Peter, L. , FULTON, Steven, J.
发明人： BARRY, James, J. , BAGLEY, Mark, C. , BURGHARDT, Peter, L. , FULTON, Steven, J.
IPC分类号： A61M
CPC分类号： A61M5/30 , A61M5/204 , A61M5/286 , A61M5/31596 , A61M2005/312 , A61M2005/3128 , A61M2005/31598
摘要： A fluid ejection system (20) comprising a cartridge (24), an ejector (32, 300) and, optionally, a fill station (28) for filling the cartridge with a fluid, such as a vaccine. In some embodiments (52), the cartridge includes a transfer passageway (96) for receiving fluid from the fill station. In other embodiments (200, 400), the cartridge includes a vented fluid reservoir (208, 408) offset from an ejection chamber (224, 420). In yet other embodiments (500, 600), the cartridge includes a vented fluid reservoir chamber (512, 636) inline with the ejection chamber (508, 644). In still other embodiments (700, 1000, 1100), the cartridge includes first and second chambers (728, 736, 1036, 1048, 1136, 1148) initially fluidly sealed from on another by a valve, e.g., either a traveling valve (704, 800, 900, 1200, 1300) or a temporarily stationary valve (1004, 1104).
摘要翻译：流体喷射系统（20），其包括筒（24），喷射器（32,300）和可选地用于用诸如疫苗的流体填充盒的填充站（28）。在一些实施例（52）中，盒包括用于从填充站接收流体的传送通道（96）。在其他实施例（200,400）中，该盒包括从喷射室（224,420）偏移的排出的流体储存器（208,408）。在其它实施例（500,600）中，该盒包括与喷射室（508,644）成直线的通气的流体储存室（512,636）。在另外的其它实施例（700,1000,1100）中，盒包括首先和第二腔室（728,736,1036,1048,1136,1148），其通过阀例如流动阀（704），800,900,1200,1300）或临时固定的阀（1004,1104）。

9. 发明申请

WO2011153406A2 NASAL AEROSOL DELIVERY SYSTEM 审中-公开
标题翻译： NASAL AEROSOL交付系统
公开(公告)号：WO2011153406A2
公开(公告)日：2011-12-08
申请号：PCT/US2011/039020
申请日：2011-06-03
申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by THE SECRETARY OF HEALTH AND HUMAN SERVICES, CENTERS FOR DISEASE CONTROL AND PREVENTION , CREARE, INCORPORATED , PAPANIA, Mark, J. , BARRY, James, J. , BAGLEY, Mark, C. , FRIETS, Eric, M. , KNAUS, Darin, A.
发明人： PAPANIA, Mark, J. , BARRY, James, J. , BAGLEY, Mark, C. , FRIETS, Eric, M. , KNAUS, Darin, A.
IPC分类号： A61M15/08
CPC分类号： A61B1/233 , A61B1/00045 , A61B1/04 , A61B1/06 , A61M11/00 , A61M11/005 , A61M11/006 , A61M11/007 , A61M15/0098 , A61M15/08 , A61M16/0488 , A61M16/107 , A61M31/00 , A61M2016/0024 , A61M2016/0042 , A61M2205/3365 , A61M2205/3375 , A61M2205/43 , A61M2205/502 , A61M2205/581 , A61M2205/6036 , A61M2205/6054 , A61M2205/6063
摘要： A nasal delivery device can include a nasal prong and an activation member. The nasal prong can comprises an opening at a top and bottom portion of the prong to allow for the passage of an aerosolized treatment agent through the nasal prong. The activation member can be positioned on the nasal delivery device at a location that is spaced apart from the subject's oral cavity when the nasal prong is received into the nostril of the subject. The activation member can be configured to detect a desired exhalation state of the subject and upon detection of the desired exhalation state, the activation member activates the delivery of the aerosolized treatment agent.
摘要翻译：鼻输送装置可以包括鼻针和激活构件。鼻插管可以包括在插脚的顶部和底部的开口，以允许雾化处理剂通过鼻插管。当鼻塞被插入到受试者的鼻孔中时，激活构件可以在与受试者的口腔间隔开的位置处定位在鼻输送装置上。激活构件可以被配置为检测对象的期望呼气状态，并且在检测到所需的呼气状态时，激活构件激活雾化处理剂的输送。

10. 发明申请

WO2006044038A1 SYSTEM AND METHOD FOR DELIVERING A BIOLOGICALLY ACTIVE MATERIAL TO A BODY LUMEN 审中-公开
标题翻译：将生物活性材料递送到身体的系统和方法
公开(公告)号：WO2006044038A1
公开(公告)日：2006-04-27
申请号：PCT/US2005/030893
申请日：2005-08-30
申请人： BOSTON SCIENTIFIC SCIMED, INC. , ROSENTHAL, Arthur, L. , BARRY, James, J.
发明人： ROSENTHAL, Arthur, L. , BARRY, James, J.
IPC分类号： A61F2/06
CPC分类号： A61F2/958 , A61F2250/0067
摘要： A medical device system that is insertable in a body lumen for treating and/or preventing injury to a body lumen wall is disclosed. The system comprises a stent comprising a sidewall having a first edge and a second edge, and a balloon capable of being disposed within the sidewall. The balloon has a first end portion that is capable of contacting the first edge of the sidewall and a second end portion that is capable of contacting the second edge of the sidewall when the balloon is expanded. At least the first end portion of the balloon comprises a first biologically active material. When the balloon is expanded, the first end portion of the balloon extends axially beyond the first edge of the sidewall in order to deliver the first biologically active material to a portion of the body lumen wall that is adjacent to the first edge of the sidewal.l. Methods for deploying the system are also disclosed.
摘要翻译：公开了一种能够插入到体腔中用于治疗和/或预防对体腔壁的损伤的医疗装置系统。该系统包括支架，其包括具有第一边缘和第二边缘的侧壁以及能够设置在侧壁内的气囊。球囊具有能够接触侧壁的第一边缘的第一端部部分和当气囊膨胀时能够接触侧壁的第二边缘的第二端部部分。至少球囊的第一端部包括第一生物活性物质。当球囊膨胀时，球囊的第一端部部分轴向地延伸超过侧壁的第一边缘，以便将第一生物活性材料递送到与侧翼的第一边缘相邻的身体腔壁的一部分。湖还公开了部署系统的方法。

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