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1. 发明申请

WO2003084583A2 PROCESSES FOR PRODUCING POLYMER COATINGS THROUGH SURFACE POLYMERIZATION 审中-公开
标题翻译：通过表面聚合制备聚合物涂料的方法
公开(公告)号：WO2003084583A2
公开(公告)日：2003-10-16
申请号：PCT/US2003/010338
申请日：2003-04-04
申请人： SCIMED LIFE SYSTEMS, INC.
发明人： HERRMANN, Robert, A. , STRICKLER, Frederick, H. , NAIMARK, Wendy , DAYTON, Peter, L.
IPC分类号： A61L31/00
CPC分类号： A61L31/10 , A61L31/16 , A61L2300/606
摘要： A medical device with a therapeutic agent-releasing polymer coating. The medical device is provided by a method that comprises: (a) attaching at least one reactive species to a medical device surface, which reactive species leads to chain growth polymerization in the presence of monomer; (b) contacting the reactive species with at least one monomer species, thereby forming a polymer coating on the surface of the medical device; and (c) providing at least one therapeutic agent within the polymer coating. The therapeutic agent may be incorporated during formation of the polymer coating or after formation of the polymer coating. The at least one reactive species can comprise, for example, a free radical species, a carbanion species, a carbocation species, a Ziegler-Natta polymerization complex, a metallocene complex, and/or an atom transfer radical polymerization initiator. Alternatively, the medical device is provided by a process comprising: (a) immobilizing least one polymerization catalyst at a medical device surface, which polymerization catalyst leads to polymerization in the presence of monomer; (b) contacting the medical device surface with at least one monomer species, thereby forming a polymer coating at the surface of the medical device; and (c) providing at least one therapeutic agent within the polymer coating.
摘要翻译：具有治疗剂释放聚合物涂层的医疗装置。该医疗装置由一种方法提供，该方法包括：（a）将至少一种反应性物质附着到医疗器械表面上，该反应性物质在单体存在下导致链增长聚合; （b）使反应性物质与至少一种单体物质接触，从而在医疗装置的表面上形成聚合物涂层; 和（c）在聚合物涂层内提供至少一种治疗剂。治疗剂可以在形成聚合物涂层期间或在形成聚合物涂层之后引入。至少一种反应性物质可以包括例如自由基物质，碳负离子物质，碳阳离子物质，齐格勒 - 纳塔聚合配合物，茂金属络合物和/或原子转移自由基聚合引发剂。或者，医疗装置由包括以下步骤的方法提供：（a）在医疗器械表面固定最少一种聚合催化剂，该聚合催化剂在单体存在下导致聚合; （b）使医疗器械表面与至少一种单体物质接触，从而在医疗装置的表面形成聚合物涂层; 和（c）在聚合物涂层内提供至少一种治疗剂。

2. 发明申请

WO2003084583A3 PROCESSES FOR PRODUCING POLYMER COATING THROUGH SURFACE POLYMERIZATION 审中-公开
公开(公告)号：WO2003084583A3
公开(公告)日：2003-10-16
申请号：PCT/US2003/010338
申请日：2003-04-04
申请人： SCIMED LIFE SYSTEMS, INC.
发明人： HERRMANN, Robert, A. , STRICKLER, Frederick, H. , NAIMARK, Wendy , DAYTON, Peter, L.
IPC分类号： A61L31/16
摘要： A medical device with a therapeutic agent-releasing polymer coating. The medical device is provided by a method that comprises: (a) attaching at least one reactive species to a medical device surface, which reactive species leads to chain growth polymerization in the presence of monomer; (b) contacting the reactive species with at least one monomer species, thereby forming a polymer coating on the surface of the medical device; and (c) providing at least one therapeutic agent within the polymer coating. The therapeutic agent may be incorporated during formation of the polymer coating or after formation of the polymer coating. The at least one reactive species can comprise, for example, a free radical species, a carbanion species, a carbocation species, a Ziegler-Natta polymerization complex, a metallocene complex, and/or an atom transfer radical polymerization initiator. Alternatively, the medical device is provided by a process comprising: (a) immobilizing least one polymerization catalyst at a medical device surface, which polymerization catalyst leads to polymerization in the presence of monomer; (b) contacting the medical device surface with at least one monomer species, thereby forming a polymer coating at the surface of the medical device; and (c) providing at least one therapeutic agent within the polymer coating.

3. 发明申请

WO2003066119A1 IMPLANTABLE OR INSERTABLE MEDICAL DEVICE RESISTANT TO MICROBIAL-GROWTH AND BIOFILM FORMATION 审中-公开
标题翻译：可植入或不可剥离的医疗器械抵抗微生物生长和生物膜形成
公开(公告)号：WO2003066119A1
公开(公告)日：2003-08-14
申请号：PCT/US2003/003624
申请日：2003-02-07
申请人： SCIMED LIFE SYSTEMS, INC.
发明人： MILLER, Kathleen, M. , SYDNEY, Gregory, T. , GEITZ, Kurt , DAYTON, Peter, L. , SAHATJIAN, Ronald, A.
IPC分类号： A61L27/36
CPC分类号： A61L2/232 , A61L29/16 , A61L31/16 , A61L2300/202 , A61L2300/206 , A61L2300/21 , A61L2300/404 , A61L2300/45 , Y10T428/1334 , Y10T428/1352 , Y10T428/1372 , Y10T428/1379 , Y10T428/1386 , Y10T428/1393
摘要： Disclosed are implantable or insertable medical devices that provide resistance to microbial growth on and in the environment of the device and resistance to microbial adhesion and biofilm formation on the device. In particular, the invention discloses implantable or insertable medical devices that comprise at least one biocompatible matrix polymer region, an antimicrobial agent for providing resistance to microbial growth and a microbial adhesion/biofilm synthesis inhibitor for inhibiting the attachment of microbes and the synthesis and accumulation of biofilm on the surface of the medical device. Also disclosed are methods of manufacturing such devices under conditions that substantially prevent preferential partitioning of any of said bioactive agents to a surface of the biocompatible matrix polymer and substantially prevent chemical modification of said bioactive agents.
摘要翻译：公开了可植入或可插入的医疗装置，其在装置的环境和环境中提供对微生物生长的抵抗力，并且抵抗微生物附着和在装置上的生物膜形成。特别地，本发明公开了可植入或可插入的医疗装置，其包括至少一个生物相容性基质聚合物区域，用于提供对微生物生长的抗性的抗微生物剂和用于抑制微生物附着的微生物粘附/生物膜合成抑制剂以及合成和积累生物膜在医疗器械的表面上。还公开了在基本上防止任何所述生物活性剂优先分配到生物相容性基质聚合物的表面并基本上防止所述生物活性剂的化学修饰的条件下制造这种装置的方法。

4. 发明申请

WO2004037309A1 COEXTRUDED MULTILAYER MEDICAL DEVICE COMPRISING POLYESTER, POLYAMIDE AND ADHESIVE MATERIAL LAYERS 审中-公开
标题翻译：包含聚酯，聚酰胺和粘合材料层的多层医用设备
公开(公告)号：WO2004037309A1
公开(公告)日：2004-05-06
申请号：PCT/US2003/020861
申请日：2003-07-01
申请人： SCIMED LIFE SYSTEMS, INC.
发明人： ST. PIERRE, Ernest, J. , SAHATJIAN, Ronald, A. , DAYTON, Peter, L. , VAFIADES, David
IPC分类号： A61L29/12
CPC分类号： A61M25/1029 , A61L29/085 , A61L29/126 , A61M2025/1075 , B29C47/0023 , B29C47/0026 , B29C47/065 , B29C47/26 , B29C47/261 , B29C47/263 , B29C47/28 , B29C47/56 , B29C47/8815 , B29C47/8835 , B29C47/8895 , B29C2035/1616 , B29C2793/009 , B29K2067/00 , B29K2077/00 , B29K2105/0085 , B29L2031/7542 , B32B7/10
摘要： Multilayer medical devices, apparatuses for making such devices, and methods of making such devices are disclosed.
摘要翻译：公开了多层医疗装置，制造这种装置的装置以及制造这种装置的方法。

5. 发明申请

WO2003094793A1 DEVICE FOR PROVIDING FULL PROTECTION TO A STENT 审中-公开
标题翻译：提供充分保护的装置
公开(公告)号：WO2003094793A1
公开(公告)日：2003-11-20
申请号：PCT/US2003/011636
申请日：2003-04-14
申请人： SCIMED LIFE SYSTEMS, INC.
发明人： STENZEL, Eric, B. , SAHATIJIAN, Ronald, A. , ZHONG, Sheng-Ping , DAO, Kinh-Luan , DAYTON, Peter, L. , KALASHIAN, Daniel, J. , CHIEN, Thomas, Yung-Hui , GRIFFIN, Stephen
IPC分类号： A61F2/06
CPC分类号： A61F2/958 , A61F2/95 , A61F2/97 , A61F2002/9505 , A61F2002/9511 , A61F2002/9583 , A61F2210/0004 , A61F2210/0023
摘要： A catheter (10) comprises a catheter shaft (18), at least a portion of which defines a medical device receiving region (22), and at least one sleeve (12, 14). The at least one sleeve comprises a tubular member (50, 51) constructed and arranged to transition between an extended state and a retracted state. The tubular member has a first portion being engaged to a portion of the catheter shaft adjacent to the medical device receiving region. In the extended state a second portion is constructed and arranged to at least partially overlay the medical device receiving region. In the retraced state the second portion is removed from about the medical device receiving region. At least one of the first portion and the second portion of the tubular member are at least partially constructed from a shape memory material.
摘要翻译：导管（10）包括导管轴（18），其至少一部分限定医疗装置接收区域（22）和至少一个套筒（12,14）。所述至少一个套筒包括构造和布置成在延伸状态和缩回状态之间转变的管状构件（50,51）。管状构件具有与导管轴的与医疗装置接收区域相邻的部分接合的第一部分。在延伸状态下，第二部分被构造和布置成至少部分地覆盖医疗装置接收区域。在回退状态下，第二部分从医疗装置接收区域周围移除。管状构件的第一部分和第二部分中的至少一个至少部分地由形状记忆材料构成。

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